Potential role for IL-5 and IL-6 in enhanced IgA secretion by Peyer's patch cells isolated from mice acutely exposed to vomitoxin.

Abstract:

:Dietary exposure to vomitoxin (VT) results in hyperelevated serum IgA and IgA nephropathy in mice. To assess the possible role of cytokines in this IgA dysregulation, the effects of a single oral exposure in B6C3F1 male mice to 0, 5 or 25 mg/kg BW VT on production of IgA and cytokines in Peyer's patch (PP) and spleen cell cultures were evaluated. IgA levels were increased significantly in PP cell cultures prepared from mice at 2 or 24 h after oral exposure to VT and subsequently stimulated with phorbol myristate acetate (PMA) and ionomycin (ION) or with lipopolysaccharide (LPS). Significant effects on IgA production were not observed in spleen cell cultures. Since cytokines such as IL-2, IL-4, IL-5 and IL-6 have been shown to promote IgA production, the effect of the same VT exposure regimen on secretion of these mediators was determined in PP and spleen cultures. Supernatant IL-2 and IL-4 levels were unaffected by the prior treatment of animals with VT. In contrast, IL-5 levels were increased significantly in 7-day PP cell cultures obtained 2 h after VT exposure both with and without PMA + ION exposure but not in other cultures. IL-6 levels were increased significantly in LPS-treated cultures prepared from PP at 2 and 24 h following exposure to VT. IL-6 levels were also elevated significantly in both PMA + ION or LPS treated cultures from spleen isolated at 2 h but not 24 h post VT exposure. To determine whether IL-5 or IL-6 play a role in IgA hyperelevation in vitro, PP and spleen cells from mice obtained 2 h after exposure to 25 mg/kg VT were cultured in the presence of neutralizing cytokine antibodies (Abs) and IgA production was monitored. Consistent with IL-5's previously documented role in IgA production, anti-IL-5 decreased IgA levels to background in cultures of both control and VT-exposed PP or spleen cells in the presence of either PMA + ION or LPS. Similar results were seen with addition of anti-IL-6. IgA levels were decreased to a lesser extent in PP cells cultured with LPS and in spleen cells cultured with PMA + ION from VT-exposed mice to which anti-IL-2 Ab was added. Thus, the potential for enhanced IgA production exists in lymphocytes as early as 2 h and as late as 24 h after a single oral exposure to VT and this may be related to the increased capacity to secrete helper cytokines of T cell and macrophage origin. Taken together, the results suggest that the superinduction of cytokine expression may, in part, be responsible for upregulation of IgA secretion in mice exposed orally to VT.

journal_name

Toxicology

journal_title

Toxicology

authors

Yan D,Zhou HR,Brooks KH,Pestka JJ

doi

10.1016/s0300-483x(97)00087-5

subject

Has Abstract

pub_date

1997-09-26 00:00:00

pages

145-58

issue

1-2

eissn

0300-483X

issn

1879-3185

pii

S0300-483X(97)00087-5

journal_volume

122

pub_type

杂志文章
  • Morphological alterations of rat lung bronchiolar epithelium produced by various trialkyl phosphorothioates.

    abstract::A single oral administration of O, O, S-trimethyl phosphorothioate (OOS-Me), an impurity in widely used organophosphorus insecticides, causes delayed toxicity (delayed death) which is accompanied by morphological changes in the bronchiolar epithelium of rat lungs. A series of simple O,O-dimethyl and O,O-diethyl S-alky...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(84)90032-5

    authors: Gandy J,Ali FA,Hasegawa L,Imamura T

    更新日期:1984-07-01 00:00:00

  • Induction of oxidative stress by bisphenol A in the epididymal sperm of rats.

    abstract::Bisphenol A has been shown to affect the reproduction of male rats and mice. However, the mechanism of action of bisphenol A on the epididymal sperm is not elucidated. The present study was undertaken to evaluate the effect of bisphenol A on the antioxidant system of rat epididymal sperm. Bisphenol A was administered ...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/s0300-483x(02)00597-8

    authors: Chitra KC,Latchoumycandane C,Mathur PP

    更新日期:2003-03-14 00:00:00

  • Nrf2 deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo.

    abstract::Several mechanisms are postulated to be responsible for nephrotoxic and nephrocarcinogenic activities of mycotoxin and food contaminant, ochratoxin A (OTA). Although Nrf2 transcription factor was suggested to be involved in OTA-mediated renal injury, comprehensive study evaluating the effect of OTA toxicity in Nrf2 kn...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2017.07.004

    authors: Loboda A,Stachurska A,Sobczak M,Podkalicka P,Mucha O,Jozkowicz A,Dulak J

    更新日期:2017-08-15 00:00:00

  • Comparison of the effects of ascorbyl palmitate and L-ascorbic acid on paracetamol-induced hepatotoxicity in the mouse.

    abstract::The effects of ascorbyl palmitate (ASCP) and free L-ascorbic acid (LAA) on the hepatotoxicity of paracetamol (acetaminophen) and the in vivo covalent binding of reactive paracetamol metabolites to hepatic proteins has been studied in male MF1 mice. The oral administration of [3H(G)]paracetamol (600 mg/kg) resulted in ...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(88)90133-3

    authors: Jonker D,Lee VS,Hargreaves RJ,Lake BG

    更新日期:1988-11-30 00:00:00

  • Time-course of toxicity of reactive sulfonamide metabolites.

    abstract::It has been suggested, on the basis of work in cell-free systems, that sulfonamide hydroxy-lamines are metabolized to nitroso metabolites which may be the proximate toxins mediating sulfonamide hypersensitivity reactions. We performed time-course experiments investigating the toxicity of the hydroxylamine and nitroso ...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(94)02900-f

    authors: Rieder MJ,Krause R,Bird IA

    更新日期:1995-01-06 00:00:00

  • Explanation of non-additive effects in mixtures of similar mode of action chemicals.

    abstract::Many models have been developed to predict the combined effect of drugs and chemicals. Most models are classified into two additive models: independent action (IA) and concentration addition (CA). It is generally considered if the modes of action of chemicals are similar then the combined effect obeys CA; however, man...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2015.06.008

    authors: Kamo M,Yokomizo H

    更新日期:2015-09-01 00:00:00

  • Prevention of acetaminophen-induced hepatotoxicity by dimethyl sulfoxide.

    abstract::Dimethyl sulfoxide (DMSO) has previously been shown to protect against acetaminophen (APAP)-induced hepatotoxicity, but the mechanism of this effect was not clear. Treatment of mice with 1 mg/kg DMSO 4 h before 250 mg/kg APAP resulted in significantly less hepatotoxicity than with APAP alone, as measured by serum glut...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(88)90202-8

    authors: Park Y,Smith RD,Combs AB,Kehrer JP

    更新日期:1988-11-14 00:00:00

  • Effects of extended sidestream smoke exposure on components of the C-fiber axon reflex.

    abstract::We have previously shown that young guinea pigs repeatedly exposed to sidestream cigarette smoke (SS) develop decreased airway reactivity of the C-fiber system without changing reactivity to one of its neurotransmitters, substance P (SP). This study was designed to determine whether the decreased reactivity was due to...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(96)03403-8

    authors: Joad JP,Avadhanam KP,Watt KC,Kott KS,Bric JM,Pinkerton KE

    更新日期:1996-09-02 00:00:00

  • Sex and strain differences of susceptibility to methylmercury toxicity in mice.

    abstract::Excretion and organ distribution of mercury and susceptibility to methylmercury (MeHg) toxicity were compared between strains and sexes after successive oral administration of MeHg chloride (5 mg/kg per day) using BALB/cA (C) and C57BL/6N (B6) mice. Every mouse died several days after initiation of toxic symptoms, and...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(88)90079-0

    authors: Yasutake A,Hirayama K

    更新日期:1988-09-01 00:00:00

  • Spontaneous development of fatty liver in ferrets in a toxicology study.

    abstract::Ferrets were maintained for 12 months on different diets (A, meat and biscuit; B, all meat; C, meat and fish; D, high fibre) to ascertain the cause of spontaneous development of fatty liver. High hepatic triglyceride contents resulted on diets B = C > D; whereas ferrets on diet A (control) showed no accumulation of li...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(96)03351-3

    authors: Shavila J,King LJ,Parke DV

    更新日期:1996-08-16 00:00:00

  • Lead affects steroidogenesis in rat Leydig cells in vivo and in vitro.

    abstract::Lead is known to impede the male reproductive function, however, the mechanisms through which the adverse effects are mediated are not clearly elucidated. In order to get insight into those mechanisms, we have examined the effects of lead on the biosynthesis of steroid hormones by Leydig cells in the rat. To determine...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(95)03107-q

    authors: Thoreux-Manlay A,Le Goascogne C,Segretain D,Jégou B,Pinon-Lataillade G

    更新日期:1995-11-20 00:00:00

  • Lung function and airway inflammation in rats following exposure to combustion products of carbon-graphite/epoxy composite material: comparison to a rodent model of acute lung injury.

    abstract::Pulmonary function and inflammation in the lungs of rodents exposed by inhalation to carbon/graphite/epoxy advanced composite material (ACM) combustion products were compared to that of a rodent model of acute lung injury (ALI) produced by pneumotoxic paraquat dichloride. This investigation was undertaken to determine...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/s0300-483x(02)00542-5

    authors: Whitehead GS,Grasman KA,Kimmel EC

    更新日期:2003-02-01 00:00:00

  • Prenatal exposure to cypermethrin modulates rat NK cell cytotoxic functions.

    abstract::The synthetic pyrethroid insecticide, cypermethrin, was given during gestation to pregnant rats by gavage in corn oil. Peripheral blood and spleen cytotoxic activity of dams and their offspring were then evaluated at different times (30, 60, 90, 120 days) after birth. Pups showed a significant increase in peripheral b...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/s0300-483x(97)03662-7

    authors: Santoni G,Cantalamessa F,Mazzucca L,Romagnoli S,Piccoli M

    更新日期:1997-07-11 00:00:00

  • Determination of mercury in fish from rivers and lakes in Hungary by atomic absorption technique.

    abstract::In 1975, in cooperation with 8 County Hygienic Stations, total mercury content in fish from rivers and lakes in Hungary was measured. The mercury content in fish muscle-tissue from 164 fish samples averaged 0.36 mg/kg. Average levels in different fish species ranged from 0.10 to 0.57 mg/kg. The amount of mercury in fi...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(77)90052-x

    authors: Gergely A,Soós K,Erdélyi L,Cieleszky V

    更新日期:1977-06-01 00:00:00

  • Development and validation of analytical methods for dietary supplements.

    abstract::The expanding use of innovative botanical ingredients in dietary supplements and foods has resulted in a flurry of research aimed at the development and validation of analytical methods for accurate measurement of active ingredients. The pressing need for these methods is being met through an expansive collaborative i...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2005.12.020

    authors: Sullivan D,Crowley R

    更新日期:2006-04-03 00:00:00

  • [Effects of methylcyclopentadienyl manganese tricarbonyl (MMT) on rat liver mitochondria. II. Activity-structure relation (author's transl)].

    abstract::The action of various manganese organic compounds, which are structural analogs of methylcyclopentadienyl manganese tricarbonyl (MMT), was investigated. Only the cyclopentadienyl manganese tricarbonyl compounds are effective inhibitors of mitochondrial respiration, but only when associated with NAD+-linked substrates....

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(77)90001-4

    authors: Autissier N,Gautheron B,Dumas P,Brosseau J,Loireau A

    更新日期:1977-10-01 00:00:00

  • Persistent suppression of delayed-type hypersensitivity in adult F344 rats after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

    abstract::Recently we observed a suppressed delayed-type hypersensitivity (DTH) response to bovine serum albumin (BSA) in the 4-5-month-old offspring of F344 rat dams receiving as little as 1.0 microg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg on gestational day (GD) 14. This study was designed to characterize better this su...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/s0300-483x(99)00024-4

    authors: Gehrs BC,Smialowicz RJ

    更新日期:1999-05-03 00:00:00

  • Toxicity of alkyldihydrofurans to metabolically active organs in the mouse.

    abstract::Alkylfurans inflict toxicity in several mammalian species to lung, liver and kidney. Organ specificity of the alkylfurans is a sensitive function of the nature of the alkyl group. To determine if this toxicity requires an aromatic ring in the compound, we synthesized 4-methyl-2,3-dihydrofuran, 4-ethyl-2,3-dihydrofuran...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(90)90006-3

    authors: Zenk P,Brinkman R,Gammal L,Penka V,Bresnahan J,Wiley R,Traiger G

    更新日期:1990-03-30 00:00:00

  • Primary DNA damage in chrome-plating workers.

    abstract::In order to evaluate the primary DNA damage due to occupational exposure to chromium (VI), DNA strand-breaks and apoptosis in peripheral lymphocytes were measured in a group of 19 chrome-plating workers. DNA strand-breaks was assessed by alkaline (pH>13) single-cell microgel electrophoresis ('comet') assay, while apop...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/s0300-483x(03)00088-x

    authors: Gambelunghe A,Piccinini R,Ambrogi M,Villarini M,Moretti M,Marchetti C,Abbritti G,Muzi G

    更新日期:2003-06-30 00:00:00

  • Plasma concentration and placental transfer of bromofenofos in rats.

    abstract::Bromofenofos (BF) was administered by gavage once to non-pregnant and pregnant rats at 50 mg/kg and the plasma concentration-time curves of BF and its metabolite dephosphate bromofenofos (DBF) were determined by high-performance liquid chromatography. DBF reached a peak at 9 h, with 113.4 +/- 5.2 micrograms/ml, follow...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(89)90019-x

    authors: Yoshimura H,Endoh YS

    更新日期:1989-05-15 00:00:00

  • Lipopolysaccharide potentiates polychlorinated biphenyl-induced disruption of the blood-brain barrier via TLR4/IRF-3 signaling.

    abstract::Exposure to polychlorinated biphenyls (PCBs) is associated with numerous adverse health effects. Although the main route of exposure to PCBs is through the gastrointestinal tract, little is known about the contribution of the gut to the health effects of PCBs. We hypothesize that PCBs can disrupt intestinal integrity,...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2012.08.001

    authors: Choi JJ,Choi YJ,Chen L,Zhang B,Eum SY,Abreu MT,Toborek M

    更新日期:2012-12-16 00:00:00

  • Sex difference in susceptibility to acetaminophen hepatotoxicity is reversed by buthionine sulfoximine.

    abstract::Gender is a factor that influences susceptibility of individuals to drug-induced liver injury in experimental animals and humans. In this study, we investigated the mechanisms underlying resistance of female mice to acetaminophen (APAP)-induced hepatotoxicity. Overnight-fasted male and female CD-1 mice were administer...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2011.05.018

    authors: Masubuchi Y,Nakayama J,Watanabe Y

    更新日期:2011-09-05 00:00:00

  • An epigrammatic (abridged) recounting of the myriad tales of astonishing deeds and dire consequences pertaining to nitric oxide and reactive oxygen species in mitochondria with an ancillary missive concerning the origins of apoptosis.

    abstract::Mitochondria play a central role in the life and death of cells. These organelles serve as the major energy-producing power-house, whereby the generation of ATP is associated with the utilization of molecular oxygen. A significant fraction (2-3%) of molecular oxygen consumed by mitochondria may be reduced in a one-ele...

    journal_title:Toxicology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tox.2004.11.027

    authors: Heck DE,Kagan VE,Shvedova AA,Laskin JD

    更新日期:2005-03-15 00:00:00

  • DNA methylation in cardiac fibrosis: new advances and perspectives.

    abstract::Cardiac fibrosis is characterized by net accumulation of extracellular matrix (ECM) proteins in the cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions. More specifically, cardiac fibroblasts are activated by a variety of pathological stimuli, th...

    journal_title:Toxicology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tox.2014.07.002

    authors: Tao H,Yang JJ,Shi KH,Deng ZY,Li J

    更新日期:2014-09-02 00:00:00

  • Chloroform-induced olfactory mucosal degeneration and osseous ethmoid hyperplasia are not associated with olfactory deficits in Fischer 344 rats.

    abstract::Adult female F-344 rats were trained (avoidance rate > 70%) over four days with a coupled tone- (n = 10 rats/dose) or 2 ppm acetaldehyde-cued (n = 6 rats/dose) foot shock paradigm. Rats were gavaged with chloroform dissolved in corn oil for 5 days/week for 3 week at 0 or 400 (tone-cued) or 0, 34, 100, or 400 (odor-cue...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/s0300-483x(97)00076-0

    authors: Dorman DC,Miller KL,D'Antonio A,James RA,Morgan KT

    更新日期:1997-09-26 00:00:00

  • Polycyclic aromatic hydrocarbons in binary mixtures modulate the efficiency of benzo[a]pyrene to form DNA adducts in human cells.

    abstract::Exposure to polycyclic aromatic hydrocarbons (PAHs) always involves complex mixtures that may induce synergistic or antagonistic effects on the genotoxic properties and make risk assessment more difficult. In this study, we evaluated how particulate PAHs modulated the formation of DNA damage induced by carcinogenic be...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2010.09.002

    authors: Tarantini A,Maître A,Lefèbvre E,Marques M,Rajhi A,Douki T

    更新日期:2011-01-11 00:00:00

  • Maternal rat serum concentrations of dimethadione do not explain intra-litter differences in the incidence of dimethadione-induced birth defects, including novel findings in foetal lung.

    abstract::To investigate mechanisms of chemical-induced congenital heart defects (CHD) we have developed a rat model using dimethadione (DMO), the N-demethylated metabolite of the anticonvulsant, trimethadione (TMD). Dosing pregnant rats with 300mg/kg DMO every 12h from the evening of gestational day (GD) 8 until the morning of...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2014.10.014

    authors: Rodger I,Lam I,Purssell E,Thompson M,Rutter A,Ozolinš TR

    更新日期:2014-12-04 00:00:00

  • Hepatic and renal Bcrp transporter expression in mice treated with perfluorooctanoic acid.

    abstract::The breast cancer resistance protein (Bcrp) is an efflux transporter that participates in the biliary and renal excretion of drugs and environmental chemicals. Recent evidence suggests that pharmacological activation of the peroxisome proliferator activated receptor alpha (PPARα) can up-regulate the hepatic expression...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/j.tox.2013.02.009

    authors: Eldasher LM,Wen X,Little MS,Bircsak KM,Yacovino LL,Aleksunes LM

    更新日期:2013-04-05 00:00:00

  • The effect of nitrofen [4-(2,4-dichlorophenoxy)nitrobenzene] on the reproductive performance of male rats.

    abstract::Technical grade nitrofen was fed to 4 groups (25/group) of male Sprague-Dawley rats for 13 weeks at dietary concentrations of 0, 100, 500, or 2500 ppm. Untreated female rats of the same age and strain were mated with treated males and fertility, gestation, and lactation indices were monitored. After mating, males were...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/0300-483x(83)90006-9

    authors: O'Hara GP,Chan PK,Harris JC,Burke SS,Smith JM,Hayes AW

    更新日期:1983-11-01 00:00:00

  • Different levels of Schistosoma mansoni infection increased the mutagenicity of benzo(a)pyrene, the activity of aryl hydrocarbon hydroxylase and the formation of hepatic microsomal hydrogen peroxide.

    abstract::The present study investigates the influence of different levels of Schistosoma mansoni infection (60, 120, 180, 300, 600 cercariae per mice) after 33 days on the activity of aryl hydrocarbon hydroxylase (AHH) and the formation of hepatic hydrogen peroxide (H(2)O(2)) during the metabolic activation of benzo(a)pyrene [...

    journal_title:Toxicology

    pub_type: 杂志文章

    doi:10.1016/s0300-483x(01)00372-9

    authors: Awney HA,Ghzlan HE,Sheweita SA,Mostafa MH

    更新日期:2001-06-21 00:00:00