Synthesis and utilization of neurotransmitters: actions of subconvulsant doses of hexachlorocyclohexane isomers on brain monoamines.

abstract：:Among exocyclic DNA adducts, etheno (epsilon) bases (epsilond A, epsilond C, N(2),3-epsilond G) are generated by reactions of DNA bases with lipid peroxidation (LPO) products derived from endogenous sources and from the carcinogens vinyl chloride or urethane. The recent development of ultrasensitive methods has made i...

journal_title：Toxicology

authors： Bartsch H,Nair J

更新日期：2000-11-16 00:00:00

abstract：:The coumarin 7-hydroxylase of mice (Coh, CYP2A5) is known to be highly selectively inducible by both a set of heavy metals such as cobalt, indium and cerium and a variety of organic nitrogen-containing heteroaromatic compounds such as 3-amino-1,2,4-triazole, pyrazine and pyrazole. The investigations presented reveal t...

journal_title：Toxicology

authors： Emde B,Tegtmeier M,Hahnemann B,Legrum W

更新日期：1996-04-15 00:00:00

abstract：:Direct ingestion of contaminated soil by depleted uranium (DU) might lead to internal exposure to DU by local populations through hand contamination. The purpose of this study was to assess the immunological changes of long-term exposure to various doses of DU in mice. Three-week-old Kunming mice were divided into the...

journal_title：Toxicology

authors： Hao Y,Ren J,Liu J,Yang Z,Liu C,Li R,Su Y

更新日期：2013-07-05 00:00:00

abstract：:Pulmonary function and inflammation in the lungs of rodents exposed by inhalation to carbon/graphite/epoxy advanced composite material (ACM) combustion products were compared to that of a rodent model of acute lung injury (ALI) produced by pneumotoxic paraquat dichloride. This investigation was undertaken to determine...

journal_title：Toxicology

authors： Whitehead GS,Grasman KA,Kimmel EC

更新日期：2003-02-01 00:00:00

abstract：:The contributions of the hepatic microsomal and cytosolic fractions in the metabolic activation of the promutagen 2-aminofluorene into mutagenic intermediates in the Ames test were investigated. Rat hepatic postmitochondrial, microsomal and cytosolic preparations could convert 2-aminofluorene to mutagens, the postmito...

journal_title：Toxicology

authors： Leist M,Ayrton AD,Ioannides C

更新日期：1992-01-01 00:00:00

abstract：:Trichloroethylene (TCE) produced bronchiolar damage when administered to mice. Administration of 2000 mg/kg caused injury in Clara cells of the bronchiolar epithelium, which was observed at 24 h following TCE treatment; increase of the dosage to 2500 mg/kg induced additionally, alterations in alveolar Type II cells of...

journal_title：Toxicology

authors： Forkert PG,Sylvestre PL,Poland JS

更新日期：1985-05-01 00:00:00

abstract：:Several different meanings have been attached to the term "chemical sensitivity" by those who use it. Feeling ill from odors is a symptom reported by approximately one-third of the population. The syndrome of chemical sensitivity, frequently called "Multiple Chemical Sensitivity" or "MCS" has been the subject of three...

journal_title：Toxicology

authors： Miller CS

更新日期：1996-07-17 00:00:00

abstract：:The reproductive toxicity of vanadium was studied in mice. Male Swiss mice were exposed to sodium metavanadate at doses of 0, 20, 40, 60, and 80 mg/kg per day given in the drinking water for 64 days. To evaluate the fertility of the vanadium-treated animals, males were mated with untreated females for 4 days. A signif...

journal_title：Toxicology

authors： Llobet JM,Colomina MT,Sirvent JJ,Domingo JL,Corbella J

更新日期：1993-06-11 00:00:00

abstract：:Some organophosphorus compounds (OP) induce a delayed polyneuropathy (OPIDP) which is initiated by the phosphorylation of the so-called neuropathy target esterase (NTE). In this work some aspects of hen sciatic nerve NTE are studied. The assay method is reported and modifications are discussed and a combined method pr...

journal_title：Toxicology

authors： Barril JB,Vilanova E,Pellin MC

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVE:Endothelins (ET) can be considered stress-responsive regulators working in paracrine and autocrine fashion. It has been suggested that elevated levels of ET may be responsible for the low coronary re-flow phenomena. Ischemia-reperfusion (I/R) was shown to stimulate ET release in rat heart; however, the mechan...

journal_title：Toxicology

authors： Ozdemir R,Parlakpinar H,Polat A,Colak C,Ermis N,Acet A

更新日期：2006-02-15 00:00:00

abstract：:The subacute toxicity of sodium saccharin and 2 hydrolytic derivatives, o-sulfamoylbenzoic acid (Compound I) and ammonium o-carboxybenzene sulfonate (Compound II) was evaluated by feeding each of the compounds alone at a dietary level of 20 000 ppm to both beagle dogs and albino rats. Additionally, groups of dogs and ...

journal_title：Toxicology

authors： Kennedy GL Jr,Fancher OE,Calandra JC

更新日期：1976-08-01 00:00:00

abstract：:Ammonium perfluorooctanoate (APFO) is a surfactant used primarily as an aid in processing various fluoropolymers. Many toxicology and epidemiological studies have been conducted with APFO; however, no specific information regarding functional reproduction was previously available. Therefore, the potential reproductive...

journal_title：Toxicology

authors： Butenhoff JL,Kennedy GL Jr,Frame SR,O'Connor JC,York RG

更新日期：2004-03-01 00:00:00

abstract：:The local lymph node assay (LLNA) is a regular method for the detection of sensitizing chemicals in mice which measures the incorporation of tritiated thymidine in lymph node cells. We have evaluated an alternative to this method based on the interleukin-2 (IL-2) production of lymph node cells. At the mRNA level, no c...

journal_title：Toxicology

authors： Azam P,Peiffer JL,Ourlin JC,Bonnet PA,Tissier MH,Vian L,Fabre I

更新日期：2005-01-15 00:00:00

abstract：:The in vivo effects of sodium cyanide and its antidotes, sodium nitrite, sodium thiosulfate and 4-dimethylaminophenol (DMAP), as well as the alpha-adrenergic blocking agent phentolamine, on rat brain cytochrome oxidase were studied. The course of inhibition was time-dependent and a peak of 40% was attained between 15 ...

journal_title：Toxicology

authors： Tadić V

更新日期：1992-11-22 00:00:00

abstract：:Flucloxacillin is a semi-synthetic penicillin widely used in the prophylaxis and treatment of staphylococcal infections. Severe liver reactions, characterised by delayed cholestatic hepatitis and a prolonged course of recovery, are associated with flucloxacillin therapy. Clinical findings are suggestive of an immune m...

journal_title：Toxicology

authors： Carey MA,van Pelt FN

更新日期：2005-12-01 00:00:00

abstract：:Dimethoate, azinphos-methyl, diazinon and pirimiphos-methyl, widely used organophosphorous insecticides, and benomyl, a benzimidazole fungicide, induce different cytotoxic effects on the human leukemia cell line HL-60. Among the insecticides tested, only azinphos and diazinon induced a dose-related inhibition of prote...

journal_title：Toxicology

authors： Marinovich M,Guizzetti M,Galli CL

更新日期：1994-11-01 00:00:00

abstract：:We examined the role of miRNAs in DNA damage response in HepG2 cells following exposure to 4-aminobiphenyl (4-ABP). The arylamine 4-ABP is a human carcinogen. Using the Comet assay, we showed that 4-ABP (18.75-300μM) induces DNA damage in HepG2 cells after 24h. DNA damage signaling pathway-based PCR arrays were used t...

journal_title：Toxicology

authors： Huan LC,Wu JC,Chiou BH,Chen CH,Ma N,Chang CY,Tsen YK,Chen SC

更新日期：2014-08-01 00:00:00

abstract：:In 1975, in cooperation with 8 County Hygienic Stations, total mercury content in fish from rivers and lakes in Hungary was measured. The mercury content in fish muscle-tissue from 164 fish samples averaged 0.36 mg/kg. Average levels in different fish species ranged from 0.10 to 0.57 mg/kg. The amount of mercury in fi...

journal_title：Toxicology

authors： Gergely A,Soós K,Erdélyi L,Cieleszky V

更新日期：1977-06-01 00:00:00

abstract：:CI-959 is an orally effective inhibitor of cellular activation in both in vitro and animal models. To assess the effects of CI-959 on immune function, male Fischer 344 rats were evaluated for splenic T- and B-lymphocyte populations, antibody-forming cell response to sheep red blood cells (sRBC), concanavalin A and pok...

journal_title：Toxicology

authors： Bleavins MR,de la Iglesia FA,McCay JA,White KL Jr,Munson AE

更新日期：1995-04-12 00:00:00

abstract：:Manganese (II) bis(glycinate)dichloride (Mn(glycinate)2) is a coordination complex of manganese with application as a contrast enhancement agent for magnetic resonance imaging in the heart. To determine the cardioactivity of the manganese ion in this chelation cage, the effects of Mn(glycinate)2 on Ca channel function...

journal_title：Toxicology

authors： Tan W,Barnett JV,Hehn GM,Quay SC,Galper JB

更新日期：1991-01-01 00:00:00

abstract：:An increasing body of data has been demonstrating that mammalian cells have elaborate networks of molecular signalling in counteracting heat shock and in developing adaptation to oxidative stress to avoid cell death. However, the precise mechanisms linking heat shock, oxidative stress and cell survival/cell death mech...

journal_title：Toxicology

authors： Santos-Marques MJ,Carvalho F,Sousa C,Remião F,Vitorino R,Amado F,Ferreira R,Duarte JA,de Lourdes Bastos M

更新日期：2006-07-25 00:00:00

abstract：:Consumption of edible oils contaminated with Argemone mexicana seed oil is known to cause various clinical manifestations. In the present study, the effect of dietary intake of argemone oil on histopathological changes, haematological indices and selected marker parameters of toxicity was investigated to observe the e...

journal_title：Toxicology

authors： Upreti KK,Das M,Kumar A,Singh GB,Khanna SK

更新日期：1989-10-16 00:00:00

abstract：:Subchronic exposure to arsenic is associated with alteration of glucose homeostasis. Arsenic treatment (as sodium arsenite) of male Wistar rats (weighing 130-150 g) at a dose of 5.55 mg kg(-1) body weight (equivalent to 35% of LD(50)) (i.p.) per day for a period of 30 days produced hypoglycemia, with associated increa...

journal_title：Toxicology

authors： Pal S,Chatterjee AK

更新日期：2005-03-01 00:00:00

abstract：:To check the possible toxicity risks of the meat from swine fed with a residue producing feed additive: Carbadox, a new methodology was used. It is the "Relay Toxicity". Swine were fed with a high dose of the additive and sacrificed without any withdrawal. In such conditions meat contains a high level of residues. The...

journal_title：Toxicology

authors： Ferrando R,Truhaut R,Raynaud JP,Spanoghe JP

更新日期：1978-10-01 00:00:00

abstract：:Inhibition of regulated exocytosis by botulinum toxins type A and B was studied in chromaffin cells. Both virtually abolished catecholamine release triggered from intact cells by depolarising stimuli, whereas the blockade by type A, but not B, was only partial after cell permeabilisation and direct stimulation of exoc...

journal_title：Toxicology

authors： Lawrence GW,Foran P,Oliver Dolly J

更新日期：2002-12-27 00:00:00

abstract：:Metabonomics involves the application of advanced analytical tools to profile the diverse metabolic complement of a given biofluid or tissue. Subsequent statistical modelling of the complex multivariate spectral profiles enables discrimination between phenotypes of interest and identifies panels of discriminatory meta...

journal_title：Toxicology

authors： Coen M

更新日期：2010-12-30 00:00:00

abstract：:Female mice were given nutrient-sufficient, purified diets containing cadmium at either 0.25, 5, or 50 ppm, as described in the accompanying publication. One-half of the females were bred for 6 consecutive 42-day rounds of pregnancy/lactation (PL mice); remaining females were non-pregnant controls (NP mice). PL mice a...

journal_title：Toxicology

authors： Bhattacharyya MH,Whelton BD,Peterson DP,Carnes BA,Guram MS,Moretti ES

更新日期：1988-07-01 00:00:00

abstract：:Rats were injected i.p. with the organophosphate insecticide ABATE and tested over the next 16 days. Animals given 1000 mg/kg showed impaired performance of a previously conditioned avoidance response 6 days after injection but not 2, 8, 10, or 16 days after injection. No behavioral changes were observed in animals gi...

journal_title：Toxicology

authors： Kurtz PJ,Weeks MH

更新日期：1979-05-01 00:00:00

abstract：:Mechanisms responsible for resistance to Cd-induced testicular necrosis in inbred mice were investigated using strains resistant (A/J) or susceptible (129/J) to Cd-induced testicular damage. Cadmium accumulation was measured in testes of both strains 15 min, 30 min, 1 h, 2 h, 6 h, 12 h and 24 h after intravenous injec...

journal_title：Toxicology

authors： Chellman GJ,Shaikh ZA,Baggs RB

更新日期：1984-03-01 00:00:00

abstract：:The effect of tamoxifen on cytosolic free Ca2+ concentrations ([Ca2+]i) and viability has not been explored in corneal epithelial cells. This study examined whether tamoxifen altered [Ca2+]i and viability in SIRC corneal epithelial cells. Tamoxifen at concentrations > or = 1 microM increased [Ca2+]i in a concentration...

journal_title：Toxicology

authors： Huang CC,Cheng HH,Lin KL,Cheng JS,Tsai JY,Liao WC,Fang YC,Jan CR

更新日期：2009-01-08 00:00:00