Abstract：
:Fifteen Chinchilla rabbits were treated by seven daily i.v. injections of two doses (25 or 50 mg/kg body wt.) of sodium borocaptate (Na2B12H11SH), an agent now widely investigated for potential use in Boron Neutron Capture Therapy (BNCT) of malignant brain tumors. Definite nephrotoxic lesions hyperemic and dilated glomeruli, degenerative necrobiosis with desquamation of tubular epithelium, granular casts in the distal convoluted and collecting tubuli were detected by histopathological examination in the kidneys of all animals without relation to dose of borocaptate. The accumulation of urea in blood and a reduction in red blood cell counts were, however, statistically significant only in rabbits receiving the higher dose (50 mg/kg body wt.) of borocaptate. In the brain the prevalent finding was dilation of perivascular (Virchow-Robin's) spaces. The growth of the animals was retarded and three animals died after injection of the 5th daily dose of borocaptate. With respect to these findings borocaptate sodium can by no means be regarded as an agent which is fully devoid of activity towards healthy non-tumor tissue. Therefore, recent proposals to enhance the effectiveness of BNCT by repeated borocaptate treatment should be considered with caution.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Janků I,Buchar E,Jiricka Zdoi
10.1016/0300-483x(93)90123-asubject
Has Abstractpub_date
1993-04-30 00:00:00pages
99-108issue
2eissn
0300-483Xissn
1879-3185pii
0300-483X(93)90123-Ajournal_volume
79pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Some chemicals are harmful in to light-exposed tissues such as skin and eyes. The 3T3 Neutral Red Uptake Phototoxicity Test has been validated and adopted by the Organization of Economic and Community Development (OECD) as a method of evaluating chemical phototoxicity using mouse 3T3 fibroblasts. However, the high rat...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2017.01.003
更新日期：2017-03-01 00:00:00
abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the biological and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dioxin-like compounds (DLC) as well as some drugs and endogenous tryptophan metabolites. Short-term activation of AhR can lead to hepatocellular s...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2015.07.005
更新日期：2015-10-02 00:00:00
abstract：:Whole body autoradiograms of mice injected with 2,2',3,3',6-[14C]pentachlorobiphenyl (I), 2,3,3',4',6-[14C]pentachlorobiphenyl (II), 2,2',3,5',6-[14C]pentachlorobiphenyl (III) and 2,3',4,5,5'-[14C]pentachlorobiphenyl (IV) showed a specific accumulation of I-III in the lung parenchyma, whereas IV did not accumulate in ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(81)90146-3
更新日期：1981-01-01 00:00:00
abstract：:The intravenous LD50 of cefuroxime sodium for mice was 10.4 g/kg. The maximum dosage administered in other acute toxicity tests was well tolerated by mice (10 g/kg, subcutaneous), by rats (4 g/kg, intravenous, 5 g/kg, subcutaneous) and by cats, dogs and monkeys (2 g/kg, intramuscularly). Cefuroxime sodium was administ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(79)80003-7
更新日期：1979-05-01 00:00:00
abstract：:Aluminium has been implicated in various neurodegenerative diseases but exact mechanism of action is still not known. Mitochondria being a major site of reactive oxygen species production are considered to be target of oxidative stress and it seems that the oxidative damage to mitochondrial proteins may underlie the p...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.10.009
更新日期：2009-01-31 00:00:00
abstract：:Isoniazid is a widely used drug for the treatment of tuberculosis, but hepatotoxicity is a major concern during treatment. Thiopronin contains an SH-group and is generally considered an antioxidant. The aim of the present study was to investigate the effects of thiopronin during liver injury and DNA damage induced by ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.08.006
更新日期：2009-10-29 00:00:00
abstract：:As an important cholesterol oxide, 7-ketocholesterol plays a deleterious role in the occurrence of cancer. Although the fact had been proved that 7-ketocholesterol could induce several biological phenomena, including apoptosis, DNA damage, et al., this issue whether 7-ketocholesterol led to mutagenesis in mammalian ce...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2020.152587
更新日期：2020-12-15 00:00:00
abstract：:Ozone (O3), a pulmonary irritant, and a major toxic component of photochemical smog, is capable of inducing pulmonary inflammation characterized by recruitment of polymorphonuclear leukocytes (PMNs) into the lung. The recruited PMNs, in turn, can release toxic mediators and produce lung injury. The mechanism of ozone-...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(98)00024-9
更新日期：1998-05-15 00:00:00
abstract：:Beside heavy metals, cadmium (Cd(2+)) is a ubiquitous toxic metal with a well established apoptotic and genotoxic effect, chronic exposure of which has been involved in a variety of pathological conditions. In the present study, we investigated by 1455 genes cDNA microarrays the toxic and apoptotic effect of Cd(2+), o...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(02)00236-6
更新日期：2002-09-02 00:00:00
abstract：:Mature rats were dosed with T3 by different routes and dose-levels at either 0.1 mg/kg for 14 days s.c. (Group A), 1 mg/kg for 3 alternative days i.p. (Group B), 5 mg/kg for 14 days p.o. (Group C), or with propylthiouracil (PTU 50 mg/day for 14 days p.o.-Group D). Measurement of cerebellar and striatal NA+,K+-ATPase a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(87)90075-8
更新日期：1987-01-01 00:00:00
abstract：:Lead exposure causes cognitive and behavioral deficits in some children. We have proposed that the effects of single nucleotide polymorphisms (SNP) of the human pseudodeficient arylsulfatase A (ARSA) gene that result in reduced levels of the enzyme, and lead concentrations that decrease ARSA activity, culminate in cel...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00387-0
更新日期：2001-06-21 00:00:00
abstract：:The possibility that nitrofurantoin is a complete carcinogen or is an initiator or promoter of urinary bladder carcinogenesis was evaluated in male weanling F344 rats. No increase in tumor incidence was observed in rats fed nitrofurantoin at a level of 0.187% of the diet for 2 years compared to a control group. Also, ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90056-m
更新日期：1990-06-01 00:00:00
abstract：:The spectrum of the anti-apoptotic potential of heparin is currently under scrutiny in various tissues and under various pathological situations. In this study, the role of a low-molecular-weight heparin derivative (LMWH), certoparin in adriamycin-induced oxidative DNA damage has been evaluated in the cardiac and rena...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.09.009
更新日期：2006-01-16 00:00:00
abstract：:Delta(9)-Tetrahydrocannabinol (Delta(9)-THC), a major constituent of marijuana, has been shown to stimulate the growth of MCF-7 breast cancer cells through cannabinoid receptor-independent signaling [Takeda, S., Yamaori, S., Motoya, E., Matsunaga, T., Kimura, T., Yamamoto, I., Watanabe, K., 2008. Delta(9)-Tetrahydroca...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.01.024
更新日期：2009-05-02 00:00:00
abstract：:We provide an overview of the functional interrelationship between genes and proteins related to DNA repair by homologous recombination and cell cycle regulation in relation to the progression and therapy resistance of human tumours. To ensure the high-fidelity transmission of genetic information from one generation t...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(03)00291-9
更新日期：2003-11-15 00:00:00
abstract：:Ethanol is able to cross the placenta, which may cause teratogenicity. Here we investigated whether ethanol consumption during pregnancy (ECDP), even at doses unable to cause malformation, might increase the susceptibility of fetal rat liver to oxidative insults. Since cholestasis is a common condition in alcoholic li...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.05.015
更新日期：2006-08-15 00:00:00
abstract：:Peroxisome proliferators (PP) are a large class of structurally diverse chemicals that mediate their effects in the liver mainly through the peroxisome proliferator-activated receptor alpha (PPARalpha). Exposure to PP results in down-regulation of CYP2C family members under control of growth hormone and sex steroids i...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.05.013
更新日期：2004-10-15 00:00:00
abstract：:Endocrine disruptors (EDs) are exogenous substances or xenoestrogens natural or synthetic, capable of interacting with different systems and altering their normal hormonal regulation, being the reproductive system one of the most affected. EDs produce their effects not only by acting on nuclear steroid receptors, but ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2013.05.014
更新日期：2013-09-06 00:00:00
abstract：:The use of accurate and sensitive methods for the measurement of cytokines in body fluids is an absolute prerequisite for the proper use of these mediators in clinical practice. Many factors contribute to the complexity of cytokines quantitation: these molecules circulate at very low levels (e.g. pg/ml) under various ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(98)00063-8
更新日期：1998-08-07 00:00:00
abstract：:The osteolathyrogenic agent semicarbazide was assayed for its toxicity and teratogenicity using early embryos of the frog Xenopus laevis. The 96-h LC50 is 1504.20 mg/l while the 96-h EC50 is 76.28 mg/l. Embryo length is altered prior to the onset of other effects indicated by a reduction in stage of development. The m...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(85)90053-8
更新日期：1985-08-01 00:00:00
abstract：:The fetotoxicity of nitrofen and 5 analogous diphenyl ethers was compared in mice, using survival on postnatal day 5 to evaluate prenatal and perinatal toxicity. The effect of each chemical on the Harderian gland weight of surviving pups was also assessed, since decreased Harderian gland weight is seen in nitrofen-exp...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90062-4
更新日期：1986-09-01 00:00:00
abstract：:Deoxynivalenol (DON) is one of the major mycotoxic contaminants of grains, which causes reduced weight gain in pigs. The cytotoxicity of DON to porcine hepatocytes was examined in this study. DON was added at the final concentration of 100, 10, 1, 0.1 or 0.01 microg/ml to the medium of primary cultured hepatocytes. Ce...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.07.001
更新日期：2004-11-15 00:00:00
abstract：:Gordonia axillaris (Roxb.) Dietrich (Theaceae) is a native to Taiwan and the leaves have been used as an astringent folk medicine. Camelliin B (CB), a macrocyclic hydrolyzable tannin, was isolated from G. axillaris and showed cytotoxic effects in human carcinoma cells. Among the target cells (SKHep-1, Ha-22T, DU-145, ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00452-8
更新日期：2001-11-30 00:00:00
abstract：:Manganese (II) bis(glycinate)dichloride (Mn(glycinate)2) is a coordination complex of manganese with application as a contrast enhancement agent for magnetic resonance imaging in the heart. To determine the cardioactivity of the manganese ion in this chelation cage, the effects of Mn(glycinate)2 on Ca channel function...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(91)90062-6
更新日期：1991-01-01 00:00:00
abstract：:Recently it has become clear that exposure to xenobiotics may result in various forms of cell death; not only passive cell deaths like necrosis, or programmed cell deaths such as apoptosis, but also regulated necrosis, autophagy, senescence, or mitotic catastrophe. Complex cell signaling networks influence the process...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2012.12.014
更新日期：2013-02-08 00:00:00
abstract：:The safety of an açai (Euterpe oleracea Mart.) pulp enriched fruit and berry juice, MonaVie Active®, fortified with the functional ingredient, glucosamine, was studied. The beverage was found not to be mutagenic, clastogenic, cytotoxic, or genotoxic, as determined by the bacterial reverse mutation assay, chromosomal a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2010.04.017
更新日期：2010-11-28 00:00:00
abstract：:There is considerable interest in gene and environment interactions in neurodegenerative diseases. The HFE (homeostatic iron regulator) gene variant (H63D) is highly prevalent in the population and has been investigated as a disease modifier in multiple neurodegenerative diseases. We have developed a mouse model to in...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2020.152525
更新日期：2020-08-01 00:00:00
abstract：:The present study was conducted in order to study the effect of the PCB congener 3,3', 4,4'-tetrachlorobiphenyl (CB-77) on fetal thyroxin homeostasis in the mouse, and to examine a possible underlying mechanism behind the effect. C57BL mice were treated with 14C-labelled or unlabelled CB-77 (1 or 10 mg/kg body wt.) on...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(95)03169-g
更新日期：1996-01-08 00:00:00
abstract：:To meet the military objective of determining criteria for incapacitation and lethality from toxic gas exposures, a series of small animal tests and data analyses were conducted. Carbon monoxide (CO), a narcotic gas and nitrogen dioxide (NO2), an irritant gas, along with carbon dioxide (CO2) were tested individually a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(96)03504-4
更新日期：1996-12-31 00:00:00
abstract：:Amiodarone is a class III anti-arrhythmic compound that is iodinated, cationic and amphiphilic in nature. The clinical use of amiodarone may be associated with various side-effects, including pulmonary and hepatic toxicity. Use of this compound during pregnancy may therefore place the fetus at risk through in utero ex...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(91)90085-f
更新日期：1991-01-01 00:00:00
