Abstract:
:The intragastric administration to male Wistar rats of T-2 toxin at 1-1.3 mg/kg body weight for 7 days caused a sharp decrease in the liver activity of lysosomal enzymes: beta-galactosidase, beta-N-acetylglucosaminidase, alpha-mannosidase, cathepsins A, B, C and D and in the activity of enzymes of the 1st phase of metabolism of xenobiotics--aniline hydroxylase and carboxylesterase, as well as in the cytochrome P-450 level. At the same time, the subacute toxic effect of T-2 toxin was manifested in a significant increase in the activity of epoxide hydrolase and an enzyme of the 2nd phase of metabolism of xenobiotics--UDP-glucuronosyltransferase. A possible mechanism of the observed enzymological changes is discussed.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Kravchenko LV,Tutelyan VA,Vasilyev AV,Kranauskas AE,Avrenyeva LIdoi
10.1016/0300-483x(86)90094-6subject
Has Abstractpub_date
1986-12-01 00:00:00pages
77-83issue
1eissn
0300-483Xissn
1879-3185pii
0300-483X(86)90094-6journal_volume
42pub_type
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