Prenatal exposure to cypermethrin modulates rat NK cell cytotoxic functions.

abstract：:Pulmonary fibrosis is one of the most common chronic interstitial lung diseases with high mortality rate after diagnosis and limited successful treatment. The present study was designed to assess the potential antifibrotic effect of thymoquinone (TQ) and whether TQ can attenuate the severity of oxidative stress and in...

journal_title：Toxicology

authors： El-Khouly D,El-Bakly WM,Awad AS,El-Mesallamy HO,El-Demerdash E

更新日期：2012-12-16 00:00:00

abstract：:Whole body autoradiograms of mice injected with 2,2',3,3',6-[14C]pentachlorobiphenyl (I), 2,3,3',4',6-[14C]pentachlorobiphenyl (II), 2,2',3,5',6-[14C]pentachlorobiphenyl (III) and 2,3',4,5,5'-[14C]pentachlorobiphenyl (IV) showed a specific accumulation of I-III in the lung parenchyma, whereas IV did not accumulate in ...

journal_title：Toxicology

authors： Brandt I,Mohammed A,Slanina P

更新日期：1981-01-01 00:00:00

abstract：:The present study was examined whether or not 2-bromoethyamine, a semicarbazide-sensitive amine oxidase (SSAO, EC; 1.4.3.6) inhibitor, would increase an active dopaminergic neurotoxin, 1-methyl-4-phenylpyridinium ion (MPP(+))-induced hydroxyl radical ((*)OH) generation in the rat striatum. Rats were anesthetized, and ...

journal_title：Toxicology

authors： Obata T

更新日期：2006-01-20 00:00:00

abstract：:Cyclosporine (CsA) is a universally used immunosuppressive drug which induces adverse side effects in several organs, but its impact on the heart is still controversial. Small heat shock proteins (sHSPs), such as HSP25 and alpha B-crystallin, are cytoprotective stress proteins exceptionally represented in the heart. T...

journal_title：Toxicology

authors： Stacchiotti A,Bonomini F,Lavazza A,Rodella LF,Rezzani R

更新日期：2009-08-21 00:00:00

abstract：:The lipid regulator gemfibrozil (GEM) is one of many human pharmaceuticals found in the aquatic environment. We previously demonstrated that GEM bioconcentrates in blood and reduces plasma testosterone levels in goldfish (Carassius auratus). In this study, we address the potential of an environmentally relevant waterb...

journal_title：Toxicology

authors： Mimeault C,Trudeau VL,Moon TW

更新日期：2006-12-07 00:00:00

abstract：:(1) Following the administration of the highly toxic agent 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to pregnant mice, exceedingly low concentrations of this substance were found in the embryo and fetus between gestational days 11 and 18 (between 0.04 and 0.14% of the maternal dose/g tissue). (2) Tissue levels of tCD...

journal_title：Toxicology

authors： Nau H,Bass R

更新日期：1981-01-01 00:00:00

abstract：:Tributyltin (TBT), a toxic and widespread environmental contaminant, has been shown to inhibit natural killer (NK) cell cytotoxic function significantly. Inhibition of NK cell cytotoxic function has the potential to increase viral infections and tumor growth. Upon NK cell binding to lysis-sensitive tumor cells, an int...

journal_title：Toxicology

authors： Aluoch AO,Odman-Ghazi SO,Whalen MM

更新日期：2006-07-25 00:00:00

abstract：:The effects of ascorbyl palmitate (ASCP) and free L-ascorbic acid (LAA) on the hepatotoxicity of paracetamol (acetaminophen) and the in vivo covalent binding of reactive paracetamol metabolites to hepatic proteins has been studied in male MF1 mice. The oral administration of [3H(G)]paracetamol (600 mg/kg) resulted in ...

journal_title：Toxicology

authors： Jonker D,Lee VS,Hargreaves RJ,Lake BG

更新日期：1988-11-30 00:00:00

abstract：:There is concern about the growing environmental levels of brominated dioxins. Brominated dioxins are known to bind and activate the transcription factor aryl hydrocarbon receptor (AhR), as their chlorinated congeners do. However, data on the potency of brominated dioxins for immunotoxicity in vivo is largely lacking,...

journal_title：Toxicology

authors： Ao K,Suzuki T,Murai H,Matsumoto M,Nagai H,Miyamoto Y,Tohyama C,Nohara K

更新日期：2009-02-04 00:00:00

abstract：:The present study investigates the influence of different levels of Schistosoma mansoni infection (60, 120, 180, 300, 600 cercariae per mice) after 33 days on the activity of aryl hydrocarbon hydroxylase (AHH) and the formation of hepatic hydrogen peroxide (H(2)O(2)) during the metabolic activation of benzo(a)pyrene [...

journal_title：Toxicology

authors： Awney HA,Ghzlan HE,Sheweita SA,Mostafa MH

更新日期：2001-06-21 00:00:00

abstract：:In an attempt to ameliorate the chemotherapy associated normal cell toxicity, in this study a known antioxidant, grape seed proanthocyanidin extract (GSPE) using Chang liver cells has been used. Chang liver cells were treated in vitro with idarubicin (Ida) (30 nM) and 4-hydroxyperoxycyclophosphamide (4-HC) (1 microg/m...

journal_title：Toxicology

authors： Joshi SS,Kuszynski CA,Bagchi M,Bagchi D

更新日期：2000-11-30 00:00:00

abstract：:Drug hypersensitivity reactions are a daily worry for the clinicians, in particular anaphylactic reactions. The tools allowing a definite diagnosis are few and poorly validated. They include a thorough clinical history, standardized skin tests, reliable biological tests, and sometimes drug provocation tests. These too...

journal_title：Toxicology

authors： Demoly P

更新日期：2005-04-15 00:00:00

abstract：:Renal markers were investigated over 96 h in male Sprague-Dawley rats after i.v. administration of 10.7 mg kg(-1) of digoxin-specific Fab fragments (DSFab). The dose was calculated by an allometric equation as equivalent to a high clinical dose. DSFab both alone and pre-incubated with digoxin were tested. None of the ...

journal_title：Toxicology

authors： Advenier E,Mouajjah S,Bazin-Redureau M,Launay JM,Scherrmann JM

更新日期：1998-04-03 00:00:00

abstract：:Hyperbilirubinemia is one of the most common clinical phenomena observed in human newborns. To achieve effective therapeutic treatment, numerous studies have been done to determine the molecular mechanisms of bilirubin-induced neuronal excitotoxicity. However, there is no conclusive evidence for the involvement of glu...

journal_title：Toxicology

authors： Li CY,Shi HB,Song NY,Yin SK

更新日期：2011-06-18 00:00:00

abstract：:The effects of monosodium L-glutamate (MSG) on the brain of mice were examined by light-microscopy under the intended conditions of use of this material. Basal diet containing 5, 10 or 15% w/w MSG was fed to pregnant, lactating and weanling mice ad libitum, resulting in the ingestion of 14.0, 42.8 or 42.0 g/kg body wt...

journal_title：Toxicology

authors： Takasaki Y

更新日期：1978-04-01 00:00:00

abstract：:Catecholamines are stress hormones and sympathetic neurotransmitters essential for control of cardiac function and metabolism. However, pathologically increased catecholamine levels may be cardiotoxic by mechanism that includes iron-catalyzed formation of reactive oxygen species. In this study, five iron chelators use...

journal_title：Toxicology

authors： Hašková P,Koubková L,Vávrová A,Macková E,Hrušková K,Kovaříková P,Vávrová K,Simůnek T

更新日期：2011-11-18 00:00:00

abstract：:Repeated intraperitoneal administration of benzene (1.0 ml/kg body wt) for 3 days produced leucopenia, lymphocytopenia and an increased number of nucleated cells in the bone marrow and significantly decreased organ weights of thymus (P less than 0.001) and spleen (P less than 0.001) in female albino rats. Iron content...

journal_title：Toxicology

authors： Pandya KP,Shanker R,Gupta A,Khan WA,Ray PK

更新日期：1986-06-01 00:00:00

abstract：:Carbon monoxide (CO) is a dangerous exogenous poison and an essential endogenous neurotransmitter. This gas when inhaled has an anaesthetic effect, which is poorly understood, but which may be fatal if compensatory mechanisms are exhausted, if cardiac oxygen (O(2)) needs exceed myocardial oxygenation and/or if apnoea ...

journal_title：Toxicology

authors： Gorman D,Drewry A,Huang YL,Sames C

更新日期：2003-05-01 00:00:00

abstract：:Both 4,4'-dichlorobiphenyl (4,4'-DCB) and 3-methylcholanthrene (3-MC) caused a substantial increase of phenacetin-induced hepatic glutathione (GSH) depletion, whereas phenobarbital (PB) had no effect, suggesting that 4,4'-DCB possesses cytochrome P-448 inducing activity. The O-deethylation of phenacetin by liver micro...

journal_title：Toxicology

authors： van Bree L,Redegeld FA,de Vries J

更新日期：1986-12-15 00:00:00

abstract：:Treatment of Chinese hamster cells with 1 mM tertiary-butylhydroperoxide (t-BuOOH) for 1 h markedly inhibited the activity of glutathione peroxidase (GSH-Px). However, the activity returned to pre-inhibition levels within 1-2 h with post-treatment incubation. The inhibition of the activity of GSH-Px by t-BuOOH was enh...

journal_title：Toxicology

authors： Ochi T

更新日期：1992-01-01 00:00:00

abstract：:Synthetic pyrethroids are used as insecticides in agriculture and a variety of household applications worldwide. Pyrethroids are widely distributed in all environmental compartments and the general populations are exposed to pyrethroids through various routes. Pyrethroids have been identified as endocrine-disrupting c...

journal_title：Toxicology

authors： Wang Q,Shen JY,Zhang R,Hong JW,Li Z,Ding Z,Wang HX,Zhang JP,Zhang MR,Xu LC

更新日期：2020-05-30 00:00:00

abstract：:In an attempt to assess the effect of ethanol on cadmium accumulation, metallothionein (MT) synthesis, Cd-binding capacity and lipid peroxidation, rats were administered either Cd, ethanol or their combination for a period of 4 weeks. A significant increase in Cd accumulation was observed in all the organs of rats und...

journal_title：Toxicology

authors： Sharma G,Nath R,Gill KD

更新日期：1992-01-01 00:00:00

abstract：:Clarification of the key regulatory steps that lead to nuclear factor-kappa B (NF-kappaB) under cellular and pathological conditions is very important. The action of p38 mitogen-activated protein kinase (MAPK) on the upstream of NF-kappaB activation remains controversial. To examine this issue using an in vivo lung in...

journal_title：Toxicology

authors： Kim HJ,Lee HS,Chong YH,Kang JL

更新日期：2006-08-01 00:00:00

abstract：:Several mechanisms are postulated to be responsible for nephrotoxic and nephrocarcinogenic activities of mycotoxin and food contaminant, ochratoxin A (OTA). Although Nrf2 transcription factor was suggested to be involved in OTA-mediated renal injury, comprehensive study evaluating the effect of OTA toxicity in Nrf2 kn...

journal_title：Toxicology

authors： Loboda A,Stachurska A,Sobczak M,Podkalicka P,Mucha O,Jozkowicz A,Dulak J

更新日期：2017-08-15 00:00:00

abstract：:Exposure to low-dose benzene may lead to hematotoxicity and cause health problems. Though peripheral blood cell count is widely used in benzene exposure assessment and health risk assessment, the reports regarding the effects of low-dose benzene exposure on blood cell count remain inconsistent. To uncover more sensiti...

journal_title：Toxicology

authors： Liang B,Zhong Y,Chen K,Zeng L,Li G,Zheng J,Jiang L,Xie Z,Que B,Lai G,Wu B,Yang X,Wu J,Xiao Y,Chen W,Huang Z

更新日期：2018-12-01 00:00:00

abstract：:The effects of 2,2,2-trichloro-1-(3,4-dichlorophenyl)ethyl acetate (Penfenate) on hepatic, renal and small intestinal drug-metabolizing enzyme activities, hepatic reduced glutathione content and urinary excretion of thioethers were studied in the rat. A single i.p. dose of Penfenate (500 mg/kg) decreased the body weig...

journal_title：Toxicology

authors： Mäntylä E,Ahotupa M,Hietanen E,Vainio H

更新日期：1983-07-01 00:00:00

abstract：:Recently, a large-scale field study in The Netherlands has focused on the effects of estrogenic contaminants on feral fish populations. The freshwater bream (Abramis brama) and the estuarine flounder (Platichthys flesus) were sampled at a large number of locations in the spring and autumn of 1999. Concentrations of th...

journal_title：Toxicology

authors： Vethaak AD,Lahr J,Kuiper RV,Grinwis GC,Rankouhi TR,Giesy JP,Gerritsen A

更新日期：2002-12-27 00:00:00

abstract：:Aluminum (Al) is recognized worldwide as serious inorganic contaminants. Exposure to Al is associated with low BMD and an increased risk of osteoporosis. However, the precise molecular mechanisms remains unclear. Thus, in this study, rats were orally exposed to 0 (control group, CG) and 0.4g/L AlCl3 (AlCl3 treated gro...

journal_title：Toxicology

authors： Sun X,Liu J,Zhuang C,Yang X,Han Y,Shao B,Song M,Li Y,Zhu Y

更新日期：2016-09-14 00:00:00

abstract：:Mitochondria are cellular powerhouses as well as metabolic and signaling hubs regulating diverse cellular functions, from basic physiology to phenotypic fate determination. It is widely accepted that reactive oxygen species (ROS) generated in mitochondria participate in the regulation of cellular signaling, and that s...

journal_title：Toxicology

authors： Blajszczak C,Bonini MG

更新日期：2017-11-01 00:00:00

abstract：:Butylated hydroxytoluene (BHT)-induced lung damage in mice is an excellent model system for studying mechanisms of chemically-induced, reversible alveolar injury. Changes in the pulmonary contents of protein kinase C (PKC) and the calcium-dependent protease, calpain, were previously noted during the repair phase follo...

journal_title：Toxicology

authors： Miller AC,Dwyer-Nield LD,Malkinson AM

更新日期：1995-03-31 00:00:00