Abstract:
:Inorganic arsenic (iAs), a ubiquitous element and a natural drinking water contaminant, has been found to impair male reproductive function. However, the effect of long-term exposure to arsenic on testis damage and its underlying mechanisms still require further evaluation. In the study, male C57BL/6 mice (4 weeks) were treated with sodium arsenite at the doses of 5 or 50 ppm arsenic via drinking water for 180 days. Sperm count, histology in testes, oxidative stress biomarkers, cell cycle progress and apoptosis were assessed. Our results showed that arsenite seriously destroyed the structure of the testes and reduced the sperm count. Arsenite significantly decreased the activity of total superoxide dismutase (T-SOD) and glutathione (GSH) content but increased the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) in testes. Furthermore, arsenite could induce G2/M phase arrest in testes, concurrent with a significant decrease in mRNA and protein levels of cdc2 and cyclin B1, the upregulation of p-cdc2, and an increase in mRNA levels of p53 and p21. Arsenite induced testicular apoptosis with a significant increase in Bax mRNA and protein levels, especially the caspase-3 activation. Testicular toxicity of the high dose group was stronger than that of the low dose group. In conclusion, testicular toxicity due to long-term exposure to arsenite may relate to oxidative damage, G2/M arrest and promoted apoptosis in the testes of mice, which contributed to the increased risk of spermatogenesis disorders and male infertility.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Zeng Q,Yi H,Huang L,An Q,Wang Hdoi
10.1016/j.tox.2018.09.010subject
Has Abstractpub_date
2019-01-01 00:00:00pages
122-132eissn
0300-483Xissn
1879-3185pii
S0300-483X(18)30396-2journal_volume
411pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::Ferrets were maintained for 12 months on different diets (A, meat and biscuit; B, all meat; C, meat and fish; D, high fibre) to ascertain the cause of spontaneous development of fatty liver. High hepatic triglyceride contents resulted on diets B = C > D; whereas ferrets on diet A (control) showed no accumulation of li...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(96)03351-3
更新日期:1996-08-16 00:00:00
abstract::Male and female B6C3F1 mice were administered dichloroacetate (DCA) and trichloroacetate (TCA) in their drinking water at concentrations of 1 or 2 g/l for up to 52 weeks. Both compounds induced hepatoproliferative lesions (HPL) in male mice, including hepatocellular nodules, adenomas and hepatocellular carcinomas with...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90195-m
更新日期:1990-09-01 00:00:00
abstract::The use of colchicine-specific Fab fragments is of interest in human poisoning. In the present study, we show the efficacy of Fab fragments in reversing colchicine toxicity in mice. High affinity antibodies (Ka = 2 x 10(10) M-1) against colchicine were raised in goats; Fab fragments were purified by DEAE chromatograph...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90015-s
更新日期:1991-01-01 00:00:00
abstract::Cadmium is a heavy metal, which is widely used in industry, affecting human health through occupational and environmental exposure. In mammals, it exerts multiple toxic effects and has been classified as a human carcinogen by the International Agency for Research on Cancer. Cadmium affects cell proliferation, differen...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(03)00305-6
更新日期:2003-11-05 00:00:00
abstract::In several separate experiments neonatal rats were intubated daily with 9, 27 or 81 mg lead acetate/kg of body weight throughout their 3-week postnatal period of development. Based on average body weights, the total daily lead intake was 0.156, 0.454 or 1.384 mg lead per animal, respectively (in addition to normal lea...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(75)90115-8
更新日期:1975-11-01 00:00:00
abstract::The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the biological and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dioxin-like compounds (DLC) as well as some drugs and endogenous tryptophan metabolites. Short-term activation of AhR can lead to hepatocellular s...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2015.07.005
更新日期:2015-10-02 00:00:00
abstract::The prime factors influencing survivability from 10 major fire-related public transport aircraft accidents were assessed. Regulatory requirements were assessed against derived criteria and alternate concepts evaluated to identify a preferred strategy for enhanced survival; the provision of passenger protective breathi...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(96)03494-4
更新日期:1996-12-31 00:00:00
abstract::The vapour pressures of 30 N-nitrosamines between 0 and 40 degrees C are calculated by means of well-known and experimentally proven formulae. The saturation concentration of the nitrosamines in air is presented as mmHg, ppm and mg/m3. For N-nitrosodimethylamine (NDMA), N-nitrosodiethylamine (NDEA) and N-nitrosopyrrol...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(82)90093-2
更新日期:1982-01-01 00:00:00
abstract::Transforming growth factor beta (TGF beta) is a multifunctional regulator of cell growth that has either a stimulatory or inhibitory effect on cell proliferation, depending on TGF beta concentration and on cell type, history and culture conditions. Cadmium mimics some of the effects of TGF beta in cultured cells. In t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(92)90063-k
更新日期:1992-01-01 00:00:00
abstract::Daunomycin-induced cardiotoxicity has been regarded to be the result of oxygen-mediated lipid peroxidation of cell membranes. The aim of the present work was to evaluate the extent of lipid peroxidation in rat heart after administration of this anticancer drug and, further, to examine possible activation of some endog...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(98)00002-x
更新日期:1998-03-13 00:00:00
abstract::Dental resin systems have been in use for several decades. (Meth)acrylic monomers are an important part of the matrix system and are either based on BPA while others lack the BPA core. The degree of conversion during restoration is in general between 50-70 % allowing leaching from unreacted monomers to the oral cavity...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.03.007
更新日期:2019-05-15 00:00:00
abstract::Zinc (Zn) is an essential nutrient that is required in humans and animals for many physiological functions, including immune and antioxidant function, growth and reproduction. The present study was conducted to investigate the effects of adequate Zn level (38 mg/kg diet, as a control) and two low levels that create Zn...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00049-5
更新日期:2002-06-14 00:00:00
abstract::Disorders in the barrier function and secretory activity of the placenta can be caused by xenobiotics (XB) present in the environment and their accumulation in tissues of living organisms. Thus, the aim of this study was to investigate the effect of 1,1,1-trichloro-2,2,-bis-4-chlorophenyl-ethane (DDT) and its metaboli...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2016.11.016
更新日期:2017-01-15 00:00:00
abstract::This study investigated the effect of astaxanthin (ASX; 3,3-dihydroxybeta, beta-carotene-4,4-dione), a water-dispersible synthetic carotenoid, on liver ischemia-reperfusion (IR) injury. Astaxanthin (5 mg/kg/day) or olive oil was administered to rats via intragastric intubation for 14 consecutive days before the induct...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.11.003
更新日期:2010-01-12 00:00:00
abstract::Trans-1,2-dichloroethylene (t-DCE), an industrial solvent, proved to be moderately toxic when studied in small laboratory animals. In adult female rats brief (8 h) and prolonged (8 h daily, on 5 consecutive days a week, for more than 16 weeks) inhalation of 200 ppm--the current TLV/MAC in various countries--produced h...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(77)90059-2
更新日期:1977-04-01 00:00:00
abstract::Increased antigen-specific IgE expression is a hallmark of the allergic response in mice. IgG1 may also be involved. Co-injection of mice with diesel exhaust particles (DEP) and ovalbumin three times over a 2 week period lead to a rapid and marked elevation of ovalbumin-specific IgE, IgG1 and also IgG2a, compared with...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00418-2
更新日期:2001-02-28 00:00:00
abstract::Oxidative DNA damage is emerging as an biomarker of effect in studies assessing the health risks of occupational chemicals. Trichloroethylene (TCE) and perchloroethylene (PERC) are used in the dry cleaning industry and their metabolism can produce reactive oxygen compounds. The present study examined the potential for...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(99)00083-9
更新日期:1999-10-29 00:00:00
abstract::The promoting effects of a combined exposure to two pollutants (NO2, O3 or H2SO4-aerosol) at near ambient levels on lung tumorigenesis induced by N-bis(2-hydroxypropyl) nitrosamine (BHPN) were investigated in male Wistar rats. The rats were given a single intraperitoneal injection of BHPN (0.5 g per kg body wt.) at 6 ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(92)90137-4
更新日期:1992-09-01 00:00:00
abstract::Several studies indicated that chloral hydrate can prolong the disappearance time of ethanol from blood in mice. This seems to result from inhibition of the enzyme alcohol dehydrogenase by chloral hydrate and trichloroethanol, its main metabolite. We examined the effect of both these compounds on the disappearance tim...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(98)00108-5
更新日期:1998-11-02 00:00:00
abstract::The zebrafish Danio rerio embryo test with metabolic activation (mDarT) was developed to assess the teratogenic effects of proteratogens. In this study induced rat liver microsomes (RLM) were used as a mammalian metabolic activation system (MAS), since they contain various cytochrome P450 (CYP) isoforms at high concen...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2010.05.012
更新日期:2010-09-10 00:00:00
abstract::The protective effect of telmisartan, the angiotensin II-receptor antagonist, against liver toxicity induced by sodium arsenite (5 mg/kg/day, p.o., for 30 days) was investigated in mice. Telmisartan treatment (10 mg/kg/day, p.o.) was applied for 30 days, starting on the same day of arsenic administration. Telmisartan ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2012.06.015
更新日期:2012-10-28 00:00:00
abstract::Bisphenol A has been shown to affect the reproduction of male rats and mice. However, the mechanism of action of bisphenol A on the epididymal sperm is not elucidated. The present study was undertaken to evaluate the effect of bisphenol A on the antioxidant system of rat epididymal sperm. Bisphenol A was administered ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00597-8
更新日期:2003-03-14 00:00:00
abstract::The carcinogenic response of NZO/BlGd inbred mice of both sexes to oral N-nitrosohexamethyleneimine (NHEX) was investigated at 2 differing dose rates, but equal cumulative doses. Mice received 52 mg NHEX (2 mg/g body wt) in drinking water over either an 8-week period (200 mg/l) or a 32-week period (50 mg/l), and were ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(84)90042-8
更新日期:1984-12-01 00:00:00
abstract::Organophosphates and pyrethroids are among the most common pesticides currently in use worldwide. Several pesticides have been reported to possess hormonal activities, and thus are classified as endocrine disruptors. The present study was planned to evaluate potential androgenic and antiandrogenic activities of the pe...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.09.028
更新日期:2008-01-14 00:00:00
abstract:OBJECTIVE:Endothelins (ET) can be considered stress-responsive regulators working in paracrine and autocrine fashion. It has been suggested that elevated levels of ET may be responsible for the low coronary re-flow phenomena. Ischemia-reperfusion (I/R) was shown to stimulate ET release in rat heart; however, the mechan...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.11.022
更新日期:2006-02-15 00:00:00
abstract::Malathion is one of the most widely used organophosphorus insecticides in agriculture. However, malathion may be involved in the etiology of human brain dysfunction. Induction of ROS has been proposed as a mechanism of malathion-induced poisoning cases, but there are few data regarding the effects of malathion on oxid...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.02.004
更新日期:2019-04-01 00:00:00
abstract::Cell death triggers the release into extracellular spaces of products of chromatin catabolism, particularly of DNA. A sensitive DNA assay has been used to investigate in the mouse whether the quantitation of plasma DNA may be used as an index of in vivo cytotoxicity. It has been found that toxic doses of bacterial lip...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90178-j
更新日期:1990-04-30 00:00:00
abstract::Chlorpyrifos (CPF) has been widely used around the world as a pesticide for both agricultural and residential application. Although various studies have reported toxicity and health-related effects from CPF exposure, the molecular mechanism of CPF toxicity to skin has not been well-characterized. The present study det...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2015.09.006
更新日期:2015-12-02 00:00:00
abstract::The fetotoxicity of nitrofen and 5 analogous diphenyl ethers was compared in mice, using survival on postnatal day 5 to evaluate prenatal and perinatal toxicity. The effect of each chemical on the Harderian gland weight of surviving pups was also assessed, since decreased Harderian gland weight is seen in nitrofen-exp...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90062-4
更新日期:1986-09-01 00:00:00
abstract::The combined effects of ethyl alcohol (ETOH) intoxication and carbon monoxide (CO) poisoning were studied in the Levine-prepared rat. Infusion or injection of ETOH before and during 90 min of CO exposure to blood levels 2-4 times those considered legally drunk in humans, increased survival at 2400 ppm, and extended th...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90111-s
更新日期:1990-05-31 00:00:00