Abstract:
:Nowadays, very little information concerning the effects on behavior in mammals of perfluorooctane sulfonate (PFOS), a widely distributed persistent environmental pollutant, is available. In the present study, we assessed the behavioral effects of PFOS on 3 months old mice after 1 month of exposure to this pollutant. Thirty adult mice were divided into three groups. Animals were given by gavage 0, 3, and 6 mg PFOS/kg/day for four consecutive weeks. After the treatment period, mice were evaluated for several skills by testing motor and sensory function by means of a functional observation battery (FOB), general activity and exploratory behavior in an open-field, and learning and memory in a water maze task. One week after behavioral testing, serum was collected for corticosterone analyses. No adverse effects were observed in the FOB. In general terms, activity in the open-field was similar in all groups being the only observed differences limited to the group given PFOS at 3mg/kg/day (spent less time in the center) and the group exposed to 6 mg PFOS/kg/day) (reduced rate of vertical activity). Concerning the effects of PFOS in the water maze, although all animals learned the task, no effect of the dose was observed during the acquisition. In the retention test, a deleterious effect of PFOS was noted. These results indicate that PFOS exposure induced only slight behavioral effects in adult male mice.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Fuentes S,Vicens P,Colomina MT,Domingo JLdoi
10.1016/j.tox.2007.09.012subject
Has Abstractpub_date
2007-12-05 00:00:00pages
123-9issue
1-3eissn
0300-483Xissn
1879-3185pii
S0300-483X(07)00650-6journal_volume
242pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::Recent studies have demonstrated that mammalian sperm are capable of generating reactive oxygen species (ROS) and that this activity is significantly accelerated in subfertile subjects. The observed decrease in penetration of zona-intact oocyte might be explained by chemical-induced ROS-related early onset of capacita...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(99)00107-9
更新日期:1999-11-29 00:00:00
abstract::Extract and fractions of city smog collected from a heavy industrialized area caused in vitro dose-dependent reduction of cell survival of mouse macrophages and a growth inhibition of human fetal diploid lung fibroblasts. Great differences were observed in both cell systems between the total extract and its different ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(80)90091-8
更新日期:1980-01-01 00:00:00
abstract::Butachlor is a systemic herbicide widely applied on rice, tea, wheat, beans and other crops; however, it concurrently exerts toxic effects on beneficial organisms like earthworms, aquatic invertebrates and other non-target animals including humans. Owing to the associated risk to humans, this chloroacetanilide class o...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2012.07.014
更新日期:2012-12-08 00:00:00
abstract::Formaldehyde (FA) is an important substance that induces sick house syndrome and diseases, such as asthma and allergies. Oxidative stress is involved in the development of respiratory disease, and diverse antioxidants may protect respiratory tract cells from apoptosis. Peroxiredoxin is a pivotal endogenous antioxidant...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2010.03.011
更新日期:2010-05-27 00:00:00
abstract::Female mice were given nutrient-sufficient, purified diets containing cadmium at either 0.25, 5, or 50 ppm, as described in the accompanying publication. One-half of the females were bred for 6 consecutive 42-day rounds of pregnancy/lactation (PL mice); remaining females were non-pregnant controls (NP mice). PL mice a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(88)90092-3
更新日期:1988-07-01 00:00:00
abstract::Among exocyclic DNA adducts, etheno (epsilon) bases (epsilond A, epsilond C, N(2),3-epsilond G) are generated by reactions of DNA bases with lipid peroxidation (LPO) products derived from endogenous sources and from the carcinogens vinyl chloride or urethane. The recent development of ultrasensitive methods has made i...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(00)00307-3
更新日期:2000-11-16 00:00:00
abstract::The objective of this study was to observe whether 1.8 GHz microwaves (MW) (SAR, 3 W/kg) exposure can influence human lymphocyte DNA damage induced by ultraviolet ray C (UVC). The lymphocytes, which were from three young healthy donors, were exposed to 254 nm UVC at the doses of 0.25, 0.5, 0.75, 1.0, 1.5 and 2.0 J m(-...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.01.019
更新日期:2007-04-11 00:00:00
abstract::The coumarin 7-hydroxylase of mice (Coh, CYP2A5) is known to be highly selectively inducible by both a set of heavy metals such as cobalt, indium and cerium and a variety of organic nitrogen-containing heteroaromatic compounds such as 3-amino-1,2,4-triazole, pyrazine and pyrazole. The investigations presented reveal t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(95)03285-n
更新日期:1996-04-15 00:00:00
abstract::T-2 toxin belongs to the large group of trichothecene mycotoxins synthesized by various Fusarium molds which can infect raw agriculture materials. Among the trichothecenes, T-2 toxin is one of the most potent mycotoxins and poses a potential health risk in human nutrition. Several acute and chronic toxic effects were ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.01.012
更新日期:2009-04-28 00:00:00
abstract::The multiple cascades of signal transduction pathways that lead from receptors on the cell membrane to the nucleus, thus translating extracellular signals into changes in gene expression, may represent important targets for neurotoxic compounds. Among the biochemical steps and pathways that have been investigated are ...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(00)00435-2
更新日期:2001-03-07 00:00:00
abstract::Feeding of rats with 1% ethoxyquin (EQ) and butylated hydroxytoluene (BHT) but not butylated hydroxyanisole (BHA) increases the formation rate of benzo[a]pyrene (BP)-4,5-dihydrodiol from BP in hepatic microsomes. The production of other BP-dihydrodiols and of BP phenols is decreased after treatment with EQ, BHT and BH...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(83)90120-8
更新日期:1983-01-01 00:00:00
abstract::Troglitazone is a thiazolidinedione antidiabetic agent with insulin-sensitizing activities that was withdrawn from the market in 2000 due to its association with idiosyncratic hepatotoxicity. To address the suspected autoantibody production associated with troglitazone, we investigated autoantibodies in sera from pati...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.07.012
更新日期:2005-12-01 00:00:00
abstract::A representative reactive oxygen species (ROS), hydroxyl radical (*OH), is a highly reactive species and induces DNA backbone breakage. *OH also oxidizes every DNA base. The interaction of *OH with guanine leads to the generation of not only piperidine-resistant 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) but also v...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.01.002
更新日期:2006-04-17 00:00:00
abstract::Immunohistochemical methods have been widely used to determine the histogenesis of spontaneous and chemically-induced mouse lung tumors. Typically, antigens for either alveolar Type II cells or bronchiolar epithelial Clara cells are studied. In the present work, the morphological and immunohistochemical phenotype of a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(03)00060-x
更新日期:2003-05-03 00:00:00
abstract::Ghrelin stimulates growth hormone (GH) release and induces positive energy balances. Previous studies have reported that ghrelin inhibits apoptosis in several cell types but the precise underlying protective mechanisms in pancreatic beta cells are poorly understood. Therefore, we investigated which pathway was related...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.05.013
更新日期:2007-07-31 00:00:00
abstract::The effects of xenobiotic drugs and toxic compounds depend largely on their kinetic properties, which can be influenced by transmembrane drug transporters like MDR1/P-glycoprotein and the drug-conjugate transporters multidrug resistance protein (MRP) 1 and 2. As the dog is a preferential species used in the pharmacolo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00354-1
更新日期:2001-01-02 00:00:00
abstract::Nitrated-polycyclic aromatic hydrocarbons (nitro-PAHs) and diesel exhaust particle extracts (DEPE) induced apoptosis in Hepa1c1c7 cells with the following potency: 1,3-dinitropyrene (1,3-DNP)>1-nitropyrene (1-NP) > DEPE > 1,8-dinitropyrene (1,8-DNP). The compounds induced cyp1a1, and activated various intracellular si...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.12.009
更新日期:2007-03-07 00:00:00
abstract::Several inhibitors of cytochrome P-450 mediated oxidative transformations, ethyl 2-diethylaminoethyl-2-phenyl-2-ethylmalonate, ethyl-2-diethyl-aminoethyl-2-ethyl-2-buthylmalonate, 2,4 dichloro-6-phenoxyethyl diethylamine, 2-diethylaminoethyl-2-phenyl- (2-propene)-4-penten-1-oate or 3-amino,1,2,4 triazole were not able...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(80)90117-1
更新日期:1980-01-01 00:00:00
abstract::Technical grade nitrofen was fed to 4 groups (25/group) of male Sprague-Dawley rats for 13 weeks at dietary concentrations of 0, 100, 500, or 2500 ppm. Untreated female rats of the same age and strain were mated with treated males and fertility, gestation, and lactation indices were monitored. After mating, males were...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(83)90006-9
更新日期:1983-11-01 00:00:00
abstract::Measurement of lymphocyte proliferation to detect hypersensitivity to beryllium (Be-LPT) in vitro is done presently using a method based on tritiated thymidine incorporation. Although this method is sensitive it gives no information on cell viability or responding lymphocyte subsets. We have developed reliable and sim...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(99)00167-5
更新日期:2000-02-21 00:00:00
abstract::Several mechanisms are postulated to be responsible for nephrotoxic and nephrocarcinogenic activities of mycotoxin and food contaminant, ochratoxin A (OTA). Although Nrf2 transcription factor was suggested to be involved in OTA-mediated renal injury, comprehensive study evaluating the effect of OTA toxicity in Nrf2 kn...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.07.004
更新日期:2017-08-15 00:00:00
abstract::In this study, some biochemical features and the extent of inhibition induced by the organophosphorous pesticide azinphos-methyl on the cholinesterase (ChE) activity present in whole soft tissue of two freshwater invertebrate species, the gastropod Biomphalaria glabrata and the oligochaete Lumbriculus variegatus were ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.02.018
更新日期:2006-05-15 00:00:00
abstract::The effect of dose and duration of treatment with chromium on its distribution in certain vital organs and the blood of rats has been investigated. The accumulation of metal was highest in liver and kidneys, followed by testes, brain and blood and was rather more dependent on the dose than on the duration of exposure....
journal_title:Toxicology
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract::There is concern about the growing environmental levels of brominated dioxins. Brominated dioxins are known to bind and activate the transcription factor aryl hydrocarbon receptor (AhR), as their chlorinated congeners do. However, data on the potency of brominated dioxins for immunotoxicity in vivo is largely lacking,...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2008.10.024
更新日期:2009-02-04 00:00:00
abstract::Adult female F-344 rats were trained (avoidance rate > 70%) over four days with a coupled tone- (n = 10 rats/dose) or 2 ppm acetaldehyde-cued (n = 6 rats/dose) foot shock paradigm. Rats were gavaged with chloroform dissolved in corn oil for 5 days/week for 3 week at 0 or 400 (tone-cued) or 0, 34, 100, or 400 (odor-cue...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00076-0
更新日期:1997-09-26 00:00:00
abstract::N-(3,5-Dichlorophenyl)succinimide (NDPS) is an agricultural fungicide which has been shown to induce acute tubular necrosis. The purpose of the present study was to determine if creatinine clearance was altered early in the development of NDPS nephrotoxicity. This study also examined the effect of autacoid modulation ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90007-n
更新日期:1991-01-01 00:00:00
abstract::Lead exposure causes cognitive and behavioral deficits in some children. We have proposed that the effects of single nucleotide polymorphisms (SNP) of the human pseudodeficient arylsulfatase A (ARSA) gene that result in reduced levels of the enzyme, and lead concentrations that decrease ARSA activity, culminate in cel...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(01)00387-0
更新日期:2001-06-21 00:00:00
abstract::Korea has a great diversity in resources of medicinal plants. The traditional herbal medicines and their preparations have been widely used in Korea as well as in China and Japan for thousands of years. One of the characteristics of Korean herbal medicine preparations is that all the herbal medicines are incorporated ...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(02)00487-0
更新日期:2002-12-27 00:00:00
abstract::Treatment of rats with beta-alanine increases the urinary taurine levels and markedly reduces the concentration of taurine in the liver. Dosing with carbon tetrachloride (CCl4) during treatment with beta-alanine results in a marked decrease in urinary taurine concomitant with a decrease in food intake. Treatment of an...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(93)90133-d
更新日期:1993-01-29 00:00:00
abstract::Drug-induced liver injury (DILI) is a major safety concern in drug development and clinical drug therapy. The pathogenesis of DILI usually involves the participation of the parent drug or metabolites that either directly affect the cell biochemistry or elicit an immune response. However, in most cases the mechanisms a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2010.05.011
更新日期:2010-09-10 00:00:00