Abstract：
:The murine local lymph node assay (LLNA) has been proposed as a predictive test for the identification of sensitizing agents. We used this test to compare the sensitization potential of NiSO4, K2Cr2O7, CoCl2, Na2PtCl6 and BeSO4, salts of metals which have all been associated with allergic contact dermatitis and either bronchial asthma orinterstitial lung disease, by either humoral or cell-mediated allergic mechanisms. BALB/c mice (n = 3 per concentration studied, three concentrations studied per metal) received three daily applications of the metal salt (in DMSO) on the dorsum of both ears. On the fourth day the draining auricular lymph nodes were removed and the incorporation of [3H]-thymidine in the lymphocytes in culture was compared to that of concurrent vehicle-treated control mice, thus enabling to derive a stimulation index (SI), indicative of immunological sensitization potential. Each experiment was performed three times. Oxazolone and toluene diisocyanate, chosen as positive controls, yielded strongly positive SI values (> 20 and > 30 respectively). Na2PtCl6 (SI 2.6 +/- 1.0 at 2.5%), CoCl2 (SI 2.8 +/- 0.5 at 5%) and possibly also K2Cr2O7 (SI 2.1 +/- 1.2 at 0.5%) were positive in the LLNA, whereas NiSO4 (SI 0.9 +/- 0.2 at 5%) and BeSO4 (SI 1.3 +/- 0.6 at 4%) were negative. Although our results are still limited by the fact that only one mice strain was tested, they indicate that there is no strict relationship between the sensitization potential of metal salts, as evaluated in the murine LLNA, and their potential to cause either respiratory or dermal allergic disease. Consequently, caution should be exercised before proposing the murine LLNA as a valid test to predict the sensitization potential of low molecular weight chemicals.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Mandervelt C,Clottens FL,Demedts M,Nemery Bdoi
10.1016/s0300-483x(97)03629-9subject
Has Abstractpub_date
1997-06-06 00:00:00pages
65-73issue
1eissn
0300-483Xissn
1879-3185pii
S0300483X97036299journal_volume
120pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Many models have been developed to predict the combined effect of drugs and chemicals. Most models are classified into two additive models: independent action (IA) and concentration addition (CA). It is generally considered if the modes of action of chemicals are similar then the combined effect obeys CA; however, man...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2015.06.008
更新日期：2015-09-01 00:00:00
abstract：:Maintenance of health is dependent on numerous regulatory interactions between organ systems. This review discusses interorgan communication between the nervous, endocrine, and immune systems and environmental and genetic influences on this neuroendocrine immune circuitry. Stresses of multiple types, including psychol...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(99)00144-4
更新日期：2000-01-17 00:00:00
abstract：:The intragastric administration to male Wistar rats of T-2 toxin at 1-1.3 mg/kg body weight for 7 days caused a sharp decrease in the liver activity of lysosomal enzymes: beta-galactosidase, beta-N-acetylglucosaminidase, alpha-mannosidase, cathepsins A, B, C and D and in the activity of enzymes of the 1st phase of met...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90094-6
更新日期：1986-12-01 00:00:00
abstract：:Hexachlorobenzene (HCB) is an organochlorine pesticide that acts as an endocrine disruptor in humans and rodents. The development of breast cancer strongly depends on endocrine conditions modulated by environmental factors. We have demonstrated that HCB is a tumor co-carcinogen in rats and an inducer of proliferation ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.12.012
更新日期：2012-03-11 00:00:00
abstract：:The present study investigates the influence of different levels of Schistosoma mansoni infection (60, 120, 180, 300, 600 cercariae per mice) after 33 days on the activity of aryl hydrocarbon hydroxylase (AHH) and the formation of hepatic hydrogen peroxide (H(2)O(2)) during the metabolic activation of benzo(a)pyrene [...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00372-9
更新日期：2001-06-21 00:00:00
abstract：:Arsenic and cadmium are both priority hazardous substances and human carcinogens. Although there is the potential for simultaneous exposure to both metals, the interactions of cadmium and arsenic are not well defined. We examined the toxicity of these metals when given alone or in alternating sequence to adult male Fi...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(96)03536-6
更新日期：1997-01-15 00:00:00
abstract：:Injection of insulin into mice and rabbit has been reported to convert the latent form of phosphoglucomutase (E X Zn) to an active form (E X Mg) without any net increase in the protein associated with this enzyme (Hashimoto et al., Biochem. Biophys. Res. Commun., 27 (1967) 369 and Peck et al., J. Biol. Chem. 242 (1971...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(85)90050-2
更新日期：1985-08-01 00:00:00
abstract：:Use of the fluoroquinolone antibiotic trovafloxacin (TVX) was restricted due to idiosyncratic, drug-induced liver injury (IDILI). Previous studies demonstrated that tumor necrosis factor-alpha (TNF) and TVX interact to cause death of hepatocytes in vitro that was associated with prolonged activation of c-Jun N-termina...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2015.03.002
更新日期：2015-05-04 00:00:00
abstract：:The trichothecenes are a group of mycotoxins that target leukocytes and have a wide range of immunomodulatory effects. Differential display analysis was applied to assess the effects of the trichothecenes deoxynivalenol (vomitoxin, DON) and satratoxin G (SG), on mRNA in the RAW 264.7 macrophage cell line. Cells were i...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(02)00605-4
更新日期：2003-04-15 00:00:00
abstract：:Transforming growth factor beta (TGF beta) is a multifunctional regulator of cell growth that has either a stimulatory or inhibitory effect on cell proliferation, depending on TGF beta concentration and on cell type, history and culture conditions. Cadmium mimics some of the effects of TGF beta in cultured cells. In t...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(92)90063-k
更新日期：1992-01-01 00:00:00
abstract：:In the clinical setting, antidotes are generally administered after the occurrence of a drug overdose. Therefore, the most pertinent evaluation of any new agent should model human exposure. This study tested whether acetaminophen (APAP) hepatotoxicity was reversed when S-adenosyl-L-methionine (SAMe) was administered a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.10.027
更新日期：2008-02-03 00:00:00
abstract：:The cardiovascular toxin allylamine (3-aminopropene) has been shown to concentrate in elastic and muscular tissues. In this study the 14C-moiety of [14C]allylamine was traced in aortas of adult Sprague-Dawley rats after intravenously injecting 30 microCi of [14C]allylamine (spec. act. = 0.4 mCi/mM). At 5, 10, 15 and 2...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(85)90014-9
更新日期：1985-06-14 00:00:00
abstract：:Long-term cadmium exposure leads to mitochondrial dysfunction in the proximal tubular epithelial cells. Mitochondrial DNA deletion may contribute to the pathogenesis of cadmium-induced nephropathy. The aim of our study is to clarify the accumulation of mitochondrial DNA deletion and mitochondrial dysfunction in the re...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.06.005
更新日期：2004-10-15 00:00:00
abstract：:We have developed a model for the treatment of data of concentration of brain neurotransmitters (particularly serotonin and the catecholamines), in which the changes induced by any given treatment on the neurotransmitter (NT) and its main metabolite (ME) are converted into 2 new parameters named S and U, that are rela...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(88)90173-4
更新日期：1988-04-01 00:00:00
abstract：:Pharmacological evidence has accumulated showing that glucocorticoids and glucocorticoid receptor (GR) facilitate several responses to different drugs of abuse. Recent findings have attributed a prominent role to the mineralocorticoid receptor (MR) in modulating behavior during the addictive process. The purpose of th...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2014.10.002
更新日期：2014-12-04 00:00:00
abstract：:Antagonistic toxic effects of selenium and lead were studied in growing rats. Chronic lead intoxication was produced by cutaneous application of lead naphthenate solution (80-200 mg Pb/kg body weight) for a period of 8 weeks and chronic selenium intoxication was induced by giving 5 ppm, 10 ppm and 15 ppm selenium in d...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(76)90041-x
更新日期：1976-11-01 00:00:00
abstract：:This study evaluated a single intradermal injection model in the guinea pig with subsequent inhalation challenge and serological analysis as a method to predict the potential of chemicals to induce respiratory allergy. Four known respiratory allergens (trimellitic anhydride, diphenyl methane diisocyanate, phthalic anh...
journal_title：Toxicology
pub_type： 杂志文章,多中心研究
doi：10.1016/0300-483x(94)03007-o
更新日期：1995-01-19 00:00:00
abstract：:The promoting effects of a combined exposure to two pollutants (NO2, O3 or H2SO4-aerosol) at near ambient levels on lung tumorigenesis induced by N-bis(2-hydroxypropyl) nitrosamine (BHPN) were investigated in male Wistar rats. The rats were given a single intraperitoneal injection of BHPN (0.5 g per kg body wt.) at 6 ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(92)90137-4
更新日期：1992-09-01 00:00:00
abstract：:The regional distribution of metallothionein (MT), zinc and copper was measured in brains of transgenic MT-I overexpressor (MT-I*) mice, MT-I/MT-II gene knockout (MT-I/MT-II null) mice, and in brains of control C57BL/6J mice with normal MT expression. Toxic milk (tx) mutant mice with abnormally high MT and copper accu...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(97)00133-9
更新日期：1997-12-19 00:00:00
abstract：:For quantitative in vitro-in vivo extrapolation (QIVIVE) of metabolism for the purposes of toxicokinetics prediction, a precise and robust analytical technique for identifying and measuring a chemical and its metabolites is an absolute prerequisite. Currently, high-resolution mass spectrometry (HR-MS) is a tool of cho...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2013.08.010
更新日期：2015-06-05 00:00:00
abstract：:The rodent Hershberger assay has been used predominantly by the pharmaceutical industry to evaluate androgenic and antiandrogenic chemicals for potential therapeutic use. However, this assay has not yet been formally validated and standardized for use in toxicology testing. There are many variations in the protocol us...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00361-4
更新日期：2001-05-11 00:00:00
abstract：:Nowadays, very little information concerning the effects on behavior in mammals of perfluorooctane sulfonate (PFOS), a widely distributed persistent environmental pollutant, is available. In the present study, we assessed the behavioral effects of PFOS on 3 months old mice after 1 month of exposure to this pollutant. ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.09.012
更新日期：2007-12-05 00:00:00
abstract：:Male and female B6C3F1 mice were administered dichloroacetate (DCA) and trichloroacetate (TCA) in their drinking water at concentrations of 1 or 2 g/l for up to 52 weeks. Both compounds induced hepatoproliferative lesions (HPL) in male mice, including hepatocellular nodules, adenomas and hepatocellular carcinomas with...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90195-m
更新日期：1990-09-01 00:00:00
abstract：:Previous studies have shown that excess dietary Al during development can affect neurobehavioral measures and decrease tissue Mn of 21-day-old weanling mice without a corresponding increase in tissue Al concentrations. Al and Mn have similar tissue concentrations and similar affinities for transferrin, which is the ma...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90154-k
更新日期：1993-07-11 00:00:00
abstract：:Polycyclic aromatic hydrocarbons (PAHs) including benzo[a]pyrene (B[a]P) and 7,12-dimethylbenz[a]anthracene (DMBA) are environmental pollutants, which undergo metabolic activation to exert their carcinogenic effects. Our earlier studies showed that naturally occurring plant phenols, protocatechuic, chlorogenic, tannic...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.07.047
更新日期：2008-09-29 00:00:00
abstract：:Haptens are classified as low molecular chemicals with an intrinsic potential to covalently modify proteins, and many of them are strong inducers of contact hypersensitivity (CHS). CHS is T cell mediated, and hapten-specific T cells have been shown to interact with hapten-modified, MHC-associated peptides. However, th...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2004.12.015
更新日期：2005-04-15 00:00:00
abstract：:N-Heterocyclic aromatics are by-products of incomplete combustion of organic material. The overall objective of this study was to determine the relative carcinogenic potencies of 7H-dibenzo[c,g]carbazole (DBC) and dibenz[a,j]acridine (DBA) in a bioassay of complete carcinogenicity on mouse skin in a sensitive strain (...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90074-4
更新日期：1994-11-11 00:00:00
abstract：:The prime factors influencing survivability from 10 major fire-related public transport aircraft accidents were assessed. Regulatory requirements were assessed against derived criteria and alternate concepts evaluated to identify a preferred strategy for enhanced survival; the provision of passenger protective breathi...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(96)03494-4
更新日期：1996-12-31 00:00:00
abstract：:Incubation of rat platelets with organotins inhibited their capacity to take up 5-hydroxytryptamine-14C (5-HT-14C) and stimulated the release of preloaded 5-HT-14C as well as endogenous 5-HT. Similar but less pronounced effects also were observed when platelets from rats treated intraperitoneally with organotins were ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(83)90037-9
更新日期：1983-12-01 00:00:00
abstract：:The synthetic pyrethroid insecticide, cypermethrin, was given during gestation to pregnant rats by gavage in corn oil. Peripheral blood and spleen cytotoxic activity of dams and their offspring were then evaluated at different times (30, 60, 90, 120 days) after birth. Pups showed a significant increase in peripheral b...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(97)03662-7
更新日期：1997-07-11 00:00:00
