Delta-aminolaevulinic acid metabolism in normal and lead-exposed humans.

abstract：:Simultaneous exposure to cadmium and arsenic is highly probable in the urban area of San Luis Potosi, Mexico due to common localization of copper and zinc smelters. Therefore, in this work, rats were intraperitoneally exposed either to cadmium or arsenic alone, or simultaneously to both metals. The effects of these tr...

journal_title：Toxicology

authors： Díaz-Barriga F,Llamas E,Mejía JJ,Carrizales L,Santoyo ME,Vega-Vega L,Yáñez L

更新日期：1990-11-01 00:00:00

abstract：:The early neonatal stage constitutes a sensitive period during which exposure to adverse events can increase the risk of neuropsychiatric disorders. Maternal deprivation (MD) is a model of early life stress that induces long-term behavioural and physiological alterations, including susceptibility to different drugs of...

journal_title：Toxicology

authors： Llorente-Berzal A,Manzanedo C,Daza-Losada M,Valero M,López-Gallardo M,Aguilar MA,Rodríguez-Arias M,Miñarro J,Viveros MP

更新日期：2013-09-06 00:00:00

abstract：:Consumption of edible oils contaminated with Argemone mexicana seed oil is known to cause various clinical manifestations. In the present study, the effect of dietary intake of argemone oil on histopathological changes, haematological indices and selected marker parameters of toxicity was investigated to observe the e...

journal_title：Toxicology

authors： Upreti KK,Das M,Kumar A,Singh GB,Khanna SK

更新日期：1989-10-16 00:00:00

abstract：:The developing nervous system is susceptible to lead (Pb) exposure but less is known about the effect of this toxic agent in adult rat brain. Since astrocytes serve as a cellular Pb deposition site, it is of importance to investigate the response of astroglial cells in the adult rat brain in a model of acute lead expo...

journal_title：Toxicology

authors： Struzyñska L,Bubko I,Walski M,Rafałowska U

更新日期：2001-08-28 00:00:00

abstract：:Measurement of lymphocyte proliferation to detect hypersensitivity to beryllium (Be-LPT) in vitro is done presently using a method based on tritiated thymidine incorporation. Although this method is sensitive it gives no information on cell viability or responding lymphocyte subsets. We have developed reliable and sim...

journal_title：Toxicology

authors： Farris GM,Newman LS,Frome EL,Shou Y,Barker E,Habbersett RC,Maier L,Smith HN,Marrone BL

更新日期：2000-02-21 00:00:00

abstract：:Chlorination of drinking water containing organic materials is known to generate toxic by-products. We suggested that such compounds may also be produced by interactions between chlorine and bacteria present in water. To confirm this hypothesis, a method based on RNA synthesis inhibition of HeLa S3 human cells in the ...

journal_title：Toxicology

authors： Ferey KA,Fauris C,Husson GP,Vilagines R

更新日期：2000-11-16 00:00:00

abstract：:Chlorpyrifos (CPF) has been widely used around the world as a pesticide for both agricultural and residential application. Although various studies have reported toxicity and health-related effects from CPF exposure, the molecular mechanism of CPF toxicity to skin has not been well-characterized. The present study det...

journal_title：Toxicology

authors： Jang Y,Lee AY,Jeong SH,Park KH,Paik MK,Cho NJ,Kim JE,Cho MH

更新日期：2015-12-02 00:00:00

abstract：:Biodegradable nanoparticles are being considered more often as drug carriers to address pharmacokinetic/pharmacodynamic issues, yet nano-product safety has not been systematically proven. In this study, haematological, biochemical and histological parameters were examined on 28 day daily dosing of rats with nano- or m...

journal_title：Toxicology

authors： Venkatpurwar VP,Rhodes S,Oien KA,Elliott MA,Tekwe CD,Jørgensen HG,Kumar MN

更新日期：2015-04-01 00:00:00

abstract：:There is a close relationship between the central nervous system activity and bone metabolism. Therefore, methamphetamine (METH), which stimulates the central nervous system, is expected to affect bone turnover. The aim of this study was to investigate the role of METH in bone metabolism. Mice were divided into 3 grou...

journal_title：Toxicology

authors： Tomita M,Katsuyama H,Watanabe Y,Okuyama T,Fushimi S,Ishikawa T,Nata M,Miyamoto O

更新日期：2014-05-07 00:00:00

abstract：:The carcinogenic response of NZO/BlGd inbred mice of both sexes to oral N-nitrosohexamethyleneimine (NHEX) was investigated at 2 differing dose rates, but equal cumulative doses. Mice received 52 mg NHEX (2 mg/g body wt) in drinking water over either an 8-week period (200 mg/l) or a 32-week period (50 mg/l), and were ...

journal_title：Toxicology

authors： Goodall CM,Lijinsky W

更新日期：1984-12-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) are important as drug metabolizing enzymes mainly in the detoxication process. To assess individual differences in susceptibility to different chemicals, it would be useful to know the activity of specific GST isozymes in individuals. In order to study individual variability, typical ...

journal_title：Toxicology

authors： Takamatsu Y,Inaba T

更新日期：1994-03-11 00:00:00

abstract：:To elucidate factors responsible for altered proliferation of preneoplastic hepatocytes in rat hepatocarcinogenesis in vivo, EGF-stimulated DNA synthesis of normal and nodular hepatocytes in primary culture was studied. In addition, the influence of 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated to clari...

journal_title：Toxicology

authors： Bock KW,Gschaidmeier H,Bock-Hennig BS,Eriksson LC

更新日期：2000-04-03 00:00:00

abstract：:Chemicals can increase carcinogenic risk by either directly damaging DNA or increasing cell replication or they can do both. These effects have different implications for a biologically-based extrapolation from rodent bioassays to humans. 2-Acetylaminofluorene (2-AAF) administered at low doses to mice for a lifetime h...

journal_title：Toxicology

authors： Cohen SM

更新日期：1995-09-01 00:00:00

abstract：:As a new method, support vector machine (SVM) were applied for prediction of toxicity of different data sets compared with other two common methods, multiple linear regression (MLR) and RBFNN. Quantitative structure-activity relationships (QSAR) models based on calculated molecular descriptors have been clearly establ...

journal_title：Toxicology

authors： Zhao CY,Zhang HX,Zhang XY,Liu MC,Hu ZD,Fan BT

更新日期：2006-01-16 00:00:00

abstract：:The ligand-activated nuclear receptor AhR (aryl hydrocarbon receptor) mediates the response of hepatocytes to various exogenous compounds. AhR is classically activated by planar, aromatic hydrocarbons, but also by other, structurally rather unrelated compounds. Recent data show that the canonical Wnt/β-catenin signali...

journal_title：Toxicology

authors： Vaas S,Kreft L,Schwarz M,Braeuning A

更新日期：2014-11-05 00:00:00

abstract：PURPOSE:The environmental endocrine disruptors, bisphenol A (BPA) and bisphenol S (BPS) are associated with the development of type 2 diabetes. We aim to study the effects of BPA or BPS exposure on adipokine expression in human adipose tissue and on adipocyte glucose uptake. METHODS:Human subcutaneous adipose tissue w...

journal_title：Toxicology

authors： Ahmed F,Sarsenbayeva A,Katsogiannos P,Aguer C,Pereira MJ

更新日期：2020-12-01 00:00:00

abstract：:This study aimed to prove that prenatal ethanol exposure (PEE) can induce nephrotic syndrome in male rat offspring and to explore the underlying intrauterine programming mechanisms. Pregnant Wistar rats were intragastrically administered ethanol (4 g/kg d) from gestational day (GD) 9 to GD 20, and the male fetuses wer...

journal_title：Toxicology

authors： Zhu Y,Zuo N,Li B,Xiong Y,Chen H,He H,Sun Z,Hu S,Cheng H,Ao Y,Wang H

更新日期：2018-05-01 00:00:00

abstract：:The effects of zinc and copper on delta-aminolaevulinic acid dehydratase were studied in vitro and in vivo. The in vitro addition of zinc alone to whole blood resulted in a highly significant increase in enzyme activity. The addition of copper alone had the opposite effect with a significant decrease in enzyme activit...

journal_title：Toxicology

authors： Nelson HM,Hughes MA,Meredith PA

更新日期：1981-01-01 00:00:00

abstract：:It has been widely accepted that microglia, which are the innate immune cells in the brain, upon activation can cause neuronal damage. In the present study, we investigated the role of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in regulating microglial nitric oxide production and its role in causing neuronal damage. T...

journal_title：Toxicology

authors： Li Y,Chen G,Zhao J,Nie X,Wan C,Liu J,Duan Z,Xu G

更新日期：2013-10-04 00:00:00

abstract：:Exposure to polychlorinated biphenyls (PCBs) is associated with numerous adverse health effects. Although the main route of exposure to PCBs is through the gastrointestinal tract, little is known about the contribution of the gut to the health effects of PCBs. We hypothesize that PCBs can disrupt intestinal integrity,...

journal_title：Toxicology

authors： Choi JJ,Choi YJ,Chen L,Zhang B,Eum SY,Abreu MT,Toborek M

更新日期：2012-12-16 00:00:00

abstract：:Several dicationic amphiphilic compounds, such as the immunomodulator tilorone and analogues, impair the lysosomal catabolism of sulphated glycosaminoglycans (GAGs). Thereby they cause lysosomal GAG storage in rats and in cultured fibroblasts of several species including man. The GAG storage is rather slowly reversibl...

journal_title：Toxicology

authors： Bispinck F,Fischer J,Lüllmann-Rauch R,von Witzendorff B

更新日期：1998-07-03 00:00:00

abstract：:The measurement of haemoglobin (Hb) adducts is an important tool for monitoring exposures to industrial chemicals such as ethylene, ethylene oxide and propylene oxide. The aim of the present study was to use this method to monitor occupational exposure to butadiene. The methodology was evaluated with Hb samples obtain...

journal_title：Toxicology

authors： Richardson KA,Megens HJ,Webb JD,van Sittert NJ

更新日期：1996-10-28 00:00:00

abstract：:The effect of amyl nitrite on the erythrocytes of adult and cord hemoglobin was examined in vitro. This study revealed that amyl nitrite caused oxyhemoglobin to become oxidized to methemoglobin wherein a rectangular hyperbolic curve was generated as the reaction progressed. This curve consisted of a reactionary log ph...

journal_title：Toxicology

authors： Tarburton JP,Metcalf WK

更新日期：1985-07-01 00:00:00

abstract：:Previous work has indicated that testosterone pretreatment protects against cadmium-induced toxicity in male rats while other data indicate that pretreatment of mice with testosterone offers no such protection against cadmium. Since cadmium toxicity may vary widely with species and strain, we examined the effect of te...

journal_title：Toxicology

authors： Shimada H,Bare RM,Hochadel JF,Waalkes MP

更新日期：1997-01-15 00:00:00

abstract：:A clonal cell line, R40F, was selected from a heterogenous population of Cd2+ and Zn2+-resistant CHO-K1 cells. These R40F cells demonstrated resistance to 120- and 4-fold higher concentrations of Cd2+ and Zn2+, respectively, than did wild type CHO-K1 cells. When cultured in the presence of low concentrations of Cd2+ (...

journal_title：Toxicology

authors： Gick GG,McCarty KS Sr

更新日期：1983-03-01 00:00:00

abstract：:Rats were injected i.p. with the organophosphate insecticide ABATE and tested over the next 16 days. Animals given 1000 mg/kg showed impaired performance of a previously conditioned avoidance response 6 days after injection but not 2, 8, 10, or 16 days after injection. No behavioral changes were observed in animals gi...

journal_title：Toxicology

authors： Kurtz PJ,Weeks MH

更新日期：1979-05-01 00:00:00

abstract：:Experiments were designed to evaluate and compare metallothionein (MT), zinc and cadmium levels in human placentas of smoking and non-smoking women. Smoking was assessed by self-reported cigarette consumption and urine cotinine levels before delivery. Smoking pregnant women with urine cotinine levels higher than 130 n...

journal_title：Toxicology

authors： Ronco AM,Arguello G,Suazo M,Llanos MN

更新日期：2005-03-01 00:00:00

abstract：:The subacute inhalation toxicity of butenolide was examined in hamsters by repeated exposure of 4 groups of 10 males and 10 females to butenolide vapour at concentrations of 0, 5.4, 25 and 130 ppm respectively (6 h/day, 5 days/week) for a period of 13 weeks. The effects found at 130 ppm included eye irritation, saliva...

journal_title：Toxicology

authors： Feron VJ,Kruysse A,Immel HR,Til HP

更新日期：1979-12-01 00:00:00

abstract：:Chronic beryllium disease (CBD) results from exposure to the light-weight metal beryllium (Be). In vitro stimulation of bronchoalveolar lavage cells from CBD subjects causes the production of high levels of TNF-alpha, IFN-gamma and IL-6. We tested the hypothesis that Be-stimulation might induce the production of TNF-a...

journal_title：Toxicology

authors： Sawyer RT,Kittle LA,Hamada H,Newman LS,Campbell PA

更新日期：2000-03-07 00:00:00

abstract：:Methylmercury is an environmental pollutant that exhibits neurotoxicity when ingested, primarily in the form of neuropathological lesions that localize along deep sulci and fissures, in addition to edematous and inflammatory changes in patient cerebrums. These conditions been known to give rise to a variety of ailment...

journal_title：Toxicology

authors： Yoshida E,Kurita M,Eto K,Kumagai Y,Kaji T

更新日期：2017-12-01 00:00:00