Abstract：
:Treatment of rats with beta-alanine increases the urinary taurine levels and markedly reduces the concentration of taurine in the liver. Dosing with carbon tetrachloride (CCl4) during treatment with beta-alanine results in a marked decrease in urinary taurine concomitant with a decrease in food intake. Treatment of animals with beta-alanine increases the hepatotoxicity of single doses of CCl4 as determined histologically and by measurement of serum alanine transaminase (ALT) and aspartate transaminase (AST) levels. Urinary creatine is also raised significantly after the administration of CCl4 in beta-alanine-treated animals. However, the accumulation of triglycerides (TRIG) in the liver caused by dosing with CCl4 was not influenced by beta-alanine treatment. The data suggest that liver taurine levels may be an important factor in determining the degree of CCl4-induced cellular necrosis but not hepatic triglyceride accumulation.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Waterfield CJ,Turton JA,Scales MD,Timbrell JAdoi
10.1016/0300-483x(93)90133-dsubject
Has Abstractpub_date
1993-01-29 00:00:00pages
7-20issue
1-2eissn
0300-483Xissn
1879-3185pii
0300-483X(93)90133-Djournal_volume
77pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:The objective of this study was to compare the disposition and metabolism of [14C]1,2-dichloropropane [( 14C]DCP) following oral and inhalation exposure since these two routes are of interest with regards to occupational and accidental exposure. [14C]DCP was administered orally to groups of four rats of each sex as a ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(91)90076-d
更新日期：1991-01-01 00:00:00
abstract：:Bisphenol A (BPA) is a suspected endocrine disruptor highly prevalent in our environment since it is used as monomer of polycarbonate plastics and epoxy resins. Recent epidemiological and animal studies have suggested that BPA exposure may influence the development of obesity and related pathologies such as type 2 dia...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2014.08.006
更新日期：2014-11-05 00:00:00
abstract：:Cardiac fibrosis is characterized by net accumulation of extracellular matrix (ECM) proteins in the cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions. More specifically, cardiac fibroblasts are activated by a variety of pathological stimuli, th...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2014.07.002
更新日期：2014-09-02 00:00:00
abstract：:Biodegradable nanoparticles are being considered more often as drug carriers to address pharmacokinetic/pharmacodynamic issues, yet nano-product safety has not been systematically proven. In this study, haematological, biochemical and histological parameters were examined on 28 day daily dosing of rats with nano- or m...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2015.01.017
更新日期：2015-04-01 00:00:00
abstract：:The effect of tert-butyl hydroperoxide (tBH) on the nucleotide level in isolated cardiomyocytes from adult rats was examined. Incubation of myocytes with the hydroperoxide resulted in loss of both ATP and NAD from mitochondria and cytosol. In contrast, only the cytosolic level of NADP was increased. The effect on myoc...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(95)03158-c
更新日期：1996-01-08 00:00:00
abstract：:Cell death triggers the release into extracellular spaces of products of chromatin catabolism, particularly of DNA. A sensitive DNA assay has been used to investigate in the mouse whether the quantitation of plasma DNA may be used as an index of in vivo cytotoxicity. It has been found that toxic doses of bacterial lip...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90178-j
更新日期：1990-04-30 00:00:00
abstract：:A single oral dose of 50 mg/kg of [14C]TOCP was administered in corn oil to male rats. Three animals were sacrificed at each of 2, 6 and 12 h and 1, 2 and 5 days following dosing, and tissues and excreta were analyzed for 14C. Within 5 days, 63 and 36% of the dose were recovered in the urine and feces, respectively. I...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90079-v
更新日期：1990-12-17 00:00:00
abstract：:Mitochondrial fission, fusion, and mitophagy are interlinked processes that regulate mitochondrial shape, number, and size, as well as metabolic activity and stress response. The fundamental importance of these processes is evident in the fact that mutations in fission (DRP1), fusion (MFN2, OPA1), and mitophagy (PINK1...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2017.05.018
更新日期：2017-07-15 00:00:00
abstract：:Organochlorine and organophosphate pesticides are compounds that can be detected in human populations as a result of occupational or residential exposure. Despite their occurrence in considerably low levels in humans, their biological effects are hazardous since they interact with a plethora of enzymes, proteins, rece...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2012.09.011
更新日期：2013-05-10 00:00:00
abstract：:High-throughput in vitro toxicity screening provides an efficient way to identify potential biological targets for environmental and industrial chemicals while conserving limited testing resources. However, reliance on the nominal chemical concentrations in these in vitro assays as an indicator of bioactivity may misr...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2014.05.012
更新日期：2015-06-05 00:00:00
abstract：:Long-term exposure to isoflurane may induce long-term developmental neurotoxicity and cognitive impairments in the neonatal brains. Trilobatin, a leaf extract from the Chinese traditional sweet tea Lithocarpus polystachyus Rehd, possesses various biological properties including anti-inflammatory and anti-oxidant prope...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2020.152537
更新日期：2020-09-01 00:00:00
abstract：:The effects of thallous cation (Tl(+)) on: (a) the production of oxidant species and (b) membrane fluidity were evaluated in human leukemia T cells (Jurkat). After 72 h of incubation in the presence of Tl(+) (5-100 microM), no significant changes in cell viability were observed, although the average cell size was decr...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.01.028
更新日期：2006-05-01 00:00:00
abstract：:Bromofenofos (BF) was administered by gavage once to non-pregnant and pregnant rats at 50 mg/kg and the plasma concentration-time curves of BF and its metabolite dephosphate bromofenofos (DBF) were determined by high-performance liquid chromatography. DBF reached a peak at 9 h, with 113.4 +/- 5.2 micrograms/ml, follow...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(89)90019-x
更新日期：1989-05-15 00:00:00
abstract：:Female mice were given nutrient-sufficient, purified diets containing cadmium at either 0.25, 5, or 50 ppm, as described in the accompanying publication. One-half of the females were bred for 6 consecutive 42-day rounds of pregnancy/lactation (PL mice); remaining females were non-pregnant controls (NP mice). PL mice a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(88)90092-3
更新日期：1988-07-01 00:00:00
abstract：:Dietary exposure to vomitoxin (VT) results in hyperelevated serum IgA and IgA nephropathy in mice. To assess the possible role of cytokines in this IgA dysregulation, the effects of a single oral exposure in B6C3F1 male mice to 0, 5 or 25 mg/kg BW VT on production of IgA and cytokines in Peyer's patch (PP) and spleen ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(97)00087-5
更新日期：1997-09-26 00:00:00
abstract：:The mouse lymphoma thymidine kinase assay (MLA) has been optimized to quantitatively determine the in vitro mutagenicity of cigarette mainstream smoke particulate phase. To test whether the MLA is able to discriminate between different cigarette types, specially constructed cigarettes each containing a single tobacco ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.07.019
更新日期：2006-10-29 00:00:00
abstract：:A flow-limited physiologically based toxicokinetic model was constructed for uptake, metabolism, and clearance of butadiene (BD) and its principal metabolite 1,2-epoxy-3-butene (EB), using physiological and biochemical parameters from the literature where available. The model includes compartments for blood, liver, lu...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(96)03424-5
更新日期：1996-10-28 00:00:00
abstract：:The neurotoxicity and developmental effects of a widely applied insecticide (methomyl) was investigated by a multi-level approach (behavior and biometry, biochemical alterations and neurodegeneration) in Caenorhabditis elegans upon a short-term exposure (1 h) and a post-exposure period (48 h). The 1-h exposure to sub-...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2021.152684
更新日期：2021-01-25 00:00:00
abstract：:Methylcyclopentadienyl manganese tricarbonyl (MMT) is an effective inhibitor of mitochondrial respiration associated with NAD+-linked substrates. At concentrations which inhibit glutamate-malate oxidation (over 80% inhibition) succinate and tetramethylphenylenediamine (TMPD)-ascorbate are inhibited less than 25%. MMT ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(77)90043-9
更新日期：1977-02-01 00:00:00
abstract：:Our previous study revealed that exposure to 0.4 ppm ozone (O(3)) enhanced nasal allergy-like reactions in guinea pigs. In the present study, we investigated the concentration-dependency of the effects of exposure to O(3) on the aggravation of nasal allergy-like reactions induced by repeated nasal administration of an...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.01.008
更新日期：2004-06-01 00:00:00
abstract：:Oxidative stress as a result of excessive generation of reactive oxygen species (ROS) or diminished antioxidative defence is regarded as a main factor in the pathophysiology of various diseases and ageing. Many flavonoids that are present in herbal edibles have antioxidative properties and possess a remarkable spectru...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.02.006
更新日期：2007-05-05 00:00:00
abstract：:N-Heterocyclic aromatics are by-products of incomplete combustion of organic material. The overall objective of this study was to determine the relative carcinogenic potencies of 7H-dibenzo[c,g]carbazole (DBC) and dibenz[a,j]acridine (DBA) in a bioassay of complete carcinogenicity on mouse skin in a sensitive strain (...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90074-4
更新日期：1994-11-11 00:00:00
abstract：:Immunotoxicology originated in the early 1970s, when scientists began investigating chemicals. During the 1970s and early 1980s, a few investigators determined that chemicals were immunotoxic, developed and/or refined immunoassays, and began to characterize immunotoxic responses. In the 1980s, many new investigators e...
journal_title：Toxicology
pub_type： 历史文章,杂志文章
doi：10.1016/s0300-483x(00)00434-0
更新日期：2001-03-07 00:00:00
abstract：:In order to monitor the effect of the procedures required to s.c. implant osmotic pumps into rats on plasma thyroid and testosterone hormone levels, male Fischer 344 rats (8-10 weeks old) were divided into six groups of 10 rats and the groups treated in the following manner: (1) controls housed 5 per cage; (2) control...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)02874-t
更新日期：1995-01-06 00:00:00
abstract：:Silver nanoparticles (AgNPs) are widely utilized in various consumer products and medical devices, especially due to their antimicrobial properties. However, several studies have associated these particles with toxic effects, such as inflammation and oxidative stress in vivo and cytotoxic and genotoxic effects in vitr...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2012.09.014
更新日期：2013-11-08 00:00:00
abstract：:The effects of ethanol on hamster hepatic and extrahepatic monooxygenases were determined in the present study. Chronic ethanol administration increased cytochrome P-450 (P-450) content and monooxygenase activities towards aniline, N-nitrosodimethylamine, and 7-ethoxyresorufin. In contrast, benzphetamine and benzo(a)p...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90006-e
更新日期：1993-07-28 00:00:00
abstract：:The effects of low doses of (S)-alpha-cyano-3-phenoxybenzyl (1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate (Roussel UCLAF, Paris, France), (deltamethrin) upon sympathetic-adrenomedullary and pituitary-adrenocortical activity were investigated in rats by measuring plasma noradrenaline (NA), adrenalin...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(88)90007-8
更新日期：1988-05-01 00:00:00
abstract：UNLABELLED:National surveys of United States households and child care centers have demonstrated that pyrethroids are widely distributed in indoor habited dwellings and this suggests that co-exposure to multiple pyrethroids occurs in nonoccupational settings. The purpose of this research was to use an environmentally r...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2014.02.016
更新日期：2014-06-05 00:00:00
abstract：:Several inhibitors of cytochrome P-450 mediated oxidative transformations, ethyl 2-diethylaminoethyl-2-phenyl-2-ethylmalonate, ethyl-2-diethyl-aminoethyl-2-ethyl-2-buthylmalonate, 2,4 dichloro-6-phenoxyethyl diethylamine, 2-diethylaminoethyl-2-phenyl- (2-propene)-4-penten-1-oate or 3-amino,1,2,4 triazole were not able...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(80)90117-1
更新日期：1980-01-01 00:00:00
abstract：:Diesel exhaust particles (DEP) affect health adversely. Our previous studies revealed that DEP extracts up-regulated expression of genes related to drug metabolism, antioxidant enzymes, cell cycle/apoptosis and coagulation, and in addition, n-hexane soluble fraction (n-HSF) of DEP extracts contains aliphatic and polyc...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.05.012
更新日期：2009-07-28 00:00:00
