Dose-related hepatotoxicity of 1,1,2-trichloro-1,2,2-trifluoroethane in short-term intermittent inhalation exposure in rats.

abstract：:The free radical scavenging activities and inhibitory effect of lipid peroxidation of a delphinidin derivative in eggplant were investigated. Delphinidin-3-(p-coumaroylrutinoside)-5-glucoside (nasunin), an anthocyanin, was isolated as purple colored crystals from eggplant peels. Using electron spin resonance spectrome...

journal_title：Toxicology

authors： Noda Y,Kneyuki T,Igarashi K,Mori A,Packer L

更新日期：2000-08-07 00:00:00

abstract：:Haptens are classified as low molecular chemicals with an intrinsic potential to covalently modify proteins, and many of them are strong inducers of contact hypersensitivity (CHS). CHS is T cell mediated, and hapten-specific T cells have been shown to interact with hapten-modified, MHC-associated peptides. However, th...

journal_title：Toxicology

authors： Thierse HJ,Gamerdinger K,Junkes C,Guerreiro N,Weltzien HU

更新日期：2005-04-15 00:00:00

abstract：:Isoniazid is a widely used drug for the treatment of tuberculosis, but hepatotoxicity is a major concern during treatment. Thiopronin contains an SH-group and is generally considered an antioxidant. The aim of the present study was to investigate the effects of thiopronin during liver injury and DNA damage induced by ...

journal_title：Toxicology

authors： Yue J,Dong G,He C,Chen J,Liu Y,Peng R

更新日期：2009-10-29 00:00:00

abstract：:Male and female B6C3F1 mice were administered dichloroacetate (DCA) and trichloroacetate (TCA) in their drinking water at concentrations of 1 or 2 g/l for up to 52 weeks. Both compounds induced hepatoproliferative lesions (HPL) in male mice, including hepatocellular nodules, adenomas and hepatocellular carcinomas with...

journal_title：Toxicology

authors： Bull RJ,Sanchez IM,Nelson MA,Larson JL,Lansing AJ

更新日期：1990-09-01 00:00:00

abstract：:Following carbon tetrachloride-induced liver injury, hepatotrophic factors are synthesized and released into the serum to facilitate the regeneration of damaged hepatic tissue. We investigated the possibility that immunosuppression could be mediated through induction of a serum factor(s) because in vivo exposure of B6...

journal_title：Toxicology

authors： Delaney B,Kaminski NE

更新日期：1993-12-15 00:00:00

abstract：:Mercury has been a known as a toxic substance for centuries. Whilst the clinical features of acute mercury poisoning have been well described, chronic low dose exposure to mercury remains poorly characterised and its potential role in various chronic disease states remains controversial. Low molecular weight thiols, i...

journal_title：Toxicology

authors： Rooney JP

更新日期：2007-05-20 00:00:00

abstract：:It has been suggested, on the basis of work in cell-free systems, that sulfonamide hydroxy-lamines are metabolized to nitroso metabolites which may be the proximate toxins mediating sulfonamide hypersensitivity reactions. We performed time-course experiments investigating the toxicity of the hydroxylamine and nitroso ...

journal_title：Toxicology

authors： Rieder MJ,Krause R,Bird IA

更新日期：1995-01-06 00:00:00

abstract：:Mycotoxins (frequently referred to as secondary metabolites of toxigenic fungi) are commonly found in foodstuffs and are important because of their association with disease. The mycotoxin diacetoxyscirpenol, or 3-hydroxy-4,15-diacetoxy-12,13-epoxytrichothec-9-ene (DAS), is produced by numerous species of Fusarium and ...

journal_title：Toxicology

authors： Mayura K,Smith EE,Clement BA,Harvey RB,Kubena LF,Phillips TD

更新日期：1987-09-01 00:00:00

abstract：:The histogenesis of coumarin-induced cholangiofibrosis in the rat has been determined. Proliferation of ductal structures was preceded by extensive damage to hepatocytes in the centrilobular region. Focal proliferation of ducts and fibrous tissue was present at 3 months and typical areas of cholangiofibrosis at 6 mont...

journal_title：Toxicology

authors： Evans JG,Appleby EC,Lake BG,Conning DM

更新日期：1989-04-01 00:00:00

abstract：:Cisplatin is used as a cytotoxic agent for the management of cervical cancer. However, the severity of the side-effects limits the use of this drug, particularly at high doses. Resistance to cisplatin is often attributed to a disruption in the normal apoptotic response via aberrant activation of pathways such as the m...

journal_title：Toxicology

authors： Leisching GR,Loos B,Botha MH,Engelbrecht AM

更新日期：2015-09-01 00:00:00

abstract：:The synthetic pyrethroid insecticide, cypermethrin, was given during gestation to pregnant rats by gavage in corn oil. Peripheral blood and spleen cytotoxic activity of dams and their offspring were then evaluated at different times (30, 60, 90, 120 days) after birth. Pups showed a significant increase in peripheral b...

journal_title：Toxicology

authors： Santoni G,Cantalamessa F,Mazzucca L,Romagnoli S,Piccoli M

更新日期：1997-07-11 00:00:00

abstract：:The development of mouse embryos was studied after intraperitoneal injection of nickel chloride in the preimplantation period. A single intraperitoneal injection of NiCl2 . 6H2O in 0.154 M NaCl corresponding to 20 mg/kg body wt was given to groups of female mice on days 1, 2, 3, 4, 5 or 6 of gestation. Control groups ...

journal_title：Toxicology

authors： Storeng R,Jonsen J

更新日期：1981-01-01 00:00:00

abstract：:Lead exposure causes cognitive and behavioral deficits in some children. We have proposed that the effects of single nucleotide polymorphisms (SNP) of the human pseudodeficient arylsulfatase A (ARSA) gene that result in reduced levels of the enzyme, and lead concentrations that decrease ARSA activity, culminate in cel...

journal_title：Toxicology

authors： Chen XG,Poretz RD

更新日期：2001-06-21 00:00:00

abstract：OBJECTIVE:We investigated the potential dose related apoptotic effect of subchronic administration of the alkylating chemotherapeutic agent ifosfamide in different sites of the small and large rabbit intestine. MATERIALS AND METHODS:Twenty New Zealand White rabbits received intravenously every week, for 10 weeks, 0 (g...

journal_title：Toxicology

authors： Ypsilantis P,Tentes L,Assimakopoulos SF,Kortsaris A,Scopa CD,Pitiakoudis M,Simopoulos C

更新日期：2004-08-05 00:00:00

abstract：:The effect of mangiferin, a naturally occurring xanthone glucoside on cyclophosphamide-induced immunotoxicity and its mode of action in the immune system were investigated. To induce immunotoxicity, adult male Wistar rats were injected weekly with cyclophosphamide intraperitoneally at 100 mg/kg bodyweight. Mangiferin ...

journal_title：Toxicology

authors： Muruganandan S,Lal J,Gupta PK

更新日期：2005-11-05 00:00:00

abstract：:Static and rotary cultures of adult rabbit hepatocytes can be produced reproducibly following their isolation by means of a simplified, inexpensive recycling perfusion system. Light and electron microscopic examination of the cultures showed that these hepatocytes retained the morphological characteristics of fully di...

journal_title：Toxicology

authors： Poole A,Chasseaud LF,Bridges JW

更新日期：1982-01-01 00:00:00

abstract：:Silicosis is a universal occupational disease, which is caused by long-term crystalline silica exposure. Recent studies have shown that noncoding RNAs participate in diverse pathological cellular pathways. However, the precise regulation mechanism remains limited in silicosis. Here, we established a silica-induced mou...

journal_title：Toxicology

authors： Cheng D,Xu Q,Liu Y,Li G,Sun W,Ma D,Ni C

更新日期：2021-01-19 00:00:00

abstract：:Adult female F-344 rats were trained (avoidance rate > 70%) over four days with a coupled tone- (n = 10 rats/dose) or 2 ppm acetaldehyde-cued (n = 6 rats/dose) foot shock paradigm. Rats were gavaged with chloroform dissolved in corn oil for 5 days/week for 3 week at 0 or 400 (tone-cued) or 0, 34, 100, or 400 (odor-cue...

journal_title：Toxicology

authors： Dorman DC,Miller KL,D'Antonio A,James RA,Morgan KT

更新日期：1997-09-26 00:00:00

abstract：:Studies showed that certain cytotoxicity assays were not suitable for assessing nanoparticle (NP) toxicity. We evaluated a lactate dehydrogenase (LDH) assay for assessing copper (Cu-40, 40nm), silver (Ag-35, 35nm; Ag-40, 40nm), and titanium dioxide (TiO(2)-25, 25nm) NPs by examining their potential to inactivate LDH a...

journal_title：Toxicology

authors： Han X,Gelein R,Corson N,Wade-Mercer P,Jiang J,Biswas P,Finkelstein JN,Elder A,Oberdörster G

更新日期：2011-09-05 00:00:00

abstract：:The effects of isoflurane, 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, on the oxidative metabolism of halothane to produce trifluoroacetic acid (TFA) and on the reductive metabolism of halothane to produce chlorodifluoroethylene (CDE) and chlorotrifluoroethane (CTE) in liver microsomes of guinea pig were exami...

journal_title：Toxicology

authors： Fujii K

更新日期：1995-12-15 00:00:00

abstract：:Reactions of ethenyloxirane with amino (RNH2) and thiol (R'SH) nucleophiles occur by an SN2 mechanism involving competing ring cleavage at C-2 and C-3. In contrast, 2-ethenyl-2-methyloxirane reacts with amino (RNH2) and thiolate (R'S-) nucleophiles in methanol by regioselective SN2 attack at C-3 ("neo-pentyl" position...

journal_title：Toxicology

authors： Bleasdale C,Small RD,Watson WP,Wilson J,Golding BT

更新日期：1996-10-28 00:00:00

abstract：:The ligand-activated nuclear receptor AhR (aryl hydrocarbon receptor) mediates the response of hepatocytes to various exogenous compounds. AhR is classically activated by planar, aromatic hydrocarbons, but also by other, structurally rather unrelated compounds. Recent data show that the canonical Wnt/β-catenin signali...

journal_title：Toxicology

authors： Vaas S,Kreft L,Schwarz M,Braeuning A

更新日期：2014-11-05 00:00:00

abstract：:The local lymph node assay (LLNA) is a regular method for the detection of sensitizing chemicals in mice which measures the incorporation of tritiated thymidine in lymph node cells. We have evaluated an alternative to this method based on the interleukin-2 (IL-2) production of lymph node cells. At the mRNA level, no c...

journal_title：Toxicology

authors： Azam P,Peiffer JL,Ourlin JC,Bonnet PA,Tissier MH,Vian L,Fabre I

更新日期：2005-01-15 00:00:00

abstract：:Arsenic is an endocrine disruptor that promotes breast cancer (BCa) development. Estrogen synthesis, through aromatase activation, is essential for BCa promotion and progression through activating the G-coupled estrogen receptor 1 (GPER1), regulating rapid nongenomic effects involved in cell proliferation and migratio...

journal_title：Toxicology

authors： Reyes-Vázquez L,Hernández AJA,Calderón-Aranda ES

更新日期：2020-05-15 00:00:00

abstract：:p-Chloro-m-cresol (PCMC) and p-chloro-m-xylenol (PCMX) are known to cause allergic contact dermatitis. For risk assessment of skin sensitizers, information on dose-response profiles in the induction and elicitation phases and cross-reactivity with analogous chemicals are important. In the non-radioactive local lymph-n...

journal_title：Toxicology

authors： Yamano T,Shimizu M,Noda T

更新日期：2003-08-28 00:00:00

abstract：:Transferrin, as the major iron-transport protein in serum and other body fluids, has a central role in managing iron the body receives. Liver is a major site of transferrin synthesis, and in this study we present evidence that liver synthesis of human transferrin is suppressed by both the toxic metal lead and bacteria...

journal_title：Toxicology

authors： Barnum-Huckins KM,Martinez AO,Rivera EV,Adrian EK Jr,Herbert DC,Weaker FJ,Walter CA,Adrian GS

更新日期：1997-03-14 00:00:00

abstract：:Cadmium (Cd) is a heavy metal with a long biological half-life in humans and is recognized as a toxic pollutant. Cd is also a potential neurotoxicant and its exposure is associated with olfactory impairment in humans. However, the molecular and cellular mechanisms of Cd neurotoxicity are not well defined. Adult neurog...

journal_title：Toxicology

authors： Wang H,Engstrom AK,Xia Z

更新日期：2017-04-01 00:00:00

abstract：:Pregnant rats were dosed with 300, 600, 1000, 2000, 3000 or 4000 ppm inorganic lead through their drinking water during pregnancy and during lactation until 21 days post partum. An effect on live litter size was noted at the higher doses as was an increased tendency for sperm positive females to fail to produce a litt...

journal_title：Toxicology

authors： Carmichael NG,Winder C,Lewis PD

更新日期：1981-01-01 00:00:00

abstract：:Bisphenol A (BPA), one of the most prevalent chemicals for daily use, has been reported as a xenoestrogen to induce reproductive toxicity, but its mechanism is poorly understood. In the present study, we aimed to explore whether CaM-CaMKII-ERK1/2 signaling pathway was involved in BPA-induced Sertoli cells injury via t...

journal_title：Toxicology

authors： Qian W,Zhu J,Mao C,Liu J,Wang Y,Wang Q,Liu Y,Gao R,Xiao H,Wang J

更新日期：2014-10-03 00:00:00

abstract：:The question as to whether or not the hypotension observed as part of the effect of tricholorofluoromethane (FC11), dichlorofluoromethane (FC 12), dichlorotetrafluoroethane (FC 114) and methyl chloroform was due to a vasodepressor component of action, in addition to the previously documented depression in myocardial c...

journal_title：Toxicology

authors： Simaan JA,Aviado DM

更新日期：1976-03-01 00:00:00