Abstract:
:Mitochondria are cellular powerhouses as well as metabolic and signaling hubs regulating diverse cellular functions, from basic physiology to phenotypic fate determination. It is widely accepted that reactive oxygen species (ROS) generated in mitochondria participate in the regulation of cellular signaling, and that some mitochondria chronically operate at a high ROS baseline. However, it is not completely understood how mitochondria adapt to persistently high ROS states and to environmental stressors that disturb the redox balance. Here we will review some of the current concepts regarding how mitochondria resist oxidative damage, how they are replaced when excessive oxidative damage compromises function, and the effect of environmental toxicants (i.e. heavy metals) on the regulation of mitochondrial ROS (mtROS) production and subsequent impact.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Blajszczak C,Bonini MGdoi
10.1016/j.tox.2017.07.013subject
Has Abstractpub_date
2017-11-01 00:00:00pages
84-89eissn
0300-483Xissn
1879-3185pii
S0300-483X(17)30202-0journal_volume
391pub_type
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