Abstract：
:Colicins are unusual bacterial toxins because they are directed against close relatives of the producing strain. They kill their targets in one of three distinct ways; via a ribonuclease or deoxyribonuclease activity or by forming pores in the target cell's membrane. This review deals with the steps involved in pore-forming colicin activity including, initial synthesis of the toxin, toxin release, receptor binding, translocation across the periplasm and pore formation in the cytoplasmic membrane. Special reference is made to the role of colicin in vivo, the structural changes occurring during pore formation and the role of the immunity protein.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Lakey JH,van der Goot FG,Pattus Fdoi
10.1016/0300-483x(94)90156-2subject
Has Abstractpub_date
1994-02-28 00:00:00pages
85-108issue
1-3eissn
0300-483Xissn
1879-3185pii
0300-483X(94)90156-2journal_volume
87pub_type
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