Abstract:
:To investigate the biological effects of terbium (Tb), male mice were intraperitoneally administered with TbCl3 at doses of 10, 50, or 250 mg Tb/kg. The Tb distribution in organs was determined after 18-20 h of injection by using a spectrofluorometer. The concentrations of Ca, Mg, Fe, and Zn in various organs were determined by atomic absorption spectrometer. Tb administered was mainly found in pancreas, seminal vesicles, spleen, liver, and testes. In each organ. Tb concentration increased according to the dosage of Tb. Contrary to our expectation, the increase of Ca concentration was obvious in organs in which high Tb concentrations were found. The correlation coefficients between Tb and Ca concentrations were from 0.863 in spleen to 0.986 in liver. In heart, lung, and blood. Tb was scarcely detected and insignificant change of Ca concentrations was observed. This result suggests that Tb induces increased Ca concentrations in organs.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Shinohara A,Chiba Mdoi
10.1016/0300-483x(91)90181-ysubject
Has Abstractpub_date
1991-02-11 00:00:00pages
93-103issue
1eissn
0300-483Xissn
1879-3185pii
0300-483X(91)90181-Yjournal_volume
66pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::The ability of cis-dichlorodiammine platinum II to cause chromosomal aberrations in rats and dominant lethality in mice was studied. Five daily intraperitoneal doses ranging from 0.25 to 2.00 mg/kg/day failed to result in the observance of dominant lethal mutations in mice. Intraperitoneal doses of 0.13 and 0.52 mg/kg...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(80)90027-x
更新日期:1980-01-01 00:00:00
abstract::p-Chloro-m-cresol (PCMC) and p-chloro-m-xylenol (PCMX) are known to cause allergic contact dermatitis. For risk assessment of skin sensitizers, information on dose-response profiles in the induction and elicitation phases and cross-reactivity with analogous chemicals are important. In the non-radioactive local lymph-n...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(03)00161-6
更新日期:2003-08-28 00:00:00
abstract::Trichloroacetic acid (TCA) is a common drinking water disinfection byproduct that produces a spectrum of liver effects, including hepatomegaly and liver tumors, in mice. It is also an oxidative metabolite of trichloroethylene (TCE), a solvent used in degreasing with widespread environmental exposure, which also produc...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.04.009
更新日期:2011-07-29 00:00:00
abstract::The toxicity of daily subcutaneously applied 500 mg/kg N-methylformamide (NMF) during a period of 8 days in female CD-mice was ameliorated when 100 mg/kg sodium ascorbate, 60 mg/kg menadione bisulfite or 80 mg/kg pyridoxal hydrochloride were applied simultaneously. The comparison of the daily s.c. application of 360 m...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90008-4
更新日期:1987-02-01 00:00:00
abstract::In the rat the hepatotoxicity of bromobenzene is greatly enhanced by the introduction of a cyano group adjacent to the bromine (i.e. o-bromobenzonitrile). Epoxide metabolites of these aryl halides are believed to be the actual toxic species, but epoxides of the latter compound also possess a second site of chemical re...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(84)90106-9
更新日期:1984-06-01 00:00:00
abstract:UNLABELLED:We recently observed a case of digoxin and insulin self-poisoning without cardiac repercussion. We raised the hypothesis that insulin may have a cardio-protective effect in case of digoxin toxicity. We have therefore evaluated the effect of glucose-insulin infusion on mortality and ECG abnormalities during a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.04.035
更新日期:2006-07-25 00:00:00
abstract::The possibility that Cd administration could activate the pituitary-adrenal axis has been studied. It was found that acute administration of Cd strongly increased serum corticosterone levels. Adrenocortical activation correlated well with serum Cd levels, suggesting that adrenal activation was dependent on the presenc...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90119-3
更新日期:1987-07-01 00:00:00
abstract::Arsenic and cadmium are both priority hazardous substances and human carcinogens. Although there is the potential for simultaneous exposure to both metals, the interactions of cadmium and arsenic are not well defined. We examined the toxicity of these metals when given alone or in alternating sequence to adult male Fi...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(96)03536-6
更新日期:1997-01-15 00:00:00
abstract::The pharmacokinetics of selected aluminum-hydroxypyridinone (Al-HP complexes were determined in rats to better understand the relationship between their disposition and elimination parameters and the safety of HPs in the chelation therapy of Al intoxication. Five complexes were administered as i.v. bolus doses of Al-H...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)90177-5
更新日期:1994-09-06 00:00:00
abstract::The action of various manganese organic compounds, which are structural analogs of methylcyclopentadienyl manganese tricarbonyl (MMT), was investigated. Only the cyclopentadienyl manganese tricarbonyl compounds are effective inhibitors of mitochondrial respiration, but only when associated with NAD+-linked substrates....
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(77)90001-4
更新日期:1977-10-01 00:00:00
abstract::Nowadays, very little information concerning the effects on behavior in mammals of perfluorooctane sulfonate (PFOS), a widely distributed persistent environmental pollutant, is available. In the present study, we assessed the behavioral effects of PFOS on 3 months old mice after 1 month of exposure to this pollutant. ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.09.012
更新日期:2007-12-05 00:00:00
abstract::The influence of the insertion of a liver into the perfusion circuit of a lung on the availability of benzo[a]pyrene and benzo[a]pyrene metabolites to the lung was examined. Perfused lungs from 5,6-benzoflavone pretreated rats release high quantities of free benzo[a]pyrene metabolites and conjugates into the perfusion...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90100-4
更新日期:1987-08-01 00:00:00
abstract::The mechanism underlying the induction of micronuclei induced by rifampicin and nicotine in mouse bone marrow was investigated by fluorescence in situ hybridization assay using mouse minor satellite DNA probe. Colchicine and mitomycin, known to be predominantly clastogenic and aneugenic, respectively were used as posi...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.03.011
更新日期:2007-06-03 00:00:00
abstract::Groups of 15 male and 15 female rats were give 0 (control), 50, 100, 200 or 800 ppm allyl alcohol in the drinking water for 15 weeks. There were no effects attributable to allyl alcohol in the results of the haematological examinations or analyses of serum. There was a dose-related reduction in the fluid intake at all...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(78)90029-x
更新日期:1978-02-01 00:00:00
abstract::Transgenic rat mutation assays can be used to assess genotoxic properties of chemicals in target organs for carcinogenicity. Mutations in transgenes are genetically neutral and accumulate during a treatment period; thus, assays are suitable for assessing the genotoxic risk of chemicals using a repeated-dose treatment ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2014.07.003
更新日期:2014-10-03 00:00:00
abstract::In the present study, we demonstrated the cytotoxic effect of a dimethylarsenic compound in seaweed, (R)-(2',3'-dihydroxypropyl) 5- deoxy-5-dimethylarsinoyl-beta-D-riboside, namely arsenosugar (AsSug), on mammalian cells, murine macrophages, in comparison with that of an inorganic arsenical, arsenite, in vitro. More t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00101-7
更新日期:1997-10-19 00:00:00
abstract::The usefulness of cDNA-directed expression of human hepatic P450s in yeast for the in vitro study of drug metabolism is emphasized. The major advantages of yeast expression are: (i) relatively high yields of heterologous P450 (approximately 5-10 nmol/l of culture medium) can be obtained; (ii) the expressed P450s are d...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(93)90058-z
更新日期:1993-10-05 00:00:00
abstract::The carcinogenic response of NZO/BlGd inbred mice of both sexes to oral N-nitrosohexamethyleneimine (NHEX) was investigated at 2 differing dose rates, but equal cumulative doses. Mice received 52 mg NHEX (2 mg/g body wt) in drinking water over either an 8-week period (200 mg/l) or a 32-week period (50 mg/l), and were ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(84)90042-8
更新日期:1984-12-01 00:00:00
abstract::We have investigated in the current study, the possible modulatory effects of dexamethasone on cisplatin cytotoxicity in Ehrlich ascites carcinoma (EAC)-bearing female Swiss albino mice. Cisplatin (3.5mg/kg) was injected IP for 3 consecutive days in mice previously inoculated SC with EAC cells in the right flank. Dexa...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.02.007
更新日期:2006-05-01 00:00:00
abstract::Glutathione S-transferases and glutathione play an important role in the detoxification of most toxic agents. In the present study, the protective effects of some antioxidants (L-ascorbic acid (AA), vitamin E (VE) or garlic) on carbon tetrachloride-induced changes in the activity of alanine amino transferase (ALT), as...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(01)00429-2
更新日期:2001-08-28 00:00:00
abstract::Challenges to improve toxicological risk assessment to meet the demands of the EU chemical's legislation, REACH, and the EU 7th Amendment of the Cosmetics Directive have accelerated the development of non-animal based methods. Unfortunately, uncertainties remain surrounding the power of alternative methods such as in ...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2013.08.012
更新日期:2015-06-05 00:00:00
abstract::T-2 toxin belongs to the large group of trichothecene mycotoxins synthesized by various Fusarium molds which can infect raw agriculture materials. Among the trichothecenes, T-2 toxin is one of the most potent mycotoxins and poses a potential health risk in human nutrition. Several acute and chronic toxic effects were ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.01.012
更新日期:2009-04-28 00:00:00
abstract::Subcutaneous administration of methyl isocyanate (MIC) in 0.5 LD50 and 1 LD50 doses in female rabbits resulted in significant changes in physiological, clinico-chemical and histological parameters. There was a fall in arterial blood pressure and cardioacceleration in both the 0.5 LD50 and 1 LD50 groups, while the resp...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(88)90152-7
更新日期:1988-10-01 00:00:00
abstract::Hesperidin (HDN) is a flavanone glycoside abundantly found in citrus fruits. HDN has been reported to possess significant activities against allergy, haemorrhoids, hormonal disorders and ulcers. Other reported activities include anti-inflammatory, analgesic, antibacterial, antifungal, antiviral, antioxidant and free r...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.06.018
更新日期:2006-09-21 00:00:00
abstract::The present study was designed to examine more fully the neurochemical and behavioral interactions that derive from continued lead and cadmium poisoning in pups, whose mothers were exposed via drinking water (300 mg/l of Pb and 10 mg/l of Cd) throughout pregnancy and lactation. At weaning, these metals produced an inc...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00137-3
更新日期:2002-07-01 00:00:00
abstract::Male and female B6C3F1 mice were administered dichloroacetate (DCA) and trichloroacetate (TCA) in their drinking water at concentrations of 1 or 2 g/l for up to 52 weeks. Both compounds induced hepatoproliferative lesions (HPL) in male mice, including hepatocellular nodules, adenomas and hepatocellular carcinomas with...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90195-m
更新日期:1990-09-01 00:00:00
abstract::We recently reported that Delta(9)-tetrahydrocannabinol (Delta(9)-THC) has the ability to stimulate the proliferation of human breast carcinoma MCF-7 cells. However, the mechanism of action remains to be clarified. The present study focused on the relationship between receptor expression and the effects of Delta(9)-TH...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.12.019
更新日期:2008-03-12 00:00:00
abstract::Molybdenum trioxide (MoO3) nanoparticles (NPs) embedded in polymer films have been proposed as a cheap way of producing antibacterial coatings on external surfaces. Recently, we synthesized MoO3 nanowires in a unique shape and degree of anisotropy, which enables their fast water dissolution and quick antimicrobial rea...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152564
更新日期:2020-11-01 00:00:00
abstract::The bioavailability of coplanar 2,3',4,4',5-pentachlorobiphenyl (PCB118) and nonplanar 2,2',5,5'-tetrachlorobiphenyl (PCB52) from soils representing a range in organic carbon (OC), clay content and pH were investigated using an in vivo rat model and an in vitro physiologically based extraction test (PBET) to assess th...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.08.012
更新日期:2006-01-05 00:00:00
abstract::Hexavalent chromium [Cr(VI)] compounds (e.g. chromates) are strong oxidants that readily enter cells where they are reduced to reactive Cr intermediates that can directly oxidize some cell components and can promote the generation of reactive oxygen and nitrogen species. Inhalation is a major route of exposure which d...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.01.001
更新日期:2011-03-15 00:00:00