Abstract：
:A single high dose, 75 mg/kg, of clotrimazole (CloTZ) was administered intragastrically (i.g.) to adult male Sprague-Dawley rats. Hepatic CloTZ concentrations were determined in organic extracts of whole liver homogenate, by high-performance liquid chromatography (HPLC). The peak liver CloTZ concentration was found at 2.5 h post dose, and the liver t1/2 was 11 h. With the present procedure CloTZ was detectable in the liver for up to 40 h and during this period, the hexobarbital sleep-time in these treated rats was prolonged. Between 40 and 120 h following a single dose of CloTZ, hexobarbital sleep-times were less than in untreated rats. The shortened sleep-time coincided with cytochrome P-450 induction which could be demonstrated in microsomal fractions obtained from the livers. Cytochrome P-450 catalyzed p-nitroanisole-demethylase activity in the microsomal fractions in vitro was inhibited in the first 24 h and induced in microsomes prepared after that time.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Pappas JB,Franklin MRdoi
10.1016/0300-483x(93)90074-3subject
Has Abstractpub_date
1993-06-04 00:00:00pages
27-35issue
1eissn
0300-483Xissn
1879-3185pii
0300-483X(93)90074-3journal_volume
80pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:For half of the 30-odd years that diacetyl-exposed workers have developed disabling lung disease, obliterative bronchiolitis was unrecognized as an occupational risk. Delays in its recognition as an occupational lung disease are attributable to the absence of a work-related temporal pattern of symptoms; failure to rec...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2016.06.009
更新日期：2017-08-01 00:00:00
abstract：:Disorders in the barrier function and secretory activity of the placenta can be caused by xenobiotics (XB) present in the environment and their accumulation in tissues of living organisms. Thus, the aim of this study was to investigate the effect of 1,1,1-trichloro-2,2,-bis-4-chlorophenyl-ethane (DDT) and its metaboli...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2016.11.016
更新日期：2017-01-15 00:00:00
abstract：:We have determined that the addition of 3-phenylamino-L-alanine (PAA), a recently reported contaminant in L-tryptophan implicated in the eosinophilia-myalgia syndrome, affects tryptophan binding by utilizing an in vitro measurement of 3H-tryptophan binding to hepatic nuclei or nuclear envelopes. PAA (10(-10) to 10(-4)...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90058-2
更新日期：1994-01-26 00:00:00
abstract：:We examined the role of miRNAs in DNA damage response in HepG2 cells following exposure to 4-aminobiphenyl (4-ABP). The arylamine 4-ABP is a human carcinogen. Using the Comet assay, we showed that 4-ABP (18.75-300μM) induces DNA damage in HepG2 cells after 24h. DNA damage signaling pathway-based PCR arrays were used t...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2014.05.003
更新日期：2014-08-01 00:00:00
abstract：:Male and female B6C3F1 mice were administered dichloroacetate (DCA) and trichloroacetate (TCA) in their drinking water at concentrations of 1 or 2 g/l for up to 52 weeks. Both compounds induced hepatoproliferative lesions (HPL) in male mice, including hepatocellular nodules, adenomas and hepatocellular carcinomas with...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90195-m
更新日期：1990-09-01 00:00:00
abstract：:Chronic ethanol intake affects various organ systems of the body. The present study evaluated modifications of fatty acid concentrations both in brain and striated skeletal muscles of rats genetically selected for voluntary high ethanol intake. Three groups of rats were tracked for 10 weeks of access to ethanol only a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.02.023
更新日期：2004-07-01 00:00:00
abstract：:Previous studies have shown that magnesium, unlike calcium, prevents cadmium carcinogenesis at the subcutaneous injection site, and that neither magnesium nor calcium has any significant influence on the production of testicular tumors by cadmium in rats. The present investigation attempts to disclose the nature of th...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(85)90173-8
更新日期：1985-03-15 00:00:00
abstract：:Adriamycin (ADR), an anthracycline antibiotic, which is widely used as an antineoplastic drug in the treatment of various solid tumors, has been shown to induce genotoxicity in erythropoietic system. The aim of the present study was to investigate the protective efficacy of DL-alpha-lipoic acid (LA) on ADR-induced cla...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.02.015
更新日期：2006-05-15 00:00:00
abstract：:The in vivo effects of sodium cyanide and its antidotes, sodium nitrite, sodium thiosulfate and 4-dimethylaminophenol (DMAP), as well as the alpha-adrenergic blocking agent phentolamine, on rat brain cytochrome oxidase were studied. The course of inhibition was time-dependent and a peak of 40% was attained between 15 ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(92)90018-a
更新日期：1992-11-22 00:00:00
abstract：:Mitochondrial dysfunction with exposure to anthropogenic contaminants is a critical concern in biomedical and ecological health. Importantly, understanding the role of mitotoxicants in modulating organismal fitness and survival, particularly in the context of species' resilience to shifts in abiotic factors with clima...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2017.07.015
更新日期：2017-11-01 00:00:00
abstract：:Ethanol is able to cross the placenta, which may cause teratogenicity. Here we investigated whether ethanol consumption during pregnancy (ECDP), even at doses unable to cause malformation, might increase the susceptibility of fetal rat liver to oxidative insults. Since cholestasis is a common condition in alcoholic li...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.05.015
更新日期：2006-08-15 00:00:00
abstract：:Between the DNA sequences of two randomly-selected human genomes, which consist of over 3 billion base pairs and twenty five thousand genes, there exists only 0.1% variation and 99.9% sequence identity. During the last couple of decades, extensive genome-wide studies have investigated the association between single-nu...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2017.03.020
更新日期：2017-05-15 00:00:00
abstract：:The effects of N-acetylcysteine (NAC), 2-mercaptopropionylglycine (MPG) and dithiothreitol (DTT) on the metabolism and toxicity of acetaminophen (APAP) were examined in isolated mouse hepatocytes maintained in primary culture on collagen-coated dishes. Both NAC and MPG increased the formation of the glutathione and su...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90106-x
更新日期：1986-10-01 00:00:00
abstract：:In this study, we examined the relationship between maternal weight gain deficits induced by protein-and-energy restriction (PER) and pregnancy outcome. We also evaluated whether PER would potentiate the developmental toxicity of cyclophosphamide (CP) and hydroxyurea (HU). Two independent experiments--employing two di...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(02)00373-6
更新日期：2002-09-30 00:00:00
abstract：:The present research examines the effects of 4-nonylphenol (4-NP) on mouse primary calvarial osteoblasts (COBs). Incubation of the cells with 4-NP at 10(-5)M and 10(-6)M striking decreased osteoblasts viability and phosphatidylserine (PS) exposure, measured by Annexin V, was greatly enhanced. In addition, an up-regula...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.10.014
更新日期：2011-12-18 00:00:00
abstract：:The expanding use of innovative botanical ingredients in dietary supplements and foods has resulted in a flurry of research aimed at the development and validation of analytical methods for accurate measurement of active ingredients. The pressing need for these methods is being met through an expansive collaborative i...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.12.020
更新日期：2006-04-03 00:00:00
abstract：:In living organisms both chemical agents and physical factors [16] may produce neurophysiological change that affects EEG activity. EEG signals are very suitable for non-invasive measurement of CNS reactions, but quite complicated equipment is necessary for measurement and analysis. We have implemented a system that p...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(88)90004-2
更新日期：1988-05-01 00:00:00
abstract：:N-Heterocyclic aromatics are by-products of incomplete combustion of organic material. The overall objective of this study was to determine the relative carcinogenic potencies of 7H-dibenzo[c,g]carbazole (DBC) and dibenz[a,j]acridine (DBA) in a bioassay of complete carcinogenicity on mouse skin in a sensitive strain (...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90074-4
更新日期：1994-11-11 00:00:00
abstract：:Bisphenol A (BPA) is a suspected endocrine disruptor highly prevalent in our environment since it is used as monomer of polycarbonate plastics and epoxy resins. Recent epidemiological and animal studies have suggested that BPA exposure may influence the development of obesity and related pathologies such as type 2 dia...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2014.08.006
更新日期：2014-11-05 00:00:00
abstract：:2,3,7,8-tetrachlorodibenzo-p-dioxin, more popularly called dioxin or TCDD and referred to in this review as 2,3,7,8-TCDD, is considered the prototype of the polychlorinated dibenzo-p-dioxins (PCDD). The PCDD are true contaminants and are formed primarily as byproducts in the manufacture of materials requiring the use ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(91)90184-3
更新日期：1991-01-01 00:00:00
abstract：:Several studies indicated that chloral hydrate can prolong the disappearance time of ethanol from blood in mice. This seems to result from inhibition of the enzyme alcohol dehydrogenase by chloral hydrate and trichloroethanol, its main metabolite. We examined the effect of both these compounds on the disappearance tim...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(98)00108-5
更新日期：1998-11-02 00:00:00
abstract：:Technical pentabrominated diphenyl ether (pentaBDE mix) is a mixture of polybrominated diphenyl ethers (PBDEs) which has been widely used as a flame retardant. Since its ban in several countries it has been replaced by other brominated flame retardants such as hexabromocyclododecane (HBCD). Both certain PBDE congeners...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.07.009
更新日期：2009-10-01 00:00:00
abstract：:Use of the fluoroquinolone antibiotic trovafloxacin (TVX) was restricted due to idiosyncratic, drug-induced liver injury (IDILI). Previous studies demonstrated that tumor necrosis factor-alpha (TNF) and TVX interact to cause death of hepatocytes in vitro that was associated with prolonged activation of c-Jun N-termina...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2015.03.002
更新日期：2015-05-04 00:00:00
abstract：:There has been an intensive debate whether dietary exposure to acrylamide could increase the risk of human cancer since the first description of the presence of acrylamide in food in 2002. As the intestinal mechanisms of acrylamide absorption are poorly investigated we studied the transport of acrylamide in differenti...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.12.014
更新日期：2007-03-22 00:00:00
abstract：:This paper introduces the special issue on quantitative in vitro-in vivo extrapolations (QIVIVE). It highlights important issues in the development of in vitro toxicology towards its implementation in toxicological risk assessment. ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2014.04.004
更新日期：2015-06-05 00:00:00
abstract：:Catecholamines are stress hormones and sympathetic neurotransmitters essential for control of cardiac function and metabolism. However, pathologically increased catecholamine levels may be cardiotoxic by mechanism that includes iron-catalyzed formation of reactive oxygen species. In this study, five iron chelators use...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.08.006
更新日期：2011-11-18 00:00:00
abstract：:Induction of hepatic metallothionein (MT) by acetaminophen was characterized in the rat and mouse. Treatment of rats with the hepatotoxin resulted in increase of liver MT in a dose-dependent manner. MT concentration was elevated by 41%, 140% and 260% following acetaminophen injection at doses of 250, 500 and 1000 mg/k...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(88)90224-7
更新日期：1988-12-30 00:00:00
abstract：:Although several specific micronutrient deficiencies are associated with disease progression and increased mortality risk in HIV/AIDS, and even a simple multivitamin/mineral supplement can prolong survival, this is typically viewed merely as nutritional support of the immune system, and only necessary if there are def...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.10.018
更新日期：2010-11-28 00:00:00
abstract：:T-2 toxin belongs to a group of mycotoxins synthesized by Fusarium fungi that are widely encountered as natural contaminants in cereals. Human lymphoid cell lines of T (MOLT-4) or B (IM-9) lineage were used to characterize the cytotoxic effects mediated by T-2 at different concentrations (0.1 pg/ml to 1 microg/ml). Af...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.01.007
更新日期：2005-05-15 00:00:00
abstract：:Daunomycin-induced cardiotoxicity has been regarded to be the result of oxygen-mediated lipid peroxidation of cell membranes. The aim of the present work was to evaluate the extent of lipid peroxidation in rat heart after administration of this anticancer drug and, further, to examine possible activation of some endog...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(98)00002-x
更新日期：1998-03-13 00:00:00
