Abstract：
:Rats were treated for 4 weeks with chlorphentermine hydrochloride (30 mg/kg, i.p., 5 days/seek), a regimen which causes a profound phospholipidosis in the alveolar macrophages (AMs). The susceptibility of these lipid-laden cells to lipid peroxidation was examined and compared to AMs from control (untreated) rats. Lipid peroxidation was induced in cells in vitro by incubation with cumene hydroperoxide (10(-5) M--10(-3) M). A dose dependent increase in malonyl dialdehyde (MDA) formation was observed with both populations of AMs. Two to three times more MDA was found in lipidotic AMs than controls at the higher dose of cumene hydroperoxide. Under these conditions, less loss of cellular viability resulted with the lipidotic AMs than controls. The partial depletion of reduced glutathione in the cells led to an even greater MDA formation by both cell-types with the lipidotic AMs being more markedly affected. Both populations of AMs experienced a greater loss of viability associated with loss of reduced glutathione with the control AMs showing more toxicity than the lipidotic cells. Therefore, while the induction of phospholipidosis renders AMs more suspectible to lipid peroxidation, they show less of a loss in cellular viability than control cells. The previously reported augmentation in the antioxidant defense mechanisms in the lipidotic cells may be partially responsible for these results.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Reasor MJdoi
10.1016/0300-483x(80)90078-5subject
Has Abstractpub_date
1980-01-01 00:00:00pages
159-68issue
2eissn
0300-483Xissn
1879-3185pii
0300-483X(80)90078-5journal_volume
18pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Synthetic pyrethroids are used as insecticides in agriculture and a variety of household applications worldwide. Pyrethroids are widely distributed in all environmental compartments and the general populations are exposed to pyrethroids through various routes. Pyrethroids have been identified as endocrine-disrupting c...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2020.152460
更新日期：2020-05-30 00:00:00
abstract：:Proliferation and differentiation of cells in female reproductive organs, the oviduct, uterus and vagina, are regulated by endogenous estrogen. In utero exposure to a synthetic estrogen, diethylstilbestrol (DES), induces vaginal clear-cell adenocarcinoma in humans. In mice, perinatal exposure to DES results in abnorma...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2012.02.010
更新日期：2012-06-14 00:00:00
abstract：:Studies on the pulmonary retention of benzo[a]pyrene after inhalation have shown that clearance is biphasic, with one component clearing with a half-time greater than 1 day and another with a half-time less than 1 day. In the work reported here we demonstrated that the amount of benzo[a]pyrene instilled in the lungs c...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(85)90066-6
更新日期：1985-06-28 00:00:00
abstract：:The cytotoxicity and cardiotoxicity of benzoyl mustard (FCE 24517) and epoxamido (FCE 24561) synthetic derivatives of distamycin A were reported in the present study. The 50% inhibiting concentration (IC50) of colony formation of FCE 24517 on human SNB-19 glioblastoma, A2780 ovarian cancer and DU 145 prostate cancer w...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(92)90003-w
更新日期：1992-11-15 00:00:00
abstract：:Drug-induced hepatotoxicity is a major problem in drug development, and oxidative stress is known as one of the causes. Superoxide dismutases (SODs) are important antioxidant enzymes against reactive oxygen species (ROS). Mitochondria are the major source of superoxide production, and SOD2 is mainly localized in mitoc...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.07.017
更新日期：2009-10-01 00:00:00
abstract：:An in vitro model of the rat nasal cavity has been used to compare the responses of nasal tissues in vitro, using loss of intracellular ATP and potassium as indices of toxicity, with the pathological changes occurring following in vivo exposure to four test compounds. Turbinates were incubated in vitro with the test c...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00180-8
更新日期：2000-04-07 00:00:00
abstract：:2,3,7,8-tetrachlorodibenzo-p-dioxin, more popularly called dioxin or TCDD and referred to in this review as 2,3,7,8-TCDD, is considered the prototype of the polychlorinated dibenzo-p-dioxins (PCDD). The PCDD are true contaminants and are formed primarily as byproducts in the manufacture of materials requiring the use ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(91)90184-3
更新日期：1991-01-01 00:00:00
abstract：:Hesperidin (HDN) is a flavanone glycoside abundantly found in citrus fruits. HDN has been reported to possess significant activities against allergy, haemorrhoids, hormonal disorders and ulcers. Other reported activities include anti-inflammatory, analgesic, antibacterial, antifungal, antiviral, antioxidant and free r...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.06.018
更新日期：2006-09-21 00:00:00
abstract：:Previous studies have shown that excess dietary Al during development can affect neurobehavioral measures and decrease tissue Mn of 21-day-old weanling mice without a corresponding increase in tissue Al concentrations. Al and Mn have similar tissue concentrations and similar affinities for transferrin, which is the ma...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90154-k
更新日期：1993-07-11 00:00:00
abstract：:Korea has a great diversity in resources of medicinal plants. The traditional herbal medicines and their preparations have been widely used in Korea as well as in China and Japan for thousands of years. One of the characteristics of Korean herbal medicine preparations is that all the herbal medicines are incorporated ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(02)00487-0
更新日期：2002-12-27 00:00:00
abstract：:Hydroquinone (HQ) is naturally found in the diet, drugs, as an environmental contaminant and endogenously generated after benzene exposure. Considering that HQ alters the immune system and its several source of exposures in the environment, we hypothesized that prolonged exposure of HQ could affect the course of an im...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.08.085
更新日期：2007-11-20 00:00:00
abstract：:Stannous chloride (SnCl2) is a reducing chemical agent used in several man-made products. SnCl2 can generate reactive oxygen species (ROS). Therefore, the present study has been carried out to investigate the antioxidant action of l-ascorbic acid (AA) in minimizing SnCl2 toxicity on lipid peroxidation, antioxidant enz...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.03.017
更新日期：2007-06-25 00:00:00
abstract：:Fenvalerate is a widely used synthetic pyrethroid insecticide and is reported to disrupt reproductive function in humans and animals. However, little is known about its influence on follicular development. In this study, rat preantral follicles were primary cultured to investigate the effects of fenvalerate on follicu...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.10.022
更新日期：2010-01-12 00:00:00
abstract：:Organochalcogens are important intermediates and useful reagents in organic synthesis, which can increase human exposure risk to these chemicals in the workplace. As well, there are a number of reported cases of acute toxicity following organochalcogen ingestion of vitamins and dietary supplements. Since, the erythroc...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(03)00250-6
更新日期：2003-09-30 00:00:00
abstract：:Challenges to improve toxicological risk assessment to meet the demands of the EU chemical's legislation, REACH, and the EU 7th Amendment of the Cosmetics Directive have accelerated the development of non-animal based methods. Unfortunately, uncertainties remain surrounding the power of alternative methods such as in ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2013.08.012
更新日期：2015-06-05 00:00:00
abstract：:Paraquat, a quarternary nitrogen herbicide, is a highly toxic compound for humans and animals and many cases of acute poisoning and death have been reported over the past few decades. The mechanisms of paraquat toxicity involve: the generation of the superoxide anion, which can lead to the formation of more toxic reac...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(02)00382-7
更新日期：2002-10-30 00:00:00
abstract：:Some effects of organophosphorus compounds (OPs) esters cannot be explained by action on currently recognized targets acetylcholinesterase or neuropathy target esterase (NTE). In previous studies, in membrane chicken brain fractions, four components (EPα, EPβ, EPγ and EPδ) of phenyl valerate esterase activity (PVase) ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2018.08.018
更新日期：2018-12-01 00:00:00
abstract：:We have previously shown that young guinea pigs repeatedly exposed to sidestream cigarette smoke (SS) develop decreased airway reactivity of the C-fiber system without changing reactivity to one of its neurotransmitters, substance P (SP). This study was designed to determine whether the decreased reactivity was due to...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(96)03403-8
更新日期：1996-09-02 00:00:00
abstract：:Manganese (II) bis(glycinate)dichloride (Mn(glycinate)2) is a coordination complex of manganese with application as a contrast enhancement agent for magnetic resonance imaging in the heart. To determine the cardioactivity of the manganese ion in this chelation cage, the effects of Mn(glycinate)2 on Ca channel function...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(91)90062-6
更新日期：1991-01-01 00:00:00
abstract：:The overall purpose of this study was to investigate how airborne house dust particles may contribute to an allergic immune response, and thereby also to asthma and other respiratory symptoms. The following aims were set: first, to quantify and characterize indoor suspended particulate matter (SPM) with regard to amou...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00292-4
更新日期：2000-11-02 00:00:00
abstract：:The prime factors influencing survivability from 10 major fire-related public transport aircraft accidents were assessed. Regulatory requirements were assessed against derived criteria and alternate concepts evaluated to identify a preferred strategy for enhanced survival; the provision of passenger protective breathi...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(96)03494-4
更新日期：1996-12-31 00:00:00
abstract：:Measurement of lymphocyte proliferation to detect hypersensitivity to beryllium (Be-LPT) in vitro is done presently using a method based on tritiated thymidine incorporation. Although this method is sensitive it gives no information on cell viability or responding lymphocyte subsets. We have developed reliable and sim...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00167-5
更新日期：2000-02-21 00:00:00
abstract：:It has been widely accepted that microglia, which are the innate immune cells in the brain, upon activation can cause neuronal damage. In the present study, we investigated the role of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in regulating microglial nitric oxide production and its role in causing neuronal damage. T...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2013.08.008
更新日期：2013-10-04 00:00:00
abstract：:The effect of potassium cyanide on mitochondria DNA (mtDNA) in mouse brain was investigated in vivo and in vitro. When potassium cyanide (0, 0.1, 1.0 or 2.0 mM) was incubated with a crude mitochondria fraction prepared from mouse brain at 37 degrees C for 60 min, the damage of mtDNA was observed in a concentration-dep...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(02)00244-5
更新日期：2002-09-30 00:00:00
abstract：:This study was designed to evaluate the cardioprotective potential of naringin on lipid peroxides, enzymatic and nonenzymatic antioxidants and histopathological findings in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Subcutaneous injection of ISO (85 mg/kg) to male Wistar rats showed a significant ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.09.005
更新日期：2006-12-07 00:00:00
abstract：:The teratogenicity of antiepilepsy drug valproic acid (VPA) mostly is found in genetic and somatic levels, causing teratogenesis involving neurotubular defects (NTDs), anencephaly, lumbosacral meningomyelocele, and leg dysfunction due to spina bifida aperta. A diversity of nutraceutics have been tried to alleviate the...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.10.015
更新日期：2012-01-27 00:00:00
abstract：:Dental resin systems have been in use for several decades. (Meth)acrylic monomers are an important part of the matrix system and are either based on BPA while others lack the BPA core. The degree of conversion during restoration is in general between 50-70 % allowing leaching from unreacted monomers to the oral cavity...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2019.03.007
更新日期：2019-05-15 00:00:00
abstract：:The use of colchicine-specific Fab fragments is of interest in human poisoning. In the present study, we show the efficacy of Fab fragments in reversing colchicine toxicity in mice. High affinity antibodies (Ka = 2 x 10(10) M-1) against colchicine were raised in goats; Fab fragments were purified by DEAE chromatograph...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(91)90015-s
更新日期：1991-01-01 00:00:00
abstract：:Several studies have reported that hydrogen peroxide (H2O2) is related to the toxicity of amyloid β (Aβ), and that the accumulation of Aβ in the lenses of humans causes lens opacification. In this study, we investigate the accumulation of Aβ1-42 in the lenses of UPL rats, which then leads to lens opacification. In add...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2013.08.003
更新日期：2014-01-06 00:00:00
abstract：:We recently reported that Delta(9)-tetrahydrocannabinol (Delta(9)-THC) has the ability to stimulate the proliferation of human breast carcinoma MCF-7 cells. However, the mechanism of action remains to be clarified. The present study focused on the relationship between receptor expression and the effects of Delta(9)-TH...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.12.019
更新日期：2008-03-12 00:00:00
