Comparative study of the damage produced by acute ethanol and acetaldehyde treatment in a human fetal hepatic cell line.

abstract：:Ammonium perfluorooctanoate (APFO) is a surfactant used primarily as an aid in processing various fluoropolymers. Many toxicology and epidemiological studies have been conducted with APFO; however, no specific information regarding functional reproduction was previously available. Therefore, the potential reproductive...

journal_title：Toxicology

authors： Butenhoff JL,Kennedy GL Jr,Frame SR,O'Connor JC,York RG

更新日期：2004-03-01 00:00:00

abstract：:The osteolathyrogenic agent semicarbazide was assayed for its toxicity and teratogenicity using early embryos of the frog Xenopus laevis. The 96-h LC50 is 1504.20 mg/l while the 96-h EC50 is 76.28 mg/l. Embryo length is altered prior to the onset of other effects indicated by a reduction in stage of development. The m...

journal_title：Toxicology

authors： Schultz TW,Dumont JN,Epler RG

更新日期：1985-08-01 00:00:00

abstract：PURPOSE:1-Bromopropane (1-BP) intoxication is associated with depression and cognitive and memory deficits. The present study tested the hypothesis that 1-BP suppresses neurogenesis in the dentate gyrus, which is involved in higher cerebral function, in adult rats. METHODS:Four groups of 12 male Wistar rats were expos...

journal_title：Toxicology

authors： Zhang L,Nagai T,Yamada K,Ibi D,Ichihara S,Subramanian K,Huang Z,Mohideen SS,Naito H,Ichihara G

更新日期：2013-02-08 00:00:00

abstract：:Pregnant CD-1 mice were administered a commercial 2,4-dichlorophenoxyacetic acid (2,4-D) formulation on days 6-16 days of gestation, in drinking water at concentrations ranging from 0 to 1.0% of the formulated product, equivalent to approximately 0-650 mg/kg per day expressed as the amine derivative. The effect of 2,4...

journal_title：Toxicology

authors： Lee K,Johnson VL,Blakley BR

更新日期：2001-08-13 00:00:00

abstract：:We performed a reporter gene assay for ERalpha-mediated transcriptional activation and an immature rat uterotrophic assay of 23 chemicals, to study the relationship between these two assays and to examine the usefulness of the reporter gene assay. The chemicals analyzed in the study were as follows: benzophenone, bisp...

journal_title：Toxicology

authors： Yamasaki K,Takeyoshi M,Yakabe Y,Sawaki M,Imatanaka N,Takatsuki M

更新日期：2002-01-15 00:00:00

abstract：:A large number of published studies support the notion that long term, low level (LTLL) exposure to organophosphorus (OP) esters may cause neurological and neurobehavioral effects. In order to differentiate these from other effects of OP such as the acute cholinergic episodes, intermediate syndrome and organophosphate...

journal_title：Toxicology

authors： Jamal GA,Hansen S,Julu PO

更新日期：2002-12-27 00:00:00

abstract：:Thimerosal (TH), an ethylmercury complex of thiosalicylic acid has been used as preservative in vaccines. In vitro neurotoxicity of TH at high nM concentrations has been reported. Although a number of toxicological experiments demonstrated high affinity of mercury to thiol groups of the extracellular amino acids and p...

journal_title：Toxicology

authors： Zieminska E,Toczylowska B,Stafiej A,Lazarewicz JW

更新日期：2010-10-29 00:00:00

abstract：:Mercury has been a known as a toxic substance for centuries. Whilst the clinical features of acute mercury poisoning have been well described, chronic low dose exposure to mercury remains poorly characterised and its potential role in various chronic disease states remains controversial. Low molecular weight thiols, i...

journal_title：Toxicology

authors： Rooney JP

更新日期：2007-05-20 00:00:00

abstract：:The Comet assay is an often used approach for the assessment of genetic damage in primary cells of exposed populations. In the majority of these studies lymphocytes are used. Therefore, we reviewed human biomonitoring studies of occupational exposure using the Comet assay with lymphocytes. We also tried to elucidate t...

journal_title：Toxicology

authors： Faust F,Kassie F,Knasmüller S,Kevekordes S,Mersch-Sundermann V

更新日期：2004-05-20 00:00:00

abstract：:To elucidate the maternal exposure effects of aflatoxin B1 (AFB1) and its metabolite aflatoxin M1, which is transferred into milk, on postnatal hippocampal neurogenesis, pregnant Sprague-Dawley rats were provided a diet containing AFB1 at 0, 0.1, 0.3, or 1.0 ppm from gestational day 6 to day 21 after delivery on weani...

journal_title：Toxicology

authors： Tanaka T,Mizukami S,Hasegawa-Baba Y,Onda N,Sugita-Konishi Y,Yoshida T,Shibutani M

更新日期：2015-10-02 00:00:00

abstract：:The measurement of haemoglobin (Hb) adducts is an important tool for monitoring exposures to industrial chemicals such as ethylene, ethylene oxide and propylene oxide. The aim of the present study was to use this method to monitor occupational exposure to butadiene. The methodology was evaluated with Hb samples obtain...

journal_title：Toxicology

authors： Richardson KA,Megens HJ,Webb JD,van Sittert NJ

更新日期：1996-10-28 00:00:00

abstract：:This study is aimed to investigate the inflammation and neurological dysfunction induced by tetrachloro-p-benzoquinone (TCBQ) through Toll-like receptor 4 (TLR4) signaling. We also investigated the protective role of melatonin as an antioxidant and anti-inflammatory agent. In vitro model was established by rat pheochr...

journal_title：Toxicology

authors： Fu J,Xia X,Liu Z,Wang Y,Wang Y,Shi Q,Song X,Song E,Song Y

更新日期：2017-04-15 00:00:00

abstract：:Human exposure assessment is frequently noted as a weak link and bottleneck in the risk assessment process. Fortunately, the World Wide Web and Internet are providing access to numerous valuable sources of human exposure assessment-related information, along with opportunities for information exchange. Internet mailin...

journal_title：Toxicology

authors： Schwela D,Hakkinen PJ

更新日期：2004-05-20 00:00:00

abstract：:The usefulness of measuring serum bile acid concentrations by RIA in a number of acute experimental liver injuries of rats was assessed by comparing the concentrations with the results of some of the routinely employed methods of examining hepatotoxic changes. Centrilobular liver cell injury produced by CCl4 revealed ...

journal_title：Toxicology

authors： Gopinath C,Prentice DE,Street AE,Crook D

更新日期：1980-01-01 00:00:00

abstract：:Exposure to low-dose benzene may lead to hematotoxicity and cause health problems. Though peripheral blood cell count is widely used in benzene exposure assessment and health risk assessment, the reports regarding the effects of low-dose benzene exposure on blood cell count remain inconsistent. To uncover more sensiti...

journal_title：Toxicology

authors： Liang B,Zhong Y,Chen K,Zeng L,Li G,Zheng J,Jiang L,Xie Z,Que B,Lai G,Wu B,Yang X,Wu J,Xiao Y,Chen W,Huang Z

更新日期：2018-12-01 00:00:00

abstract：:Nine structurally different polycyclic aromatic hydrocarbons (PAHs) were tested for their ability to either agonize or antagonize the human androgen receptor (hAR) in a sensitive reporter gene assay based on CHO cells transiently cotransfected with a hAR vector and an MMTV-LUC vector. Benz[a]anthracene (B[a]A), benzo[...

journal_title：Toxicology

authors： Vinggaard AM,Hnida C,Larsen JC

更新日期：2000-04-14 00:00:00

abstract：:The oxidation of guanine to 8-oxo-2'-deoxyguanosine (8-oxo-dG) is one of the most abundant and best studied oxidative DNA lesions and is commonly used as a biomarker for oxidative stress. Over the last decades, various methods for the detection of DNA oxidation products have been established and optimized. However, so...

journal_title：Toxicology

authors： Müller N,Moreno-Villanueva M,Fischbach A,Kienhöfer J,Martello R,Dedon PC,Ullrich V,Bürkle A,Mangerich A

更新日期：2013-08-09 00:00:00

abstract：:Oxidative DNA damage is emerging as an biomarker of effect in studies assessing the health risks of occupational chemicals. Trichloroethylene (TCE) and perchloroethylene (PERC) are used in the dry cleaning industry and their metabolism can produce reactive oxygen compounds. The present study examined the potential for...

journal_title：Toxicology

authors： Toraason M,Clark J,Dankovic D,Mathias P,Skaggs S,Walker C,Werren D

更新日期：1999-10-29 00:00:00

abstract：:The subacute toxicity of sodium saccharin and 2 hydrolytic derivatives, o-sulfamoylbenzoic acid (Compound I) and ammonium o-carboxybenzene sulfonate (Compound II) was evaluated by feeding each of the compounds alone at a dietary level of 20 000 ppm to both beagle dogs and albino rats. Additionally, groups of dogs and ...

journal_title：Toxicology

authors： Kennedy GL Jr,Fancher OE,Calandra JC

更新日期：1976-08-01 00:00:00

abstract：:Calf thymus DNA was reacted with 1,2-epoxybutene (BDO) in phosphate buffered saline at 37 degrees C for 12 h. DNA was ethanol precipitated and hydrolyzed with 1 M HCl to release DNA bases. Adenine (A)-BDO and guanine (Gua)-BDO adducts were analyzed in the ethanol supernatant and DNA hydrolysate using LC/ESI MS/MS. Rea...

journal_title：Toxicology

authors： Kambouris SJ,Chaudhary AK,Blair IA

更新日期：1996-10-28 00:00:00

abstract：:(1) Following the administration of the highly toxic agent 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to pregnant mice, exceedingly low concentrations of this substance were found in the embryo and fetus between gestational days 11 and 18 (between 0.04 and 0.14% of the maternal dose/g tissue). (2) Tissue levels of tCD...

journal_title：Toxicology

authors： Nau H,Bass R

更新日期：1981-01-01 00:00:00

abstract：:Chronic ethanol intake affects various organ systems of the body. The present study evaluated modifications of fatty acid concentrations both in brain and striated skeletal muscles of rats genetically selected for voluntary high ethanol intake. Three groups of rats were tracked for 10 weeks of access to ethanol only a...

journal_title：Toxicology

authors： Berrettini M,Fedeli D,Falcioni G,Bevilacqua C,Massi M,Polidori C

更新日期：2004-07-01 00:00:00

abstract：:The effects of mercury (Hg(2+)) and selenite (Se(4+)) on delta-aminolevulinic acid dehydratase (delta-ALA-D) activity, 2-thiobarbituric acid reactive substances (TBARS) and nonprotein sulfhydryl content (NPSH) in mouse kidney and liver were investigated. Male mice were given a single i.p. injection of Hg(2+) and/or Se...

journal_title：Toxicology

authors： Farina M,Brandão R,de Lara FS,Pagliosa LB,Soares FA,Souza DO,Rocha JB

更新日期：2003-03-03 00:00:00

abstract：:Acrylonitrile (AN) is widely used in the manufacturing of fibers, plastics and pharmaceuticals. Free radical-mediated lipid peroxidation is implicated in the toxicity of AN. The present study was designed to examine the ability of curcumin, a natural polyphenolic compound, to attenuate acute AN-induced lipid peroxidat...

journal_title：Toxicology

authors： Guangwei X,Rongzhu L,Wenrong X,Suhua W,Xiaowu Z,Shizhong W,Ye Z,Aschner M,Kulkarni SK,Bishnoi M

更新日期：2010-01-12 00:00:00

abstract：:The murine local lymph node assay (LLNA) has been proposed as a predictive test for the identification of sensitizing agents. We used this test to compare the sensitization potential of NiSO4, K2Cr2O7, CoCl2, Na2PtCl6 and BeSO4, salts of metals which have all been associated with allergic contact dermatitis and either...

journal_title：Toxicology

authors： Mandervelt C,Clottens FL,Demedts M,Nemery B

更新日期：1997-06-06 00:00:00

abstract：:Toxicology and carcinogenesis studies of 2 structurally-related p-phenylenediamines, HC Blue No. 1, and HC Blue No. 2 were conducted by administering each chemical in feed for 103 weeks to both sexes of Fischer 344/N rats and B6C3F1 (C57BL/6N x C3H/HEN) mice. Diets containing 0, 1500, or 3000 ppm HC Blue 1 were fed to...

journal_title：Toxicology

authors： Kari FW,Mennear JH,Farnell D,Thompson RB,Huff JE

更新日期：1989-06-01 00:00:00

abstract：:The cytotoxicity and cardiotoxicity of benzoyl mustard (FCE 24517) and epoxamido (FCE 24561) synthetic derivatives of distamycin A were reported in the present study. The 50% inhibiting concentration (IC50) of colony formation of FCE 24517 on human SNB-19 glioblastoma, A2780 ovarian cancer and DU 145 prostate cancer w...

journal_title：Toxicology

authors： Agen C,Sironi AM,Danesi R,Costa M,Bernardini N,Paparelli A,Della Torre P,Del Tacca M

更新日期：1992-11-15 00:00:00

abstract：:As a new method, support vector machine (SVM) were applied for prediction of toxicity of different data sets compared with other two common methods, multiple linear regression (MLR) and RBFNN. Quantitative structure-activity relationships (QSAR) models based on calculated molecular descriptors have been clearly establ...

journal_title：Toxicology

authors： Zhao CY,Zhang HX,Zhang XY,Liu MC,Hu ZD,Fan BT

更新日期：2006-01-16 00:00:00

abstract：:Gordonia axillaris (Roxb.) Dietrich (Theaceae) is a native to Taiwan and the leaves have been used as an astringent folk medicine. Camelliin B (CB), a macrocyclic hydrolyzable tannin, was isolated from G. axillaris and showed cytotoxic effects in human carcinoma cells. Among the target cells (SKHep-1, Ha-22T, DU-145, ...

journal_title：Toxicology

authors： Wang CC,Chen LG,Yang LL

更新日期：2001-11-30 00:00:00

abstract：:Alkylfurans inflict toxicity in several mammalian species to lung, liver and kidney. Organ specificity of the alkylfurans is a sensitive function of the nature of the alkyl group. To determine if this toxicity requires an aromatic ring in the compound, we synthesized 4-methyl-2,3-dihydrofuran, 4-ethyl-2,3-dihydrofuran...

journal_title：Toxicology

authors： Zenk P,Brinkman R,Gammal L,Penka V,Bresnahan J,Wiley R,Traiger G

更新日期：1990-03-30 00:00:00