Abstract:
:Certain derivatives of p-phenylenediamine have been shown to cause necrosis of cardiac and skeletal muscle in rats; in vitro, such compounds are known to autoxidize to the corresponding radical cations, with concomitant formation of oxygen free-radicals. In the present study, the autoxidation rates of p-phenylenediamine and its N-methyl, dimethyl, trimethyl and tetramethyl derivatives have been determined and compared with the severity of the muscle necrosis induced by each of these compounds in rats. A close correlation was observed between autoxidation rate in vitro and toxicity in vivo, suggesting that free-radical species may be involved in the initiation of the muscle damage caused by these substances.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Munday R,Manns E,Fowke EA,Hoggard GKdoi
10.1016/0300-483x(89)90118-2subject
Has Abstractpub_date
1989-08-01 00:00:00pages
303-14issue
3eissn
0300-483Xissn
1879-3185pii
0300-483X(89)90118-2journal_volume
57pub_type
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