Acute toxicity of methyl isocyanate, administered subcutaneously in rabbits: changes in physiological, clinico-chemical and histological parameters.

abstract：:Several dicationic amphiphilic compounds, such as the immunomodulator tilorone and analogues, impair the lysosomal catabolism of sulphated glycosaminoglycans (GAGs). Thereby they cause lysosomal GAG storage in rats and in cultured fibroblasts of several species including man. The GAG storage is rather slowly reversibl...

journal_title：Toxicology

authors： Bispinck F,Fischer J,Lüllmann-Rauch R,von Witzendorff B

更新日期：1998-07-03 00:00:00

abstract：:Thiols are known to influence the metabolism of glutathione. In a previous study (Toxicology 156 (2001) 93) dithiothreitol (DTT) did not show any effect on intra- or extracellular glutathione concentrations in HeLa cell cultures but increased the effects of mercury ions on glutathione concentrations, whereas monothiol...

journal_title：Toxicology

authors： Hultberg B,Andersson A,Isaksson A

更新日期：2002-06-14 00:00:00

abstract：:Long-term exposure to pharmacological agents can select for cells that overexpress efflux transporters. We previously showed that mouse J774 macrophages cultivated for a prolonged period of time with toxic concentrations of the fluoroquinolone ciprofloxacin overexpress the efflux transporter Mrp4 and display a reduced...

journal_title：Toxicology

authors： Vallet CM,Marquez B,Nhiri N,Anantharajah A,Mingeot-Leclercq MP,Tulkens PM,Lallemand JY,Jacquet E,Van Bambeke F

更新日期：2011-12-18 00:00:00

abstract：:The two major mammalian metabolites of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), namely 2-hydroxy-3,7,8-trichlorodibenzo-p-dioxin and 2-hydroxy-1,3,7,8-tetrachlorodibenzo-p-dioxin, have been synthesized. The compounds were individually administered to immature male Wistar rats and their effects on body weight loss, ...

journal_title：Toxicology

authors： Mason G,Safe S

更新日期：1986-10-01 00:00:00

abstract：:The anticonvulsant, valproic acid (VPA) is a suspected human teratogen. This study, employing the rhesus monkey as an animal model, demonstrates that VPA has a significant teratogenic potential in the monkey. Timed pregnant monkeys were exposed orally to VPA at approx. 1X, 10X, and 30X (20, 200, and 600 mg/kg/day, res...

journal_title：Toxicology

authors： Mast TJ,Cukierski MA,Nau H,Hendrickx AG

更新日期：1986-05-01 00:00:00

abstract：:Effects of methylmercury on the cell growth of mouse glioma in vitro were studied in relation to the microtubules as a possible target. The electron microscopic observation revealed that methylmercury added in culture medium specifically attacked microtubules in the cells at growth inhibitory concentration, while merc...

journal_title：Toxicology

authors： Imura N,Miura K,Inokawa M,Nakada S

更新日期：1980-01-01 00:00:00

abstract：:The effects of isoflurane, 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, on the oxidative metabolism of halothane to produce trifluoroacetic acid (TFA) and on the reductive metabolism of halothane to produce chlorodifluoroethylene (CDE) and chlorotrifluoroethane (CTE) in liver microsomes of guinea pig were exami...

journal_title：Toxicology

authors： Fujii K

更新日期：1995-12-15 00:00:00

abstract：:This paper presents an overview of issues related to surface water contamination arising from uranium mining activities in the Alligator Rivers Region (ARR) of northern Australia, and a program of research and monitoring that must assess the potential and actual effects on ecosystem and human health. The program of as...

journal_title：Toxicology

authors： van Dam RA,Humphrey CL,Martin P

更新日期：2002-12-27 00:00:00

abstract：:Rats were exposed to 1.5 +/- 0.1 mg ozone/m3 for 4 days and the activities of glucose-6-P dehydrogenase (G6PDH), glutathione reductase (GR) and glutathione peroxidase (GSHPx) were measured in the cytosolic fraction of lungs from exposed and control rats. Enzyme activities were also measured in isolated alveolar macrop...

journal_title：Toxicology

authors： Rietjens IM,Van Bree L,Marra M,Poelen MC,Rombout PJ,Alink GM

更新日期：1985-12-01 00:00:00

abstract：:The mechanism underlying the induction of micronuclei induced by rifampicin and nicotine in mouse bone marrow was investigated by fluorescence in situ hybridization assay using mouse minor satellite DNA probe. Colchicine and mitomycin, known to be predominantly clastogenic and aneugenic, respectively were used as posi...

journal_title：Toxicology

authors： Attia SM

更新日期：2007-06-03 00:00:00

abstract：:The nitric oxide (NO) donor, O(2)-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), is metabolized by P450 enzymes to release NO in the liver and possibly other tissues. V-PYRRO/NO has been shown to be hepatoprotective, but little is known about its effect in the kidney, another organ rich in P450s. Thus...

journal_title：Toxicology

authors： Li C,Liu J,Saavedra JE,Keefer LK,Waalkes MP

更新日期：2003-08-01 00:00:00

abstract：:In urban areas with a predominance of early to mid-20th century housing stock, islands of children possessing blood lead levels (PbB) in excess of CDC guidelines (>10μg/dL) exist. Many of these children are also exposed to environmental tobacco smoke (ETS). The current study examined the impact of Pb-exposure (PbB lev...

journal_title：Toxicology

authors： Lutz PM,Kelty EA,Brown TD,Wilson TJ,Brock G,Neal RE

更新日期：2012-01-27 00:00:00

abstract：:Recently, a large-scale field study in The Netherlands has focused on the effects of estrogenic contaminants on feral fish populations. The freshwater bream (Abramis brama) and the estuarine flounder (Platichthys flesus) were sampled at a large number of locations in the spring and autumn of 1999. Concentrations of th...

journal_title：Toxicology

authors： Vethaak AD,Lahr J,Kuiper RV,Grinwis GC,Rankouhi TR,Giesy JP,Gerritsen A

更新日期：2002-12-27 00:00:00

abstract：:The activity of the haem biosynthetic enzymes delta-aminolaevulinic acid synthetase (ALA.S) and delta-aminolaevulinic acid dehydratase (ALA.D) were measured in the peripheral blood of a group of lead workers and control subjects. The haem precursor delta-aminolaevulinic acid (ALA) was measured in blood and urine, whil...

journal_title：Toxicology

authors： Meredith PA,Moore MR,Campbell BC,Thompson GG,Goldberg A

更新日期：1978-02-01 00:00:00

abstract：:No clinical data are available on the acute cutaneous toxicity of spin traps which are frequently used in combination with the electron paramagnetic resonance (EPR) technique for detection of free radicals and reactive oxygen/nitrogen species. The purpose of this study was to evaluate the acute dermatotoxicity of the ...

journal_title：Toxicology

authors： Fuchs J,Groth N,Herrling T

更新日期：2000-10-26 00:00:00

abstract：:The effect of tert-butyl hydroperoxide (tBH) on the nucleotide level in isolated cardiomyocytes from adult rats was examined. Incubation of myocytes with the hydroperoxide resulted in loss of both ATP and NAD from mitochondria and cytosol. In contrast, only the cytosolic level of NADP was increased. The effect on myoc...

journal_title：Toxicology

authors： Andersson BS,Vidal RF,Sundberg M,Rajs J,Sótonyi P

更新日期：1996-01-08 00:00:00

abstract：:Isolated perfused rat kidneys were used to determine the contribution of filtration and tubular transport of cisplatin to its nephrotoxicity. Perfusion of kidneys with 0.5 mM cisplatin concomitantly reduced tubular reabsorption of electrolytes and glomerular filtration rate in a time-dependent manner. These renal func...

journal_title：Toxicology

authors： Miura K,Goldstein RS,Pasino DA,Hook JB

更新日期：1987-05-01 00:00:00

abstract：:Dioxins, including the most toxic congener, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), exert diverse biological effects in humans and animals. Host resistance, especially to virus infections, is considered one of the most sensitive targets of TCDD-toxicity, while a recent study showed that the vulnerability to TCDD o...

journal_title：Toxicology

authors： Nohara K,Izumi H,Tamura Si,Nagata R,Tohyama C

更新日期：2002-01-15 00:00:00

abstract：:Allylamine (3-aminopropene) is a specific cardiac toxicant that causes aortic, valvular and myocardial lesions in many species. Myocardial necrosis can be observed 24 h after a single dose. Acute toxicity is believed to involve metabolism of allylamine to highly reactive acrolein (2-propenal). Allylamine has been show...

journal_title：Toxicology

authors： Biagini RE,Toraason MA,Lynch DW,Winston GW

更新日期：1990-05-14 00:00:00

abstract：:Short term exposure of cultured chick ganglia nerve fibers and neuroglia to selenite produced half maximal inhibitory growth effects in concentrations of 6.2 (2.9--13.0) X 10(-5) M and 1.1 (0.7--1.7) X 10(-4) M, respectively. Complete inhibition of growth for both cell types was apparent at 1 X 10(-3) M, while slight ...

journal_title：Toxicology

authors： Obersteiner EJ,Sharma RP

更新日期：1978-02-01 00:00:00

abstract：:Carbendazim (MBC), the bioactive metabolite of the fungicide benomyl, has been reported to induce a number of testicular alterations in male rats. Since it is possible that extragonadal changes contribute to the appearance of such effects, the present study focused on the presence of concurrent endocrine changes in th...

journal_title：Toxicology

authors： Goldman JM,Rehnberg GL,Cooper RL,Gray LE Jr,Hein JF,McElroy WK

更新日期：1989-07-17 00:00:00

abstract：:The majority of insecticides currently in use throughout the world belong to the class of the organophosphorus insecticides. Many of these compounds, such as the phosphorothioate insecticides, exert their mammalian toxicity only after undergoing metabolic activation by a variety of cytochrome P450 isoforms to produce ...

journal_title：Toxicology

authors： Ramos S,Sultatos L

更新日期：1998-11-16 00:00:00

abstract：:Cadmium (Cd) is a heavy metal with a long biological half-life in humans and is recognized as a toxic pollutant. Cd is also a potential neurotoxicant and its exposure is associated with olfactory impairment in humans. However, the molecular and cellular mechanisms of Cd neurotoxicity are not well defined. Adult neurog...

journal_title：Toxicology

authors： Wang H,Engstrom AK,Xia Z

更新日期：2017-04-01 00:00:00

abstract：:Resistance to chemotherapy is a major obstacle for the effective treatment of cancers. The mechanism of chemo-resistance is still poorly understood, however, mounting evidence supports a role for microRNAs (miRNAs) in modulating key cellular pathways mediating response to chemotherapy. microRNA-21 (miR-21) has been im...

journal_title：Toxicology

authors： Yang SM,Huang C,Li XF,Yu MZ,He Y,Li J

更新日期：2013-04-05 00:00:00

abstract：:Exposure to heavy metals contributes to most of the unexplained male infertility. Lead (Pb) is a well- known heavy metal, which disrupt the male reproductive system. This study was conducted to investigate the therapeutic and protective effects of green tea active principle, epigallocatechin gallate (EGCG), on the lea...

journal_title：Toxicology

authors： Hassan E,Kahilo K,Kamal T,Hassan M,Saleh Elgawish M

更新日期：2019-06-15 00:00:00

abstract：:Several nitrocompounds have been screened for carcinogenicity in rodents, but this is a lengthy and expensive process, taking two years and typically costing 2.5 million dollars, and uses large numbers of animals. There is, therefore, much impetus to develop suitable alternative methods. One possible way of predicting...

journal_title：Toxicology

authors： Morales AH,Pérez MA,Combes RD,González MP

更新日期：2006-03-01 00:00:00

abstract：:Zearalenone (ZEN) is a non-steroidal oestrogenic mycotoxin produced by several Fusarium species growing on cereals. ZEN and its metabolites bind to human oestrogen receptors and hence display oestrogenic and anabolic properties. Several lines of investigation suggest that ZEN may be genotoxic in vivo. ZEN damages DNA ...

journal_title：Toxicology

authors： Abid-Essefi S,Baudrimont I,Hassen W,Ouanes Z,Mobio TA,Anane R,Creppy EE,Bacha H

更新日期：2003-11-05 00:00:00

abstract：:Cadmium, an environmental neurotoxic compound, produces cognitive disorders, although the mechanism remains unknown. Previously, we described that cadmium induces a more pronounced cell death on cholinergic neurons from basal forebrain (BF). This effect, partially mediated by M1 receptor blockade, triggering it throug...

journal_title：Toxicology

authors： Moyano P,de Frias M,Lobo M,Anadon MJ,Sola E,Pelayo A,Díaz MJ,Frejo MT,Del Pino J

更新日期：2018-02-01 00:00:00

abstract：:Lead exposure causes cognitive and behavioral deficits in some children. We have proposed that the effects of single nucleotide polymorphisms (SNP) of the human pseudodeficient arylsulfatase A (ARSA) gene that result in reduced levels of the enzyme, and lead concentrations that decrease ARSA activity, culminate in cel...

journal_title：Toxicology

authors： Chen XG,Poretz RD

更新日期：2001-06-21 00:00:00

abstract：:To investigate the toxic effect of terephthalic acid (TPA) on testicular functions of rats, male Sprague-Dawley rats were orally administered TPA in diet at the levels 0 (control), 0.2, 1 and 5% for 90 days. Testicular functions were assessed by histopathology, testicular sperm head counts, daily sperm production, spe...

journal_title：Toxicology

authors： Cui L,Dai G,Xu L,Wang S,Song L,Zhao R,Xiao H,Zhou J,Wang X

更新日期：2004-09-01 00:00:00