Abstract:
:The overall purpose of this study was to investigate how airborne house dust particles may contribute to an allergic immune response, and thereby also to asthma and other respiratory symptoms. The following aims were set: first, to quantify and characterize indoor suspended particulate matter (SPM) with regard to amount, as well as elemental and size distribution, second, to identify possible mechanisms by which SPM may affect the allergic immune response. A vast majority of the particles in SPM samples from homes in Oslo were found to be less than 2.5 microm in diameter. This PM(2.5) fraction contained, in addition to a large amount of sulfur aerosols and silicates, a lot of soot particles. Most of these were less than 1 microm in diameter. Using an immunogold labeling technique, we found that these soot particles carried cat, dog and birch allergens on their surface. These results show that indoor SPM contains a lot of potential allergen carriers, i.e. soot particles (carbon aggregates), most of them less that 1 microm in diameter and therefore able to transport allergens deep into the respiratory tree. We further found that diesel exhaust particles (DEP), which is likely the main soot component of SPM, adsorbed several well-known allergens in vitro. Furthermore, SPM was found to elicit a local lymph node inflammatory response, and to have an adjuvant activity on the production of IgE antibodies to ovalbumin (OA).
journal_name
Toxicologyjournal_title
Toxicologyauthors
Ormstad Hdoi
10.1016/s0300-483x(00)00292-4keywords:
subject
Has Abstractpub_date
2000-11-02 00:00:00pages
53-68issue
1-3eissn
0300-483Xissn
1879-3185pii
S0300483X00002924journal_volume
152pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::The influence of pretreatment with the drug mixture (pyridostigmine, benactyzine and trihexyphenidyle), and antidotal treatment (the oxime HI-6 in combination with benactyzine) on respiration, circulation and survival of experimental animals poisoned with supralethal doses of soman (2 x LD50) was investigated in a rat...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00186-8
更新日期:1998-06-26 00:00:00
abstract::Amiodarone is a class III anti-arrhythmic compound that is iodinated, cationic and amphiphilic in nature. The clinical use of amiodarone may be associated with various side-effects, including pulmonary and hepatic toxicity. Use of this compound during pregnancy may therefore place the fetus at risk through in utero ex...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90085-f
更新日期:1991-01-01 00:00:00
abstract::Food allergy is a significant health issue in the UK, affecting between 1 and 2% of adults and 5 and 8% of children. The UK Food Standards Agency seeks to ensure the safety of food allergic consumers by providing them with information and guidance on food choices. Since 1995, with the aim of addressing important polic...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2010.08.007
更新日期:2010-12-30 00:00:00
abstract::The Internet = s global reach offers new powerful tools to professionals in Occupational and Environmental Health (OEH). The World Wide Web includes extensive free and commercially available reference materials on toxicology, regulatory issues, environmental epidemiology and prevention programs. Much of this especiall...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(02)00028-8
更新日期:2002-04-25 00:00:00
abstract::Repeated abuse of stimulant drugs, cocaine and amphetamine, is associated with extraneuronal dopamine accumulation in specific brain areas. Dopamine may be cytotoxic through the generation of reactive oxygen species, namely hydrogen peroxide (H2O2), resulting from dopamine oxidative metabolism. In this work, we studie...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.08.022
更新日期:2006-01-05 00:00:00
abstract::Inorganic arsenic (iAs), a ubiquitous element and a natural drinking water contaminant, has been found to impair male reproductive function. However, the effect of long-term exposure to arsenic on testis damage and its underlying mechanisms still require further evaluation. In the study, male C57BL/6 mice (4 weeks) we...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2018.09.010
更新日期:2019-01-01 00:00:00
abstract::The intravenous toxicity of phytic acid (inositol hexakisphosphate, IHP) has recently become of interest because of the potential for IHP incorporation into red blood cells to achieve a therapeutically useful shift in the hemoglobin-oxygen dissociation curve (Gersonde, K. and Nicolau, C., Blut, 39 (1979) 1). The obser...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(81)90022-6
更新日期:1981-01-01 00:00:00
abstract::Ferrets were maintained for 12 months on different diets (A, meat and biscuit; B, all meat; C, meat and fish; D, high fibre) to ascertain the cause of spontaneous development of fatty liver. High hepatic triglyceride contents resulted on diets B = C > D; whereas ferrets on diet A (control) showed no accumulation of li...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(96)03351-3
更新日期:1996-08-16 00:00:00
abstract::Osteoblasts dysfunction, induced by aluminum (Al), plays a critical role in the osteoporosis etiology. Ginsenoside Rb1 (Rb1) has the therapeutic properties for osteoporosis. This study aimed to assess the efficiency of Rb1 in ameliorating Al-induced osteoblasts dysfunction. The osteoblasts were divided into four group...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2016.07.014
更新日期:2016-08-10 00:00:00
abstract::The use of zinc as a nutritional supplement has become common in many countries. Since zinc has diverse actions, it may be difficult to predict its synergistic and/or antagonistic action in simultaneous presence of drug(s). The combination of imidazole antifungals, but not triazole antifungals, with 3-30 microM ZnCl2 ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2008.03.022
更新日期:2008-06-27 00:00:00
abstract::The spectrum of the anti-apoptotic potential of heparin is currently under scrutiny in various tissues and under various pathological situations. In this study, the role of a low-molecular-weight heparin derivative (LMWH), certoparin in adriamycin-induced oxidative DNA damage has been evaluated in the cardiac and rena...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.09.009
更新日期:2006-01-16 00:00:00
abstract::The influence of the insertion of a liver into the perfusion circuit of a lung on the availability of benzo[a]pyrene and benzo[a]pyrene metabolites to the lung was examined. Perfused lungs from 5,6-benzoflavone pretreated rats release high quantities of free benzo[a]pyrene metabolites and conjugates into the perfusion...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90100-4
更新日期:1987-08-01 00:00:00
abstract::A single high dose, 75 mg/kg, of clotrimazole (CloTZ) was administered intragastrically (i.g.) to adult male Sprague-Dawley rats. Hepatic CloTZ concentrations were determined in organic extracts of whole liver homogenate, by high-performance liquid chromatography (HPLC). The peak liver CloTZ concentration was found at...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(93)90074-3
更新日期:1993-06-04 00:00:00
abstract::Chalcones are phenolic compounds that can be isolated from plants. Previous studies have described some pharmacological applications for these compounds. Making use of our established reporter gene system, we determined the effect of five hydroxychalcones--2-hydroxychalcone, 2'-hydroxychalcone, 4-hydroxychalcone, 4,2'...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.10.005
更新日期:2005-02-14 00:00:00
abstract::Insulin and dexamethasone are potent inhibitors of apoptosis induced by transforming growth factor-beta1 (TGF-beta) in hepatoma cells. Using FTO-2B rat hepatoma cells, we determined whether the anti-apoptotic effects of these agents result from interference within or upstream of the TGF-beta-induced caspase cascade. A...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.06.020
更新日期:2004-11-15 00:00:00
abstract::The organophosphorus nerve agent soman is an irreversible cholinesterase (ChE) inhibitor that can produce long-lasting seizures and seizure-related brain damage (SRBD) in which acetylcholine and glutamate are involved. Since these neurotransmitters play a key-role in the auditory function, it was hypothesized that a h...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2010.08.014
更新日期:2010-11-09 00:00:00
abstract::Preclinical drug safety assessment includes in vitro studies with physiologically relevant cell cultures. As an in vitro system for hepatic toxicology testing, we have been generating cell clones of human hepatoblastoma cell line HepG2 by lentiviral transduction of phase I cytochrome P450 (CYP) enzymes. Here, we prese...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2018.11.008
更新日期:2019-01-15 00:00:00
abstract::The toxic oil syndrome (TOS), a multisystemic disease, that occurred in Spain in 1981, was caused by the ingestion of rapeseed oil denatured with 2% aniline. Due to the clinical course of the disease, immunopathological mechanisms have been suspected but a direct connection was never demonstrated. To analyse this poss...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)90085-x
更新日期:1994-11-11 00:00:00
abstract::Maize co-contamination with aflatoxin B1 (AFB1) and fumonisin B1 (FB1) is frequently found in several countries. Although the alterations on nutritional and immunologic parameters induced by these mycotoxins, when administered individually, are partially characterised, little is known about the effects induced in anim...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00603-0
更新日期:2003-04-15 00:00:00
abstract::The role of nitric oxide (NO) in acute renal failure (ARF) is debatable. In the present study, we investigated the effect of acute administration of NO donor, Sodium nitroprusside (SNP), L-Arginine (L-Arg) and NO synthase inhibitor, N(omega)-L-arginine methyl ester (L-NAME) in Fe-NTA induced renal toxicity. Rats were ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.01.009
更新日期:2007-04-11 00:00:00
abstract::The osteolathyrogenic agent semicarbazide was assayed for its toxicity and teratogenicity using early embryos of the frog Xenopus laevis. The 96-h LC50 is 1504.20 mg/l while the 96-h EC50 is 76.28 mg/l. Embryo length is altered prior to the onset of other effects indicated by a reduction in stage of development. The m...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(85)90053-8
更新日期:1985-08-01 00:00:00
abstract::Toxicology and carcinogenesis studies of 2 structurally-related p-phenylenediamines, HC Blue No. 1, and HC Blue No. 2 were conducted by administering each chemical in feed for 103 weeks to both sexes of Fischer 344/N rats and B6C3F1 (C57BL/6N x C3H/HEN) mice. Diets containing 0, 1500, or 3000 ppm HC Blue 1 were fed to...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(89)90130-3
更新日期:1989-06-01 00:00:00
abstract::This study is aimed to investigate the inflammation and neurological dysfunction induced by tetrachloro-p-benzoquinone (TCBQ) through Toll-like receptor 4 (TLR4) signaling. We also investigated the protective role of melatonin as an antioxidant and anti-inflammatory agent. In vitro model was established by rat pheochr...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.02.015
更新日期:2017-04-15 00:00:00
abstract::The toxicity of two new monofunctional sulfur mustard derivatives was tested. The compound (4-carboxybutyl 2-chloroethyl sulfide, CBCS; 10-carboxydecyl 2-chloroethyl sulfide, CDCS) possess the 2-chloroethyl sulfide moiety present in mustard gas. Exposure of guinea pig skin to CBCS resulted in a dose-related ulcerative...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(95)03288-q
更新日期:1996-04-15 00:00:00
abstract::Trichloroacetic acid (TCA) is a common drinking water disinfection byproduct that produces a spectrum of liver effects, including hepatomegaly and liver tumors, in mice. It is also an oxidative metabolite of trichloroethylene (TCE), a solvent used in degreasing with widespread environmental exposure, which also produc...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.04.009
更新日期:2011-07-29 00:00:00
abstract::The developing nervous system is susceptible to lead (Pb) exposure but less is known about the effect of this toxic agent in adult rat brain. Since astrocytes serve as a cellular Pb deposition site, it is of importance to investigate the response of astroglial cells in the adult rat brain in a model of acute lead expo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(01)00415-2
更新日期:2001-08-28 00:00:00
abstract::The effect of sodium metavanadate (NaVO3) consumption on trace element metabolism, components of the antioxidant defense system and lipid oxidative damage were studied in control (CON) and streptozotocin-induced diabetic (DIAB) rats. Ten days after injection, CON and DIAB rats received either 0 mM NaVO3/80 mM NaCl (0 ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(93)90096-b
更新日期:1993-10-25 00:00:00
abstract::Oral administration of sodium pyridinethione together with 63Ni2+, 109Cd2+ or 65Zn2+ to non-pregnant mice resulted in very markedly increased levels of the metals in several tissues in comparison with animals given the metals alone. For 63Ni2+ the sodium pyridinethione induced a strong labelling of the pancreatic isle...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90148-4
更新日期:1986-03-01 00:00:00
abstract::Benzene, an important industrial solvent, is also present in unleaded gasoline and cigarette smoke. The hematotoxic effects of benzene in humans are well documented and include aplastic anemia and pancytopenia, and acute myelogenous leukemia. A combination of metabolites (hydroquinone and phenol for example) is appare...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(95)03217-4
更新日期:1995-12-28 00:00:00
abstract::Rats which were treated intraperitoneally (i.p.) with FeCl2 X 4H2O expired ethane which increased with increasing doses of iron. The same amount of ethane was expired by animals exposed to 20% or 100% oxygen. The mobilization by FeCl2 of stored ethane from the body was excluded. Propane expiration was also stimulated ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(83)90103-8
更新日期:1983-09-01 00:00:00