Abstract：
:Dioxins, including the most toxic congener, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), exert diverse biological effects in humans and animals. Host resistance, especially to virus infections, is considered one of the most sensitive targets of TCDD-toxicity, while a recent study showed that the vulnerability to TCDD of host resistance to viruses varied form experiment to experiment. Burleson et al. [Fundam. Appl. Toxicol. 29 (1996) 40] reported that a single oral dose as low as 10 ng TCDD/kg increased the mortality of mice infected with influenza A virus. If this value had been adopted as the basis for the tolerable daily intake (TDI) of dioxins, the TDI of 1-4 pg toxic equivalent (TEQ)/kg per day recommended by WHO would have to be lower. In the present study, we used the same experimental protocol described by Burleson et al. to determine whether low-dose TCDD consistently compromises the host resistance of mice infected with influenza A virus. To do so, we investigated the effect of TCDD in the dose range of 0-500 ng/kg on the mortality of virus-infected female B6C3F1 mice. We also investigated the sex- and strain-dependency of host resistance in male B6C3F1 mice and in female C57Bl/6, Balb/c, and DBA/2 mice by administering the same dose range of TCDD. The results showed that TCDD doses up to 500 ng/kg did not increase the mortality of virus-infected mice in any of the strains. Further studies on the mechanism underlying the toxicity of TCDD are needed to assess the risk of exposure to this compound in influenza A virus infection.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Nohara K,Izumi H,Tamura Si,Nagata R,Tohyama Cdoi
10.1016/s0300-483x(01)00535-2keywords:
subject
Has Abstractpub_date
2002-01-15 00:00:00pages
131-8issue
1-2eissn
0300-483Xissn
1879-3185pii
S0300483X01005352journal_volume
170pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Chalcones are phenolic compounds that can be isolated from plants. Previous studies have described some pharmacological applications for these compounds. Making use of our established reporter gene system, we determined the effect of five hydroxychalcones--2-hydroxychalcone, 2'-hydroxychalcone, 4-hydroxychalcone, 4,2'...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.10.005
更新日期：2005-02-14 00:00:00
abstract：:Nitrated-polycyclic aromatic hydrocarbons (nitro-PAHs) and diesel exhaust particle extracts (DEPE) induced apoptosis in Hepa1c1c7 cells with the following potency: 1,3-dinitropyrene (1,3-DNP)>1-nitropyrene (1-NP) > DEPE > 1,8-dinitropyrene (1,8-DNP). The compounds induced cyp1a1, and activated various intracellular si...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.12.009
更新日期：2007-03-07 00:00:00
abstract：:Asthma, which is primarily an allergic type of respiratory disease, has increased in the U.S. and Europe by 30% over the last decade. Air pollution may play a role in this rise, since during episodes of smog, hospital admissions due to asthma increase. Ambient air quality has generally improved since the Clean Air Act...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(95)03230-d
更新日期：1995-12-28 00:00:00
abstract：:The pharmacokinetics of selected aluminum-hydroxypyridinone (Al-HP complexes were determined in rats to better understand the relationship between their disposition and elimination parameters and the safety of HPs in the chelation therapy of Al intoxication. Five complexes were administered as i.v. bolus doses of Al-H...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90177-5
更新日期：1994-09-06 00:00:00
abstract：:Groups of 15 male and 15 female rats were give 0 (control), 50, 100, 200 or 800 ppm allyl alcohol in the drinking water for 15 weeks. There were no effects attributable to allyl alcohol in the results of the haematological examinations or analyses of serum. There was a dose-related reduction in the fluid intake at all...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(78)90029-x
更新日期：1978-02-01 00:00:00
abstract：:T-2 toxin belongs to a group of mycotoxins synthesized by Fusarium fungi that are widely encountered as natural contaminants in cereals. Human lymphoid cell lines of T (MOLT-4) or B (IM-9) lineage were used to characterize the cytotoxic effects mediated by T-2 at different concentrations (0.1 pg/ml to 1 microg/ml). Af...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.01.007
更新日期：2005-05-15 00:00:00
abstract：:Exposure to low-dose benzene may lead to hematotoxicity and cause health problems. Though peripheral blood cell count is widely used in benzene exposure assessment and health risk assessment, the reports regarding the effects of low-dose benzene exposure on blood cell count remain inconsistent. To uncover more sensiti...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2018.09.004
更新日期：2018-12-01 00:00:00
abstract：:The possible juvenilizing effects of Dimilin and Altosid against larvae of Culex pipiens L. were studied. Apart from delayed lethal action, possible effect on the mean number of basal follicles developed per female has been considered. A baseline exposure was found which caused only low mortalities of the early 4th la...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(81)90137-2
更新日期：1981-01-01 00:00:00
abstract：:Effects of methylmercury on the cell growth of mouse glioma in vitro were studied in relation to the microtubules as a possible target. The electron microscopic observation revealed that methylmercury added in culture medium specifically attacked microtubules in the cells at growth inhibitory concentration, while merc...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(80)90101-8
更新日期：1980-01-01 00:00:00
abstract：:Rats were injected i.p. with the organophosphate insecticide ABATE and tested over the next 16 days. Animals given 1000 mg/kg showed impaired performance of a previously conditioned avoidance response 6 days after injection but not 2, 8, 10, or 16 days after injection. No behavioral changes were observed in animals gi...
journal_title：Toxicology
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
abstract：:Young adult male and female Wistar rats were inhalationally exposed head-only for 1 or 4 h to different anticholinesterase aerosols. The compounds tested were dichlorvos, fenamiphos, methamidophos, parathion, a pyrimidine thiophosphate and the carbamate propoxur. These compounds are direct or indirect inhibitors of ch...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(87)90126-0
更新日期：1987-10-30 00:00:00
abstract：:Our previous study revealed that exposure to 0.4 ppm ozone (O(3)) enhanced nasal allergy-like reactions in guinea pigs. In the present study, we investigated the concentration-dependency of the effects of exposure to O(3) on the aggravation of nasal allergy-like reactions induced by repeated nasal administration of an...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.01.008
更新日期：2004-06-01 00:00:00
abstract：:Catecholamines are stress hormones and sympathetic neurotransmitters essential for control of cardiac function and metabolism. However, pathologically increased catecholamine levels may be cardiotoxic by mechanism that includes iron-catalyzed formation of reactive oxygen species. In this study, five iron chelators use...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.08.006
更新日期：2011-11-18 00:00:00
abstract：:The popliteal lymph node assay (PLNA) is being considered as a tool to predict the potential of drugs for inducing systemic autoimmune and hypersensitivity reactions. Despite the use of different technical approaches and the evaluation of over 130 compounds, the sensitivity and specificity of the PLNA are still debata...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.03.010
更新日期：2004-08-05 00:00:00
abstract：:Nonylphenol (NP) has been identified at low levels in surface waters throughout North America. This industrial chemical is primarily used for the production of certain non-ionic surfactants, and has been reported to have weak estrogen-like activity. As estrogen has immunoregulatory properties and is crucial for normal...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2003.11.009
更新日期：2004-03-15 00:00:00
abstract：:Heavy metal neurotoxicity is one of the major challenges in today's era due to the large scale and widespread mechanisation of the production. However, the causative factors responsible for neurotoxicity are neither known nor do we have the availability of therapeutic approaches to deal with it. One of the major causa...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2020.152542
更新日期：2020-09-01 00:00:00
abstract：:Methylmercury is an environmental pollutant that exhibits neurotoxicity when ingested, primarily in the form of neuropathological lesions that localize along deep sulci and fissures, in addition to edematous and inflammatory changes in patient cerebrums. These conditions been known to give rise to a variety of ailment...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2017.09.013
更新日期：2017-12-01 00:00:00
abstract：:Adult female F-344 rats were trained (avoidance rate > 70%) over four days with a coupled tone- (n = 10 rats/dose) or 2 ppm acetaldehyde-cued (n = 6 rats/dose) foot shock paradigm. Rats were gavaged with chloroform dissolved in corn oil for 5 days/week for 3 week at 0 or 400 (tone-cued) or 0, 34, 100, or 400 (odor-cue...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(97)00076-0
更新日期：1997-09-26 00:00:00
abstract：:Recently it has become clear that exposure to xenobiotics may result in various forms of cell death; not only passive cell deaths like necrosis, or programmed cell deaths such as apoptosis, but also regulated necrosis, autophagy, senescence, or mitotic catastrophe. Complex cell signaling networks influence the process...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2012.12.014
更新日期：2013-02-08 00:00:00
abstract：:High doses of cephaloridine produce necrosis of renal proximal tubular cells and this nephrotoxicity has been shown to be reduced by piperonyl butoxide (a mixed-function oxidase inhibitor) in rats and rabbits, and potentiated by phenobarbital (a mixed-function oxidase inducer) in rabbits but not rats. Phenobarbital is...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(82)90011-7
更新日期：1982-01-01 00:00:00
abstract：:Renal markers were investigated over 96 h in male Sprague-Dawley rats after i.v. administration of 10.7 mg kg(-1) of digoxin-specific Fab fragments (DSFab). The dose was calculated by an allometric equation as equivalent to a high clinical dose. DSFab both alone and pre-incubated with digoxin were tested. None of the ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(98)00022-5
更新日期：1998-04-03 00:00:00
abstract：:Simple and efficient ex vivo/in vitro screening systems for contact allergens are developed for alternative to conventional animal tests. We have previously proposed an ex vivo/in vitro proliferation assay as a first stage screening method with advantages over existing alternatives, using lymph node cells (LNC) from s...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(96)89846-5
更新日期：1996-11-15 00:00:00
abstract：:Atrazine (ATZ) is used throughout North America to control annual broadleaf weeds and grasses in various crops including; corn, sorghum, and sugar cane. Unfortunately, contamination of surface and ground water has occurred as a result of ATZ's chemical and physical properties, and its widespread use throughout the U.S...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.12.002
更新日期：2005-04-01 00:00:00
abstract：:The ability of cis-dichlorodiammine platinum II to cause chromosomal aberrations in rats and dominant lethality in mice was studied. Five daily intraperitoneal doses ranging from 0.25 to 2.00 mg/kg/day failed to result in the observance of dominant lethal mutations in mice. Intraperitoneal doses of 0.13 and 0.52 mg/kg...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(80)90027-x
更新日期：1980-01-01 00:00:00
abstract：:A flow-through rat tracheal implant system is described which permits the quantitative and repetitive exposure of respiratory epithelia to test gaseous substances. To investigate the acute toxicity of formaldehyde gas with this new system, open-ended rat tracheal implants were exposed to the gas for 1 h twice a week f...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(84)90142-2
更新日期：1984-04-16 00:00:00
abstract：:The neurotoxic effect on the central and peripheral nervous system of dichlorvos (DDVP) was investigated by a computer system in acute and subchronic experiments in CFY male rats. The administered peroral doses were given by gavage; the acute group was given a single 88 mg/kg dose and the 2 subchronic groups were give...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(88)90186-2
更新日期：1988-04-01 00:00:00
abstract：:Pregnant rats were dosed with 300, 600, 1000, 2000, 3000 or 4000 ppm inorganic lead through their drinking water during pregnancy and during lactation until 21 days post partum. An effect on live litter size was noted at the higher doses as was an increased tendency for sperm positive females to fail to produce a litt...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(81)90122-0
更新日期：1981-01-01 00:00:00
abstract：:The effect of administration of a glutamate-containing protein hydrolysate on the arcuate nucleus of 10-day-old mice was studied by two methods. Arcuate nucleus damage resulted when administration was by a single large subcutaneous dose (100 ml/kg). When the same total dose was administered subcutaneously in five smal...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(75)90070-0
更新日期：1975-09-01 00:00:00
abstract：:A 20-year-old man on oral substitution of pancreatic enzymes after hemipancreatectomy injected an enzyme preparation of fungal origin intravenously after dissolving it in water. Within a few hours chills, headache, nausea and vomiting, fever of 40.8 degrees C, and shock occurred. The acute illness might have been caus...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(89)90189-3
更新日期：1989-04-01 00:00:00
abstract：:Trichloroacetic acid (TCA) is a common drinking water disinfection byproduct that produces a spectrum of liver effects, including hepatomegaly and liver tumors, in mice. It is also an oxidative metabolite of trichloroethylene (TCE), a solvent used in degreasing with widespread environmental exposure, which also produc...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.04.009
更新日期：2011-07-29 00:00:00
