Abstract：
:The subacute toxicity of sodium saccharin and 2 hydrolytic derivatives, o-sulfamoylbenzoic acid (Compound I) and ammonium o-carboxybenzene sulfonate (Compound II) was evaluated by feeding each of the compounds alone at a dietary level of 20 000 ppm to both beagle dogs and albino rats. Additionally, groups of dogs and rats were fed combinations of the 3 materials at levels up to 20 000 ppm (2000 ppm sodium saccharin, 9000 ppm of both Compound I and II). Dogs were maintained on the test diets for 16 weeks, rats for 13 weeks. No signs of a pharmacotoxic response to the test materials were observed. Parameters determined for treated animals, including growth, food consumption, hematologic profiles, clinical blood chemistry studies, urinalyses, organ weight and ratio data, and both gross and microscopic pathologic evaluation, were not significantly different from control values. From these findings, it is suggested that there is little toxicologic hazard associated with ingestion of the 2 hydrolytic derivatives of sodium saccharin.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Kennedy GL Jr,Fancher OE,Calandra JCdoi
10.1016/0300-483x(76)90015-9subject
Has Abstractpub_date
1976-08-01 00:00:00pages
133-8issue
2eissn
0300-483Xissn
1879-3185pii
0300-483X(76)90015-9journal_volume
6pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:The fetotoxicity of nitrofen and 5 analogous diphenyl ethers was compared in mice, using survival on postnatal day 5 to evaluate prenatal and perinatal toxicity. The effect of each chemical on the Harderian gland weight of surviving pups was also assessed, since decreased Harderian gland weight is seen in nitrofen-exp...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90062-4
更新日期：1986-09-01 00:00:00
abstract：:Osteoblasts dysfunction, induced by aluminum (Al), plays a critical role in the osteoporosis etiology. Ginsenoside Rb1 (Rb1) has the therapeutic properties for osteoporosis. This study aimed to assess the efficiency of Rb1 in ameliorating Al-induced osteoblasts dysfunction. The osteoblasts were divided into four group...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2016.07.014
更新日期：2016-08-10 00:00:00
abstract：:Butylated hydroxytoluene (BHT)-induced lung damage in mice is an excellent model system for studying mechanisms of chemically-induced, reversible alveolar injury. Changes in the pulmonary contents of protein kinase C (PKC) and the calcium-dependent protease, calpain, were previously noted during the repair phase follo...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)02943-o
更新日期：1995-03-31 00:00:00
abstract：:During the past decade, several assessments have estimated the carcinogenic risk of inhaled 1,3-butadiene (BD) to the general population as well as for occupational exposures. Although most of the risk assessments have been based on inhalation bioassays in mice, some of the assessments have included the 2-year inhalat...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(96)03447-6
更新日期：1996-10-28 00:00:00
abstract：:Simultaneous exposure to cadmium and arsenic is highly probable in the urban area of San Luis Potosi, Mexico due to common localization of copper and zinc smelters. Therefore, in this work, rats were intraperitoneally exposed either to cadmium or arsenic alone, or simultaneously to both metals. The effects of these tr...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90135-4
更新日期：1990-11-01 00:00:00
abstract：:The term "health/functional food" (HFF) refers to food supplements containing nutrients or other substances (in a concentrated form) that have a nutritional or physiological effect whose purpose is to supplement the normal diet. The Korean Health/Functional Food Act that came into effect in 2004 requires these product...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.01.016
更新日期：2006-04-03 00:00:00
abstract：BACKGROUND/AIMS:Liver fibrosis has been reported to be inhibited in vivo by oleanolic and ursolic acids. However, the mechanisms of the action of those triterpenoids are poorly understood. In this study, we aimed to determine the antifibrotic potential of other triterpenes, betulin and betulinic acid, and to characteri...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2010.12.006
更新日期：2011-02-27 00:00:00
abstract：:Static and rotary cultures of adult rabbit hepatocytes can be produced reproducibly following their isolation by means of a simplified, inexpensive recycling perfusion system. Light and electron microscopic examination of the cultures showed that these hepatocytes retained the morphological characteristics of fully di...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(82)90052-x
更新日期：1982-01-01 00:00:00
abstract：:In the rat the hepatotoxicity of bromobenzene is greatly enhanced by the introduction of a cyano group adjacent to the bromine (i.e. o-bromobenzonitrile). Epoxide metabolites of these aryl halides are believed to be the actual toxic species, but epoxides of the latter compound also possess a second site of chemical re...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(84)90106-9
更新日期：1984-06-01 00:00:00
abstract：:It is reported that gambogic acid (GA), the main active compound of gamboge which is a dry resin extracted from Garcinia hanburyi tree, has potent antitumor activity both in vivo and in vitro. Activation of mitochondrial apoptotic pathway in cancer cells is one effective therapy for cancer treatment. In the present st...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.03.010
更新日期：2009-06-16 00:00:00
abstract：:Korea has a great diversity in resources of medicinal plants. The traditional herbal medicines and their preparations have been widely used in Korea as well as in China and Japan for thousands of years. One of the characteristics of Korean herbal medicine preparations is that all the herbal medicines are incorporated ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(02)00487-0
更新日期：2002-12-27 00:00:00
abstract：:To evaluate the developmental toxicity of uranium, 5 groups of 20 pregnant Swiss mice were given by gavage daily doses of 0, 5, 10, 25 and 50 mg/kg of uranyl acetate dihydrate on gestational days 6-15. Cesarean sections were performed on all females on gestation day 18. Fetuses were examined for external, visceral, an...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(89)90181-9
更新日期：1989-04-01 00:00:00
abstract：:Rats were exposed to 1.5 +/- 0.1 mg ozone/m3 for 4 days and the activities of glucose-6-P dehydrogenase (G6PDH), glutathione reductase (GR) and glutathione peroxidase (GSHPx) were measured in the cytosolic fraction of lungs from exposed and control rats. Enzyme activities were also measured in isolated alveolar macrop...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(85)90083-6
更新日期：1985-12-01 00:00:00
abstract：:In order to test the hypothesis that Leydig cells are required for the acute toxic effect of cadmium on the testis, adult male rats were treated with the Leydig cell toxin ethane dimethanesulphonate (EDS). Four days later, when all Leydig cells are removed from the testis, the EDS treated and control rats were given a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90041-e
更新日期：1990-08-01 00:00:00
abstract：:Epidemiological studies have implicated fine particulate matter (PM2.5) as a risk factor for neurodegenerative diseases and neurodevelopmental disorders. However, the underlying molecular mechanisms and the influences of different components remain largely elusive. Here, we extended our previous work to investigate th...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2017.01.017
更新日期：2017-04-01 00:00:00
abstract：:Paraquat, a quarternary nitrogen herbicide, is a highly toxic compound for humans and animals and many cases of acute poisoning and death have been reported over the past few decades. The mechanisms of paraquat toxicity involve: the generation of the superoxide anion, which can lead to the formation of more toxic reac...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(02)00382-7
更新日期：2002-10-30 00:00:00
abstract：:Rats were treated with a single dose of thallium acetate (32 mg/kg i.p.) and the antidotal effect of D-penicillamine and prussian blue given alone or in combination was assessed by means of evaluation of the thallium-induced cerebellar histological lesions. After thallium poisoning (24 h), antidotes were administered ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90129-5
更新日期：1994-03-25 00:00:00
abstract：:To evaluate hydroperoxide generation as a potential mechanism of cyanide neurotoxicity, mice were treated with KCN (7 mg/kg, subcutaneously (s.c.)) and the level of lipid peroxidation (expressed as conjugated dienes) was measured later in various organs. Brain showed elevated conjugated diene levels after cyanide but ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90221-6
更新日期：1994-04-18 00:00:00
abstract：:Fusarenon-X (FX), a trichothecene mycotoxin, is well known to be cytotoxic to mammalian cells. Our previous study revealed that FX induced apoptosis in mouse thymocytes both in vivo and in vitro. We investigated the mode of apoptosis induced by FX using HL-60 cell culture. When FX at a final concentration of 0.5 micro...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00586-8
更新日期：2002-03-20 00:00:00
abstract：:Five male and female rats per dose-group received 2,3,7,8-tetrabromodibenzo-p-dioxin (2,3,7,8-TBDD) once on the first day of the study. Doses of 10, 33, 100, or 300 micrograms 2,3,7,8-TBDD/kg body wt. and the vehicle control were administered by gavage. About 20% of 2,3,7,8-TBDD was excreted via feces. Severe body wei...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(92)90170-j
更新日期：1992-01-01 00:00:00
abstract：:Solar radiation induces acute and chronic reactions in human and animal skin. Chronic repeated exposures are the primary cause of benign and malignant skin tumors, including malignant melanoma. Among types of solar radiation, ultraviolet B (290-320 nm) radiation is highly mutagenic and carcinogenic in animal experimen...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(03)00150-1
更新日期：2003-07-15 00:00:00
abstract：:Organochlorine and organophosphate pesticides are compounds that can be detected in human populations as a result of occupational or residential exposure. Despite their occurrence in considerably low levels in humans, their biological effects are hazardous since they interact with a plethora of enzymes, proteins, rece...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2012.09.011
更新日期：2013-05-10 00:00:00
abstract：:We have investigated in the current study, the possible modulatory effects of dexamethasone on cisplatin cytotoxicity in Ehrlich ascites carcinoma (EAC)-bearing female Swiss albino mice. Cisplatin (3.5mg/kg) was injected IP for 3 consecutive days in mice previously inoculated SC with EAC cells in the right flank. Dexa...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.02.007
更新日期：2006-05-01 00:00:00
abstract：:Among exocyclic DNA adducts, etheno (epsilon) bases (epsilond A, epsilond C, N(2),3-epsilond G) are generated by reactions of DNA bases with lipid peroxidation (LPO) products derived from endogenous sources and from the carcinogens vinyl chloride or urethane. The recent development of ultrasensitive methods has made i...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(00)00307-3
更新日期：2000-11-16 00:00:00
abstract：:Previous reports from this laboratory have established the propensity of chlordecone to potentiate the hepatotoxicity and lethality in male and female rats. The present study was designed to investigate the hepatotoxicity of CCl4 in chlordecone (CD) pretreated, ovariectomized rats. Ten days after bilateral ovariectomy...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(84)90163-x
更新日期：1984-02-01 00:00:00
abstract：:The cytochrome P-450 enzymes are responsible for the oxidation of xenobiotic chemicals including drugs, pesticides, and carcinogens. These enzymes include cytochrome P450, cytochrome b(5), arylhydrocarbon (benzo[a]pyrene) hydroxylase (AHH), NADPH-cytochrome C reductase and dimethylnitrosamine N-demethylase I (DMN-dI)....
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00473-5
更新日期：2001-12-14 00:00:00
abstract：:Deltamethrin, a synthetic dibromo-pyrethroid insecticide, is extensively used in agriculture, forestry and in household products because of its high activity against a broad spectrum of insect pests (both adults and larvae), its low animal toxicity and its lack of persistence in the environment. Data on the genotoxici...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(98)00097-3
更新日期：1998-09-15 00:00:00
abstract：:Exposure to heavy metals contributes to most of the unexplained male infertility. Lead (Pb) is a well- known heavy metal, which disrupt the male reproductive system. This study was conducted to investigate the therapeutic and protective effects of green tea active principle, epigallocatechin gallate (EGCG), on the lea...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2019.04.015
更新日期：2019-06-15 00:00:00
abstract：:Adverse drug reactions (ADR) are common and many are thought to have a genetic predisposition. There has been a great deal of interest in the role of P450 enzyme gene polymorphisms in the pathogenesis of adverse reactions. The major impact to date of polymorphic P450 expression has been on pre-clinical drug developmen...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(03)00247-6
更新日期：2003-10-01 00:00:00
abstract：:Aluminum (Al) is recognized worldwide as serious inorganic contaminants. Exposure to Al is associated with low BMD and an increased risk of osteoporosis. However, the precise molecular mechanisms remains unclear. Thus, in this study, rats were orally exposed to 0 (control group, CG) and 0.4g/L AlCl3 (AlCl3 treated gro...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2016.10.002
更新日期：2016-09-14 00:00:00
