Abstract:
:The multiple cascades of signal transduction pathways that lead from receptors on the cell membrane to the nucleus, thus translating extracellular signals into changes in gene expression, may represent important targets for neurotoxic compounds. Among the biochemical steps and pathways that have been investigated are the metabolism of cyclic nucleotides, the formation of nitric oxide, the metabolism of membrane phospholipids, the activation of a multitude of protein kinases and the induction of transcription factors. This brief review will focus on the interactions of three known neurotoxicants, lead, ethanol and polychlorinated biphenyls, with signal transduction pathways, particularly the family of protein kinase C isozymes, and discusses how such effects may be involved in their neurotoxicity.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Costa LG,Guizzetti M,Lu H,Bordi F,Vitalone A,Tita B,Palmery M,Valeri P,Silvestrini Bdoi
10.1016/s0300-483x(00)00435-2keywords:
subject
Has Abstractpub_date
2001-03-07 00:00:00pages
19-26issue
1-3eissn
0300-483Xissn
1879-3185pii
S0300483X00004352journal_volume
160pub_type
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