Abstract:
:Lead-exposed mice were found to show a significantly increased frequency of acrosome-reacted spermatozoa. The number of spermatozoa bound to the zona pellucida of denuded mouse eggs was also significant increased, probably as a result of an acceleration of the processes involved in the capacitation of the spermatozoa and thereby of the acrosome reaction. However, the ability of spermatozoa from the lead-exposed mice to penetrate the investments surrounding the oocyte, e.g. the zona pellucida and the plasma membrane, was significantly reduced. No significant differences were detected in the frequency of motile spermatozoa or in the swimming speed between spermatozoa from the lead-exposed and the control group of mice. These results indicate that the previously observed reduction in fertility after exposure to lead, may be due to a disturbed interaction of the spermatozoa with the oocyte.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Johansson Ldoi
10.1016/0300-483x(89)90041-3subject
Has Abstractpub_date
1989-02-01 00:00:00pages
151-62issue
2eissn
0300-483Xissn
1879-3185pii
0300-483X(89)90041-3journal_volume
54pub_type
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