Sequencing and tissue distribution of the canine MRP2 gene compared with MRP1 and MDR1.

abstract：:We recently reported that Delta(9)-tetrahydrocannabinol (Delta(9)-THC) has the ability to stimulate the proliferation of human breast carcinoma MCF-7 cells. However, the mechanism of action remains to be clarified. The present study focused on the relationship between receptor expression and the effects of Delta(9)-TH...

journal_title：Toxicology

authors： Takeda S,Yamaori S,Motoya E,Matsunaga T,Kimura T,Yamamoto I,Watanabe K

更新日期：2008-03-12 00:00:00

abstract：:The nitric oxide (NO) donor, O(2)-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), is metabolized by P450 enzymes to release NO in the liver and possibly other tissues. V-PYRRO/NO has been shown to be hepatoprotective, but little is known about its effect in the kidney, another organ rich in P450s. Thus...

journal_title：Toxicology

authors： Li C,Liu J,Saavedra JE,Keefer LK,Waalkes MP

更新日期：2003-08-01 00:00:00

abstract：:Atrazine (ATZ) is used throughout North America to control annual broadleaf weeds and grasses in various crops including; corn, sorghum, and sugar cane. Unfortunately, contamination of surface and ground water has occurred as a result of ATZ's chemical and physical properties, and its widespread use throughout the U.S...

journal_title：Toxicology

authors： Karrow NA,McCay JA,Brown RD,Musgrove DL,Guo TL,Germolec DR,White KL Jr

更新日期：2005-04-01 00:00:00

abstract：:Resistance to chemotherapy is a major obstacle for the effective treatment of cancers. The mechanism of chemo-resistance is still poorly understood, however, mounting evidence supports a role for microRNAs (miRNAs) in modulating key cellular pathways mediating response to chemotherapy. microRNA-21 (miR-21) has been im...

journal_title：Toxicology

authors： Yang SM,Huang C,Li XF,Yu MZ,He Y,Li J

更新日期：2013-04-05 00:00:00

abstract：:Previous studies on the immunotoxicity of a complex mixture of polynuclear aromatic hydrocarbon (PAH) by-products from a manufactured gas plant indicated possible synergistic interactions which were investigated by determining the immunosuppressive effects of a reconstituted PAH mixture in female B6C3F1 mice challenge...

journal_title：Toxicology

authors： Harper N,Steinberg M,Safe S

更新日期：1996-05-03 00:00:00

abstract：:Although manufactured magnetic nanoparticles (NPs) are currently used in many fields, NPs have potential toxicity on cardiovascular system especially atherosclerosis. In our previous study, we prepared novel Fe3O4 nanoparticles surface-coated with aminoguanidine (Fe3O4-AG NPs) which could remove acid dyes from aqueous...

journal_title：Toxicology

authors： Qu G,Wu Q,Zhao B,Miao J,Su L

更新日期：2019-05-01 00:00:00

abstract：:A flow-through rat tracheal implant system is described which permits the quantitative and repetitive exposure of respiratory epithelia to test gaseous substances. To investigate the acute toxicity of formaldehyde gas with this new system, open-ended rat tracheal implants were exposed to the gas for 1 h twice a week f...

journal_title：Toxicology

authors： Shiba M,Marchok AC,Klein-Szanto AJ

更新日期：1984-04-16 00:00:00

abstract：:Chlorpyrifos (CPF) is a commonly used diethylphosphorothionate organophosphorus (OP) insecticide. Diethylphosphate (DEP), diethylthiophosphate (DETP) and 3,5,6-trichloro-2-pyridinol (TCPy) are products of both in vivo metabolism and environmental degradation of CPF and are routinely measured in urine as biomarkers of ...

journal_title：Toxicology

authors： Busby-Hjerpe AL,Campbell JA,Smith JN,Lee S,Poet TS,Barr DB,Timchalk C

更新日期：2010-01-31 00:00:00

abstract：:Pregnant M. ochrogaster received single intraperitoneal (i.p.) doses of 0.06, 0.125, 0.25, 0.5, 1,2, or 5 mg phenyl mercuric acetate (PMA/kg of body weight on day 8, 9, or 10 of gestation or 0.5 mg PMA/kg on day 7, 8, 9, 10, 11, or 12 of gestation. No toxicity was exhibited, and no abnormal fetuses were observed in an...

journal_title：Toxicology

authors： Hartke GT,Oehme FW,Leipold HW,Kruckenberg SM

更新日期：1976-11-01 00:00:00

abstract：:The cytotoxicity and cardiotoxicity of benzoyl mustard (FCE 24517) and epoxamido (FCE 24561) synthetic derivatives of distamycin A were reported in the present study. The 50% inhibiting concentration (IC50) of colony formation of FCE 24517 on human SNB-19 glioblastoma, A2780 ovarian cancer and DU 145 prostate cancer w...

journal_title：Toxicology

authors： Agen C,Sironi AM,Danesi R,Costa M,Bernardini N,Paparelli A,Della Torre P,Del Tacca M

更新日期：1992-11-15 00:00:00

abstract：:In the current study, we used pathway-specific cDNA arrays to detect the transcriptional signature induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in vivo by studying simultaneously the expression profiles of 83 genes involved in apoptosis, cytokine production and angiogenesis. To this end, C57BL/6 mice were inj...

journal_title：Toxicology

authors： Zeytun A,McKallip RJ,Fisher M,Camacho I,Nagarkatti M,Nagarkatti PS

更新日期：2002-09-16 00:00:00

abstract：:The in vivo effects of sodium cyanide and its antidotes, sodium nitrite, sodium thiosulfate and 4-dimethylaminophenol (DMAP), as well as the alpha-adrenergic blocking agent phentolamine, on rat brain cytochrome oxidase were studied. The course of inhibition was time-dependent and a peak of 40% was attained between 15 ...

journal_title：Toxicology

authors： Tadić V

更新日期：1992-11-22 00:00:00

abstract：:Aluminum (Al) is recognized worldwide as serious inorganic contaminants. Exposure to Al is associated with low BMD and an increased risk of osteoporosis. However, the precise molecular mechanisms remains unclear. Thus, in this study, rats were orally exposed to 0 (control group, CG) and 0.4g/L AlCl3 (AlCl3 treated gro...

journal_title：Toxicology

authors： Sun X,Liu J,Zhuang C,Yang X,Han Y,Shao B,Song M,Li Y,Zhu Y

更新日期：2016-09-14 00:00:00

abstract：:It is reported that diesel exhaust particles contain more 1-nitropyrene (1-NP) than benzo[a]pyrene (B[a]P), both of which are potent carcinogenic compounds. In this study, we show that 1-NP is more potent in reducing cell viability than B[a]P, pyrene, nitrobenzene, and nitromethane. Aldo-keto reductases (AKRs) are enz...

journal_title：Toxicology

authors： Su JG,Liao PJ,Huang MC,Chu WC,Lin SC,Chang YJ

更新日期：2008-02-28 00:00:00

abstract：:This study aimed to prove that prenatal ethanol exposure (PEE) can induce nephrotic syndrome in male rat offspring and to explore the underlying intrauterine programming mechanisms. Pregnant Wistar rats were intragastrically administered ethanol (4 g/kg d) from gestational day (GD) 9 to GD 20, and the male fetuses wer...

journal_title：Toxicology

authors： Zhu Y,Zuo N,Li B,Xiong Y,Chen H,He H,Sun Z,Hu S,Cheng H,Ao Y,Wang H

更新日期：2018-05-01 00:00:00

abstract：:Novel dexrazoxane derivative JR-311 was prepared to investigate structure-activity relationships and mechanism(s) of protection against anthracycline cardiotoxicity. Its cardioprotective, antiproliferative, iron (Fe) chelation and inhibitory and/or depletory activities on topoisomerase IIbeta (TOP2B) were examined and...

journal_title：Toxicology

authors： Bures J,Jirkovska A,Sestak V,Jansova H,Karabanovich G,Roh J,Sterba M,Simunek T,Kovarikova P

更新日期：2017-12-01 00:00:00

abstract：:Clarification of the key regulatory steps that lead to nuclear factor-kappa B (NF-kappaB) under cellular and pathological conditions is very important. The action of p38 mitogen-activated protein kinase (MAPK) on the upstream of NF-kappaB activation remains controversial. To examine this issue using an in vivo lung in...

journal_title：Toxicology

authors： Kim HJ,Lee HS,Chong YH,Kang JL

更新日期：2006-08-01 00:00:00

abstract：:Inorganic arsenic (iAs) and its metabolites are transferred to the foetus through the placental barrier and this exposure can compromise the normal development of the unborn. For this reason, we assessed the toxicity of sodium arsenite (iAs(III)) and its metabolites dimethylarsinic acid (DMA(V)), monomethylarsonic aci...

journal_title：Toxicology

authors： Ferrario D,Croera C,Brustio R,Collotta A,Bowe G,Vahter M,Gribaldo L

更新日期：2008-07-30 00:00:00

abstract：:The effects of mercury (Hg(2+)) and selenite (Se(4+)) on delta-aminolevulinic acid dehydratase (delta-ALA-D) activity, 2-thiobarbituric acid reactive substances (TBARS) and nonprotein sulfhydryl content (NPSH) in mouse kidney and liver were investigated. Male mice were given a single i.p. injection of Hg(2+) and/or Se...

journal_title：Toxicology

authors： Farina M,Brandão R,de Lara FS,Pagliosa LB,Soares FA,Souza DO,Rocha JB

更新日期：2003-03-03 00:00:00

abstract：:Phthalate esters belong to a large class of compounds known as peroxisome proliferators (PP). PP include chemicals that activate different subtypes of the peroxisome proliferator-activated receptor (PPAR) family. The ability of phthalate esters and their metabolites to activate responses through different PPAR subtype...

journal_title：Toxicology

authors： Lapinskas PJ,Brown S,Leesnitzer LM,Blanchard S,Swanson C,Cattley RC,Corton JC

更新日期：2005-02-01 00:00:00

abstract：:Deltamethrin is a synthetic pyrethroid insecticide used worldwide in agriculture, home pest control, protection of foodstuff and disease vector control. The objective of this study was to investigate the propensity of deltamethrin to induce oxidative stress and changes in biochemical parameters and enzyme activities i...

journal_title：Toxicology

authors： Yousef MI,Awad TI,Mohamed EH

更新日期：2006-10-29 00:00:00

abstract：:The ubiquitous presence of nanoparticles (NPs) together with increasing evidence linking them to negative health effects points towards the need to develop the understanding of mechanisms by which they exert toxic effects. This study was designed to investigate the role of surface area and oxidative stress in the cell...

journal_title：Toxicology

authors： Hussain S,Boland S,Baeza-Squiban A,Hamel R,Thomassen LC,Martens JA,Billon-Galland MA,Fleury-Feith J,Moisan F,Pairon JC,Marano F

更新日期：2009-06-16 00:00:00

abstract：:Gordonia axillaris (Roxb.) Dietrich (Theaceae) is a native to Taiwan and the leaves have been used as an astringent folk medicine. Camelliin B (CB), a macrocyclic hydrolyzable tannin, was isolated from G. axillaris and showed cytotoxic effects in human carcinoma cells. Among the target cells (SKHep-1, Ha-22T, DU-145, ...

journal_title：Toxicology

authors： Wang CC,Chen LG,Yang LL

更新日期：2001-11-30 00:00:00

abstract：:The effects of zinc and copper on delta-aminolaevulinic acid dehydratase were studied in vitro and in vivo. The in vitro addition of zinc alone to whole blood resulted in a highly significant increase in enzyme activity. The addition of copper alone had the opposite effect with a significant decrease in enzyme activit...

journal_title：Toxicology

authors： Nelson HM,Hughes MA,Meredith PA

更新日期：1981-01-01 00:00:00

abstract：:Administration of the antiarrhythmic drug amiodarone to humans or animals may result in lung damage. Amiodarone is metabolized to desethylamiodarone and other minor metabolites. Because amiodarone and the metabolites accumulate in the lungs, it is not possible to ascertain the role of each of these compounds in the in...

journal_title：Toxicology

authors： Ogle CL,Reasor MJ

更新日期：1990-05-31 00:00:00

abstract：:Solar radiation induces acute and chronic reactions in human and animal skin. Chronic repeated exposures are the primary cause of benign and malignant skin tumors, including malignant melanoma. Among types of solar radiation, ultraviolet B (290-320 nm) radiation is highly mutagenic and carcinogenic in animal experimen...

journal_title：Toxicology

authors： Ichihashi M,Ueda M,Budiyanto A,Bito T,Oka M,Fukunaga M,Tsuru K,Horikawa T

更新日期：2003-07-15 00:00:00

abstract：:This study compares changes in cardiopulmonary function, selected endpoints in exhaled breath, blood, and bronchoalveolar lavage fluid (BAL) following a single, high-level 30-min nose-only exposure of rats to chlorine and phosgene gas. The time-course of lung injury was systematically examined up to 1-day post-exposur...

journal_title：Toxicology

authors： Luo S,Trübel H,Wang C,Pauluhn J

更新日期：2014-12-04 00:00:00

abstract：:Bromate (BrO3-) is a rodent carcinogen that is formed as a drinking water ozone disinfection by-product and also used in some food and consumer products. Therefore, bromate is subject to assessment for its risk to humans. Because the selection of an appropriate model for conducting quantitative cancer risk assessment ...

journal_title：Toxicology

authors： Moore MM,Chen T

更新日期：2006-04-17 00:00:00

abstract：:Deltamethrin, a synthetic dibromo-pyrethroid insecticide, is extensively used in agriculture, forestry and in household products because of its high activity against a broad spectrum of insect pests (both adults and larvae), its low animal toxicity and its lack of persistence in the environment. Data on the genotoxici...

journal_title：Toxicology

authors： Villarini M,Moretti M,Pasquini R,Scassellati-Sforzolini G,Fatigoni C,Marcarelli M,Monarca S,Rodríguez AV

更新日期：1998-09-15 00:00:00

abstract：:Mutagenicity analysis of urine from rats treated by oral gavage with MX at a dose of 64 mg/kg for 14 days revealed that only 0.3% of the administered compound was excreted in a genotoxically active form. At lower doses, mutagenicity was not detectable. No evidence of micronucleus induction in peripheral blood erythroc...

journal_title：Toxicology

authors： Meier JR,Monarca S,Patterson KS,Villarini M,Daniel FB,Moretti M,Pasquini R

更新日期：1996-06-17 00:00:00