Abstract:
:The effect of fly ash inhalation on xenobiotic metabolizing enzymes and heme metabolism in lung and liver has been studied in rats. Fly ash inhalation induced pulmonary and hepatic cytochrome P-450 content, aryl hydrocarbon hydroxylase and glutathione S-transferase activity. Induction of cytochrome P-450 was accompanied by induction of delta-amino levulinic acid synthetase in lung and inhibition of heme oxygenase in both lung and liver. Fly ash inhalation induced those species of cytochrome P-450 which closely resembled cytochrome P-448 in spectral properties and electrophoretic mobility.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Chauhan SS,Singh SK,Misra UKdoi
10.1016/0300-483x(89)90215-1subject
Has Abstractpub_date
1989-05-31 00:00:00pages
95-105issue
1eissn
0300-483Xissn
1879-3185pii
0300-483X(89)90215-1journal_volume
56pub_type
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