Increased carbon tetrachloride hepatotoxicity after low-level ethanol consumption.

abstract：:Treatment of rats with beta-alanine increases the urinary taurine levels and markedly reduces the concentration of taurine in the liver. Dosing with carbon tetrachloride (CCl4) during treatment with beta-alanine results in a marked decrease in urinary taurine concomitant with a decrease in food intake. Treatment of an...

journal_title：Toxicology

authors： Waterfield CJ,Turton JA,Scales MD,Timbrell JA

更新日期：1993-01-29 00:00:00

abstract：:Novel dexrazoxane derivative JR-311 was prepared to investigate structure-activity relationships and mechanism(s) of protection against anthracycline cardiotoxicity. Its cardioprotective, antiproliferative, iron (Fe) chelation and inhibitory and/or depletory activities on topoisomerase IIbeta (TOP2B) were examined and...

journal_title：Toxicology

authors： Bures J,Jirkovska A,Sestak V,Jansova H,Karabanovich G,Roh J,Sterba M,Simunek T,Kovarikova P

更新日期：2017-12-01 00:00:00

abstract：:Excretion and organ distribution of mercury and susceptibility to methylmercury (MeHg) toxicity were compared between strains and sexes after successive oral administration of MeHg chloride (5 mg/kg per day) using BALB/cA (C) and C57BL/6N (B6) mice. Every mouse died several days after initiation of toxic symptoms, and...

journal_title：Toxicology

authors： Yasutake A,Hirayama K

更新日期：1988-09-01 00:00:00

abstract：:Chemicals can increase carcinogenic risk by either directly damaging DNA or increasing cell replication or they can do both. These effects have different implications for a biologically-based extrapolation from rodent bioassays to humans. 2-Acetylaminofluorene (2-AAF) administered at low doses to mice for a lifetime h...

journal_title：Toxicology

authors： Cohen SM

更新日期：1995-09-01 00:00:00

abstract：:Envenoming by the pitviper Bothrops jararacussu produces cardiovascular alterations, including coagulopathy, systemic hemorrhage, hypotension, circulatory shock and renal failure. In this work, we examined the activity of this venom in rat isolated right atria. Incubation with venom (0.025, 0.05, 0.1 and 0.2mg/ml) cau...

journal_title：Toxicology

authors： Rodrigues MA,Dias L,Rennó AL,Sousa NC,Smaal A,da Silva DA,Hyslop S

更新日期：2014-09-02 00:00:00

abstract：:Static and rotary cultures of adult rabbit hepatocytes can be produced reproducibly following their isolation by means of a simplified, inexpensive recycling perfusion system. Light and electron microscopic examination of the cultures showed that these hepatocytes retained the morphological characteristics of fully di...

journal_title：Toxicology

authors： Poole A,Chasseaud LF,Bridges JW

更新日期：1982-01-01 00:00:00

abstract：:Malathion is one of the most widely used organophosphorus insecticides in agriculture. However, malathion may be involved in the etiology of human brain dysfunction. Induction of ROS has been proposed as a mechanism of malathion-induced poisoning cases, but there are few data regarding the effects of malathion on oxid...

journal_title：Toxicology

authors： Shieh P,Jan CR,Liang WZ

更新日期：2019-04-01 00:00:00

abstract：:Indoor suspended particulate matter (SPM) consists of many different types of particles, the vast majority of which are less than 2.5 microm in diameter. An important question is how these particles, being inhalable, contribute to asthma and respiratory symptoms. One possibility is that these particles have an adjuvan...

journal_title：Toxicology

authors： Ormstad H,Gaarder PI,Johansen BV,Løvik M

更新日期：1998-08-21 00:00:00

abstract：:Antagonistic toxic effects of selenium and lead were studied in growing rats. Chronic lead intoxication was produced by cutaneous application of lead naphthenate solution (80-200 mg Pb/kg body weight) for a period of 8 weeks and chronic selenium intoxication was induced by giving 5 ppm, 10 ppm and 15 ppm selenium in d...

journal_title：Toxicology

authors： Rastogi SC,Clausen J,Srivastava KC

更新日期：1976-11-01 00:00:00

abstract：:Because occupational hazards of small-scale industries were severe and the occupational health management lagged behind in Shanghai, we selected some districts as experimental units to explore a model of community management and service for the occupational health in small-scale industries for controlling occupational...

journal_title：Toxicology

authors： Wei L,Shi-Da W

更新日期：2004-05-20 00:00:00

abstract：:A neuron spinal chord x hybrid (NSC-34) cell culture derived from neonatal mouse was characterized for studies on mercury toxicity. Exposure of NSC-34 cells to methyl mercury chloride (MeHgCl) (0-16 microM) resulted in significant dose-dependent cell damage and death (P < 0.05). MeHgCl was more toxic than inorganic me...

journal_title：Toxicology

authors： Chapman LA,Chan HM

更新日期：1999-02-15 00:00:00

abstract：:Enantioselectivity in toxicology, and health risk of chiral xenobiotics have become important topics at the forefront of chemistry and toxicology research. Our previous results showed that cis-bifenthrin (cis-BF) induced cytotoxicity and genotoxicity in human amnion epithelial (FL) cells, in an enantioselective manner...

journal_title：Toxicology

authors： Liu H,Xu L,Zhao M,Liu W,Zhang C,Zhou S

更新日期：2009-07-10 00:00:00

abstract：:To elucidate factors responsible for altered proliferation of preneoplastic hepatocytes in rat hepatocarcinogenesis in vivo, EGF-stimulated DNA synthesis of normal and nodular hepatocytes in primary culture was studied. In addition, the influence of 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated to clari...

journal_title：Toxicology

authors： Bock KW,Gschaidmeier H,Bock-Hennig BS,Eriksson LC

更新日期：2000-04-03 00:00:00

abstract：:The osteolathyrogenic agent semicarbazide was assayed for its toxicity and teratogenicity using early embryos of the frog Xenopus laevis. The 96-h LC50 is 1504.20 mg/l while the 96-h EC50 is 76.28 mg/l. Embryo length is altered prior to the onset of other effects indicated by a reduction in stage of development. The m...

journal_title：Toxicology

authors： Schultz TW,Dumont JN,Epler RG

更新日期：1985-08-01 00:00:00

abstract：:Although it is well known that microcystin-LR (MC-LR) may cause male reproductive toxicity, less is known on its potential impact on the development of prostate. In this study, from the 12th day in the embryonic period to the 21st day after birth, 4 randomly assigned groups of pregnant mice were exposed to 0, 1, 10, a...

journal_title：Toxicology

authors： Zhang H,Wang L,Shen S,Wang C,Xiang Z,Han X,Li D

更新日期：2017-04-01 00:00:00

abstract：:Chronic beryllium disease (CBD) results from exposure to the light-weight metal beryllium (Be). In vitro stimulation of bronchoalveolar lavage cells from CBD subjects causes the production of high levels of TNF-alpha, IFN-gamma and IL-6. We tested the hypothesis that Be-stimulation might induce the production of TNF-a...

journal_title：Toxicology

authors： Sawyer RT,Kittle LA,Hamada H,Newman LS,Campbell PA

更新日期：2000-03-07 00:00:00

abstract：:We compared the results of the multiple-dose guinea pig maximization test (GPMT) and the non-radioactive murine local lymph-node assay (LLNA) for various biocides. Thirteen out of 17 positive biocides in the GPMT gave positive results in the LLNA. In the GPMT, the minimum first induction doses ranged over four orders ...

journal_title：Toxicology

authors： Yamano T,Shimizu M,Noda T

更新日期：2005-07-01 00:00:00

abstract：:Paracetamol, in toxic doses, is associated with extensive liver damage. This represents one of the common causes of morbidity and mortality in drug poisoning cases. This study was undertaken to investigate the possible potentiation of the hepatoprotective action of N-acetylcysteine (NAC) by cimetidine (CMD), an inhibi...

journal_title：Toxicology

authors： Al-Mustafa ZH,Al-Ali AK,Qaw FS,Abdul-Cader Z

更新日期：1997-09-05 00:00:00

abstract：:Organochlorine and organophosphate pesticides are compounds that can be detected in human populations as a result of occupational or residential exposure. Despite their occurrence in considerably low levels in humans, their biological effects are hazardous since they interact with a plethora of enzymes, proteins, rece...

journal_title：Toxicology

authors： Androutsopoulos VP,Hernandez AF,Liesivuori J,Tsatsakis AM

更新日期：2013-05-10 00:00:00

abstract：PURPOSE:The environmental endocrine disruptors, bisphenol A (BPA) and bisphenol S (BPS) are associated with the development of type 2 diabetes. We aim to study the effects of BPA or BPS exposure on adipokine expression in human adipose tissue and on adipocyte glucose uptake. METHODS:Human subcutaneous adipose tissue w...

journal_title：Toxicology

authors： Ahmed F,Sarsenbayeva A,Katsogiannos P,Aguer C,Pereira MJ

更新日期：2020-12-01 00:00:00

abstract：:Exposure of rats to 0.1 and 0.5 mg Cd/kg subcutaneously (s.c.) thrice weekly for 5 weeks resulted in an accumulation of cadmium in the liver in concentrations of 40 and 95 micrograms/g tissue, respectively, and a microsomal burden of Cd amounting to approx. 2-3% of the retained cadmium. The cytoplasm contained about 8...

journal_title：Toxicology

authors： Klimczak J,Wiśniewska-Knypl JM,Kolakowski J

更新日期：1984-09-14 00:00:00

abstract：:Benzo(a)pyrene (B(a)P) is an environment carcinogen that can enhance cell proliferation by disturbing the signal transduction pathways in cell cycle regulation. The p53 tumor suppressor as a cell cycle check-point determinant plays a critical role in cell proliferation. However, the mechanism of p53 that accounts for ...

journal_title：Toxicology

authors： Wang Z,Qi Y,Chen Q,Yang D,Tang S,Jin X,Gao J,Fu J,Zhou Z,Wang J,Xiao X

更新日期：2009-02-04 00:00:00

abstract：:NLRC5, a newly found member of the NLR family and the largest member of nucleotide-binding, has been reported to regulate immune responses and is associated with hepatocellular carcinoma (HCC). We investigated the mechanisms and signaling pathways of NLRC5 in HCC progression. Increased expression of NLRC5, vascular en...

journal_title：Toxicology

authors： He YH,Li MF,Zhang XY,Meng XM,Huang C,Li J

更新日期：2016-06-01 00:00:00

abstract：:This study is aimed to investigate the inflammation and neurological dysfunction induced by tetrachloro-p-benzoquinone (TCBQ) through Toll-like receptor 4 (TLR4) signaling. We also investigated the protective role of melatonin as an antioxidant and anti-inflammatory agent. In vitro model was established by rat pheochr...

journal_title：Toxicology

authors： Fu J,Xia X,Liu Z,Wang Y,Wang Y,Shi Q,Song X,Song E,Song Y

更新日期：2017-04-15 00:00:00

abstract：:In the present investigation the influence of gossypol on the male sex function and toxicology in the rat have been studied. Gossypol was injected daily for 5 weeks to adult male rats of the Sprague-Dawley strain with 1 or 10 mg/kg body wt. The low dose of gossypol (1 mg/kg body wt.) did not have any effect on the fol...

journal_title：Toxicology

authors： Gåfvels M,Wang J,Bergh A,Damber JE,Selstam G

更新日期：1984-09-28 00:00:00

abstract：:The ubiquitous presence of nanoparticles (NPs) together with increasing evidence linking them to negative health effects points towards the need to develop the understanding of mechanisms by which they exert toxic effects. This study was designed to investigate the role of surface area and oxidative stress in the cell...

journal_title：Toxicology

authors： Hussain S,Boland S,Baeza-Squiban A,Hamel R,Thomassen LC,Martens JA,Billon-Galland MA,Fleury-Feith J,Moisan F,Pairon JC,Marano F

更新日期：2009-06-16 00:00:00

abstract：:The mechanism underlying the induction of micronuclei induced by rifampicin and nicotine in mouse bone marrow was investigated by fluorescence in situ hybridization assay using mouse minor satellite DNA probe. Colchicine and mitomycin, known to be predominantly clastogenic and aneugenic, respectively were used as posi...

journal_title：Toxicology

authors： Attia SM

更新日期：2007-06-03 00:00:00

abstract：:For half of the 30-odd years that diacetyl-exposed workers have developed disabling lung disease, obliterative bronchiolitis was unrecognized as an occupational risk. Delays in its recognition as an occupational lung disease are attributable to the absence of a work-related temporal pattern of symptoms; failure to rec...

journal_title：Toxicology

authors： Kreiss K

更新日期：2017-08-01 00:00:00

abstract：:The effects of triethyl lead chloride (TEL) on the expression of two detoxication enzyme families, glutathione S-transferases (GSTs) and NAD(P)H:quinone oxidoreductase (QR) were determined in rat liver and kidney. Fischer 344 rats were given one intraperitoneal (i.p.) injection of TEL. GST activity, GST isoenzyme leve...

journal_title：Toxicology

authors： Daggett DA,Nuwaysir EF,Nelson SA,Wright LS,Kornguth SE,Siegel FL

更新日期：1997-02-14 00:00:00

abstract：:The mouse lymphoma thymidine kinase assay (MLA) has been optimized to quantitatively determine the in vitro mutagenicity of cigarette mainstream smoke particulate phase. To test whether the MLA is able to discriminate between different cigarette types, specially constructed cigarettes each containing a single tobacco ...

journal_title：Toxicology

authors： Schramke H,Meisgen TJ,Tewes FJ,Gomm W,Roemer E

更新日期：2006-10-29 00:00:00