Abstract：
:The effects of zinc and copper on delta-aminolaevulinic acid dehydratase were studied in vitro and in vivo. The in vitro addition of zinc alone to whole blood resulted in a highly significant increase in enzyme activity. The addition of copper alone had the opposite effect with a significant decrease in enzyme activity. When both elements were added to whole blood the inhibitory effect of copper was reduced. In in vivo studies of plasma zinc, plasma copper and whole blood delta-aminolaevulinic acid dehydratase, a positive correlation was found between plasma zinc and whole blood delta-aminolaevulinic acid dehydratase and a negative correlation was found between plasma copper and enzyme activity.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Nelson HM,Hughes MA,Meredith PAdoi
10.1016/0300-483x(81)90161-xsubject
Has Abstractpub_date
1981-01-01 00:00:00pages
261-6issue
3eissn
0300-483Xissn
1879-3185pii
0300-483X(81)90161-Xjournal_volume
21pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Evidence from epidemiological studies indicates that acute exposure to airborne pollutants is associated with an increased risk of morbidity and mortality attributed to cardiovascular diseases. The present study investigated the effects of combustion-derived ultrafine particles (diesel exhaust particles) as well as en...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.08.018
更新日期：2008-11-20 00:00:00
abstract：:Gambogic acid (GA), a major active component of gamboge, exhibits potent anticancer activity in many kinds of cancer cells. However, the anticancer mechanism of GA is not clearly understood. Here we showed that GA could cause growth inhibition, induce the G0/G1 phase cell cycle arrest and apoptosis in human chronic my...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.04.059
更新日期：2009-08-03 00:00:00
abstract：:Solar radiation induces acute and chronic reactions in human and animal skin. Chronic repeated exposures are the primary cause of benign and malignant skin tumors, including malignant melanoma. Among types of solar radiation, ultraviolet B (290-320 nm) radiation is highly mutagenic and carcinogenic in animal experimen...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(03)00150-1
更新日期：2003-07-15 00:00:00
abstract：:Among exocyclic DNA adducts, etheno (epsilon) bases (epsilond A, epsilond C, N(2),3-epsilond G) are generated by reactions of DNA bases with lipid peroxidation (LPO) products derived from endogenous sources and from the carcinogens vinyl chloride or urethane. The recent development of ultrasensitive methods has made i...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(00)00307-3
更新日期：2000-11-16 00:00:00
abstract：:A neuron spinal chord x hybrid (NSC-34) cell culture derived from neonatal mouse was characterized for studies on mercury toxicity. Exposure of NSC-34 cells to methyl mercury chloride (MeHgCl) (0-16 microM) resulted in significant dose-dependent cell damage and death (P < 0.05). MeHgCl was more toxic than inorganic me...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(98)00151-6
更新日期：1999-02-15 00:00:00
abstract：:Gordonia axillaris (Roxb.) Dietrich (Theaceae) is a native to Taiwan and the leaves have been used as an astringent folk medicine. Camelliin B (CB), a macrocyclic hydrolyzable tannin, was isolated from G. axillaris and showed cytotoxic effects in human carcinoma cells. Among the target cells (SKHep-1, Ha-22T, DU-145, ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00452-8
更新日期：2001-11-30 00:00:00
abstract：:NLRC5, a newly found member of the NLR family and the largest member of nucleotide-binding, has been reported to regulate immune responses and is associated with hepatocellular carcinoma (HCC). We investigated the mechanisms and signaling pathways of NLRC5 in HCC progression. Increased expression of NLRC5, vascular en...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2016.06.012
更新日期：2016-06-01 00:00:00
abstract：:Between the DNA sequences of two randomly-selected human genomes, which consist of over 3 billion base pairs and twenty five thousand genes, there exists only 0.1% variation and 99.9% sequence identity. During the last couple of decades, extensive genome-wide studies have investigated the association between single-nu...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2017.03.020
更新日期：2017-05-15 00:00:00
abstract：:Experiments were done in vivo to determine the effect of oxygen at high pressure (OHP) on NAD+ and NADH in mouse brain cortex. A 7% decrease (N.S.) in NADH was found in brain cortex from mice exposed to 6 atm of 100% oxygen for 8 min, while a 20% decrease (P less than 0.01) in cortical NADH, when compared to controls,...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(82)90014-2
更新日期：1982-01-01 00:00:00
abstract：:To investigate the mechanism of hepatocarcinogenesis due to dicyclanil (DC), an insect growth regulator for sheep, histopathological and molecular biological analyses were performed in the liver of male ICR mice fed on a diet containing 1500 ppm of DC for 2 weeks (Experiment I; Exp. I). In gene expression analyses usi...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.10.011
更新日期：2005-02-28 00:00:00
abstract：:Intratracheal injection of zinc oxide dust, a component of many cosmetic preparations caused elevation of alkaline phosphatase and lactate dehydrogenase in serum and lung of guinea pigs. Clearance of zinc oxide dust from lungs through zinc-carrying proteins was evident. ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90120-4
更新日期：1986-02-01 00:00:00
abstract：:The usefulness of urinary taurine as a non-invasive measure of hepatotoxicity of aflatoxin B1 (AFB1) was evaluated: changes in urinary taurine were characterized in a dose-response, acute toxicity experiment and in two sub-chronic, low dose exposure experiments. Urine of young, male, F344 rats was collected for 4 days...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(96)03610-4
更新日期：1997-03-28 00:00:00
abstract：:Arsenic and cadmium are both priority hazardous substances and human carcinogens. Although there is the potential for simultaneous exposure to both metals, the interactions of cadmium and arsenic are not well defined. We examined the toxicity of these metals when given alone or in alternating sequence to adult male Fi...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(96)03536-6
更新日期：1997-01-15 00:00:00
abstract：:The ubiquitous presence of nanoparticles (NPs) together with increasing evidence linking them to negative health effects points towards the need to develop the understanding of mechanisms by which they exert toxic effects. This study was designed to investigate the role of surface area and oxidative stress in the cell...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.04.001
更新日期：2009-06-16 00:00:00
abstract：:D-Serine causes selective necrosis to the straight portion of the rat renal proximal tubules. The onset is rapid, occurring within 3-4 h and accompanied by proteinuria, glucosuria and aminoaciduria. The metabolism of D-serine by D-amino acid oxidase (D-AAO) may be involved in the mechanism of toxicity. D-AAO is locali...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.08.008
更新日期：2005-02-01 00:00:00
abstract：:In our previous study, di-n-butyltin diacetate has been shown to cause malformations such as cleft mandible, ankyloglossia, fused ribs, etc. in rat fetuses after oral treatment of maternal rats on day 8 of gestation. In this study, teratogenic effects of five di-n-butyltin compounds with different anions and also buty...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90039-u
更新日期：1993-12-31 00:00:00
abstract：OBJECTIVE:Endothelins (ET) can be considered stress-responsive regulators working in paracrine and autocrine fashion. It has been suggested that elevated levels of ET may be responsible for the low coronary re-flow phenomena. Ischemia-reperfusion (I/R) was shown to stimulate ET release in rat heart; however, the mechan...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.11.022
更新日期：2006-02-15 00:00:00
abstract：:Double-stranded RNA-dependent protein kinase (PKR) is a component of signal transduction pathways mediating various stress signals including oxidative stress and endoplasmic reticulum (ER) stress and is suggested to be implicated in several neurodegenerative diseases. Cell death in neurodegenerative conditions has bee...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2019.02.012
更新日期：2019-04-15 00:00:00
abstract：:Aromatase enzyme plays a central role in steroidogenesis by converting androgens to estrogens and has been proposed as an important molecular target for many environmental endocrine disrupters chemicals. In this study, we have screened 30 selected pesticides with known, unknown or supposed effects on aromatase activit...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.08.021
更新日期：2006-11-10 00:00:00
abstract：:Fifteen Chinchilla rabbits were treated by seven daily i.v. injections of two doses (25 or 50 mg/kg body wt.) of sodium borocaptate (Na2B12H11SH), an agent now widely investigated for potential use in Boron Neutron Capture Therapy (BNCT) of malignant brain tumors. Definite nephrotoxic lesions hyperemic and dilated glo...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90123-a
更新日期：1993-04-30 00:00:00
abstract：:Exposure to heavy metals contributes to most of the unexplained male infertility. Lead (Pb) is a well- known heavy metal, which disrupt the male reproductive system. This study was conducted to investigate the therapeutic and protective effects of green tea active principle, epigallocatechin gallate (EGCG), on the lea...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2019.04.015
更新日期：2019-06-15 00:00:00
abstract：:Epidemiological studies in humans and experimental work in rodents suggest that exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a persistent environmental toxicant, is associated with incidence of heart disease. Although TCDD toxicity depends by and large on the aryl hydrocarbon receptor (AHR), the role of the...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2016.05.006
更新日期：2016-04-29 00:00:00
abstract：:Many studies have demonstrated that polycyclic aromatic hydrocarbons adversely affect mature mammalian immune systems. However, little is known about the cellular mechanism(s) mediating this immunosuppression or the potential for these ubiquitous environmental chemicals to similarly compromise lymphocyte development (...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(92)90103-l
更新日期：1992-01-01 00:00:00
abstract：:The measurement of levels of organic pollutants and/or their metabolites in body tissues or fluids are specific markers of internal dose and, provided that the pharmacokinetic properties of the compounds in question are known, these levels may also be used as predictors of effects. Although historical data still remai...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(95)03017-a
更新日期：1995-07-26 00:00:00
abstract：:Aluminium has been implicated in various neurodegenerative diseases but exact mechanism of action is still not known. Mitochondria being a major site of reactive oxygen species production are considered to be target of oxidative stress and it seems that the oxidative damage to mitochondrial proteins may underlie the p...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.10.009
更新日期：2009-01-31 00:00:00
abstract：:Osteotoxic compounds administered during pregnancy can initiate skeletal congenital anomalies in the embryo. In vitro, developmental osteotoxicity of a compound can be predicted with the embryonic stem cell test (EST), the only in vitro embryotoxicity model identified to date that entirely abrogates the use of animals...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2010.08.016
更新日期：2010-11-09 00:00:00
abstract：:Numerous dietary compounds, ubiquitous in fruits, vegetables and spices have been isolated and evaluated during recent years for their therapeutic potential. These compounds include flavonoid and non-flavonoid polyphenols, which describe beneficial effects against a variety of ailments. The notion that these plant pro...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2009.11.008
更新日期：2010-11-28 00:00:00
abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the biological and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dioxin-like compounds (DLC) as well as some drugs and endogenous tryptophan metabolites. Short-term activation of AhR can lead to hepatocellular s...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2015.07.005
更新日期：2015-10-02 00:00:00
abstract：:The mechanism underlying the induction of micronuclei induced by rifampicin and nicotine in mouse bone marrow was investigated by fluorescence in situ hybridization assay using mouse minor satellite DNA probe. Colchicine and mitomycin, known to be predominantly clastogenic and aneugenic, respectively were used as posi...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.03.011
更新日期：2007-06-03 00:00:00
abstract：PURPOSE:The environmental endocrine disruptors, bisphenol A (BPA) and bisphenol S (BPS) are associated with the development of type 2 diabetes. We aim to study the effects of BPA or BPS exposure on adipokine expression in human adipose tissue and on adipocyte glucose uptake. METHODS:Human subcutaneous adipose tissue w...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2020.152600
更新日期：2020-12-01 00:00:00
