Abstract：
:Aluminium has been implicated in various neurodegenerative diseases but exact mechanism of action is still not known. Mitochondria being a major site of reactive oxygen species production are considered to be target of oxidative stress and it seems that the oxidative damage to mitochondrial proteins may underlie the pathogenesis of aluminium induced neurodegeneration. Thus, the present study was undertaken to reveal the effects of chronic aluminium exposure (10mg/kg b.wt, intragastrically for 12 weeks) on the oxidative damage to mitochondrial proteins in male albino Wistar rats. Chronic aluminium exposure resulted in decrease in the activity of mitochondrial superoxide dismutase (MnSOD) and aconitase in different regions of rat brain suggesting increased oxidative stress. This decrease in MnSOD activity in turn might be responsible for the increased protein oxidation as observed in our study. All these processes taken together may cause increased oxidative damage to mitochondrial proteins in general. By taking the advantage of recent immunochemical probe for oxidatively modified proteins, we identified MnSOD to be susceptible to oxidative damage in aluminium treated animals. The quantitative RT-PCR analysis for Lon protease, a protease involved in the removal of oxidatively modified proteins from mitochondria, showed decreased mRNA expression suggesting increased oxidative damage and decreased removal of mitochondrial proteins. The identification of specific proteins as targets of oxidative damage may provide new therapeutic measures to reverse the effects of aluminium induced neurodegeneration.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Kumar V,Bal A,Gill KDdoi
10.1016/j.tox.2008.10.009subject
Has Abstractpub_date
2009-01-31 00:00:00pages
117-23issue
3eissn
0300-483Xissn
1879-3185pii
S0300-483X(08)00468-Xjournal_volume
255pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Studies on the pulmonary retention of benzo[a]pyrene after inhalation have shown that clearance is biphasic, with one component clearing with a half-time greater than 1 day and another with a half-time less than 1 day. In the work reported here we demonstrated that the amount of benzo[a]pyrene instilled in the lungs c...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(85)90066-6
更新日期：1985-06-28 00:00:00
abstract：:Catecholamines are stress hormones and sympathetic neurotransmitters essential for control of cardiac function and metabolism. However, pathologically increased catecholamine levels may be cardiotoxic by mechanism that includes iron-catalyzed formation of reactive oxygen species. In this study, five iron chelators use...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.08.006
更新日期：2011-11-18 00:00:00
abstract：:A single oral administration of O, O, S-trimethyl phosphorothioate (OOS-Me), an impurity in widely used organophosphorus insecticides, causes delayed toxicity (delayed death) which is accompanied by morphological changes in the bronchiolar epithelium of rat lungs. A series of simple O,O-dimethyl and O,O-diethyl S-alky...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(84)90032-5
更新日期：1984-07-01 00:00:00
abstract：:The effects of ascorbyl palmitate (ASCP) and free L-ascorbic acid (LAA) on the hepatotoxicity of paracetamol (acetaminophen) and the in vivo covalent binding of reactive paracetamol metabolites to hepatic proteins has been studied in male MF1 mice. The oral administration of [3H(G)]paracetamol (600 mg/kg) resulted in ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(88)90133-3
更新日期：1988-11-30 00:00:00
abstract：:Recent Canadian research efforts have been directed towards the development of a reactive skin decontaminant (RSD) lotion active against classical nerve agents and mustard. The formulation presently under study consists of a 1.25 molal solution of potassium 2,3-butanedione monoximate (KBDO) in polyethylene glycol meth...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(91)90028-y
更新日期：1991-05-01 00:00:00
abstract：:The standard treatment of poisoning by organophosphorus (OP) nerve agents with atropine and oximes is not sufficiently effective against all types of nerve agents. Alternative therapeutic strategies are required and bispyridinium non-oximes, acting as nicotinic antagonists, were identified as promising compounds. A pr...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2012.02.002
更新日期：2012-04-11 00:00:00
abstract：:The in vivo toxicity of the novel copper-based anticancer agent, casiopeina II (Cu(4,7-dimethyl-1,10-phenanthroline)(glycine)NO3) (CII), was investigated. Casiopeinas are a family of copper-coordinated complexes that have shown promising anticancer activity. The major toxic effect attributed to a single i.v. administr...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2003.08.009
更新日期：2003-12-15 00:00:00
abstract：:Dimethyl sulfoxide (DMSO) has previously been shown to protect against acetaminophen (APAP)-induced hepatotoxicity, but the mechanism of this effect was not clear. Treatment of mice with 1 mg/kg DMSO 4 h before 250 mg/kg APAP resulted in significantly less hepatotoxicity than with APAP alone, as measured by serum glut...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(88)90202-8
更新日期：1988-11-14 00:00:00
abstract：:Some organophosphorus compounds (OP) induce a delayed polyneuropathy (OPIDP) which is initiated by the phosphorylation of the so-called neuropathy target esterase (NTE). In this work some aspects of hen sciatic nerve NTE are studied. The assay method is reported and modifications are discussed and a combined method pr...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(88)90181-3
更新日期：1988-04-01 00:00:00
abstract：:Simultaneous exposure to cadmium and arsenic is highly probable in the urban area of San Luis Potosi, Mexico due to common localization of copper and zinc smelters. Therefore, in this work, rats were intraperitoneally exposed either to cadmium or arsenic alone, or simultaneously to both metals. The effects of these tr...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90135-4
更新日期：1990-11-01 00:00:00
abstract：:It has been suggested that one possible contributor to the increasing prevalence of atopic (IgE-mediated) allergic diseases and asthma in Europe and the US is exposure to chemicals that may act as adjuvants. Certain commonly used phthalate plasticisers, such as di-(2-ethylhexyl) phthalate, have been implicated in this...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2010.03.020
更新日期：2010-05-27 00:00:00
abstract：:It has been suggested that the measurement of DNA-protein cross-links (DPCs) may be of value in the assessment of an individual's exposure to specific environmental insults. For a biomarker to be reliable, its results should be consistent and specific. In the present study, the precision and specificity of the K(+)-SD...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(96)03318-5
更新日期：1996-06-17 00:00:00
abstract：:Chlordecone (CD) impairs biliary excretion of organic anions (including phenolphthalein glucuronide (PG), imipramine polar metabolites, and taurocholate) without evidence of hepatocellular necrosis in rats. In this study we investigated the hypothesis that CD-induced hepatobiliary dysfunction is dependent on CD concen...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90057-4
更新日期：1994-01-26 00:00:00
abstract：:Polycyclic aromatic hydrocarbons (PAHs) with molecular weight 278 are a group of PAHs that are mostly not covered by the current monitoring programs, despite their relative abundance in environmental samples and possible carcinogenicity. Although benzo[g]chrysene (BgChry) and dibenz[a,h]anthracene (DBahA) have been fo...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.12.024
更新日期：2007-03-22 00:00:00
abstract：:The osteolathyrogenic agent semicarbazide was assayed for its toxicity and teratogenicity using early embryos of the frog Xenopus laevis. The 96-h LC50 is 1504.20 mg/l while the 96-h EC50 is 76.28 mg/l. Embryo length is altered prior to the onset of other effects indicated by a reduction in stage of development. The m...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(85)90053-8
更新日期：1985-08-01 00:00:00
abstract：:A qualitative assessment of developmental toxicity within a series of 12 structurally related compounds, 11 of which were active dopamine mimetics and one was inactive, was conducted in rats treated orally by gavage during the major period of organogenesis. Doses were chosen where possible to be equipotent in terms of...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(92)90189-l
更新日期：1992-12-04 00:00:00
abstract：:A flow-limited physiologically based toxicokinetic model was constructed for uptake, metabolism, and clearance of butadiene (BD) and its principal metabolite 1,2-epoxy-3-butene (EB), using physiological and biochemical parameters from the literature where available. The model includes compartments for blood, liver, lu...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(96)03424-5
更新日期：1996-10-28 00:00:00
abstract：:Oxybutynin hydrochloride, an anti-cholinergic/anti-spasmodic agent, was examined for its effect on fertility and peri-post natal development in the rat and its embryotoxic potential in the rat and rabbit. In the rat effects on reproductive performance included a slight increase in the incidence of foetal malformations...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90044-2
更新日期：1986-07-01 00:00:00
abstract：:Atrazine (ATZ) is used throughout North America to control annual broadleaf weeds and grasses in various crops including; corn, sorghum, and sugar cane. Unfortunately, contamination of surface and ground water has occurred as a result of ATZ's chemical and physical properties, and its widespread use throughout the U.S...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.12.002
更新日期：2005-04-01 00:00:00
abstract：:Haptens are classified as low molecular chemicals with an intrinsic potential to covalently modify proteins, and many of them are strong inducers of contact hypersensitivity (CHS). CHS is T cell mediated, and hapten-specific T cells have been shown to interact with hapten-modified, MHC-associated peptides. However, th...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2004.12.015
更新日期：2005-04-15 00:00:00
abstract：:There is considerable interest in gene and environment interactions in neurodegenerative diseases. The HFE (homeostatic iron regulator) gene variant (H63D) is highly prevalent in the population and has been investigated as a disease modifier in multiple neurodegenerative diseases. We have developed a mouse model to in...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2020.152525
更新日期：2020-08-01 00:00:00
abstract：:The effects of thallous cation (Tl(+)) on: (a) the production of oxidant species and (b) membrane fluidity were evaluated in human leukemia T cells (Jurkat). After 72 h of incubation in the presence of Tl(+) (5-100 microM), no significant changes in cell viability were observed, although the average cell size was decr...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.01.028
更新日期：2006-05-01 00:00:00
abstract：:Increased antigen-specific IgE expression is a hallmark of the allergic response in mice. IgG1 may also be involved. Co-injection of mice with diesel exhaust particles (DEP) and ovalbumin three times over a 2 week period lead to a rapid and marked elevation of ovalbumin-specific IgE, IgG1 and also IgG2a, compared with...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00418-2
更新日期：2001-02-28 00:00:00
abstract：:The subacute toxicity of sodium saccharin and 2 hydrolytic derivatives, o-sulfamoylbenzoic acid (Compound I) and ammonium o-carboxybenzene sulfonate (Compound II) was evaluated by feeding each of the compounds alone at a dietary level of 20 000 ppm to both beagle dogs and albino rats. Additionally, groups of dogs and ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(76)90015-9
更新日期：1976-08-01 00:00:00
abstract：:Trans-1,2-dichloroethylene (t-DCE), an industrial solvent, proved to be moderately toxic when studied in small laboratory animals. In adult female rats brief (8 h) and prolonged (8 h daily, on 5 consecutive days a week, for more than 16 weeks) inhalation of 200 ppm--the current TLV/MAC in various countries--produced h...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(77)90059-2
更新日期：1977-04-01 00:00:00
abstract：:The cytotoxicity and cardiotoxicity of benzoyl mustard (FCE 24517) and epoxamido (FCE 24561) synthetic derivatives of distamycin A were reported in the present study. The 50% inhibiting concentration (IC50) of colony formation of FCE 24517 on human SNB-19 glioblastoma, A2780 ovarian cancer and DU 145 prostate cancer w...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(92)90003-w
更新日期：1992-11-15 00:00:00
abstract：:The local lymph node assay (LLNA) is a regular method for the detection of sensitizing chemicals in mice which measures the incorporation of tritiated thymidine in lymph node cells. We have evaluated an alternative to this method based on the interleukin-2 (IL-2) production of lymph node cells. At the mRNA level, no c...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.09.003
更新日期：2005-01-15 00:00:00
abstract：:A 20-year-old man on oral substitution of pancreatic enzymes after hemipancreatectomy injected an enzyme preparation of fungal origin intravenously after dissolving it in water. Within a few hours chills, headache, nausea and vomiting, fever of 40.8 degrees C, and shock occurred. The acute illness might have been caus...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(89)90189-3
更新日期：1989-04-01 00:00:00
abstract：:Experiments were done in vivo to determine the effect of oxygen at high pressure (OHP) on NAD+ and NADH in mouse brain cortex. A 7% decrease (N.S.) in NADH was found in brain cortex from mice exposed to 6 atm of 100% oxygen for 8 min, while a 20% decrease (P less than 0.01) in cortical NADH, when compared to controls,...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(82)90014-2
更新日期：1982-01-01 00:00:00
abstract：:Repeated intraperitoneal administration of benzene (1.0 ml/kg body wt) for 3 days produced leucopenia, lymphocytopenia and an increased number of nucleated cells in the bone marrow and significantly decreased organ weights of thymus (P less than 0.001) and spleen (P less than 0.001) in female albino rats. Iron content...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90029-6
更新日期：1986-06-01 00:00:00
