Abstract：
:For the first time, kinetic parameters of the effect of tacrine, an anti-cholinesterase inhibitor of therapeutic potential in Alzheimer's disease has been studied on human retinal acetyl-cholinesterase (AChE). Tacrine inhibited the AChE activity in a concentration dependent manner, the IC(50) being about 45 nM. The Michaelis-Menten constant (K(m)) for the hydrolysis of acetylthiocholine iodide was found to be 0.120 mM and this value was increased by 4-52.8% in the presence of tacrine. V(max) was observed to be 2.23 micromol/h per mg protein for the control system, while it was decreased by 14.73-56.25% in the tacrine treated systems. Dixon as well as Lineweaver-Burk plots and their secondary replots indicated that the nature of the inhibition was of the mixed type, i. e. a combination of competitive and noncompetitive inhibition. The values of K(i) and K(I) were estimated to be as 37.76 and 64.36 nM, respectively.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Alhomida AS,Al-Rajhi AA,Kamal MA,Al-Jafari AAdoi
10.1016/s0300-483x(00)00177-3keywords:
subject
Has Abstractpub_date
2000-05-19 00:00:00pages
33-9issue
1eissn
0300-483Xissn
1879-3185pii
S0300483X00001773journal_volume
147pub_type
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