Abstract:
:This paper looks at toxicology digital sources produced and available in the United Kingdom (UK). It includes products aggregating a number of sources, which may include information from other countries, and for the convenience of the reader and information seeker these have also been described.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Pantry Sdoi
10.1016/s0300-483x(03)00198-7keywords:
subject
Has Abstractpub_date
2003-08-21 00:00:00pages
75-91issue
1-2eissn
0300-483Xissn
1879-3185pii
S0300483X03001987journal_volume
190pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::Glutathione (GSH) plays an important role in the metabolism of arsenite and arsenate by generating arsenic-glutathione complexes. Although dimethylarsinic acid (DMA(V)) is the major metabolite of inorganic arsenicals (iAs) in urine, it is not clear how DMA(V) is produced from iAs. In the present study we report that S...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.07.009
更新日期:2006-10-03 00:00:00
abstract::The subacute toxicity of sodium saccharin and 2 hydrolytic derivatives, o-sulfamoylbenzoic acid (Compound I) and ammonium o-carboxybenzene sulfonate (Compound II) was evaluated by feeding each of the compounds alone at a dietary level of 20 000 ppm to both beagle dogs and albino rats. Additionally, groups of dogs and ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(76)90015-9
更新日期:1976-08-01 00:00:00
abstract::An increasing body of data has been demonstrating that mammalian cells have elaborate networks of molecular signalling in counteracting heat shock and in developing adaptation to oxidative stress to avoid cell death. However, the precise mechanisms linking heat shock, oxidative stress and cell survival/cell death mech...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.04.028
更新日期:2006-07-25 00:00:00
abstract::The local lymph node assay (LLNA) is a regular method for the detection of sensitizing chemicals in mice which measures the incorporation of tritiated thymidine in lymph node cells. We have evaluated an alternative to this method based on the interleukin-2 (IL-2) production of lymph node cells. At the mRNA level, no c...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.09.003
更新日期:2005-01-15 00:00:00
abstract::Transferrin, as the major iron-transport protein in serum and other body fluids, has a central role in managing iron the body receives. Liver is a major site of transferrin synthesis, and in this study we present evidence that liver synthesis of human transferrin is suppressed by both the toxic metal lead and bacteria...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(96)03586-x
更新日期:1997-03-14 00:00:00
abstract::The chlorinated acetic acids, in particular dichloroacetic acid (DCA), are found as chlorine disinfection by-products in finished drinking water supplies. DCA has previously been demonstrated to be a mouse liver carcinogen. Chronic studies are described in which male Fischer (F344) rats were exposed to DCA in their dr...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(96)03510-x
更新日期:1996-12-18 00:00:00
abstract::T- and B-cells recognise drugs when bound as haptens to carrier molecules. Recent studies suggest that drugs might also bind in a non-covalent form to MHC-peptide complexes and T cell receptors, and are thereby able to stimulate T cells. This has, however, only been shown for drug-specific T cell clones. Functional an...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(00)00399-1
更新日期:2001-02-02 00:00:00
abstract::In 1975, in cooperation with 8 County Hygienic Stations, total mercury content in fish from rivers and lakes in Hungary was measured. The mercury content in fish muscle-tissue from 164 fish samples averaged 0.36 mg/kg. Average levels in different fish species ranged from 0.10 to 0.57 mg/kg. The amount of mercury in fi...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(77)90052-x
更新日期:1977-06-01 00:00:00
abstract::Pregnant rats were dosed with 300, 600, 1000, 2000, 3000 or 4000 ppm inorganic lead through their drinking water during pregnancy and during lactation until 21 days post partum. An effect on live litter size was noted at the higher doses as was an increased tendency for sperm positive females to fail to produce a litt...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(81)90122-0
更新日期:1981-01-01 00:00:00
abstract::Human liver microsomes, supersomes from baculovirus-transformed insect cells expressing different human CYP450 isoforms, and control and CYP3A4 cDNA-transfected V79 Chinese hamster cells were tested for their ability to metabolize territrem B (TRB) and territrem C (TRC). Two TRB metabolites, designated MB(2) and MB(4)...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.10.010
更新日期:2006-02-01 00:00:00
abstract::The contributions of the hepatic microsomal and cytosolic fractions in the metabolic activation of the promutagen 2-aminofluorene into mutagenic intermediates in the Ames test were investigated. Rat hepatic postmitochondrial, microsomal and cytosolic preparations could convert 2-aminofluorene to mutagens, the postmito...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(92)90050-o
更新日期:1992-01-01 00:00:00
abstract::Both simultaneous and sequential exposure to heavy metals and aryl hydrocarbon receptor (AHR)-ligands potentially occur in human populations, yet there have been relatively few studies of combined effects of heavy metals and AHR-ligands on AHR-regulated genes. To investigate the effects of heavy metals on AHR-regulate...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.04.011
更新日期:2004-09-01 00:00:00
abstract::In our experiments on acutely lead exposed rats we observed a marked increase (a 2-fold or 3-fold increase with 30 mg/kg or 60 mg/kg lead acetate, respectively) in [3H]quinuclidinyl benzilate [( 3H]QNB) specific binding to muscarine receptors from striatum and cortex, without any change in receptor affinity. Muscarine...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(84)90005-2
更新日期:1984-05-14 00:00:00
abstract::Envenoming by the pitviper Bothrops jararacussu produces cardiovascular alterations, including coagulopathy, systemic hemorrhage, hypotension, circulatory shock and renal failure. In this work, we examined the activity of this venom in rat isolated right atria. Incubation with venom (0.025, 0.05, 0.1 and 0.2mg/ml) cau...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2014.06.010
更新日期:2014-09-02 00:00:00
abstract::The ability of 27 compounds to mediate depletion of glutathione (GSH) in a fortified liver microsome incubation via production of reactive metabolites generated by microsomal mono-oxygenase (MMO) metabolism has been studied. The majority of compounds tested of this type were positive in this assay, with the exception ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(89)90082-6
更新日期:1989-01-01 00:00:00
abstract::It has been suggested that one possible contributor to the increasing prevalence of atopic (IgE-mediated) allergic diseases and asthma in Europe and the US is exposure to chemicals that may act as adjuvants. Certain commonly used phthalate plasticisers, such as di-(2-ethylhexyl) phthalate, have been implicated in this...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2010.03.020
更新日期:2010-05-27 00:00:00
abstract::Mercury is one of the major heavy metal pollutants occurring in elemental, inorganic and organic forms. Due to ban on most inorganic mercury containing products, human exposure to mercury generally occurs as methylmercury (MeHg) by consumption of contaminated fish and other sea food. Animal and epidemiological studies...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.05.006
更新日期:2017-07-01 00:00:00
abstract::The importance of dietary factors for prostate carcinogenesis has been proven by epidemiological studies of immigrants from Asia into the USA. Intake of foodstuffs rich in fat, including meat, is suggested to be a risk factor. Experimentally, while some studies demonstrated high fat intake to promote rat prostate carc...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(02)00260-3
更新日期:2002-12-27 00:00:00
abstract:PURPOSE:The environmental endocrine disruptors, bisphenol A (BPA) and bisphenol S (BPS) are associated with the development of type 2 diabetes. We aim to study the effects of BPA or BPS exposure on adipokine expression in human adipose tissue and on adipocyte glucose uptake. METHODS:Human subcutaneous adipose tissue w...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152600
更新日期:2020-12-01 00:00:00
abstract::We investigate the ability of S-adenosylmethionine (SAMe) to antagonize the cyclosporine A (CyA)-induced inhibition of biliary glutathione efflux induced by long-term administration of CyA (10 mg/kg per day-CyA(10) or 20 mg/kg per day-CyA(20) for 4 weeks) in rats. CyA treatment reduced the liver content of total gluta...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.02.030
更新日期:2004-07-15 00:00:00
abstract::Tetrahydrocannabinol (THC), a psychoactive component of marijuana, is known to exert cytotoxicity in immune cells. In the present study, we examined the cytotoxicity of Δ⁸-THC in mouse macrophage J774-1 cells and a possible involvement of cannabinoid receptors and stress-responsive mitogen-activated protein kinases (M...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2013.10.007
更新日期:2013-12-15 00:00:00
abstract::We examined the role of miRNAs in DNA damage response in HepG2 cells following exposure to 4-aminobiphenyl (4-ABP). The arylamine 4-ABP is a human carcinogen. Using the Comet assay, we showed that 4-ABP (18.75-300μM) induces DNA damage in HepG2 cells after 24h. DNA damage signaling pathway-based PCR arrays were used t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2014.05.003
更新日期:2014-08-01 00:00:00
abstract::Troglitazone is a thiazolidinedione antidiabetic agent with insulin-sensitizing activities that was withdrawn from the market in 2000 due to its association with idiosyncratic hepatotoxicity. To address the suspected autoantibody production associated with troglitazone, we investigated autoantibodies in sera from pati...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.07.012
更新日期:2005-12-01 00:00:00
abstract::Double-stranded RNA-dependent protein kinase (PKR) is a component of signal transduction pathways mediating various stress signals including oxidative stress and endoplasmic reticulum (ER) stress and is suggested to be implicated in several neurodegenerative diseases. Cell death in neurodegenerative conditions has bee...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.02.012
更新日期:2019-04-15 00:00:00
abstract::The immunohistochemical localization of G alpha q/G alpha 11 was studied in the olfactory neuroepithelium of the channel catfish. Antigenicity in the rosette was found at the apical surfaces of cells, within the apical neck regions of some cells, and within the area of the basal nerve tracts. Specific labeling was eli...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(96)03558-5
更新日期:1997-02-28 00:00:00
abstract::The concept that the highly reactive hydroxyl radical (HO) could be generated from an interaction between superoxide (O(2)(-)) and hydrogen peroxide (H(2)O(2)) was proposed (with Joseph Weiss) in Professor Haber's final paper published in 1934. Until it was recognized that free radicals are produced in biological syst...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(00)00231-6
更新日期:2000-08-14 00:00:00
abstract::Extract and fractions of city smog collected from a heavy industrialized area caused in vitro dose-dependent reduction of cell survival of mouse macrophages and a growth inhibition of human fetal diploid lung fibroblasts. Great differences were observed in both cell systems between the total extract and its different ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(80)90091-8
更新日期:1980-01-01 00:00:00
abstract::National and international law is an essential component of the array of measures serving to protect against the hostile release of biological or chemical agents, and to help to mitigate the consequences should such a release nevertheless take place. These includes the Geneva Protocol of 1925, the Chemical Weapons Con...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.06.017
更新日期:2005-10-30 00:00:00
abstract::In several separate experiments neonatal rats were intubated daily with 9, 27 or 81 mg lead acetate/kg of body weight throughout their 3-week postnatal period of development. Based on average body weights, the total daily lead intake was 0.156, 0.454 or 1.384 mg lead per animal, respectively (in addition to normal lea...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(75)90115-8
更新日期:1975-11-01 00:00:00
abstract::Genetic polymorphism of drug metabolizing enzymes (DME) can lead to severe toxicity or therapeutic failure of pharmacotherapy. Additionally, genetically determined differences in the activity of the metabolic enzymes can increase an individual's susceptibility to certain types of chemically induced cancers and possibl...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(99)00199-7
更新日期:2000-04-03 00:00:00