Abstract：
:Numerous dietary compounds, ubiquitous in fruits, vegetables and spices have been isolated and evaluated during recent years for their therapeutic potential. These compounds include flavonoid and non-flavonoid polyphenols, which describe beneficial effects against a variety of ailments. The notion that these plant products have health promoting effects emerged because their intake was related to a reduced incidence of cancer, cardiovascular, neurological, respiratory, and age-related diseases. Exposure of the body to a stressful environment challenges cell survival and increases the risk of chronic disease developing. The polyphenols afford protection against various stress-induced toxicities through modulating intercellular cascades which inhibit inflammatory molecule synthesis, the formation of free radicals, nuclear damage and induce antioxidant enzyme expression. These responses have the potential to increase life expectancy. The present review article focuses on curcumin, resveratrol, and flavonoids and seeks to summarize their anti-inflammatory, cytoprotective and DNA-protective properties.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Bisht K,Wagner KH,Bulmer ACdoi
10.1016/j.tox.2009.11.008subject
Has Abstractpub_date
2010-11-28 00:00:00pages
88-100issue
1eissn
0300-483Xissn
1879-3185pii
S0300-483X(09)00584-8journal_volume
278pub_type
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