Abstract:
:The osteolathyrogenic agent semicarbazide was assayed for its toxicity and teratogenicity using early embryos of the frog Xenopus laevis. The 96-h LC50 is 1504.20 mg/l while the 96-h EC50 is 76.28 mg/l. Embryo length is altered prior to the onset of other effects indicated by a reduction in stage of development. The major malformation is associated with the notochord where the notochordal sheath is reduced owing to the disruption in the maturation and/or deposition of the connective tissue fibers.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Schultz TW,Dumont JN,Epler RGdoi
10.1016/0300-483x(85)90053-8subject
Has Abstractpub_date
1985-08-01 00:00:00pages
183-98issue
2-3eissn
0300-483Xissn
1879-3185pii
0300-483X(85)90053-8journal_volume
36pub_type
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