Abstract:
:The two major mammalian metabolites of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), namely 2-hydroxy-3,7,8-trichlorodibenzo-p-dioxin and 2-hydroxy-1,3,7,8-tetrachlorodibenzo-p-dioxin, have been synthesized. The compounds were individually administered to immature male Wistar rats and their effects on body weight loss, thymic atrophy, liver and spleen weights and their activities as inducers of hepatic microsomal benzo[a]pyrene hydroxylase, 4-chlorobiphenyl hydroxylase and ethoxyresorufin O-deethylase were determined using dose levels of 100, 1000 and 5000 micrograms/kg. The 2 metabolites did not affect organ or body weights after 14 days of exposure and only 2-hydroxy-3,7,8-trichlorodibenzo-p-dioxin was active as an inducer of the microsomal monooxygenases at dose levels of 1000 and 5000 micrograms/kg. A comparison of the relative enzyme induction activities of 2,3,7,8-TCDD and 2-hydroxy-3,7,8-trichlorodibenzo-p-dioxin indicates that the former compound was greater than 3 orders of magnitude more active than the metabolite.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Mason G,Safe Sdoi
10.1016/0300-483x(86)90196-4subject
Has Abstractpub_date
1986-10-01 00:00:00pages
153-9issue
2eissn
0300-483Xissn
1879-3185pii
0300-483X(86)90196-4journal_volume
41pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::The effects of thallous cation (Tl(+)) on: (a) the production of oxidant species and (b) membrane fluidity were evaluated in human leukemia T cells (Jurkat). After 72 h of incubation in the presence of Tl(+) (5-100 microM), no significant changes in cell viability were observed, although the average cell size was decr...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.01.028
更新日期:2006-05-01 00:00:00
abstract::The subacute inhalation toxicity of butenolide was examined in hamsters by repeated exposure of 4 groups of 10 males and 10 females to butenolide vapour at concentrations of 0, 5.4, 25 and 130 ppm respectively (6 h/day, 5 days/week) for a period of 13 weeks. The effects found at 130 ppm included eye irritation, saliva...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(79)90020-9
更新日期:1979-12-01 00:00:00
abstract::This study compares changes in cardiopulmonary function, selected endpoints in exhaled breath, blood, and bronchoalveolar lavage fluid (BAL) following a single, high-level 30-min nose-only exposure of rats to chlorine and phosgene gas. The time-course of lung injury was systematically examined up to 1-day post-exposur...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2014.10.010
更新日期:2014-12-04 00:00:00
abstract::Oxybutynin hydrochloride, an anti-cholinergic/anti-spasmodic agent, was examined for its effect on fertility and peri-post natal development in the rat and its embryotoxic potential in the rat and rabbit. In the rat effects on reproductive performance included a slight increase in the incidence of foetal malformations...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90044-2
更新日期:1986-07-01 00:00:00
abstract::The therapy of organophosphorus compound (OP) poisoning is still a challenge to clinical toxicologists. To alleviate peripheral respiratory failure oximes, e.g. obidoxime and pralidoxime, are used to reactivate inhibited acetylcholinesterase (AChE) with the intention to restore the disturbed neuromuscular function. In...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2010.04.002
更新日期:2010-06-04 00:00:00
abstract::Asthma, which is primarily an allergic type of respiratory disease, has increased in the U.S. and Europe by 30% over the last decade. Air pollution may play a role in this rise, since during episodes of smog, hospital admissions due to asthma increase. Ambient air quality has generally improved since the Clean Air Act...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(95)03230-d
更新日期:1995-12-28 00:00:00
abstract::Aluminium has been implicated in various neurodegenerative diseases but exact mechanism of action is still not known. Mitochondria being a major site of reactive oxygen species production are considered to be target of oxidative stress and it seems that the oxidative damage to mitochondrial proteins may underlie the p...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2008.10.009
更新日期:2009-01-31 00:00:00
abstract::The possibility that nitrofurantoin is a complete carcinogen or is an initiator or promoter of urinary bladder carcinogenesis was evaluated in male weanling F344 rats. No increase in tumor incidence was observed in rats fed nitrofurantoin at a level of 0.187% of the diet for 2 years compared to a control group. Also, ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90056-m
更新日期:1990-06-01 00:00:00
abstract::We investigate the ability of S-adenosylmethionine (SAMe) to antagonize the cyclosporine A (CyA)-induced inhibition of biliary glutathione efflux induced by long-term administration of CyA (10 mg/kg per day-CyA(10) or 20 mg/kg per day-CyA(20) for 4 weeks) in rats. CyA treatment reduced the liver content of total gluta...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.02.030
更新日期:2004-07-15 00:00:00
abstract::The safety of an açai (Euterpe oleracea Mart.) pulp enriched fruit and berry juice, MonaVie Active®, fortified with the functional ingredient, glucosamine, was studied. The beverage was found not to be mutagenic, clastogenic, cytotoxic, or genotoxic, as determined by the bacterial reverse mutation assay, chromosomal a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2010.04.017
更新日期:2010-11-28 00:00:00
abstract::For the first time, kinetic parameters of the effect of tacrine, an anti-cholinesterase inhibitor of therapeutic potential in Alzheimer's disease has been studied on human retinal acetyl-cholinesterase (AChE). Tacrine inhibited the AChE activity in a concentration dependent manner, the IC(50) being about 45 nM. The Mi...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00177-3
更新日期:2000-05-19 00:00:00
abstract::Rats exposed by inhalation to 3-trifluoromethylpyridine (3-FMP) for 10, 30 or 90 days showed an unusual response in the nasal passages. Focal histological change including reduction in the number of cell layers, disorganisation, vacuolation and minimal necrosis was confined to the olfactory epithelium. Axon bundles an...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(88)90121-7
更新日期:1988-06-01 00:00:00
abstract::The spectrum of the anti-apoptotic potential of heparin is currently under scrutiny in various tissues and under various pathological situations. In this study, the role of a low-molecular-weight heparin derivative (LMWH), certoparin in adriamycin-induced oxidative DNA damage has been evaluated in the cardiac and rena...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.09.009
更新日期:2006-01-16 00:00:00
abstract::Though, oxidative stress has been implicated in silica nanoparticles induced toxicity both in vitro and in vivo, but no similarities exist regarding dose-response relationship. This discrepancy may, partly, be due to associated impurities of trace metals that may present in varying amounts. Here, cytotoxicity and oxid...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2010.07.010
更新日期:2010-10-09 00:00:00
abstract::The ligand-activated nuclear receptor AhR (aryl hydrocarbon receptor) mediates the response of hepatocytes to various exogenous compounds. AhR is classically activated by planar, aromatic hydrocarbons, but also by other, structurally rather unrelated compounds. Recent data show that the canonical Wnt/β-catenin signali...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2014.08.010
更新日期:2014-11-05 00:00:00
abstract::The present work includes a study on the glycosaminoglycanuric condition induced by adriamycin (ADR, a chemotherapeutic agent) and the accompanying secondary hyperlipidemia, wherein the treatment with a low-molecular-weight heparin-derivative (LMWH), certoparin, is evaluated for its protective role (if any) on these p...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.02.009
更新日期:2005-07-01 00:00:00
abstract::The administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to a variety of cultured cells may alter their ability to proliferate and die. In a previous study we demonstrated that TCDD induced proliferation in Madin-Darby Bovine Kidney (MDBK) cells where no signs of apoptosis were observed, but herein, analysis o...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.10.004
更新日期:2011-12-18 00:00:00
abstract::The nonsteroidal anti-inflammatory drug (NSAID) diclofenac (DF) is associated with idiosyncratic hepatotoxicity and several other distinct hypersensitivity reactions. The mechanism(s) are unknown but evidence suggests both cell-mediated and antibody-mediated immune effector systems may be involved. In the present stud...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00008-2
更新日期:2002-04-02 00:00:00
abstract::D-Serine causes selective necrosis to the straight portion of the rat renal proximal tubules. The onset is rapid, occurring within 3-4 h and accompanied by proteinuria, glucosuria and aminoaciduria. The metabolism of D-serine by D-amino acid oxidase (D-AAO) may be involved in the mechanism of toxicity. D-AAO is locali...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.08.008
更新日期:2005-02-01 00:00:00
abstract::An embryotoxicity study on Ponceau 4 R was carried out in SPF Wistar rats. The substance was given by gavage from day 1 to 20 of the gestation period in doses of 0, 1000, 2000, and 4000 mg/kg bw per day, dissolved in distilled water. The foetuses were removed on day 21. No effect due to the treatment with the dye was ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(75)90117-1
更新日期:1975-11-01 00:00:00
abstract::Sixteen polycyclic aromatic hydrocarbons (PAHs) were screened for their ability to be directly cytotoxic to a cell line from the rainbow trout gill, RTgill-W1. Exposure times of 2 h or less were sufficient for direct cytotoxicity to be detected, which appeared to be caused by a common mechanism, the general perturbati...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(98)00030-4
更新日期:1998-05-15 00:00:00
abstract::Rats which were treated intraperitoneally (i.p.) with FeCl2 X 4H2O expired ethane which increased with increasing doses of iron. The same amount of ethane was expired by animals exposed to 20% or 100% oxygen. The mobilization by FeCl2 of stored ethane from the body was excluded. Propane expiration was also stimulated ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(83)90103-8
更新日期:1983-09-01 00:00:00
abstract::The ability to overcome cellular barriers in the body is crucial for efficient delivery of drugs to the target where intervention is needed. For drugs acting in the brain it is essential to overcome the blood-brain barrier (BBB). Such drugs include antidotes for the treatment of organophosphate poisoning, a current wa...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152541
更新日期:2020-10-01 00:00:00
abstract::The ubiquitous presence of nanoparticles (NPs) together with increasing evidence linking them to negative health effects points towards the need to develop the understanding of mechanisms by which they exert toxic effects. This study was designed to investigate the role of surface area and oxidative stress in the cell...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.04.001
更新日期:2009-06-16 00:00:00
abstract::A recent epidemiological study showed an increased risk for bone fractures after chronic low-level cadmium exposure. This finding agrees with those of cadmium accumulation in rat bones after chronic oral exposure which reduced the mechanical strength of the bones. There are indications that ossicular cadmium uptake ma...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00364-4
更新日期:2001-02-21 00:00:00
abstract::Acrylonitrile (AN) is widely used in the manufacturing of fibers, plastics and pharmaceuticals. Free radical-mediated lipid peroxidation is implicated in the toxicity of AN. The present study was designed to examine the ability of curcumin, a natural polyphenolic compound, to attenuate acute AN-induced lipid peroxidat...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.11.001
更新日期:2010-01-12 00:00:00
abstract::Genetic polymorphism of drug metabolizing enzymes (DME) can lead to severe toxicity or therapeutic failure of pharmacotherapy. Additionally, genetically determined differences in the activity of the metabolic enzymes can increase an individual's susceptibility to certain types of chemically induced cancers and possibl...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(99)00199-7
更新日期:2000-04-03 00:00:00
abstract::Inorganic arsenic (iAs), a ubiquitous element and a natural drinking water contaminant, has been found to impair male reproductive function. However, the effect of long-term exposure to arsenic on testis damage and its underlying mechanisms still require further evaluation. In the study, male C57BL/6 mice (4 weeks) we...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2018.09.010
更新日期:2019-01-01 00:00:00
abstract::For quantitative in vitro-in vivo extrapolation (QIVIVE) of metabolism for the purposes of toxicokinetics prediction, a precise and robust analytical technique for identifying and measuring a chemical and its metabolites is an absolute prerequisite. Currently, high-resolution mass spectrometry (HR-MS) is a tool of cho...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2013.08.010
更新日期:2015-06-05 00:00:00
abstract::The present study investigates the influence of different levels of Schistosoma mansoni infection (60, 120, 180, 300, 600 cercariae per mice) after 33 days on the activity of aryl hydrocarbon hydroxylase (AHH) and the formation of hepatic hydrogen peroxide (H(2)O(2)) during the metabolic activation of benzo(a)pyrene [...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(01)00372-9
更新日期:2001-06-21 00:00:00