The influence of sodium ascorbate, menadione sodium bisulfite or pyridoxal hydrochloride on the toxic and antineoplastic action of N-methylformamide in P 388 leukemia or M 5076 sarcoma in mice.

abstract：:This paper looks at toxicology digital sources produced and available in the United Kingdom (UK). It includes products aggregating a number of sources, which may include information from other countries, and for the convenience of the reader and information seeker these have also been described. ...

journal_title：Toxicology

authors： Pantry S

更新日期：2003-08-21 00:00:00

abstract：:Cell cycle aberration was immunohistochemically examined in relation to preneoplastic liver cell foci expressing glutathione S-transferase placental form (GST-P) at early stages of tumor-promotion in rats with thioacetamide (TAA), a hepatocarcinogen facilitating liver cell regeneration. Immunoexpression of p16(Ink4a) ...

journal_title：Toxicology

authors： Tsuchiya T,Wang L,Yafune A,Kimura M,Ohishi T,Suzuki K,Mitsumori K,Shibutani M

更新日期：2012-09-28 00:00:00

abstract：:Evidence from epidemiological studies indicates that acute exposure to airborne pollutants is associated with an increased risk of morbidity and mortality attributed to cardiovascular diseases. The present study investigated the effects of combustion-derived ultrafine particles (diesel exhaust particles) as well as en...

journal_title：Toxicology

authors： Helfenstein M,Miragoli M,Rohr S,Müller L,Wick P,Mohr M,Gehr P,Rothen-Rutishauser B

更新日期：2008-11-20 00:00:00

abstract：:Beside heavy metals, cadmium (Cd(2+)) is a ubiquitous toxic metal with a well established apoptotic and genotoxic effect, chronic exposure of which has been involved in a variety of pathological conditions. In the present study, we investigated by 1455 genes cDNA microarrays the toxic and apoptotic effect of Cd(2+), o...

journal_title：Toxicology

authors： Tsangaris GT,Botsonis A,Politis I,Tzortzatou-Stathopoulou F

更新日期：2002-09-02 00:00:00

abstract：:T-2 toxin belongs to a group of mycotoxins synthesized by Fusarium fungi that are widely encountered as natural contaminants in cereals. Human lymphoid cell lines of T (MOLT-4) or B (IM-9) lineage were used to characterize the cytotoxic effects mediated by T-2 at different concentrations (0.1 pg/ml to 1 microg/ml). Af...

journal_title：Toxicology

authors： Minervini F,Fornelli F,Lucivero G,Romano C,Visconti A

更新日期：2005-05-15 00:00:00

abstract：:Heavy metals, such as iron and manganese, are involved in neurologic disease. Most often these diseases are associated with abnormal environmental exposures or abnormal accumulations of heavy metals in the body. There is increasing recognition that heavy metals normally present in the body also may play a role in dise...

journal_title：Toxicology

authors： Montgomery EB Jr

更新日期：1995-03-31 00:00:00

abstract：:Ethanol is able to cross the placenta, which may cause teratogenicity. Here we investigated whether ethanol consumption during pregnancy (ECDP), even at doses unable to cause malformation, might increase the susceptibility of fetal rat liver to oxidative insults. Since cholestasis is a common condition in alcoholic li...

journal_title：Toxicology

authors： Perez MJ,Velasco E,Monte MJ,Gonzalez-Buitrago JM,Marin JJ

更新日期：2006-08-15 00:00:00

abstract：:Intraperitoneal administration of Thimet (0.6 mg/kg) on alternate days for a period of 30 days produced various pathological and biochemical changes in the liver and testes of male gerbils. Histology of the liver showed necrosis, enlarged hepatocytes and fatty degeneration. Histological changes seen in the testes were...

journal_title：Toxicology

authors： Saxena AK,Sarin K

更新日期：1980-01-01 00:00:00

abstract：:Manganese (II) bis(glycinate)dichloride (Mn(glycinate)2) is a coordination complex of manganese with application as a contrast enhancement agent for magnetic resonance imaging in the heart. To determine the cardioactivity of the manganese ion in this chelation cage, the effects of Mn(glycinate)2 on Ca channel function...

journal_title：Toxicology

authors： Tan W,Barnett JV,Hehn GM,Quay SC,Galper JB

更新日期：1991-01-01 00:00:00

abstract：:Carbon monoxide (CO) is a dangerous exogenous poison and an essential endogenous neurotransmitter. This gas when inhaled has an anaesthetic effect, which is poorly understood, but which may be fatal if compensatory mechanisms are exhausted, if cardiac oxygen (O(2)) needs exceed myocardial oxygenation and/or if apnoea ...

journal_title：Toxicology

authors： Gorman D,Drewry A,Huang YL,Sames C

更新日期：2003-05-01 00:00:00

abstract：:The rodent Hershberger assay has been used predominantly by the pharmaceutical industry to evaluate androgenic and antiandrogenic chemicals for potential therapeutic use. However, this assay has not yet been formally validated and standardized for use in toxicology testing. There are many variations in the protocol us...

journal_title：Toxicology

authors： Yamada T,Sunami O,Kunimatsu T,Kamita Y,Okuno Y,Seki T,Nakatsuka I,Matsuo M

更新日期：2001-05-11 00:00:00

abstract：:This paper presents an overview of issues related to surface water contamination arising from uranium mining activities in the Alligator Rivers Region (ARR) of northern Australia, and a program of research and monitoring that must assess the potential and actual effects on ecosystem and human health. The program of as...

journal_title：Toxicology

authors： van Dam RA,Humphrey CL,Martin P

更新日期：2002-12-27 00:00:00

abstract：:Organotellurides are important intermediates in organic synthesis and, consequently, the occupational exposure to them is a constant risk for laboratory workers. These compounds can elicit many neurotoxic events in the central nervous system (CNS) that are associated with several neurological symptoms. In contrast, or...

journal_title：Toxicology

authors： Funchal C,Moretto MB,Vivian L,Zeni G,Rocha JB,Pessoa-Pureur R

更新日期：2006-05-01 00:00:00

abstract：:The lipid regulator gemfibrozil (GEM) is one of many human pharmaceuticals found in the aquatic environment. We previously demonstrated that GEM bioconcentrates in blood and reduces plasma testosterone levels in goldfish (Carassius auratus). In this study, we address the potential of an environmentally relevant waterb...

journal_title：Toxicology

authors： Mimeault C,Trudeau VL,Moon TW

更新日期：2006-12-07 00:00:00

abstract：:Ammonium perfluorooctanoate (APFO) is a surfactant used primarily as an aid in processing various fluoropolymers. Many toxicology and epidemiological studies have been conducted with APFO; however, no specific information regarding functional reproduction was previously available. Therefore, the potential reproductive...

journal_title：Toxicology

authors： Butenhoff JL,Kennedy GL Jr,Frame SR,O'Connor JC,York RG

更新日期：2004-03-01 00:00:00

abstract：:The development of mouse embryos was studied after intraperitoneal injection of nickel chloride in the preimplantation period. A single intraperitoneal injection of NiCl2 . 6H2O in 0.154 M NaCl corresponding to 20 mg/kg body wt was given to groups of female mice on days 1, 2, 3, 4, 5 or 6 of gestation. Control groups ...

journal_title：Toxicology

authors： Storeng R,Jonsen J

更新日期：1981-01-01 00:00:00

abstract：:Chemicals can increase carcinogenic risk by either directly damaging DNA or increasing cell replication or they can do both. These effects have different implications for a biologically-based extrapolation from rodent bioassays to humans. 2-Acetylaminofluorene (2-AAF) administered at low doses to mice for a lifetime h...

journal_title：Toxicology

authors： Cohen SM

更新日期：1995-09-01 00:00:00

abstract：:Injection of insulin into mice and rabbit has been reported to convert the latent form of phosphoglucomutase (E X Zn) to an active form (E X Mg) without any net increase in the protein associated with this enzyme (Hashimoto et al., Biochem. Biophys. Res. Commun., 27 (1967) 369 and Peck et al., J. Biol. Chem. 242 (1971...

journal_title：Toxicology

authors： Fleming J,Miller H,Joshi JG

更新日期：1985-08-01 00:00:00

abstract：:Dental resin systems have been in use for several decades. (Meth)acrylic monomers are an important part of the matrix system and are either based on BPA while others lack the BPA core. The degree of conversion during restoration is in general between 50-70 % allowing leaching from unreacted monomers to the oral cavity...

journal_title：Toxicology

authors： Vervliet P,Den Plas JV,De Nys S,Duca RC,Boonen I,Elskens M,Van Landuyt KL,Covaci A

更新日期：2019-05-15 00:00:00

abstract：:Unfortunately, the principal routine toxicology methods employed for the safety assessment of new products are over 40 years old and rely primarily on histopathological evaluation. It is difficult to introduce newer immunotoxicology or molecular toxicology methods into toxicity assessment without extensive and time co...

journal_title：Toxicology

authors： Dean JH

更新日期：1997-04-11 00:00:00

abstract：:Osteoblasts dysfunction, induced by aluminum (Al), plays a critical role in the osteoporosis etiology. Ginsenoside Rb1 (Rb1) has the therapeutic properties for osteoporosis. This study aimed to assess the efficiency of Rb1 in ameliorating Al-induced osteoblasts dysfunction. The osteoblasts were divided into four group...

journal_title：Toxicology

authors： Zhu Y,Hu C,Zheng P,Miao L,Yan X,Li H,Wang Z,Gao B,Li Y

更新日期：2016-08-10 00:00:00

abstract：:4-Amino-2,6-dichlorophenol (ADCP) is a potent acute nephrotoxicant in vivo inducing prominent renal corticomedullary necrosis. In vitro, ADCP exposure increases lactate dehydrogenase (LDH) release from rat renal cortical slices at 0.05 mM or greater. The purpose of this study was to examine the ability of antioxidants...

journal_title：Toxicology

authors： Rankin GO,Hong SK,Anestis DK,Ball JG,Valentovic MA

更新日期：2008-03-12 00:00:00

abstract：:Methylmercury is an environmental pollutant that exhibits neurotoxicity when ingested, primarily in the form of neuropathological lesions that localize along deep sulci and fissures, in addition to edematous and inflammatory changes in patient cerebrums. These conditions been known to give rise to a variety of ailment...

journal_title：Toxicology

authors： Yoshida E,Kurita M,Eto K,Kumagai Y,Kaji T

更新日期：2017-12-01 00:00:00

abstract：:Relative cytotoxicity and mechanism of action of thiophenes were investigated in suspensions of freshly isolated renal proximal tubular (PT) and distal tubular (DT) cells using 4-(2-thienyl)butyric acid (TByA) as a model compound. TByA produced significantly greater time- and concentration-dependent cytotoxicity, as a...

journal_title：Toxicology

authors： Lash LH,Tokarz JJ

更新日期：1995-12-10 00:00:00

abstract：:We investigated the ability of alachlor to cause DNA damage by measuring single-strand breaks (SSB) in DNA, after metabolic activation by freshly isolated rat hepatocytes. Incubation of different concentrations of alachlor with rat hepatocytes led to numerous metabolites. The majority, isolated and identified by GC-MS...

journal_title：Toxicology

authors： Bonfanti M,Taverna P,Chiappetta L,Villa P,D'Incalci M,Bagnati R,Fanelli R

更新日期：1992-01-01 00:00:00

abstract：:Catecholamines are stress hormones and sympathetic neurotransmitters essential for control of cardiac function and metabolism. However, pathologically increased catecholamine levels may be cardiotoxic by mechanism that includes iron-catalyzed formation of reactive oxygen species. In this study, five iron chelators use...

journal_title：Toxicology

authors： Hašková P,Koubková L,Vávrová A,Macková E,Hrušková K,Kovaříková P,Vávrová K,Simůnek T

更新日期：2011-11-18 00:00:00

abstract：:Groups of 15 male and 15 female rats were give 0 (control), 50, 100, 200 or 800 ppm allyl alcohol in the drinking water for 15 weeks. There were no effects attributable to allyl alcohol in the results of the haematological examinations or analyses of serum. There was a dose-related reduction in the fluid intake at all...

journal_title：Toxicology

authors： Carpanini FM,Gaunt IF,Hardy J,Gangolli SD,Butterworth KR,Lloyd AG

更新日期：1978-02-01 00:00:00

abstract：:The aim of this study is to explore the potent neuroprotective effect of calpeptin (CP) on neuron damage induced by acrylamide (ACR) and its mechanism. Behavioural indicators such as hind limb splay, rota-rod performance, and gait analysis were assessed weekly to evaluate neurobehavioural changes after ACR and/or CP a...

journal_title：Toxicology

authors： Su B,Guan Q,Wang M,Liu N,Wei X,Wang S,Yang X,Jiang W,Xu M,Yu S

更新日期：2018-05-01 00:00:00

abstract：:Epidemiological studies have implicated fine particulate matter (PM2.5) as a risk factor for neurodegenerative diseases and neurodevelopmental disorders. However, the underlying molecular mechanisms and the influences of different components remain largely elusive. Here, we extended our previous work to investigate th...

journal_title：Toxicology

authors： Wei H,Feng Y,Liang F,Cheng W,Wu X,Zhou R,Wang Y

更新日期：2017-04-01 00:00:00

abstract：:Cardiac fibrosis is characterized by net accumulation of extracellular matrix (ECM) proteins in the cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions. More specifically, cardiac fibroblasts are activated by a variety of pathological stimuli, th...

journal_title：Toxicology

authors： Tao H,Yang JJ,Shi KH,Deng ZY,Li J

更新日期：2014-09-02 00:00:00