Abstract:
:The effects of ascorbyl palmitate (ASCP) and free L-ascorbic acid (LAA) on the hepatotoxicity of paracetamol (acetaminophen) and the in vivo covalent binding of reactive paracetamol metabolites to hepatic proteins has been studied in male MF1 mice. The oral administration of [3H(G)]paracetamol (600 mg/kg) resulted in covalent binding to hepatic proteins, a depletion of hepatic non-protein sulphydryl (NPS) groups after 2 h, and a marked elevation of plasma alanine aminotransferase (ALAT) activity after 24 h. The co-administration of paracetamol and ASCP (1412 mg/kg, equivalent to 600 mg/kg free LAA), but not paracetamol and LAA (600 mg/kg), significantly reduced covalent binding of paracetamol metabolites at 2 and 4 h after treatment. In addition ASCP, but not LAA, significantly reduced the depletion of NPS groups and the elevation of plasma ALAT activity. ASCP also completely prevented the 35% mortality observed at 24 h in paracetamol treated mice. These results demonstrate that ASCP, but not LAA, when co-administered orally with the analgesic is an effective inhibitor of paracetamol-induced hepatotoxicity in the mouse. The mechanism by which ASCP prevents liver injury appears to involve destruction of reactive paracetamol metabolites which is associated with a sparing action on hepatic reduced glutathione levels.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Jonker D,Lee VS,Hargreaves RJ,Lake BGdoi
10.1016/0300-483x(88)90133-3subject
Has Abstractpub_date
1988-11-30 00:00:00pages
287-95issue
3eissn
0300-483Xissn
1879-3185pii
0300-483X(88)90133-3journal_volume
52pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::In an attempt to assess the effect of ethanol on cadmium accumulation, metallothionein (MT) synthesis, Cd-binding capacity and lipid peroxidation, rats were administered either Cd, ethanol or their combination for a period of 4 weeks. A significant increase in Cd accumulation was observed in all the organs of rats und...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(92)90177-g
更新日期:1992-01-01 00:00:00
abstract::The long-term clinical usefulness of doxorubicin (DOX), an anthracycline with potent antitumor activity, is limited by DOX-induced cardiotoxicity. Kaempferol, one of the most common dietary flavonoids, is known to have anti-apoptotic, anti-oxidative, and anti-inflammatory properties. The current study aimed to investi...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.11.018
更新日期:2012-02-06 00:00:00
abstract::Experiments were designed to assess the mechanisms of diisopropyl fluorophosphate (DFP)-induced changes in thermoregulation of the rat. In one study, male rats of the Long-Evans strain were injected with DFP (s.c.) at doses ranging from 0 to 2.0 mg/kg while maintained at an ambient temperature (Ta) of 20--24 degrees C...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90159-x
更新日期:1991-03-25 00:00:00
abstract::The possible juvenilizing effects of Dimilin and Altosid against larvae of Culex pipiens L. were studied. Apart from delayed lethal action, possible effect on the mean number of basal follicles developed per female has been considered. A baseline exposure was found which caused only low mortalities of the early 4th la...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(81)90137-2
更新日期:1981-01-01 00:00:00
abstract::Alkylfurans inflict toxicity in several mammalian species to lung, liver and kidney. Organ specificity of the alkylfurans is a sensitive function of the nature of the alkyl group. To determine if this toxicity requires an aromatic ring in the compound, we synthesized 4-methyl-2,3-dihydrofuran, 4-ethyl-2,3-dihydrofuran...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90006-3
更新日期:1990-03-30 00:00:00
abstract::Fifteen Chinchilla rabbits were treated by seven daily i.v. injections of two doses (25 or 50 mg/kg body wt.) of sodium borocaptate (Na2B12H11SH), an agent now widely investigated for potential use in Boron Neutron Capture Therapy (BNCT) of malignant brain tumors. Definite nephrotoxic lesions hyperemic and dilated glo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(93)90123-a
更新日期:1993-04-30 00:00:00
abstract::Organotellurides are important intermediates in organic synthesis and, consequently, the occupational exposure to them is a constant risk for laboratory workers. These compounds can elicit many neurotoxic events in the central nervous system (CNS) that are associated with several neurological symptoms. In contrast, or...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.02.009
更新日期:2006-05-01 00:00:00
abstract::The influence of pretreatment with the drug mixture (pyridostigmine, benactyzine and trihexyphenidyle), and antidotal treatment (the oxime HI-6 in combination with benactyzine) on respiration, circulation and survival of experimental animals poisoned with supralethal doses of soman (2 x LD50) was investigated in a rat...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00186-8
更新日期:1998-06-26 00:00:00
abstract::This paper looks at toxicology digital sources produced and available in the United Kingdom (UK). It includes products aggregating a number of sources, which may include information from other countries, and for the convenience of the reader and information seeker these have also been described. ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(03)00198-7
更新日期:2003-08-21 00:00:00
abstract::Although NO2-induced cytotoxic responses have been well characterized, the specific mechanisms responsible for initiating toxicity remain equivocal. The inhomogeneous distribution of epithelial injury suggests that differential interactions between NO2 and the lung surfaces may contribute to the extent of regional res...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(94)90099-x
更新日期:1994-05-20 00:00:00
abstract::The induction of unscheduled DNA synthesis (UDS) in early spermatid stages of mice was studied after treatment with hydrazine or procarbazine (Natulan). The UDS response was assayed by measuring the levels of [3H]dThd in the nuclei of sperm cells derived from treated and untreated early spermatid stages. The radioacti...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(82)90030-0
更新日期:1982-01-01 00:00:00
abstract::In a Japanese chemical factory, a lung disease like pneumoconiosis appeared at a high rate among workers handling cross-linked water-soluble acrylic acid polymer (CWAAP). To our knowledge, no such case was known in the world until very recently. The present study was designed to elucidate the effect of single intratra...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152647
更新日期:2021-01-30 00:00:00
abstract::Several epidemiological studies have shown that acute exposure to particulate air pollution is associated with increases in cardiovascular morbidity and mortality, and that these effects are especially exacerbated among individuals with pre-existing compromised cardiovascular function such as hypertension. This study ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.03.018
更新日期:2011-07-11 00:00:00
abstract::Chemical carcinogens are generally classified as genotoxic or non-genotoxic. However, weak genotoxicity at high concentrations is sometimes observed and interpretation is often problematic. In addition, certain rodent carcinogens exert their effects at doses associated with cytotoxicity and compensatory hyperplasia ma...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(03)00058-1
更新日期:2003-05-03 00:00:00
abstract::The combined effects of ethyl alcohol (ETOH) intoxication and carbon monoxide (CO) poisoning were studied in the Levine-prepared rat. Infusion or injection of ETOH before and during 90 min of CO exposure to blood levels 2-4 times those considered legally drunk in humans, increased survival at 2400 ppm, and extended th...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90111-s
更新日期:1990-05-31 00:00:00
abstract::Deltamethrin, an alpha-cyano type II synthetic pyrethroid insecticide is used to control a wide range of insects on a variety of crops. Deltamethrin is reported to cause many adverse effects on non-target species. Deltamethrin is reported to cause DNA damage and micronuclei induction in human lymphocytes. It is highly...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00416-9
更新日期:2001-05-28 00:00:00
abstract::Amiodarone is a class III anti-arrhythmic compound that is iodinated, cationic and amphiphilic in nature. The clinical use of amiodarone may be associated with various side-effects, including pulmonary and hepatic toxicity. Use of this compound during pregnancy may therefore place the fetus at risk through in utero ex...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90085-f
更新日期:1991-01-01 00:00:00
abstract::In the rat the hepatotoxicity of bromobenzene is greatly enhanced by the introduction of a cyano group adjacent to the bromine (i.e. o-bromobenzonitrile). Epoxide metabolites of these aryl halides are believed to be the actual toxic species, but epoxides of the latter compound also possess a second site of chemical re...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(84)90106-9
更新日期:1984-06-01 00:00:00
abstract::Recently we observed a suppressed delayed-type hypersensitivity (DTH) response to bovine serum albumin (BSA) in the 4-5-month-old offspring of F344 rat dams receiving as little as 1.0 microg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg on gestational day (GD) 14. This study was designed to characterize better this su...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(99)00024-4
更新日期:1999-05-03 00:00:00
abstract::Thiols are known to influence the metabolism of glutathione. In a previous study (Toxicology 156 (2001) 93) dithiothreitol (DTT) did not show any effect on intra- or extracellular glutathione concentrations in HeLa cell cultures but increased the effects of mercury ions on glutathione concentrations, whereas monothiol...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00060-4
更新日期:2002-06-14 00:00:00
abstract::For half of the 30-odd years that diacetyl-exposed workers have developed disabling lung disease, obliterative bronchiolitis was unrecognized as an occupational risk. Delays in its recognition as an occupational lung disease are attributable to the absence of a work-related temporal pattern of symptoms; failure to rec...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2016.06.009
更新日期:2017-08-01 00:00:00
abstract::Tobacco smoking is the largest preventable risk factor for morbidity and mortality in industrialized countries. WHO estimates that tobacco will become the largest single health problem by 2020, causing an estimated 8.4 million deaths annually. Tobacco has central importance in the etiology of cancers of the lung, head...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(01)00445-0
更新日期:2001-09-14 00:00:00
abstract::To establish a paraquat-resistant Wistar rat strain, we carried out continuous sister-brother mating among rats that survived high-dose intraperitoneal administration of paraquat dichloride (360 mg/kg). The percentages of paraquat-resistant rats among wild rats and among the fifth-generations were 7.1% and 20.6%, resp...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00299-7
更新日期:2000-11-23 00:00:00
abstract::Butachlor is a systemic herbicide widely applied on rice, tea, wheat, beans and other crops; however, it concurrently exerts toxic effects on beneficial organisms like earthworms, aquatic invertebrates and other non-target animals including humans. Owing to the associated risk to humans, this chloroacetanilide class o...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2012.07.014
更新日期:2012-12-08 00:00:00
abstract::A quantitative animal model was developed to study amelioration of carbon tetrachloride-induced hepatic injury by post-toxicant administration of cystamine. Amelioration of CCl4-induced injury by post-toxicant cystamine treatment was compared to prevention of injury by cystamine pretreatment and possible mechanisms of...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90131-9
更新日期:1986-05-01 00:00:00
abstract::Cyclosporine (CsA) is a universally used immunosuppressive drug which induces adverse side effects in several organs, but its impact on the heart is still controversial. Small heat shock proteins (sHSPs), such as HSP25 and alpha B-crystallin, are cytoprotective stress proteins exceptionally represented in the heart. T...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.06.007
更新日期:2009-08-21 00:00:00
abstract::The influence of the known hepatotoxic agent, cerium (Ce) on the activity of liver microsomal monoxygenases, especially coumarin 7-hydroxylase (COH) was investigated in two inbred strains of male mice, DBA/2N and C57BL/6N. Ce was injected intravenously in three doses (0.5, 1.0 and 2.0 mg/kg body wt) and the animals we...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90148-t
更新日期:1991-01-01 00:00:00
abstract::Bisphenol A (BPA), is an artificial estrogen initially produced for medical purposes but is today widely used in polycarbonate plastics and epoxy resins. Exposure-related reproductive disorders have been found, but recently it has also been suggested that BPA may be involved in obesity, diabetes, myocardial hypertroph...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2016.02.007
更新日期:2016-03-10 00:00:00
abstract::Cell death triggers the release into extracellular spaces of products of chromatin catabolism, particularly of DNA. A sensitive DNA assay has been used to investigate in the mouse whether the quantitation of plasma DNA may be used as an index of in vivo cytotoxicity. It has been found that toxic doses of bacterial lip...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90178-j
更新日期:1990-04-30 00:00:00
abstract::This review concerns some of the cell culture systems that are most frequently used in toxicology investigations. In particular, it sets out to evaluate the effectiveness of these cell culture systems in assessing the toxic potential of chemicals. Metabolic studies and general and specific toxicology investigations ar...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(81)90046-9
更新日期:1981-01-01 00:00:00