Abstract:
:Induction of hepatic metallothionein (MT) by acetaminophen was characterized in the rat and mouse. Treatment of rats with the hepatotoxin resulted in increase of liver MT in a dose-dependent manner. MT concentration was elevated by 41%, 140% and 260% following acetaminophen injection at doses of 250, 500 and 1000 mg/kg, respectively. The cadmium-binding protein was identified as MT by Sephadex G-75 gel filtration (Ve/Vo = 2.1). In the mouse the hepatotoxin was more potent i.e. maximal effect (increase of 230%) was achieved at the lowest applied dose (250 mg/kg). In both species maximal induction was observed 24 h post exposure and thereafter the hepatic MT content declined, indicating a relatively short half-life of the protein. The elevation of the intracellular concentration of a sulfhydryl-rich protein such as MT may serve as self protecting mechanism of the hepatocyte against highly reactive metabolites of toxic substances.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Wormser U,Calp Ddoi
10.1016/0300-483x(88)90224-7subject
Has Abstractpub_date
1988-12-30 00:00:00pages
323-9issue
2-3eissn
0300-483Xissn
1879-3185pii
0300-483X(88)90224-7journal_volume
53pub_type
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