Abstract：
:Because occupational hazards of small-scale industries were severe and the occupational health management lagged behind in Shanghai, we selected some districts as experimental units to explore a model of community management and service for the occupational health in small-scale industries for controlling occupational hazards. The results indicated that the model is useful. The features of occupational health in these small-scale industries have been improved markedly. For example, the monitoring rate of occupational hazards increased, the rate for occupational health recording and training also increased, and the knowledge of the occupational health among managers and employees has been also enhanced after implementing the new management model. The practice has shown that it is a low-cost and wide-covered, effective model. The communities may offer the standard, agreeable and low-price occupational health management and service to the small-scale industries which are able to pay the service fee although their economic base is comparatively weak. A solution for protecting the occupational population with relatively high mobility and keeping small-scale industries sustainable development has been reported.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Wei L,Shi-Da Wdoi
10.1016/j.tox.2004.01.019keywords:
subject
Has Abstractpub_date
2004-05-20 00:00:00pages
55-61issue
1-3eissn
0300-483Xissn
1879-3185pii
S0300483X04000794journal_volume
198pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Colicins are unusual bacterial toxins because they are directed against close relatives of the producing strain. They kill their targets in one of three distinct ways; via a ribonuclease or deoxyribonuclease activity or by forming pores in the target cell's membrane. This review deals with the steps involved in pore-f...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(94)90156-2
更新日期：1994-02-28 00:00:00
abstract：:Food labels are an important educational tool to assist consumers in making healthy food choices. In addition to mandatory nutritional labeling information, manufacturers have a variety of options on the food/supplement packages to communicate the nutrition/health benefits of their products. This paper describes the d...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.12.021
更新日期：2006-04-03 00:00:00
abstract：:Long-term exposure to pharmacological agents can select for cells that overexpress efflux transporters. We previously showed that mouse J774 macrophages cultivated for a prolonged period of time with toxic concentrations of the fluoroquinolone ciprofloxacin overexpress the efflux transporter Mrp4 and display a reduced...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.09.003
更新日期：2011-12-18 00:00:00
abstract：:The effects of N-acetylcysteine (NAC), 2-mercaptopropionylglycine (MPG) and dithiothreitol (DTT) on the metabolism and toxicity of acetaminophen (APAP) were examined in isolated mouse hepatocytes maintained in primary culture on collagen-coated dishes. Both NAC and MPG increased the formation of the glutathione and su...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90106-x
更新日期：1986-10-01 00:00:00
abstract：:The effect of tamoxifen on cytosolic free Ca2+ concentrations ([Ca2+]i) and viability has not been explored in corneal epithelial cells. This study examined whether tamoxifen altered [Ca2+]i and viability in SIRC corneal epithelial cells. Tamoxifen at concentrations > or = 1 microM increased [Ca2+]i in a concentration...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.10.001
更新日期：2009-01-08 00:00:00
abstract：:Tributyltin (TBT), a toxic and widespread environmental contaminant, has been shown to inhibit natural killer (NK) cell cytotoxic function significantly. Inhibition of NK cell cytotoxic function has the potential to increase viral infections and tumor growth. Upon NK cell binding to lysis-sensitive tumor cells, an int...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.05.002
更新日期：2006-07-25 00:00:00
abstract：:To investigate whether sensitivity to the induction of micronuclei by acetaldehyde is associated with genetic polymorphisms of the aldehyde dehydrogenase-2 (ALDH2) gene, cytokinesis-block micronucleus (CBMN) assays were performed on peripheral lymphocytes from 47 healthy human subjects exposed to acetaldehyde in vitro...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.01.016
更新日期：2005-06-01 00:00:00
abstract：:Dimethyl sulfoxide (DMSO) has previously been shown to protect against acetaminophen (APAP)-induced hepatotoxicity, but the mechanism of this effect was not clear. Treatment of mice with 1 mg/kg DMSO 4 h before 250 mg/kg APAP resulted in significantly less hepatotoxicity than with APAP alone, as measured by serum glut...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(88)90202-8
更新日期：1988-11-14 00:00:00
abstract：:The ability of cis-dichlorodiammine platinum II to cause chromosomal aberrations in rats and dominant lethality in mice was studied. Five daily intraperitoneal doses ranging from 0.25 to 2.00 mg/kg/day failed to result in the observance of dominant lethal mutations in mice. Intraperitoneal doses of 0.13 and 0.52 mg/kg...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(80)90027-x
更新日期：1980-01-01 00:00:00
abstract：:The histogenesis of coumarin-induced cholangiofibrosis in the rat has been determined. Proliferation of ductal structures was preceded by extensive damage to hepatocytes in the centrilobular region. Focal proliferation of ducts and fibrous tissue was present at 3 months and typical areas of cholangiofibrosis at 6 mont...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(89)90187-x
更新日期：1989-04-01 00:00:00
abstract：:Oxidative DNA damage is emerging as an biomarker of effect in studies assessing the health risks of occupational chemicals. Trichloroethylene (TCE) and perchloroethylene (PERC) are used in the dry cleaning industry and their metabolism can produce reactive oxygen compounds. The present study examined the potential for...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00083-9
更新日期：1999-10-29 00:00:00
abstract：:A number of studies reported that the MTS in vitro cytotoxicity assay is a convenient method for assessing cell viability. The main features found with this assay are its ease of use, accuracy and rapid indication of toxicity. It might well be a useful tool in human health risk assessment if it can be shown that this ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(97)00151-0
更新日期：1997-12-31 00:00:00
abstract：:The effects of lindane on alpha-aminoisobutyric acid and uridine uptake were studied in the rat line C-6 of glial origin. Different levels of modifications could be distinguished by use of 2 modes of investigation. One study, carried out within minutes of contact with lindane, has shown that the inhibition of alpha-am...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(80)90103-1
更新日期：1980-01-01 00:00:00
abstract：:As an important cholesterol oxide, 7-ketocholesterol plays a deleterious role in the occurrence of cancer. Although the fact had been proved that 7-ketocholesterol could induce several biological phenomena, including apoptosis, DNA damage, et al., this issue whether 7-ketocholesterol led to mutagenesis in mammalian ce...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2020.152587
更新日期：2020-12-15 00:00:00
abstract：:Aluminium (Al) oxyhydroxide (Alhydrogel®), the main adjuvant licensed for human and animal vaccines, consists of primary nanoparticles that spontaneously agglomerate. Concerns about its safety emerged following recognition of its unexpectedly long-lasting biopersistence within immune cells in some individuals, and rep...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2016.11.018
更新日期：2017-01-15 00:00:00
abstract：:Pentachlorophenol (PCP) is an inhibitor of phenol-sulfotransferases and has been used to ascertain the role of sulfation in toxicology. Recently, molybdate has been shown to inhibit the sulfation of various chemicals by decreasing hepatic concentrations of the cosubstrate, 3'-phosphoadenosine 5'-phosphosulfate (PAPS)....
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00159-1
更新日期：2000-04-20 00:00:00
abstract：:Oxybutynin hydrochloride, an anti-cholinergic/anti-spasmodic agent, was examined for its effect on fertility and peri-post natal development in the rat and its embryotoxic potential in the rat and rabbit. In the rat effects on reproductive performance included a slight increase in the incidence of foetal malformations...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90044-2
更新日期：1986-07-01 00:00:00
abstract：:Hexavalent chromium [Cr(VI)] compounds (e.g. chromates) are strong oxidants that readily enter cells where they are reduced to reactive Cr intermediates that can directly oxidize some cell components and can promote the generation of reactive oxygen and nitrogen species. Inhalation is a major route of exposure which d...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.01.001
更新日期：2011-03-15 00:00:00
abstract：:The majority of insecticides currently in use throughout the world belong to the class of the organophosphorus insecticides. Many of these compounds, such as the phosphorothioate insecticides, exert their mammalian toxicity only after undergoing metabolic activation by a variety of cytochrome P450 isoforms to produce ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(98)00125-5
更新日期：1998-11-16 00:00:00
abstract：:The toxicity of two new monofunctional sulfur mustard derivatives was tested. The compound (4-carboxybutyl 2-chloroethyl sulfide, CBCS; 10-carboxydecyl 2-chloroethyl sulfide, CDCS) possess the 2-chloroethyl sulfide moiety present in mustard gas. Exposure of guinea pig skin to CBCS resulted in a dose-related ulcerative...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(95)03288-q
更新日期：1996-04-15 00:00:00
abstract：:The effects of ethanol on hamster hepatic and extrahepatic monooxygenases were determined in the present study. Chronic ethanol administration increased cytochrome P-450 (P-450) content and monooxygenase activities towards aniline, N-nitrosodimethylamine, and 7-ethoxyresorufin. In contrast, benzphetamine and benzo(a)p...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90006-e
更新日期：1993-07-28 00:00:00
abstract：:Cultures of the human cell line NHIK 3025 were exposed over an 18-month period to 0.5 mumol/1 potassium dichromate (K2Cr2O7) containing 1 mumol/1 hexavalent chromium. The chronically exposed cells increased their tolerance to K2Cr2O7 in comparison to control populations. The doubling time of the chronically exposed ce...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(81)90083-4
更新日期：1981-01-01 00:00:00
abstract：:Endocrine disruptors (EDs) are exogenous substances or xenoestrogens natural or synthetic, capable of interacting with different systems and altering their normal hormonal regulation, being the reproductive system one of the most affected. EDs produce their effects not only by acting on nuclear steroid receptors, but ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2013.05.014
更新日期：2013-09-06 00:00:00
abstract：:Long-term cadmium exposure leads to mitochondrial dysfunction in the proximal tubular epithelial cells. Mitochondrial DNA deletion may contribute to the pathogenesis of cadmium-induced nephropathy. The aim of our study is to clarify the accumulation of mitochondrial DNA deletion and mitochondrial dysfunction in the re...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.06.005
更新日期：2004-10-15 00:00:00
abstract：:Chemicals can increase carcinogenic risk by either directly damaging DNA or increasing cell replication or they can do both. These effects have different implications for a biologically-based extrapolation from rodent bioassays to humans. 2-Acetylaminofluorene (2-AAF) administered at low doses to mice for a lifetime h...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(95)03044-g
更新日期：1995-09-01 00:00:00
abstract：:The nephrotoxicant and nephrocarcinogen tris(2,3-dibromopropyl)-phosphate (Tris-BP) is activated to products which bind covalently to microsomal protein by a cytochrome P-450 dependent oxidation reaction. Binding to rat liver microsomes proceeds 15 times faster than with kidney microsomes. The binding in liver microso...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(81)90144-x
更新日期：1981-01-01 00:00:00
abstract：:In our previous study, di-n-butyltin diacetate has been shown to cause malformations such as cleft mandible, ankyloglossia, fused ribs, etc. in rat fetuses after oral treatment of maternal rats on day 8 of gestation. In this study, teratogenic effects of five di-n-butyltin compounds with different anions and also buty...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90039-u
更新日期：1993-12-31 00:00:00
abstract：:In a Japanese chemical factory, a lung disease like pneumoconiosis appeared at a high rate among workers handling cross-linked water-soluble acrylic acid polymer (CWAAP). To our knowledge, no such case was known in the world until very recently. The present study was designed to elucidate the effect of single intratra...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2020.152647
更新日期：2021-01-30 00:00:00
abstract：:4-Amino-2,6-dichlorophenol (ADCP) is a potent acute nephrotoxicant in vivo inducing prominent renal corticomedullary necrosis. In vitro, ADCP exposure increases lactate dehydrogenase (LDH) release from rat renal cortical slices at 0.05 mM or greater. The purpose of this study was to examine the ability of antioxidants...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.12.014
更新日期：2008-03-12 00:00:00
abstract：:Antidepressants are generally used for treatment of various mood and anxiety disorders. Several studies have shown the anti-tumor and cytotoxic activities of some antidepressants, but the underlying mechanisms were unclear. Maprotiline is a tetracyclic antidepressant and possesses a highly selective norepinephrine reu...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2012.11.013
更新日期：2013-02-08 00:00:00
