[Effects of methylcyclopentadienyl manganese tricarbonyl (MMT) of rat liver mitochondria. I. Effects, in vitro, on the oxidative phosphorylation (author's transl)].

abstract：:Antidepressants are generally used for treatment of various mood and anxiety disorders. Several studies have shown the anti-tumor and cytotoxic activities of some antidepressants, but the underlying mechanisms were unclear. Maprotiline is a tetracyclic antidepressant and possesses a highly selective norepinephrine reu...

journal_title：Toxicology

authors： Jan CR,Su JA,Teng CC,Sheu ML,Lin PY,Chi MC,Chang CH,Liao WC,Kuo CC,Chou CT

更新日期：2013-02-08 00:00:00

abstract：:Rats were exposed to isopropanol by inhalation of 200,2000 and 8000 ppm for 2 weeks with a daily exposure of 6 h. A pilot group exposed to 8000 ppm was given a recovery period of 4 weeks. Kidney and liver microsomal metabolism of n-hexane was investigated in vitro concomitant with activities of cytochrome P-450 and GS...

journal_title：Toxicology

authors： Zahlsen K,Aarstad K,Nilsen OG

更新日期：1985-01-01 00:00:00

abstract：:Conditions for the optimal expression of the human CYP1B1 hemoprotein in Escherichia coli have been investigated. CYP1B1 cDNA was prepared from a retinal cDNA template and used to generate cDNA fragments with modified 5'-sequences reported to allow enhanced expression in E. coli DH5alpha. Plasmids were constructed, us...

journal_title：Toxicology

authors： Jansson I,Stoilov I,Sarfarazi M,Schenkman JB

更新日期：2000-04-03 00:00:00

abstract：:Epidemiological studies have implicated fine particulate matter (PM2.5) as a risk factor for neurodegenerative diseases and neurodevelopmental disorders. However, the underlying molecular mechanisms and the influences of different components remain largely elusive. Here, we extended our previous work to investigate th...

journal_title：Toxicology

authors： Wei H,Feng Y,Liang F,Cheng W,Wu X,Zhou R,Wang Y

更新日期：2017-04-01 00:00:00

abstract：:Pentachlorophenol (PCP) is an inhibitor of phenol-sulfotransferases and has been used to ascertain the role of sulfation in toxicology. Recently, molybdate has been shown to inhibit the sulfation of various chemicals by decreasing hepatic concentrations of the cosubstrate, 3'-phosphoadenosine 5'-phosphosulfate (PAPS)....

journal_title：Toxicology

authors： Boles JW,Klaassen CD

更新日期：2000-04-20 00:00:00

abstract：:Inhibition of fungal lanosterol-14 alpha-demethylase (CYP51) is the working principle of the antifungal activity of azoles used in agriculture and medicine. Inhibition of human CYP51 may result in endocrine disruption since follicular fluid-meiosis activating steroid (FF-MAS), the direct product of lanosterol demethyl...

journal_title：Toxicology

authors： Trösken ER,Adamska M,Arand M,Zarn JA,Patten C,Völkel W,Lutz WK

更新日期：2006-11-10 00:00:00

abstract：:Age-related differences in susceptibility to cephaloridine nephrotoxicity were evaluated in male Fischer-344 rats. Rats, 2.5, 4, 10-12 and 27-29 months old, were administered a single intraperitoneal dose of cephaloridine and renal function evaluated 24 h later. Susceptibility to cephaloridine-induced nephrotoxicity w...

journal_title：Toxicology

authors： Goldstein RS,Pasino DA,Hook JB

更新日期：1986-01-01 00:00:00

abstract：:During the past decade, several assessments have estimated the carcinogenic risk of inhaled 1,3-butadiene (BD) to the general population as well as for occupational exposures. Although most of the risk assessments have been based on inhalation bioassays in mice, some of the assessments have included the 2-year inhalat...

journal_title：Toxicology

authors： Cagen SZ,MacDonald RL,Van Gelder G

更新日期：1996-10-28 00:00:00

abstract：:The possibility that nitrofurantoin is a complete carcinogen or is an initiator or promoter of urinary bladder carcinogenesis was evaluated in male weanling F344 rats. No increase in tumor incidence was observed in rats fed nitrofurantoin at a level of 0.187% of the diet for 2 years compared to a control group. Also, ...

journal_title：Toxicology

authors： Hasegawa R,Murasaki G,St John MK,Zenser TV,Cohen SM

更新日期：1990-06-01 00:00:00

abstract：:A qualitative assessment of developmental toxicity within a series of 12 structurally related compounds, 11 of which were active dopamine mimetics and one was inactive, was conducted in rats treated orally by gavage during the major period of organogenesis. Doses were chosen where possible to be equipotent in terms of...

journal_title：Toxicology

authors： Ridings JE,Baldwin JA

更新日期：1992-12-04 00:00:00

abstract：:Bisphenol A (BPA), is an artificial estrogen initially produced for medical purposes but is today widely used in polycarbonate plastics and epoxy resins. Exposure-related reproductive disorders have been found, but recently it has also been suggested that BPA may be involved in obesity, diabetes, myocardial hypertroph...

journal_title：Toxicology

authors： Ljunggren SA,Iggland M,Rönn M,Lind L,Lind PM,Karlsson H

更新日期：2016-03-10 00:00:00

abstract：:Previously, we evaluated the effects of lactational exposure to a representative mixture of the six indicator non-dioxin-like polychlorinated biphenyls (∑6 NDL-PCBs) at low levels on the neurobiological changes and developmental/behavioral performances in mice. In this study, we analyzed the global gene expression pro...

journal_title：Toxicology

authors： Elnar AA,Desor F,Marin F,Soulimani R,Nemos C

更新日期：2015-02-03 00:00:00

abstract：:As vaccines are undoubtedly classified as pharmaceuticals, they have to be submitted to strict non-clinical safety evaluation. The context of their prophylactic use requires that every effort is made to ensure their safe use. Their safety evaluation is complex as they act through a multistage mechanism in which the va...

journal_title：Toxicology

authors： Verdier F

更新日期：2002-05-15 00:00:00

abstract：:Pulmonary fibrosis is one of the most common chronic interstitial lung diseases with high mortality rate after diagnosis and limited successful treatment. The present study was designed to assess the potential antifibrotic effect of thymoquinone (TQ) and whether TQ can attenuate the severity of oxidative stress and in...

journal_title：Toxicology

authors： El-Khouly D,El-Bakly WM,Awad AS,El-Mesallamy HO,El-Demerdash E

更新日期：2012-12-16 00:00:00

abstract：:Measurement of lymphocyte proliferation to detect hypersensitivity to beryllium (Be-LPT) in vitro is done presently using a method based on tritiated thymidine incorporation. Although this method is sensitive it gives no information on cell viability or responding lymphocyte subsets. We have developed reliable and sim...

journal_title：Toxicology

authors： Farris GM,Newman LS,Frome EL,Shou Y,Barker E,Habbersett RC,Maier L,Smith HN,Marrone BL

更新日期：2000-02-21 00:00:00

abstract：:Fifteen Chinchilla rabbits were treated by seven daily i.v. injections of two doses (25 or 50 mg/kg body wt.) of sodium borocaptate (Na2B12H11SH), an agent now widely investigated for potential use in Boron Neutron Capture Therapy (BNCT) of malignant brain tumors. Definite nephrotoxic lesions hyperemic and dilated glo...

journal_title：Toxicology

authors： Janků I,Buchar E,Jiricka Z

更新日期：1993-04-30 00:00:00

abstract：:For half of the 30-odd years that diacetyl-exposed workers have developed disabling lung disease, obliterative bronchiolitis was unrecognized as an occupational risk. Delays in its recognition as an occupational lung disease are attributable to the absence of a work-related temporal pattern of symptoms; failure to rec...

journal_title：Toxicology

authors： Kreiss K

更新日期：2017-08-01 00:00:00

abstract：:Field observations of endocrine disruption (ED) in fish and other aquatic species have contributed to a global effort to establish test methods for detecting ED effects in wildlife species. For ecological risk assessment, validated tests are needed for Amphibia, fish and aquatic invertebrates, supported by a tiered ap...

journal_title：Toxicology

authors： Hutchinson TH,Pickford DB

更新日期：2002-12-27 00:00:00

abstract：:Dioxins, including the most toxic congener, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), exert diverse biological effects in humans and animals. Host resistance, especially to virus infections, is considered one of the most sensitive targets of TCDD-toxicity, while a recent study showed that the vulnerability to TCDD o...

journal_title：Toxicology

authors： Nohara K,Izumi H,Tamura Si,Nagata R,Tohyama C

更新日期：2002-01-15 00:00:00

abstract：:Both 4,4'-dichlorobiphenyl (4,4'-DCB) and 3-methylcholanthrene (3-MC) caused a substantial increase of phenacetin-induced hepatic glutathione (GSH) depletion, whereas phenobarbital (PB) had no effect, suggesting that 4,4'-DCB possesses cytochrome P-448 inducing activity. The O-deethylation of phenacetin by liver micro...

journal_title：Toxicology

authors： van Bree L,Redegeld FA,de Vries J

更新日期：1986-12-15 00:00:00

abstract：:The effects of thallous cation (Tl(+)) on: (a) the production of oxidant species and (b) membrane fluidity were evaluated in human leukemia T cells (Jurkat). After 72 h of incubation in the presence of Tl(+) (5-100 microM), no significant changes in cell viability were observed, although the average cell size was decr...

journal_title：Toxicology

authors： Verstraeten SV

更新日期：2006-05-01 00:00:00

abstract：:A neuron spinal chord x hybrid (NSC-34) cell culture derived from neonatal mouse was characterized for studies on mercury toxicity. Exposure of NSC-34 cells to methyl mercury chloride (MeHgCl) (0-16 microM) resulted in significant dose-dependent cell damage and death (P < 0.05). MeHgCl was more toxic than inorganic me...

journal_title：Toxicology

authors： Chapman LA,Chan HM

更新日期：1999-02-15 00:00:00

abstract：:Recently, a large-scale field study in The Netherlands has focused on the effects of estrogenic contaminants on feral fish populations. The freshwater bream (Abramis brama) and the estuarine flounder (Platichthys flesus) were sampled at a large number of locations in the spring and autumn of 1999. Concentrations of th...

journal_title：Toxicology

authors： Vethaak AD,Lahr J,Kuiper RV,Grinwis GC,Rankouhi TR,Giesy JP,Gerritsen A

更新日期：2002-12-27 00:00:00

abstract：:The function of the neuromuscular transmission in rats dosed with phoxim (P), methomyl (M), fenvalerate (F), and mixtures of P+M and P+F was studied by using both the stimulation single fiber electromyography (SSFEMG) and repetitive nerve stimulations (RNS) to determine the single muscle fiber action potential and com...

journal_title：Toxicology

authors： Yang D,He F,Li T

更新日期：2001-03-21 00:00:00

abstract：:This study aimed to prove that prenatal ethanol exposure (PEE) can induce nephrotic syndrome in male rat offspring and to explore the underlying intrauterine programming mechanisms. Pregnant Wistar rats were intragastrically administered ethanol (4 g/kg d) from gestational day (GD) 9 to GD 20, and the male fetuses wer...

journal_title：Toxicology

authors： Zhu Y,Zuo N,Li B,Xiong Y,Chen H,He H,Sun Z,Hu S,Cheng H,Ao Y,Wang H

更新日期：2018-05-01 00:00:00

abstract：:The action of various manganese organic compounds, which are structural analogs of methylcyclopentadienyl manganese tricarbonyl (MMT), was investigated. Only the cyclopentadienyl manganese tricarbonyl compounds are effective inhibitors of mitochondrial respiration, but only when associated with NAD+-linked substrates....

journal_title：Toxicology

authors： Autissier N,Gautheron B,Dumas P,Brosseau J,Loireau A

更新日期：1977-10-01 00:00:00

abstract：:The toxicity to HeLa cells of 29 plasticizers was determined in the MIT-24 test system. The 7-day IC50 for HeLa cells varied from 260 to 1.5 g/l. Phthalates, adipates, sebacates, azelates and phosphates with long carbon chain alcohols were very non-toxic to the cells, probably due to insolubility in water of the compo...

journal_title：Toxicology

authors： Ekwall B,Nordensten C,Albanus L

更新日期：1982-01-01 00:00:00

abstract：:This review deals with some of our contributions to the use of chemotaxis, as a tool in evaluating effects of industrial xenobiotics on PMN, either in vitro or ex vivo. In vitro experiments have shown that lead, arsenic, styrene and 2,5-hexanedione, a major neurotoxicant metabolite of n-hexane, reduce chemotaxis. The ...

journal_title：Toxicology

authors： Governa M,Valentino M,Visonà I

更新日期：1994-07-01 00:00:00

abstract：:The in vivo effects of sodium cyanide and its antidotes, sodium nitrite, sodium thiosulfate and 4-dimethylaminophenol (DMAP), as well as the alpha-adrenergic blocking agent phentolamine, on rat brain cytochrome oxidase were studied. The course of inhibition was time-dependent and a peak of 40% was attained between 15 ...

journal_title：Toxicology

authors： Tadić V

更新日期：1992-11-22 00:00:00

abstract：:Though, oxidative stress has been implicated in silica nanoparticles induced toxicity both in vitro and in vivo, but no similarities exist regarding dose-response relationship. This discrepancy may, partly, be due to associated impurities of trace metals that may present in varying amounts. Here, cytotoxicity and oxid...

journal_title：Toxicology

authors： Akhtar MJ,Ahamed M,Kumar S,Siddiqui H,Patil G,Ashquin M,Ahmad I

更新日期：2010-10-09 00:00:00