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Gender-linked haematopoietic and metabolic disturbances induced by a pesticide mixture administered at low dose to mice.

Abstract：

:Defining the impact on health of exposure to a low-dose pesticide mixture via food intake is a topical question since epidemiological studies suggest that this may increase the risk of pathologies and particularly haematopoietic malignancies. Here we investigated on the haematopoietic system of mice, the effect of a mixture of six pesticides frequently ingested through the intake of fruits and vegetables produced in France (alachlor, captan, diazinon, endosulfan, maneb, mancozeb). The mixture was administered repeatedly by gavage to mice for 4 weeks at levels derived from the human Acceptable Daily Intake (ADI) level adapted to the mean weight of mice. Using a NMR-based metabonomic approach, we show that this treatment led to specific gender-linked variations in the level of hepatic metabolites involved in oxidative stress and in the regulation of glucose metabolism, indicating a metabolic signature for this repeated administration. Interestingly, exposure to the low-dose pesticide mixture induced significant changes in the blood cell counts with modifications in the clonogenic and differentiating capacities of haematopoietic progenitors showing abnormalities in the granulocytic and monocytic lineages in female and male mice, respectively. From a molecular point of view, the changes induced by the pesticide treatment correlated with modifications of the PI 3-kinase/Akt signalling pathway, the tyrosine kinase Pyk2 and the c-Myc transcription factor, which are involved in the balance between self-renewal and differentiation of haematopoietic stem cells. Our results point to a significant effect of a very low dose of a mixture of commonly used pesticides on mice metabolism and haematopoietic system with major differences between males and females.

journal_name

Toxicology

journal_title

Toxicology

authors

Merhi M,Demur C,Racaud-Sultan C,Bertrand J,Canlet C,Estrada FB,Gamet-Payrastre L

doi

10.1016/j.tox.2009.10.024

subject

Has Abstract

pub_date

2010-01-12 00:00:00

pages

80-90

issue

1-3

eissn

0300-483X

issn

1879-3185

pii

S0300-483X(09)00528-9

journal_volume

267

pub_type

杂志文章

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Gender-linked haematopoietic and metabolic disturbances induced by a pesticide mixture administered at low dose to mice.