Abstract：
:Effects of methylmercury on the cell growth of mouse glioma in vitro were studied in relation to the microtubules as a possible target. The electron microscopic observation revealed that methylmercury added in culture medium specifically attacked microtubules in the cells at growth inhibitory concentration, while mercuric mercury injured microtubules to the same extent as other cell organelles. However the latter showed a little stronger depressing effect on tubulin polymerization in vitro than the former. Further, 3 other inorganic metal ions (Cd2+, Cu2+ and Cr3+), which were reported to suppress tubulin polymerization in vitro, did not disturb the microtubule networks even at their cell growth inhibitory concentrations. Therefore, of these metal compounds tested, when they were added in the culture medium, methylmercury seemed to specifically interact with microtubules and cause inhibition of cell growth.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Imura N,Miura K,Inokawa M,Nakada Sdoi
10.1016/0300-483x(80)90101-8subject
Has Abstractpub_date
1980-01-01 00:00:00pages
241-54issue
2eissn
0300-483Xissn
1879-3185pii
0300-483X(80)90101-8journal_volume
17pub_type
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