当前位置： SCI文献检索 > TOXICOLOGY期刊下所有文献 > Carcinogenicity of 7H-dibenzo[c,g]carbazole, dibenz[a,j]acridine and benzo[a]pyrene in mouse skin and liver following topical application.

Carcinogenicity of 7H-dibenzo[c,g]carbazole, dibenz[a,j]acridine and benzo[a]pyrene in mouse skin and liver following topical application.

Abstract：

:N-Heterocyclic aromatics are by-products of incomplete combustion of organic material. The overall objective of this study was to determine the relative carcinogenic potencies of 7H-dibenzo[c,g]carbazole (DBC) and dibenz[a,j]acridine (DBA) in a bioassay of complete carcinogenicity on mouse skin in a sensitive strain (Hsd:ICR(Br)) which has been used in metabolism and DNA binding studies of N-heterocyclic aromatics. No-treatment, acetone and benzo[a]pyrene (BaP)-treated animals were used as negative and positive control groups. DBC (50 nmol), DBA (50 nmol), BaP (50 nmol) or DBC plus BaP (25 nmol + 25 nmol) were applied twice weekly in 50 microliters acetone to the backs of 50 female mice/group for 99 weeks or until the appearance of a tumor. DBC, DBA, BaP and DBC plus BaP produced skin tumors in 43, 32, 49 and 42 of 50 mice each based on weekly visual observations with latent periods of 55.1, 62.2, 33.4 and 33.8 weeks, respectively. The histopathology data indicated primary skin lesions in 42, 27, 48 and 47 mice for DBC, DBA, BaP and DBC plus BaP, respectively. In addition, primary liver lesions in 37 mice were present in the DBC group. The morphological and morphometric data indicated a significant increase (P < or = 0.05) in mononuclear cells in the dermis for the BaP and DBC plus BaP groups relative to the control group. Significant increases (P < or = 0.05) were observed in the nuclear area, nucleoli per nucleus and cellular area of hepatocytes in the DBC treatment group relative to the control group. These data indicate that DBC is a potent liver carcinogen as well as a skin carcinogen following topical application.

journal_name

Toxicology

journal_title

Toxicology

authors

Warshawsky D,Barkley W,Miller ML,LaDow K,Andringa A

doi

10.1016/0300-483x(94)90074-4

subject

Has Abstract

pub_date

1994-11-11 00:00:00

pages

135-49

issue

2-3

eissn

0300-483X

issn

1879-3185

pii

0300-483X(94)90074-4

journal_volume

93

pub_type

杂志文章

相关文献

TOXICOLOGY文献大全
  • Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice.

    abstract：:Bisphenol A (BPA) is a suspected endocrine disruptor highly prevalent in our environment since it is used as monomer of polycarbonate plastics and epoxy resins. Recent epidemiological and animal studies have suggested that BPA exposure may influence the development of obesity and related pathologies such as type 2 dia...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2014.08.006

    authors： Marmugi A,Lasserre F,Beuzelin D,Ducheix S,Huc L,Polizzi A,Chetivaux M,Pineau T,Martin P,Guillou H,Mselli-Lakhal L

    更新日期：2014-11-05 00:00:00

  • Polymorphism of cytochrome P450 and xenobiotic toxicity.

    abstract：:The majority of human P450-dependent xenobiotic metabolism is carried out by polymorphic enzymes which can cause abolished, quantitatively or qualitatively altered or enhanced metabolism. The latter situation is due to stable duplication, multiduplication or amplification of active genes, most likely in response to di...

    journal_title：Toxicology

    pub_type： 杂志文章,评审

    doi：10.1016/s0300-483x(02)00492-4

    authors： Ingelman-Sundberg M

    更新日期：2002-12-27 00:00:00

  • Combined exposure to NO2, O3 and H2SO4-aerosol and lung tumor formation in rats.

    abstract：:The promoting effects of a combined exposure to two pollutants (NO2, O3 or H2SO4-aerosol) at near ambient levels on lung tumorigenesis induced by N-bis(2-hydroxypropyl) nitrosamine (BHPN) were investigated in male Wistar rats. The rats were given a single intraperitoneal injection of BHPN (0.5 g per kg body wt.) at 6 ...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/0300-483x(92)90137-4

    authors： Ichinose T,Sagai M

    更新日期：1992-09-01 00:00:00

  • Internet resources for occupational and environmental health professionals.

    abstract：:The Internet = s global reach offers new powerful tools to professionals in Occupational and Environmental Health (OEH). The World Wide Web includes extensive free and commercially available reference materials on toxicology, regulatory issues, environmental epidemiology and prevention programs. Much of this especiall...

    journal_title：Toxicology

    pub_type： 杂志文章,评审

    doi：10.1016/s0300-483x(02)00028-8

    authors： Greenberg GN

    更新日期：2002-04-25 00:00:00

  • Effects of repeated ozone exposure on pulmonary function and bronchial responsiveness in mice sensitized with ovalbumin.

    abstract：:We examined the effect of repeated ozone exposure on the respiratory system in mice, sensitized with ovalbumin (OA). OA-sensitized mice and saline-treated control mice were exposed to 1.0 ppm ozone or clean air for 6 h daily and five days weekly for five weeks. Subsequently, these mice were exposed to 1.0 ppm ozone fo...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2004.06.047

    authors： Funabashi H,Shima M,Kuwaki T,Hiroshima K,Kuriyama T

    更新日期：2004-11-01 00:00:00

  • Subacute toxicity studies with sodium saccharin and two hydrolytic derivatives.

    abstract：:The subacute toxicity of sodium saccharin and 2 hydrolytic derivatives, o-sulfamoylbenzoic acid (Compound I) and ammonium o-carboxybenzene sulfonate (Compound II) was evaluated by feeding each of the compounds alone at a dietary level of 20 000 ppm to both beagle dogs and albino rats. Additionally, groups of dogs and ...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/0300-483x(76)90015-9

    authors： Kennedy GL Jr,Fancher OE,Calandra JC

    更新日期：1976-08-01 00:00:00

  • Induction of oxidative stress by bisphenol A in the epididymal sperm of rats.

    abstract：:Bisphenol A has been shown to affect the reproduction of male rats and mice. However, the mechanism of action of bisphenol A on the epididymal sperm is not elucidated. The present study was undertaken to evaluate the effect of bisphenol A on the antioxidant system of rat epididymal sperm. Bisphenol A was administered ...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/s0300-483x(02)00597-8

    authors： Chitra KC,Latchoumycandane C,Mathur PP

    更新日期：2003-03-14 00:00:00

  • Benzoyl peroxide cytotoxicity evaluated in vitro with the human keratinocyte cell line, RHEK-1.

    abstract：:The human keratinocyte cell line, RHEK-1, was used to evaluate the cytotoxicity of benzoyl peroxide (BZP). As determined with the neutral red (NR) cytotoxicity assay, the 24-h midpoint (NR50) toxicity values, in mM, were 0.11 for BZP and 29.5 for benzoic acid, the stable metabolite of BZP. Irreversible cytotoxicity oc...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/0300-483x(95)03189-m

    authors： Babich H,Zuckerbraun HL,Wurzburger BJ,Rubin YL,Borenfreund E,Blau L

    更新日期：1996-01-08 00:00:00

  • The management of aircraft passenger survival in fire.

    abstract：:The prime factors influencing survivability from 10 major fire-related public transport aircraft accidents were assessed. Regulatory requirements were assessed against derived criteria and alternate concepts evaluated to identify a preferred strategy for enhanced survival; the provision of passenger protective breathi...

    journal_title：Toxicology

    pub_type： 杂志文章,评审

    doi：10.1016/s0300-483x(96)03494-4

    authors： Trimble EJ

    更新日期：1996-12-31 00:00:00

  • Fenvalerate inhibits the growth of primary cultured rat preantral ovarian follicles.

    abstract：:Fenvalerate is a widely used synthetic pyrethroid insecticide and is reported to disrupt reproductive function in humans and animals. However, little is known about its influence on follicular development. In this study, rat preantral follicles were primary cultured to investigate the effects of fenvalerate on follicu...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2009.10.022

    authors： Fei J,Qu JH,Ding XL,Xue K,Lu CC,Chen JF,Song L,Xia YK,Wang SL,Wang XR

    更新日期：2010-01-12 00:00:00

  • Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression.

    abstract：:In the present study, we investigated the inducibility of the drug conjugate transporter genes MRP1 and MRP2 by redox-active compounds such as tertiary butylated hydroquinone (tBHQ) and quercetin and by chemicals known to activate the pregnane X receptor (PXR) such as rifampicin and clotrimazol and by the metalloid co...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/s0300-483x(01)00570-4

    authors： Kauffmann HM,Pfannschmidt S,Zöller H,Benz A,Vorderstemann B,Webster JI,Schrenk D

    更新日期：2002-02-28 00:00:00

  • Issues with introducing new immunotoxicology methods into the safety assessment of pharmaceuticals.

    abstract：:Unfortunately, the principal routine toxicology methods employed for the safety assessment of new products are over 40 years old and rely primarily on histopathological evaluation. It is difficult to introduce newer immunotoxicology or molecular toxicology methods into toxicity assessment without extensive and time co...

    journal_title：Toxicology

    pub_type： 杂志文章,评审

    doi：10.1016/s0300-483x(96)03601-3

    authors： Dean JH

    更新日期：1997-04-11 00:00:00

  • Protective effect of sulforaphane pretreatment against cisplatin-induced liver and mitochondrial oxidant damage in rats.

    abstract：:In the present work was analyzed whether sulforaphane (SFN) may protect against cisplatin (CIS)-induced hepatic damage, oxidant stress and mitochondrial dysfunction. Four groups of male Wistar rats were studied: control, CIS, CIS+SFN and SFN. SFN was given i.p. (500 μg/kg/d × 3 days) before CIS administration (single ...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2011.04.014

    authors： Gaona-Gaona L,Molina-Jijón E,Tapia E,Zazueta C,Hernández-Pando R,Calderón-Oliver M,Zarco-Márquez G,Pinzón E,Pedraza-Chaverri J

    更新日期：2011-08-15 00:00:00

  • In vitro genotoxic effects of the insecticide deltamethrin in human peripheral blood leukocytes: DNA damage ('comet' assay) in relation to the induction of sister-chromatid exchanges and micronuclei.

    abstract：:Deltamethrin, a synthetic dibromo-pyrethroid insecticide, is extensively used in agriculture, forestry and in household products because of its high activity against a broad spectrum of insect pests (both adults and larvae), its low animal toxicity and its lack of persistence in the environment. Data on the genotoxici...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/s0300-483x(98)00097-3

    authors： Villarini M,Moretti M,Pasquini R,Scassellati-Sforzolini G,Fatigoni C,Marcarelli M,Monarca S,Rodríguez AV

    更新日期：1998-09-15 00:00:00

  • A comparison of the suppression of human transferrin synthesis by lead and lipopolysaccharide.

    abstract：:Transferrin, as the major iron-transport protein in serum and other body fluids, has a central role in managing iron the body receives. Liver is a major site of transferrin synthesis, and in this study we present evidence that liver synthesis of human transferrin is suppressed by both the toxic metal lead and bacteria...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/s0300-483x(96)03586-x

    authors： Barnum-Huckins KM,Martinez AO,Rivera EV,Adrian EK Jr,Herbert DC,Weaker FJ,Walter CA,Adrian GS

    更新日期：1997-03-14 00:00:00

  • T-2 toxin immunotoxicity on human B and T lymphoid cell lines.

    abstract：:T-2 toxin belongs to a group of mycotoxins synthesized by Fusarium fungi that are widely encountered as natural contaminants in cereals. Human lymphoid cell lines of T (MOLT-4) or B (IM-9) lineage were used to characterize the cytotoxic effects mediated by T-2 at different concentrations (0.1 pg/ml to 1 microg/ml). Af...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2005.01.007

    authors： Minervini F,Fornelli F,Lucivero G,Romano C,Visconti A

    更新日期：2005-05-15 00:00:00

  • An assessment of the ability of phthalates to influence immune and allergic responses.

    abstract：:It has been suggested that one possible contributor to the increasing prevalence of atopic (IgE-mediated) allergic diseases and asthma in Europe and the US is exposure to chemicals that may act as adjuvants. Certain commonly used phthalate plasticisers, such as di-(2-ethylhexyl) phthalate, have been implicated in this...

    journal_title：Toxicology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tox.2010.03.020

    authors： Kimber I,Dearman RJ

    更新日期：2010-05-27 00:00:00

  • Arsenic-cadmium interaction in rats.

    abstract：:Simultaneous exposure to cadmium and arsenic is highly probable in the urban area of San Luis Potosi, Mexico due to common localization of copper and zinc smelters. Therefore, in this work, rats were intraperitoneally exposed either to cadmium or arsenic alone, or simultaneously to both metals. The effects of these tr...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/0300-483x(90)90135-4

    authors： Díaz-Barriga F,Llamas E,Mejía JJ,Carrizales L,Santoyo ME,Vega-Vega L,Yáñez L

    更新日期：1990-11-01 00:00:00

  • Hepatic clotrimazole concentrations and hepatic drug metabolizing enzyme activities in adult male Sprague-Dawley rats.

    abstract：:A single high dose, 75 mg/kg, of clotrimazole (CloTZ) was administered intragastrically (i.g.) to adult male Sprague-Dawley rats. Hepatic CloTZ concentrations were determined in organic extracts of whole liver homogenate, by high-performance liquid chromatography (HPLC). The peak liver CloTZ concentration was found at...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/0300-483x(93)90074-3

    authors： Pappas JB,Franklin MR

    更新日期：1993-06-04 00:00:00

  • Use of primary blood cells for the assessment of exposure to occupational genotoxicants in human biomonitoring studies.

    abstract：:The Comet assay is an often used approach for the assessment of genetic damage in primary cells of exposed populations. In the majority of these studies lymphocytes are used. Therefore, we reviewed human biomonitoring studies of occupational exposure using the Comet assay with lymphocytes. We also tried to elucidate t...

    journal_title：Toxicology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tox.2004.02.010

    authors： Faust F,Kassie F,Knasmüller S,Kevekordes S,Mersch-Sundermann V

    更新日期：2004-05-20 00:00:00

  • Multivariate statistical analysis of organ weights in toxicity studies.

    abstract：:Toxicity studies with drugs in animals are performed to establish the toxicity profile including the no-toxic-effect-level in the animals. One of the responses used in the search for effects is organ weight. Since organ weight is related to body weight of the animal, the analysis of organ weight has to be adjusted. A ...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/s0300-483x(99)00056-6

    authors： Andersen H,Larsen S,Spliid H,Christensen ND

    更新日期：1999-08-31 00:00:00

  • Enhancement by dexamethasone of the therapeutic benefits of cisplatin via regulation of tumor angiogenesis and cell cycle kinetics in a murine tumor paradigm.

    abstract：:We have investigated in the current study, the possible modulatory effects of dexamethasone on cisplatin cytotoxicity in Ehrlich ascites carcinoma (EAC)-bearing female Swiss albino mice. Cisplatin (3.5mg/kg) was injected IP for 3 consecutive days in mice previously inoculated SC with EAC cells in the right flank. Dexa...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2006.02.007

    authors： Arafa HM,Abdel-Hamid MA,El-Khouly AA,Elmazar MM,Osman AM

    更新日期：2006-05-01 00:00:00

  • Effect of thimerosal, a preservative in vaccines, on intracellular Ca2+ concentration of rat cerebellar neurons.

    abstract：:The effect of thimerosal, an organomercurial preservative in vaccines, on cerebellar neurons dissociated from 2-week-old rats was compared with those of methylmercury using a flow cytometer with appropriate fluorescent dyes. Thimerosal and methylmercury at concentrations ranging from 0.3 to 10 microM increased the int...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2003.09.002

    authors： Ueha-Ishibashi T,Oyama Y,Nakao H,Umebayashi C,Nishizaki Y,Tatsuishi T,Iwase K,Murao K,Seo H

    更新日期：2004-01-15 00:00:00

  • Smoking cessation in cancer prevention.

    abstract：:Tobacco smoking is the largest preventable risk factor for morbidity and mortality in industrialized countries. WHO estimates that tobacco will become the largest single health problem by 2020, causing an estimated 8.4 million deaths annually. Tobacco has central importance in the etiology of cancers of the lung, head...

    journal_title：Toxicology

    pub_type： 杂志文章,评审

    doi：10.1016/s0300-483x(01)00445-0

    authors： Vainio H,Weiderpass E,Kleihues P

    更新日期：2001-09-14 00:00:00

  • Effects of triethyl lead administration on the expression of glutathione S-transferase isoenzymes and quinone reductase in rat kidney and liver.

    abstract：:The effects of triethyl lead chloride (TEL) on the expression of two detoxication enzyme families, glutathione S-transferases (GSTs) and NAD(P)H:quinone oxidoreductase (QR) were determined in rat liver and kidney. Fischer 344 rats were given one intraperitoneal (i.p.) injection of TEL. GST activity, GST isoenzyme leve...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/s0300-483x(96)03555-x

    authors： Daggett DA,Nuwaysir EF,Nelson SA,Wright LS,Kornguth SE,Siegel FL

    更新日期：1997-02-14 00:00:00

  • Hemodynamic effects of aerosol propellants. III. Vascular resistance in the canine hind limb.

    abstract：:The question as to whether or not the hypotension observed as part of the effect of tricholorofluoromethane (FC11), dichlorofluoromethane (FC 12), dichlorotetrafluoroethane (FC 114) and methyl chloroform was due to a vasodepressor component of action, in addition to the previously documented depression in myocardial c...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/0300-483x(76)90048-2

    authors： Simaan JA,Aviado DM

    更新日期：1976-03-01 00:00:00

  • Chlorpyrifos induces NLRP3 inflammasome and pyroptosis/apoptosis via mitochondrial oxidative stress in human keratinocyte HaCaT cells.

    abstract：:Chlorpyrifos (CPF) has been widely used around the world as a pesticide for both agricultural and residential application. Although various studies have reported toxicity and health-related effects from CPF exposure, the molecular mechanism of CPF toxicity to skin has not been well-characterized. The present study det...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2015.09.006

    authors： Jang Y,Lee AY,Jeong SH,Park KH,Paik MK,Cho NJ,Kim JE,Cho MH

    更新日期：2015-12-02 00:00:00

  • Comparative study of the damage produced by acute ethanol and acetaldehyde treatment in a human fetal hepatic cell line.

    abstract：:The effects of acute ethanol and acetaldehyde treatment on cell proliferation, cell adhesion capacity, neutral red incorporation into lysosomes, glutathione content, protein sulfhydryl compounds, lipid peroxidation, inner mitochondrial membrane integrity (MTT test), lactate dehydrogenase activity (LDH) and ultrastruct...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/s0300-483x(97)03650-0

    authors： Olivares IP,Bucio L,Souza V,Cárabez A,Gutiérrez-Ruiz MC

    更新日期：1997-06-27 00:00:00

  • UV-induced skin damage.

    abstract：:Solar radiation induces acute and chronic reactions in human and animal skin. Chronic repeated exposures are the primary cause of benign and malignant skin tumors, including malignant melanoma. Among types of solar radiation, ultraviolet B (290-320 nm) radiation is highly mutagenic and carcinogenic in animal experimen...

    journal_title：Toxicology

    pub_type： 杂志文章,评审

    doi：10.1016/s0300-483x(03)00150-1

    authors： Ichihashi M,Ueda M,Budiyanto A,Bito T,Oka M,Fukunaga M,Tsuru K,Horikawa T

    更新日期：2003-07-15 00:00:00

  • Receptor-dependent regulation of the CYP3A4 gene.

    abstract：:A CYP3A4 promoter-reporter gene construct has been used to assess the ability of 16 known (in vivo) and putative (in vitro) inducers to transactivate a CYP3A4 reporter gene in HepG2 cells. With the exception of pravastatin, the remaining 15 compounds transactivated the CYP3A4 reporter gene with differing inductive abi...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/s0300-483x(02)00281-0

    authors： Gibson GG,el-Sankary W,Plant NJ

    更新日期：2002-12-27 00:00:00