Abstract:
:The possible role of ionotropics glutamate receptors on the HgCl(2)-induced dopamine (DA) release from rat striatum was investigated by using in vivo brain microdialysis technique after administration of selective NMDA and AMPA/Kainate receptors antagonists dizocilpine (MK-801), D (-)-2-amino-5-phoshonopentanoic acid (AP5), and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). Moreover, we have also studied the effects of nitric oxide synthase (NOS) inhibitors L-nitro-arginine methyl ester (L-NAME) and 7-nitro-indazol (7-NI) on HgCl(2)-induced DA release. Intraestriatal infusion of 1mM HgCl(2) increased striatal DA to 1717.2+/-375.4% respect to basal levels. Infusion of 1mM HgCl(2) in 400 microM MK-801 pre-treated animals produced an increase on striatal DA levels 61% smaller than that induced in non-pre-treated animals. In the case of AP5, this treatment reduced 92% the increase produced by HgCl(2) as compared to non-pre-treated rats. Nevertheless, the administration of CNQX did not produce any effect on HgCl(2)-induced dopamine release. Intrastriatal infusion of 1mM HgCl(2) in 100 microM L-NAME pre-treated animals produced an increase on extracellular DA levels 82% smaller than produced by HgCl(2) alone. In addition, the pre-treatment with 7-NI reduced 90% the increase produced by infusion of HgCl(2) alone in rats. Thus, HgCl(2)-induced DA release could be produced at last in part, by overstimulation of NMDA receptors with NO production, since administration of NMDA receptor antagonists and NOS inhibitors protected against HgCl(2) effects on DA release.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Vidal L,Durán R,Faro LF,Campos F,Cervantes RC,Alfonso Mdoi
10.1016/j.tox.2007.05.025subject
Has Abstractpub_date
2007-09-05 00:00:00pages
140-6issue
2-3eissn
0300-483Xissn
1879-3185pii
S0300-483X(07)00316-2journal_volume
238pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::Mitochondria are cellular powerhouses as well as metabolic and signaling hubs regulating diverse cellular functions, from basic physiology to phenotypic fate determination. It is widely accepted that reactive oxygen species (ROS) generated in mitochondria participate in the regulation of cellular signaling, and that s...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2017.07.013
更新日期:2017-11-01 00:00:00
abstract::Increased antigen-specific IgE expression is a hallmark of the allergic response in mice. IgG1 may also be involved. Co-injection of mice with diesel exhaust particles (DEP) and ovalbumin three times over a 2 week period lead to a rapid and marked elevation of ovalbumin-specific IgE, IgG1 and also IgG2a, compared with...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00418-2
更新日期:2001-02-28 00:00:00
abstract::Adverse drug reactions (ADR) are common and many are thought to have a genetic predisposition. There has been a great deal of interest in the role of P450 enzyme gene polymorphisms in the pathogenesis of adverse reactions. The major impact to date of polymorphic P450 expression has been on pre-clinical drug developmen...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(03)00247-6
更新日期:2003-10-01 00:00:00
abstract::N-Heterocyclic aromatics are by-products of incomplete combustion of organic material. The overall objective of this study was to determine the relative carcinogenic potencies of 7H-dibenzo[c,g]carbazole (DBC) and dibenz[a,j]acridine (DBA) in a bioassay of complete carcinogenicity on mouse skin in a sensitive strain (...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)90074-4
更新日期:1994-11-11 00:00:00
abstract::Acute and subchronic toxicities of VRCTC-310, a combination product of crotoxin (CT) and cardiotoxin (CD), which has shown antitumor activity in vivo, have been studied in Beagle dogs. Single i.m. doses of 0.25, 0.5 and 1.0 mg/kg resulted in dose-dependent local muscular toxicity consisting of myofiber atrophy, inters...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)02995-7
更新日期:1995-05-05 00:00:00
abstract::Urinary dialkylphosphates (DAPs) are measured to assess exposure to organophosphorus pesticides (OPs), but they are common metabolites of OPs and not specific indices for individual agents. Biomonitoring (BM) of urinary DAPs has been widely adopted as an assessment of individual exposure in general environments, howev...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2021.152679
更新日期:2021-01-15 00:00:00
abstract::The objective of this study was to compare the disposition and metabolism of [14C]1,2-dichloropropane [( 14C]DCP) following oral and inhalation exposure since these two routes are of interest with regards to occupational and accidental exposure. [14C]DCP was administered orally to groups of four rats of each sex as a ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90076-d
更新日期:1991-01-01 00:00:00
abstract::The in vivo toxicity of the novel copper-based anticancer agent, casiopeina II (Cu(4,7-dimethyl-1,10-phenanthroline)(glycine)NO3) (CII), was investigated. Casiopeinas are a family of copper-coordinated complexes that have shown promising anticancer activity. The major toxic effect attributed to a single i.v. administr...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2003.08.009
更新日期:2003-12-15 00:00:00
abstract::Calf thymus DNA was reacted with 1,2-epoxybutene (BDO) in phosphate buffered saline at 37 degrees C for 12 h. DNA was ethanol precipitated and hydrolyzed with 1 M HCl to release DNA bases. Adenine (A)-BDO and guanine (Gua)-BDO adducts were analyzed in the ethanol supernatant and DNA hydrolysate using LC/ESI MS/MS. Rea...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(96)03468-3
更新日期:1996-10-28 00:00:00
abstract::Trichloroethylene (TCE) produced bronchiolar damage when administered to mice. Administration of 2000 mg/kg caused injury in Clara cells of the bronchiolar epithelium, which was observed at 24 h following TCE treatment; increase of the dosage to 2500 mg/kg induced additionally, alterations in alveolar Type II cells of...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(85)90028-9
更新日期:1985-05-01 00:00:00
abstract:UNLABELLED:We recently observed a case of digoxin and insulin self-poisoning without cardiac repercussion. We raised the hypothesis that insulin may have a cardio-protective effect in case of digoxin toxicity. We have therefore evaluated the effect of glucose-insulin infusion on mortality and ECG abnormalities during a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.04.035
更新日期:2006-07-25 00:00:00
abstract::The concept that the highly reactive hydroxyl radical (HO) could be generated from an interaction between superoxide (O(2)(-)) and hydrogen peroxide (H(2)O(2)) was proposed (with Joseph Weiss) in Professor Haber's final paper published in 1934. Until it was recognized that free radicals are produced in biological syst...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(00)00231-6
更新日期:2000-08-14 00:00:00
abstract::Male and female B6C3F1 mice were administered dichloroacetate (DCA) and trichloroacetate (TCA) in their drinking water at concentrations of 1 or 2 g/l for up to 52 weeks. Both compounds induced hepatoproliferative lesions (HPL) in male mice, including hepatocellular nodules, adenomas and hepatocellular carcinomas with...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90195-m
更新日期:1990-09-01 00:00:00
abstract::The effects of cadmium on some mitochondrial enzymes of kidney, testis and lung were investigated in male rats. Rats were injected intraperitoneally with 3 mg Cd/kg body weight and its effects were studied 24, 72 and 144 h later. Succinic dehydrogenase and cytochrome c oxidase activities were significantly inhibited i...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(83)90077-x
更新日期:1983-05-01 00:00:00
abstract::In order to monitor the effect of the procedures required to s.c. implant osmotic pumps into rats on plasma thyroid and testosterone hormone levels, male Fischer 344 rats (8-10 weeks old) were divided into six groups of 10 rats and the groups treated in the following manner: (1) controls housed 5 per cage; (2) control...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)02874-t
更新日期:1995-01-06 00:00:00
abstract::Arsenicals are known to induce ROS, which can lead to DNA damage, oxidative stress, and carcinogenesis. A human urothelial cell line, UROtsa, was used to study the effects of arsenicals on the human bladder. Arsenite [As(III)] and monomethylarsonous acid [MMA(III)] induce oxidative stress in UROtsa cells after exposur...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2008.05.018
更新日期:2008-08-19 00:00:00
abstract::Mycotoxins (frequently referred to as secondary metabolites of toxigenic fungi) are commonly found in foodstuffs and are important because of their association with disease. The mycotoxin diacetoxyscirpenol, or 3-hydroxy-4,15-diacetoxy-12,13-epoxytrichothec-9-ene (DAS), is produced by numerous species of Fusarium and ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90016-3
更新日期:1987-09-01 00:00:00
abstract::The mechanism of delta-aminolevulinate dehydratase (delta-ALA-D) inhibition by phenyl selenoacetylene in vitro was investigated in this study. Phenyl selenoacetylene (40-400 microM) inhibition of delta-aminolevulinate dehydratase from rat liver (low speed supernatant fraction, S1 fraction) was partially prevented by i...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.08.001
更新日期:2005-01-31 00:00:00
abstract::Metyrapone tartrate, 400 mg/kg i.p. raised the LD50 for acetaminophen from 340 mg/kg i.p. to 540 mg/kg i.p. in fasting male Swiss white mice. The minimum protective dose of metyrapone was 200 mg/kg. Metyrapone was effective in preventing death when given up to 2 h after acetaminophen administration. The LD50 for metyr...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(80)90029-3
更新日期:1980-01-01 00:00:00
abstract::We studied the effect of O,S,S-trimethyl phosphorodithioate (OSS-Me) on macrophage function and the immune responses of both T- and B-cells using an in vitro system. The involvement of glutathione (GSH) in the bioactivation of OSS-Me to suppress such responses was investigated after either direct culture with spleen o...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90155-1
更新日期:1986-04-01 00:00:00
abstract::A new methodology for estimating the probabilistic risk from acute toxic exposures is planned as a support tool for the Air Force at the Eastern and Western Ranges. Two such methodologies are programs entitled the Launch Area Toxic Analysis program (LATRA) and the Cold Spill Toxic Risk Analysis program (COSTRA). These...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(96)03380-x
更新日期:1996-07-17 00:00:00
abstract::The effect of potassium cyanide on mitochondria DNA (mtDNA) in mouse brain was investigated in vivo and in vitro. When potassium cyanide (0, 0.1, 1.0 or 2.0 mM) was incubated with a crude mitochondria fraction prepared from mouse brain at 37 degrees C for 60 min, the damage of mtDNA was observed in a concentration-dep...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00244-5
更新日期:2002-09-30 00:00:00
abstract::Effects of metallothionein (MT) synthesis inhibiting compounds (actinomycin D, cycloheximide), MT synthesis stimulating compounds (dexamethasone, dibu-cAMP) and interfering metals (Cd, Zn) on copper accumulation were investigated in rat hepatoma tissue culture cells. Copper-metallothionein (Cu-MT) and MT-associated co...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)90168-6
更新日期:1994-09-06 00:00:00
abstract::The ability to overcome cellular barriers in the body is crucial for efficient delivery of drugs to the target where intervention is needed. For drugs acting in the brain it is essential to overcome the blood-brain barrier (BBB). Such drugs include antidotes for the treatment of organophosphate poisoning, a current wa...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152541
更新日期:2020-10-01 00:00:00
abstract::Amiodarone is a class III anti-arrhythmic compound that is iodinated, cationic and amphiphilic in nature. The clinical use of amiodarone may be associated with various side-effects, including pulmonary and hepatic toxicity. Use of this compound during pregnancy may therefore place the fetus at risk through in utero ex...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90085-f
更新日期:1991-01-01 00:00:00
abstract::Cadmium, an environmental neurotoxic compound, produces cognitive disorders, although the mechanism remains unknown. Previously, we described that cadmium induces a more pronounced cell death on cholinergic neurons from basal forebrain (BF). This effect, partially mediated by M1 receptor blockade, triggering it throug...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.12.006
更新日期:2018-02-01 00:00:00
abstract::Extract and fractions of city smog collected from a heavy industrialized area caused in vitro dose-dependent reduction of cell survival of mouse macrophages and a growth inhibition of human fetal diploid lung fibroblasts. Great differences were observed in both cell systems between the total extract and its different ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(80)90091-8
更新日期:1980-01-01 00:00:00
abstract::Molybdenum trioxide (MoO3) nanoparticles (NPs) embedded in polymer films have been proposed as a cheap way of producing antibacterial coatings on external surfaces. Recently, we synthesized MoO3 nanowires in a unique shape and degree of anisotropy, which enables their fast water dissolution and quick antimicrobial rea...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152564
更新日期:2020-11-01 00:00:00
abstract::Immunohistochemical methods have been widely used to determine the histogenesis of spontaneous and chemically-induced mouse lung tumors. Typically, antigens for either alveolar Type II cells or bronchiolar epithelial Clara cells are studied. In the present work, the morphological and immunohistochemical phenotype of a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(03)00060-x
更新日期:2003-05-03 00:00:00
abstract::Polycyclic aromatic hydrocarbons (PAHs) including benzo[a]pyrene (B[a]P) and 7,12-dimethylbenz[a]anthracene (DMBA) are environmental pollutants, which undergo metabolic activation to exert their carcinogenic effects. Our earlier studies showed that naturally occurring plant phenols, protocatechuic, chlorogenic, tannic...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2008.07.047
更新日期:2008-09-29 00:00:00