Effect of ethanol on the distribution of cadmium between the cadmium metallothionein- and non-metallothionein-bound cadmium pools in cadmium-exposed rats.

abstract：:Fusarenon-X (FX), a trichothecene mycotoxin, is well known to be cytotoxic to mammalian cells. Our previous study revealed that FX induced apoptosis in mouse thymocytes both in vivo and in vitro. We investigated the mode of apoptosis induced by FX using HL-60 cell culture. When FX at a final concentration of 0.5 micro...

journal_title：Toxicology

authors： Miura K,Aminova L,Murayama Y

更新日期：2002-03-20 00:00:00

abstract：:The promoting effects of a combined exposure to two pollutants (NO2, O3 or H2SO4-aerosol) at near ambient levels on lung tumorigenesis induced by N-bis(2-hydroxypropyl) nitrosamine (BHPN) were investigated in male Wistar rats. The rats were given a single intraperitoneal injection of BHPN (0.5 g per kg body wt.) at 6 ...

journal_title：Toxicology

authors： Ichinose T,Sagai M

更新日期：1992-09-01 00:00:00

abstract：:Asthma, which is primarily an allergic type of respiratory disease, has increased in the U.S. and Europe by 30% over the last decade. Air pollution may play a role in this rise, since during episodes of smog, hospital admissions due to asthma increase. Ambient air quality has generally improved since the Clean Air Act...

journal_title：Toxicology

authors： Gilmour MI

更新日期：1995-12-28 00:00:00

abstract：:The cytotoxicity and cardiotoxicity of benzoyl mustard (FCE 24517) and epoxamido (FCE 24561) synthetic derivatives of distamycin A were reported in the present study. The 50% inhibiting concentration (IC50) of colony formation of FCE 24517 on human SNB-19 glioblastoma, A2780 ovarian cancer and DU 145 prostate cancer w...

journal_title：Toxicology

authors： Agen C,Sironi AM,Danesi R,Costa M,Bernardini N,Paparelli A,Della Torre P,Del Tacca M

更新日期：1992-11-15 00:00:00

abstract：:The immunohistochemical localization of G alpha q/G alpha 11 was studied in the olfactory neuroepithelium of the channel catfish. Antigenicity in the rosette was found at the apical surfaces of cells, within the apical neck regions of some cells, and within the area of the basal nerve tracts. Specific labeling was eli...

journal_title：Toxicology

authors： Andreini I,DellaCorte C,Johnson LC,Hughes S,Kalinoski DL

更新日期：1997-02-28 00:00:00

abstract：:A clonal cell line, R40F, was selected from a heterogenous population of Cd2+ and Zn2+-resistant CHO-K1 cells. These R40F cells demonstrated resistance to 120- and 4-fold higher concentrations of Cd2+ and Zn2+, respectively, than did wild type CHO-K1 cells. When cultured in the presence of low concentrations of Cd2+ (...

journal_title：Toxicology

authors： Gick GG,McCarty KS Sr

更新日期：1983-03-01 00:00:00

abstract：:We provide an overview of the functional interrelationship between genes and proteins related to DNA repair by homologous recombination and cell cycle regulation in relation to the progression and therapy resistance of human tumours. To ensure the high-fidelity transmission of genetic information from one generation t...

journal_title：Toxicology

authors： Henning W,Stürzbecher HW

更新日期：2003-11-15 00:00:00

abstract：:Amiodarone is a class III anti-arrhythmic compound that is iodinated, cationic and amphiphilic in nature. The clinical use of amiodarone may be associated with various side-effects, including pulmonary and hepatic toxicity. Use of this compound during pregnancy may therefore place the fetus at risk through in utero ex...

journal_title：Toxicology

authors： Hill DA,Reasor MJ

更新日期：1991-01-01 00:00:00

abstract：:The spectrum of the anti-apoptotic potential of heparin is currently under scrutiny in various tissues and under various pathological situations. In this study, the role of a low-molecular-weight heparin derivative (LMWH), certoparin in adriamycin-induced oxidative DNA damage has been evaluated in the cardiac and rena...

journal_title：Toxicology

authors： Deepa PR,Varalakshmi P

更新日期：2006-01-16 00:00:00

abstract：:Catecholamines are stress hormones and sympathetic neurotransmitters essential for control of cardiac function and metabolism. However, pathologically increased catecholamine levels may be cardiotoxic by mechanism that includes iron-catalyzed formation of reactive oxygen species. In this study, five iron chelators use...

journal_title：Toxicology

authors： Hašková P,Koubková L,Vávrová A,Macková E,Hrušková K,Kovaříková P,Vávrová K,Simůnek T

更新日期：2011-11-18 00:00:00

abstract：:In the present study, we investigated the inducibility of the drug conjugate transporter genes MRP1 and MRP2 by redox-active compounds such as tertiary butylated hydroquinone (tBHQ) and quercetin and by chemicals known to activate the pregnane X receptor (PXR) such as rifampicin and clotrimazol and by the metalloid co...

journal_title：Toxicology

authors： Kauffmann HM,Pfannschmidt S,Zöller H,Benz A,Vorderstemann B,Webster JI,Schrenk D

更新日期：2002-02-28 00:00:00

abstract：:The tissue uptake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during infection was studied in a mouse model using the common human virus Coxsackievirus B3 (CB3), adapted here to the mouse. Male A/J-mice were infected with the CB3 virus and subsequently, on days 4 and 7 of the infection, injected with 0.5 microCi [14...

journal_title：Toxicology

authors： Funseth E,Ilbäck NG

更新日期：1994-05-31 00:00:00

abstract：:To investigate the biological effects of terbium (Tb), male mice were intraperitoneally administered with TbCl3 at doses of 10, 50, or 250 mg Tb/kg. The Tb distribution in organs was determined after 18-20 h of injection by using a spectrofluorometer. The concentrations of Ca, Mg, Fe, and Zn in various organs were det...

journal_title：Toxicology

authors： Shinohara A,Chiba M

更新日期：1991-02-11 00:00:00

abstract：:Stannous chloride (SnCl2) is a reducing chemical agent used in several man-made products. SnCl2 can generate reactive oxygen species (ROS). Therefore, the present study has been carried out to investigate the antioxidant action of l-ascorbic acid (AA) in minimizing SnCl2 toxicity on lipid peroxidation, antioxidant enz...

journal_title：Toxicology

authors： Yousef MI,Awad TI,Elhag FA,Khaled FA

更新日期：2007-06-25 00:00:00

abstract：:Heavy metals, such as iron and manganese, are involved in neurologic disease. Most often these diseases are associated with abnormal environmental exposures or abnormal accumulations of heavy metals in the body. There is increasing recognition that heavy metals normally present in the body also may play a role in dise...

journal_title：Toxicology

authors： Montgomery EB Jr

更新日期：1995-03-31 00:00:00

abstract：:The intravenous LD50 of cefuroxime sodium for mice was 10.4 g/kg. The maximum dosage administered in other acute toxicity tests was well tolerated by mice (10 g/kg, subcutaneous), by rats (4 g/kg, intravenous, 5 g/kg, subcutaneous) and by cats, dogs and monkeys (2 g/kg, intramuscularly). Cefuroxime sodium was administ...

journal_title：Toxicology

authors： Capel-Edwards K,Atkinson RM,Pratt DA

更新日期：1979-05-01 00:00:00

abstract：:Aniline and its halogenated derivatives are widely used as chemical intermediates. The purpose of this study was to determine the hepatotoxic and nephrotoxic potential of the 2-haloanilines. Male Fischer 344 rats (n > or = 4) were injected (i.p.) with 1.0 or 1.25 mmol/kg of: aniline (A), 2-fluoroaniline (2-FA), 2-chlo...

journal_title：Toxicology

authors： Valentovic MA,Ball JG,Anestis DK,Beers KW,Madan E,Hubbard JL,Rankin GO

更新日期：1992-11-01 00:00:00

abstract：:Groups of 15 male and 15 female rats were give 0 (control), 50, 100, 200 or 800 ppm allyl alcohol in the drinking water for 15 weeks. There were no effects attributable to allyl alcohol in the results of the haematological examinations or analyses of serum. There was a dose-related reduction in the fluid intake at all...

journal_title：Toxicology

authors： Carpanini FM,Gaunt IF,Hardy J,Gangolli SD,Butterworth KR,Lloyd AG

更新日期：1978-02-01 00:00:00

abstract：:The chlorinated acetic acids, in particular dichloroacetic acid (DCA), are found as chlorine disinfection by-products in finished drinking water supplies. DCA has previously been demonstrated to be a mouse liver carcinogen. Chronic studies are described in which male Fischer (F344) rats were exposed to DCA in their dr...

journal_title：Toxicology

authors： DeAngelo AB,Daniel FB,Most BM,Olson GR

更新日期：1996-12-18 00:00:00

abstract：:The majority of human P450-dependent xenobiotic metabolism is carried out by polymorphic enzymes which can cause abolished, quantitatively or qualitatively altered or enhanced metabolism. The latter situation is due to stable duplication, multiduplication or amplification of active genes, most likely in response to di...

journal_title：Toxicology

authors： Ingelman-Sundberg M

更新日期：2002-12-27 00:00:00

abstract：:The ubiquitous presence of nanoparticles (NPs) together with increasing evidence linking them to negative health effects points towards the need to develop the understanding of mechanisms by which they exert toxic effects. This study was designed to investigate the role of surface area and oxidative stress in the cell...

journal_title：Toxicology

authors： Hussain S,Boland S,Baeza-Squiban A,Hamel R,Thomassen LC,Martens JA,Billon-Galland MA,Fleury-Feith J,Moisan F,Pairon JC,Marano F

更新日期：2009-06-16 00:00:00

abstract：:T-2 toxin belongs to the large group of trichothecene mycotoxins synthesized by various Fusarium molds which can infect raw agriculture materials. Among the trichothecenes, T-2 toxin is one of the most potent mycotoxins and poses a potential health risk in human nutrition. Several acute and chronic toxic effects were ...

journal_title：Toxicology

authors： Königs M,Mulac D,Schwerdt G,Gekle M,Humpf HU

更新日期：2009-04-28 00:00:00

abstract：:The induction of unscheduled DNA synthesis (UDS) in early spermatid stages of mice was studied after treatment with hydrazine or procarbazine (Natulan). The UDS response was assayed by measuring the levels of [3H]dThd in the nuclei of sperm cells derived from treated and untreated early spermatid stages. The radioacti...

journal_title：Toxicology

authors： Sotomayor RE,Chauhan PS,Ehling UH

更新日期：1982-01-01 00:00:00

abstract：:Gambogic acid (GA), a major active component of gamboge, exhibits potent anticancer activity in many kinds of cancer cells. However, the anticancer mechanism of GA is not clearly understood. Here we showed that GA could cause growth inhibition, induce the G0/G1 phase cell cycle arrest and apoptosis in human chronic my...

journal_title：Toxicology

authors： Li R,Chen Y,Zeng LL,Shu WX,Zhao F,Wen L,Liu Y

更新日期：2009-08-03 00:00:00

abstract：:In a Japanese chemical factory, a lung disease like pneumoconiosis appeared at a high rate among workers handling cross-linked water-soluble acrylic acid polymer (CWAAP). To our knowledge, no such case was known in the world until very recently. The present study was designed to elucidate the effect of single intratra...

journal_title：Toxicology

authors： Suka M,Kido T,Yoshioka W,Hachisuka E,Okoshi H,Yamauchi T,Hano H,Okano T,Yokoyama M,Yanagisawa H

更新日期：2021-01-30 00:00:00

abstract：:Testicular injury is often observed in drug development. Serum hormones are usually used as noninvasive biomarkers for testicular injury; however, their sensitivities are low. Therefore, it is difficult to monitor testicular injury in drug development. In recent years, molecules in body fluid exosomes have attracted a...

journal_title：Toxicology

authors： Kawata R,Kagawa T,Koya Y,Kajiyama H,Oda S,Yokoi T

更新日期：2020-07-01 00:00:00

abstract：:Heavy metal neurotoxicity is one of the major challenges in today's era due to the large scale and widespread mechanisation of the production. However, the causative factors responsible for neurotoxicity are neither known nor do we have the availability of therapeutic approaches to deal with it. One of the major causa...

journal_title：Toxicology

authors： Namgyal D,Ali S,Mehta R,Sarwat M

更新日期：2020-09-01 00:00:00

abstract：:Little is known about the potential toxicity of polybrominated diphenyl ethers (PBDEs) on hepatic and renal tissues. In this study, we investigated the modifications in endogenous antioxidant capacity and oxidative damage in liver and kidney of rats by exposure to one of the most persistent PBDE congeners, the 2,2',4,...

journal_title：Toxicology

authors： Albina ML,Alonso V,Linares V,Bellés M,Sirvent JJ,Domingo JL,Sánchez DJ

更新日期：2010-04-30 00:00:00

abstract：:Although manufactured magnetic nanoparticles (NPs) are currently used in many fields, NPs have potential toxicity on cardiovascular system especially atherosclerosis. In our previous study, we prepared novel Fe3O4 nanoparticles surface-coated with aminoguanidine (Fe3O4-AG NPs) which could remove acid dyes from aqueous...

journal_title：Toxicology

authors： Qu G,Wu Q,Zhao B,Miao J,Su L

更新日期：2019-05-01 00:00:00

abstract：:During the past decade, several assessments have estimated the carcinogenic risk of inhaled 1,3-butadiene (BD) to the general population as well as for occupational exposures. Although most of the risk assessments have been based on inhalation bioassays in mice, some of the assessments have included the 2-year inhalat...

journal_title：Toxicology

authors： Cagen SZ,MacDonald RL,Van Gelder G

更新日期：1996-10-28 00:00:00