Stimulation of lipid peroxidation and heme oxygenase activity with inhibition of cytochrome P-450 monooxygenase in the liver of rats repeatedly exposed to cadmium.

abstract：:A 20-year-old man on oral substitution of pancreatic enzymes after hemipancreatectomy injected an enzyme preparation of fungal origin intravenously after dissolving it in water. Within a few hours chills, headache, nausea and vomiting, fever of 40.8 degrees C, and shock occurred. The acute illness might have been caus...

journal_title：Toxicology

authors： Seitz R,Adler G,Koop I,Koop H,Egbring R

更新日期：1989-04-01 00:00:00

abstract：:Previously, we evaluated the effects of lactational exposure to a representative mixture of the six indicator non-dioxin-like polychlorinated biphenyls (∑6 NDL-PCBs) at low levels on the neurobiological changes and developmental/behavioral performances in mice. In this study, we analyzed the global gene expression pro...

journal_title：Toxicology

authors： Elnar AA,Desor F,Marin F,Soulimani R,Nemos C

更新日期：2015-02-03 00:00:00

abstract：:The influence of the insertion of a liver into the perfusion circuit of a lung on the availability of benzo[a]pyrene and benzo[a]pyrene metabolites to the lung was examined. Perfused lungs from 5,6-benzoflavone pretreated rats release high quantities of free benzo[a]pyrene metabolites and conjugates into the perfusion...

journal_title：Toxicology

authors： Mollière M,Foth H,Kahl R,Kahl GF

更新日期：1987-08-01 00:00:00

abstract：:The function of the neuromuscular transmission in rats dosed with phoxim (P), methomyl (M), fenvalerate (F), and mixtures of P+M and P+F was studied by using both the stimulation single fiber electromyography (SSFEMG) and repetitive nerve stimulations (RNS) to determine the single muscle fiber action potential and com...

journal_title：Toxicology

authors： Yang D,He F,Li T

更新日期：2001-03-21 00:00:00

abstract：:Nine structurally different polycyclic aromatic hydrocarbons (PAHs) were tested for their ability to either agonize or antagonize the human androgen receptor (hAR) in a sensitive reporter gene assay based on CHO cells transiently cotransfected with a hAR vector and an MMTV-LUC vector. Benz[a]anthracene (B[a]A), benzo[...

journal_title：Toxicology

authors： Vinggaard AM,Hnida C,Larsen JC

更新日期：2000-04-14 00:00:00

abstract：:The free radical scavenging activities and inhibitory effect of lipid peroxidation of a delphinidin derivative in eggplant were investigated. Delphinidin-3-(p-coumaroylrutinoside)-5-glucoside (nasunin), an anthocyanin, was isolated as purple colored crystals from eggplant peels. Using electron spin resonance spectrome...

journal_title：Toxicology

authors： Noda Y,Kneyuki T,Igarashi K,Mori A,Packer L

更新日期：2000-08-07 00:00:00

abstract：:Exposure to cadmium (Cd) can cause a variety of biological effects including alterations of immune responses in animals and humans. Both immunosuppression and immunoenhancement have been reported. The present study was aimed at investigating the consequences of exposure to Cd on the human immunoglobulin (Ig) E synthes...

journal_title：Toxicology

authors： Jelovcan S,Gutschi A,Kleinhappl B,Sedlmayr P,Barth S,Marth E

更新日期：2003-06-03 00:00:00

abstract：:Natural antioxidants like catechin are now known to have a modulatory role on physiological functions and biotransformation reactions involved in the detoxification process, thereby affording protection from toxic metabolic actions of xenobiotics. Reactive oxygen intermediates have been demonstrated to play an etiolog...

journal_title：Toxicology

authors： Parvez S,Tabassum H,Rehman H,Banerjee BD,Athar M,Raisuddin S

更新日期：2006-08-15 00:00:00

abstract：:Natural phytochemicals derived from dietary sources or medicinal plants have gained significant recognition in the potential management of several human clinical conditions. Much research has also been geared towards the evaluation of plant extracts as effective prophylactic agents since they can act on specific and/o...

journal_title：Toxicology

authors： Neergheen VS,Bahorun T,Taylor EW,Jen LS,Aruoma OI

更新日期：2010-12-05 00:00:00

abstract：:In living organisms both chemical agents and physical factors [16] may produce neurophysiological change that affects EEG activity. EEG signals are very suitable for non-invasive measurement of CNS reactions, but quite complicated equipment is necessary for measurement and analysis. We have implemented a system that p...

journal_title：Toxicology

authors： Kubát J,Formánek J,Fuchs A,Rehák P,Zajícek P,Dvorák J,Vanícková M

更新日期：1988-05-01 00:00:00

abstract：:We recently reported that Delta(9)-tetrahydrocannabinol (Delta(9)-THC) has the ability to stimulate the proliferation of human breast carcinoma MCF-7 cells. However, the mechanism of action remains to be clarified. The present study focused on the relationship between receptor expression and the effects of Delta(9)-TH...

journal_title：Toxicology

authors： Takeda S,Yamaori S,Motoya E,Matsunaga T,Kimura T,Yamamoto I,Watanabe K

更新日期：2008-03-12 00:00:00

abstract：:The study of hepatic fibrosis, or scarring in response to chronic liver injury, has witnessed tremendous progress in the past two decades. Clarification of the cellular sources of scar, and emergence of hepatic stellate cells not only as a fibrogenic cell type, but also as a critical immunomodulatory and homeostatic r...

journal_title：Toxicology

authors： Friedman SL

更新日期：2008-12-30 00:00:00

abstract：:Induction of hepatic metallothionein (MT) by acetaminophen was characterized in the rat and mouse. Treatment of rats with the hepatotoxin resulted in increase of liver MT in a dose-dependent manner. MT concentration was elevated by 41%, 140% and 260% following acetaminophen injection at doses of 250, 500 and 1000 mg/k...

journal_title：Toxicology

authors： Wormser U,Calp D

更新日期：1988-12-30 00:00:00

abstract：:Effects of metallothionein (MT) synthesis inhibiting compounds (actinomycin D, cycloheximide), MT synthesis stimulating compounds (dexamethasone, dibu-cAMP) and interfering metals (Cd, Zn) on copper accumulation were investigated in rat hepatoma tissue culture cells. Copper-metallothionein (Cu-MT) and MT-associated co...

journal_title：Toxicology

authors： Steinebach OM,Wolterbeek HT

更新日期：1994-09-06 00:00:00

abstract：:Indomethacin (IMC) has been shown to reduce post-operative inflammation and to decrease intraocular irritation after cataract extraction and in cystoid macular edema; however, the clinical use of its most commonly used eye drops is limited due to topical side-effects that include burning sensation, irritation and epit...

journal_title：Toxicology

authors： Nagai N,Ito Y,Okamoto N,Shimomura Y

更新日期：2014-05-07 00:00:00

abstract：:Chlorpyrifos (CPF) is a commonly used diethylphosphorothionate organophosphorus (OP) insecticide. Diethylphosphate (DEP), diethylthiophosphate (DETP) and 3,5,6-trichloro-2-pyridinol (TCPy) are products of both in vivo metabolism and environmental degradation of CPF and are routinely measured in urine as biomarkers of ...

journal_title：Toxicology

authors： Busby-Hjerpe AL,Campbell JA,Smith JN,Lee S,Poet TS,Barr DB,Timchalk C

更新日期：2010-01-31 00:00:00

abstract：:Tobacco smoking is the largest preventable risk factor for morbidity and mortality in industrialized countries. WHO estimates that tobacco will become the largest single health problem by 2020, causing an estimated 8.4 million deaths annually. Tobacco has central importance in the etiology of cancers of the lung, head...

journal_title：Toxicology

authors： Vainio H,Weiderpass E,Kleihues P

更新日期：2001-09-14 00:00:00

abstract：:In the current study, we used pathway-specific cDNA arrays to detect the transcriptional signature induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in vivo by studying simultaneously the expression profiles of 83 genes involved in apoptosis, cytokine production and angiogenesis. To this end, C57BL/6 mice were inj...

journal_title：Toxicology

authors： Zeytun A,McKallip RJ,Fisher M,Camacho I,Nagarkatti M,Nagarkatti PS

更新日期：2002-09-16 00:00:00

abstract：:Gender is a factor that influences susceptibility of individuals to drug-induced liver injury in experimental animals and humans. In this study, we investigated the mechanisms underlying resistance of female mice to acetaminophen (APAP)-induced hepatotoxicity. Overnight-fasted male and female CD-1 mice were administer...

journal_title：Toxicology

authors： Masubuchi Y,Nakayama J,Watanabe Y

更新日期：2011-09-05 00:00:00

abstract：:Beside heavy metals, cadmium (Cd(2+)) is a ubiquitous toxic metal with a well established apoptotic and genotoxic effect, chronic exposure of which has been involved in a variety of pathological conditions. In the present study, we investigated by 1455 genes cDNA microarrays the toxic and apoptotic effect of Cd(2+), o...

journal_title：Toxicology

authors： Tsangaris GT,Botsonis A,Politis I,Tzortzatou-Stathopoulou F

更新日期：2002-09-02 00:00:00

abstract：:Several different meanings have been attached to the term "chemical sensitivity" by those who use it. Feeling ill from odors is a symptom reported by approximately one-third of the population. The syndrome of chemical sensitivity, frequently called "Multiple Chemical Sensitivity" or "MCS" has been the subject of three...

journal_title：Toxicology

authors： Miller CS

更新日期：1996-07-17 00:00:00

abstract：:Ultrafine titanium dioxide (TiO(2)) particles have been shown to exhibit strong cytotoxicity when exposed to UVA radiation, but are regarded as a biocompatible material in the absence of photoactivation. In contrast to this concept, the present results indicate that anatase-sized (10 and 20 nm) TiO(2) particles in the...

journal_title：Toxicology

authors： Gurr JR,Wang AS,Chen CH,Jan KY

更新日期：2005-09-15 00:00:00

abstract：:Previous studies have shown that excess dietary Al during development can affect neurobehavioral measures and decrease tissue Mn of 21-day-old weanling mice without a corresponding increase in tissue Al concentrations. Al and Mn have similar tissue concentrations and similar affinities for transferrin, which is the ma...

journal_title：Toxicology

authors： Golub MS,Han B,Keen CL,Gershwin ME

更新日期：1993-07-11 00:00:00

abstract：:The nature of cancer initiation by fumonisin B(1) (FB(1)) was investigated in rat liver by monitoring the effect of phenobarbital (PB) as cancer promoter and evaluating the involvement of spontaneously initiated cells. A PB promoting regimen (0.05% in the diet) stimulated the outgrowth of FB(1)-induced placental gluta...

journal_title：Toxicology

authors： Gelderblom WC,Marasas WF,Lebepe-Mazur S,Swanevelder S,Abel S

更新日期：2008-09-04 00:00:00

abstract：:Maize co-contamination with aflatoxin B1 (AFB1) and fumonisin B1 (FB1) is frequently found in several countries. Although the alterations on nutritional and immunologic parameters induced by these mycotoxins, when administered individually, are partially characterised, little is known about the effects induced in anim...

journal_title：Toxicology

authors： Theumer MG,López AG,Masih DT,Chulze SN,Rubinstein HR

更新日期：2003-04-15 00:00:00

abstract：:Inhibition of regulated exocytosis by botulinum toxins type A and B was studied in chromaffin cells. Both virtually abolished catecholamine release triggered from intact cells by depolarising stimuli, whereas the blockade by type A, but not B, was only partial after cell permeabilisation and direct stimulation of exoc...

journal_title：Toxicology

authors： Lawrence GW,Foran P,Oliver Dolly J

更新日期：2002-12-27 00:00:00

abstract：:Pregnant M. ochrogaster received single intraperitoneal (i.p.) doses of 0.06, 0.125, 0.25, 0.5, 1,2, or 5 mg phenyl mercuric acetate (PMA/kg of body weight on day 8, 9, or 10 of gestation or 0.5 mg PMA/kg on day 7, 8, 9, 10, 11, or 12 of gestation. No toxicity was exhibited, and no abnormal fetuses were observed in an...

journal_title：Toxicology

authors： Hartke GT,Oehme FW,Leipold HW,Kruckenberg SM

更新日期：1976-11-01 00:00:00

abstract：:The effects of cadmium on some mitochondrial enzymes of kidney, testis and lung were investigated in male rats. Rats were injected intraperitoneally with 3 mg Cd/kg body weight and its effects were studied 24, 72 and 144 h later. Succinic dehydrogenase and cytochrome c oxidase activities were significantly inhibited i...

journal_title：Toxicology

authors： Prasada Rao PV

更新日期：1983-05-01 00:00:00

abstract：:Many studies have demonstrated that polycyclic aromatic hydrocarbons adversely affect mature mammalian immune systems. However, little is known about the cellular mechanism(s) mediating this immunosuppression or the potential for these ubiquitous environmental chemicals to similarly compromise lymphocyte development (...

journal_title：Toxicology

authors： Hinoshita F,Hardin JA,Sherr DH

更新日期：1992-01-01 00:00:00

abstract：:The measurement of levels of organic pollutants and/or their metabolites in body tissues or fluids are specific markers of internal dose and, provided that the pharmacokinetic properties of the compounds in question are known, these levels may also be used as predictors of effects. Although historical data still remai...

journal_title：Toxicology

authors： Larsen JC

更新日期：1995-07-26 00:00:00