Abstract：
:Some workers have suggested that 6 days xylitol administration to rats results in hepatic dysfunction. In our study xylitol was administered to rats by daily gastric intubation for a period of 14 days. Dose levels were 1.25, 2.5, 5 and 10 g/kg. During treatment (2, 5 and 14 days), animals were submitted to careful clinical examinations and to blood serum analysis related to hepatic functions. They were sacrificed after 2, 5, and 14 days treatment. In the 2 and 5 days treatment groups, main organs were submitted to histological study. This examination was only performed on liver in the 14 days treatment group. No evidence of hepatotoxicity was recorded. Serum levels of all parameters measured were within normal limits (including bilirubin and serum alkaline phosphatase (SAP). No anomalies were shown histologically.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Truhaut,Coquet B,Fouillet X,Galland L,Guyot D,Rouaud JL,Long DWdoi
10.1016/0300-483x(77)90025-7subject
Has Abstractpub_date
1977-08-01 00:00:00pages
79-85issue
1eissn
0300-483Xissn
1879-3185pii
0300-483X(77)90025-7journal_volume
8pub_type
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