Abstract：
:The fetotoxicity of nitrofen and 5 analogous diphenyl ethers was compared in mice, using survival on postnatal day 5 to evaluate prenatal and perinatal toxicity. The effect of each chemical on the Harderian gland weight of surviving pups was also assessed, since decreased Harderian gland weight is seen in nitrofen-exposed pups at levels of treatment that do not cause mortality. All treatments were percutaneous. 2,4,5-Trichlorophenyl 4'-nitrophenyl ether was significantly more fetotoxic than nitrofen, but 2,4,6-trichlorophenyl 4'-nitrophenyl ether (CNP) was not fetotoxic at the doses used. Neither of the 2 monochlorinated 4'-nitrophenyl ethers nor the unchlorinated 4'-nitrophenyl ether were fetotoxic at the doses tested. Absent Harderian glands resulted only from exposure to nitrofen (71% of litters) or to 2,4,5-trichlorophenyl 4'-nitrophenyl ether (22% of litters), which were also the only compounds to decrease Harderian gland weight significantly.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Francis BMdoi
10.1016/0300-483x(86)90062-4subject
Has Abstractpub_date
1986-09-01 00:00:00pages
297-309issue
3eissn
0300-483Xissn
1879-3185pii
0300-483X(86)90062-4journal_volume
40pub_type
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