Examination of the structure-toxicity relationships of L-cysteine-S-conjugates of halogenated alkenes and their corresponding mercapturic acids in rat renal tissue slices.

abstract：:Toxicology and carcinogenesis studies of 2 structurally-related p-phenylenediamines, HC Blue No. 1, and HC Blue No. 2 were conducted by administering each chemical in feed for 103 weeks to both sexes of Fischer 344/N rats and B6C3F1 (C57BL/6N x C3H/HEN) mice. Diets containing 0, 1500, or 3000 ppm HC Blue 1 were fed to...

journal_title：Toxicology

authors： Kari FW,Mennear JH,Farnell D,Thompson RB,Huff JE

更新日期：1989-06-01 00:00:00

abstract：:The action of various manganese organic compounds, which are structural analogs of methylcyclopentadienyl manganese tricarbonyl (MMT), was investigated. Only the cyclopentadienyl manganese tricarbonyl compounds are effective inhibitors of mitochondrial respiration, but only when associated with NAD+-linked substrates....

journal_title：Toxicology

authors： Autissier N,Gautheron B,Dumas P,Brosseau J,Loireau A

更新日期：1977-10-01 00:00:00

abstract：:Carbon monoxide (CO) is a dangerous exogenous poison and an essential endogenous neurotransmitter. This gas when inhaled has an anaesthetic effect, which is poorly understood, but which may be fatal if compensatory mechanisms are exhausted, if cardiac oxygen (O(2)) needs exceed myocardial oxygenation and/or if apnoea ...

journal_title：Toxicology

authors： Gorman D,Drewry A,Huang YL,Sames C

更新日期：2003-05-01 00:00:00

abstract：:The subacute inhalation toxicity of butenolide was examined in hamsters by repeated exposure of 4 groups of 10 males and 10 females to butenolide vapour at concentrations of 0, 5.4, 25 and 130 ppm respectively (6 h/day, 5 days/week) for a period of 13 weeks. The effects found at 130 ppm included eye irritation, saliva...

journal_title：Toxicology

authors： Feron VJ,Kruysse A,Immel HR,Til HP

更新日期：1979-12-01 00:00:00

abstract：:Paracetamol, in toxic doses, is associated with extensive liver damage. This represents one of the common causes of morbidity and mortality in drug poisoning cases. This study was undertaken to investigate the possible potentiation of the hepatoprotective action of N-acetylcysteine (NAC) by cimetidine (CMD), an inhibi...

journal_title：Toxicology

authors： Al-Mustafa ZH,Al-Ali AK,Qaw FS,Abdul-Cader Z

更新日期：1997-09-05 00:00:00

abstract：:Mercury has been a known as a toxic substance for centuries. Whilst the clinical features of acute mercury poisoning have been well described, chronic low dose exposure to mercury remains poorly characterised and its potential role in various chronic disease states remains controversial. Low molecular weight thiols, i...

journal_title：Toxicology

authors： Rooney JP

更新日期：2007-05-20 00:00:00

abstract：:Rats which were treated intraperitoneally (i.p.) with FeCl2 X 4H2O expired ethane which increased with increasing doses of iron. The same amount of ethane was expired by animals exposed to 20% or 100% oxygen. The mobilization by FeCl2 of stored ethane from the body was excluded. Propane expiration was also stimulated ...

journal_title：Toxicology

authors： Muliawan H,Kappus H

更新日期：1983-09-01 00:00:00

abstract：:The use of zinc as a nutritional supplement has become common in many countries. Since zinc has diverse actions, it may be difficult to predict its synergistic and/or antagonistic action in simultaneous presence of drug(s). The combination of imidazole antifungals, but not triazole antifungals, with 3-30 microM ZnCl2 ...

journal_title：Toxicology

authors： Matsui H,Sakanashi Y,Oyama TM,Oyama Y,Yokota S,Ishida S,Okano Y,Oyama TB,Nishimura Y

更新日期：2008-06-27 00:00:00

abstract：:The human keratinocyte cell line, RHEK-1, was used to evaluate the cytotoxicity of benzoyl peroxide (BZP). As determined with the neutral red (NR) cytotoxicity assay, the 24-h midpoint (NR50) toxicity values, in mM, were 0.11 for BZP and 29.5 for benzoic acid, the stable metabolite of BZP. Irreversible cytotoxicity oc...

journal_title：Toxicology

authors： Babich H,Zuckerbraun HL,Wurzburger BJ,Rubin YL,Borenfreund E,Blau L

更新日期：1996-01-08 00:00:00

abstract：:Following carbon tetrachloride-induced liver injury, hepatotrophic factors are synthesized and released into the serum to facilitate the regeneration of damaged hepatic tissue. We investigated the possibility that immunosuppression could be mediated through induction of a serum factor(s) because in vivo exposure of B6...

journal_title：Toxicology

authors： Delaney B,Kaminski NE

更新日期：1993-12-15 00:00:00

abstract：:Metal working fluids (MWFs) have been widely known to cause asthma and neoplasia of the larynx, pancreas, rectum, skin and urinary bladder (Textbook of Clinical Occupational and Environmental Medicine (1994) 814; Am. J. Ind. Med. 32 (1997) 240; Am. J. Ind. Med. 33 (1997) 282; Am. J. Ind. Med. 22 (1994) 185). Other non...

journal_title：Toxicology

authors： Shvedova AA,Kisin E,Murray A,Goldsmith T,Reynolds JS,Castranova V,Frazer DG,Kommineni C

更新日期：2002-08-15 00:00:00

abstract：:The agricultural fungicide, N-(3,5-dichlorophenyl)succinimide (NDPS) induces acute polyuric renal failure which is attenuated by pretreatment with the glutathione depletors, diethyl maleate or buthionine sulfoximine (BSO). In the present study, the temporal aspects of BSO attenuation of NDPS nephrotoxicity were invest...

journal_title：Toxicology

authors： Rankin GO,Beers KW,Teets VJ,Nicoll DW,Anestis DK

更新日期：1997-02-28 00:00:00

abstract：:Mutagenicity analysis of urine from rats treated by oral gavage with MX at a dose of 64 mg/kg for 14 days revealed that only 0.3% of the administered compound was excreted in a genotoxically active form. At lower doses, mutagenicity was not detectable. No evidence of micronucleus induction in peripheral blood erythroc...

journal_title：Toxicology

authors： Meier JR,Monarca S,Patterson KS,Villarini M,Daniel FB,Moretti M,Pasquini R

更新日期：1996-06-17 00:00:00

abstract：:The present study investigates the influence of different levels of Schistosoma mansoni infection (60, 120, 180, 300, 600 cercariae per mice) after 33 days on the activity of aryl hydrocarbon hydroxylase (AHH) and the formation of hepatic hydrogen peroxide (H(2)O(2)) during the metabolic activation of benzo(a)pyrene [...

journal_title：Toxicology

authors： Awney HA,Ghzlan HE,Sheweita SA,Mostafa MH

更新日期：2001-06-21 00:00:00

abstract：:There is considerable interest in gene and environment interactions in neurodegenerative diseases. The HFE (homeostatic iron regulator) gene variant (H63D) is highly prevalent in the population and has been investigated as a disease modifier in multiple neurodegenerative diseases. We have developed a mouse model to in...

journal_title：Toxicology

authors： Song IY,Snyder AM,Kim Y,Neely EB,Wade QW,Connor JR

更新日期：2020-08-01 00:00:00

abstract：:The ability of cis-dichlorodiammine platinum II to cause chromosomal aberrations in rats and dominant lethality in mice was studied. Five daily intraperitoneal doses ranging from 0.25 to 2.00 mg/kg/day failed to result in the observance of dominant lethal mutations in mice. Intraperitoneal doses of 0.13 and 0.52 mg/kg...

journal_title：Toxicology

authors： Levine BS,Preache MM,Pergament E

更新日期：1980-01-01 00:00:00

abstract：:Thimerosal (TH), an ethylmercury complex of thiosalicylic acid has been used as preservative in vaccines. In vitro neurotoxicity of TH at high nM concentrations has been reported. Although a number of toxicological experiments demonstrated high affinity of mercury to thiol groups of the extracellular amino acids and p...

journal_title：Toxicology

authors： Zieminska E,Toczylowska B,Stafiej A,Lazarewicz JW

更新日期：2010-10-29 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is a cellular process during which epithelial polarized cells become motile mesenchymal-appearing cells, which in turn promotes carcinoma invasion and metastasis. Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural polyphenolic compound found in grapes, red wine and se...

journal_title：Toxicology

authors： Wang H,Zhang H,Tang L,Chen H,Wu C,Zhao M,Yang Y,Chen X,Liu G

更新日期：2013-01-07 00:00:00

abstract：:Because it had been suggested that alpha-tocopherol might protect protein thiols (PSH) from oxidation, we were interested in determining if alpha-tocopherol could prevent or mitigate nitrofurantoin-induced changes in the glutathione (GSH) or PSH status of the liver. Isolated rat livers were perfused in the single pass...

journal_title：Toxicology

authors： Hoener B,Hjalmarson AC

更新日期：1991-04-08 00:00:00

abstract：:Subacute exposure of male rats to various concentrations (70-1000 ppm) of dichloromethane (DCM) produces a selective reduction of dopamine (DA) levels without a change of DA turnover in certain types of forebrain DA nerve terminal systems. In the low concentration (70 ppm) a selective reduction of DA turnover was obse...

journal_title：Toxicology

authors： Fuxe K,Andersson K,Hansson T,Agnati LF,Eneroth P,Gustafsson JA

更新日期：1984-02-01 00:00:00

abstract：:Indoor suspended particulate matter (SPM) consists of many different types of particles, the vast majority of which are less than 2.5 microm in diameter. An important question is how these particles, being inhalable, contribute to asthma and respiratory symptoms. One possibility is that these particles have an adjuvan...

journal_title：Toxicology

authors： Ormstad H,Gaarder PI,Johansen BV,Løvik M

更新日期：1998-08-21 00:00:00

abstract：:Nonylphenol (NP) has been identified at low levels in surface waters throughout North America. This industrial chemical is primarily used for the production of certain non-ionic surfactants, and has been reported to have weak estrogen-like activity. As estrogen has immunoregulatory properties and is crucial for normal...

journal_title：Toxicology

authors： Karrow NA,Guo TL,Delclos KB,Newbold RR,Weis C,Germolec DR,White KL Jr,McCay JA

更新日期：2004-03-15 00:00:00

abstract：:We have previously shown that young guinea pigs repeatedly exposed to sidestream cigarette smoke (SS) develop decreased airway reactivity of the C-fiber system without changing reactivity to one of its neurotransmitters, substance P (SP). This study was designed to determine whether the decreased reactivity was due to...

journal_title：Toxicology

authors： Joad JP,Avadhanam KP,Watt KC,Kott KS,Bric JM,Pinkerton KE

更新日期：1996-09-02 00:00:00

abstract：:Chemical carcinogens are generally classified as genotoxic or non-genotoxic. However, weak genotoxicity at high concentrations is sometimes observed and interpretation is often problematic. In addition, certain rodent carcinogens exert their effects at doses associated with cytotoxicity and compensatory hyperplasia ma...

journal_title：Toxicology

authors： Beddowes EJ,Faux SP,Chipman JK

更新日期：2003-05-03 00:00:00

abstract：:Direct ingestion of contaminated soil by depleted uranium (DU) might lead to internal exposure to DU by local populations through hand contamination. The purpose of this study was to assess the immunological changes of long-term exposure to various doses of DU in mice. Three-week-old Kunming mice were divided into the...

journal_title：Toxicology

authors： Hao Y,Ren J,Liu J,Yang Z,Liu C,Li R,Su Y

更新日期：2013-07-05 00:00:00

abstract：:Excretion and organ distribution of mercury and susceptibility to methylmercury (MeHg) toxicity were compared between strains and sexes after successive oral administration of MeHg chloride (5 mg/kg per day) using BALB/cA (C) and C57BL/6N (B6) mice. Every mouse died several days after initiation of toxic symptoms, and...

journal_title：Toxicology

authors： Yasutake A,Hirayama K

更新日期：1988-09-01 00:00:00

abstract：:Peroxisome proliferators (PP) are a large class of structurally diverse chemicals that mediate their effects in the liver mainly through the peroxisome proliferator-activated receptor alpha (PPARalpha). Exposure to PP results in down-regulation of CYP2C family members under control of growth hormone and sex steroids i...

journal_title：Toxicology

authors： Fan LQ,Brown-Borg H,Brown S,Westin S,Mode A,Corton JC

更新日期：2004-10-15 00:00:00

abstract：:It is well known that selenium is highly toxic to several species of mammals. Here we report the potential neurotoxicity of diselenides, as measured by the manifestation of seizures. The modulation of various neurotransmitter systems potentially involved in seizure episodes and death was also evaluated. The results of...

journal_title：Toxicology

authors： Nogueira CW,Meotti FC,Curte E,Pilissão C,Zeni G,Rocha JB

更新日期：2003-02-01 00:00:00

abstract：:Several inhibitors of cytochrome P-450 mediated oxidative transformations, ethyl 2-diethylaminoethyl-2-phenyl-2-ethylmalonate, ethyl-2-diethyl-aminoethyl-2-ethyl-2-buthylmalonate, 2,4 dichloro-6-phenoxyethyl diethylamine, 2-diethylaminoethyl-2-phenyl- (2-propene)-4-penten-1-oate or 3-amino,1,2,4 triazole were not able...

journal_title：Toxicology

authors： de Ferreyra EC,de Fenos OM,Castro JA

更新日期：1980-01-01 00:00:00

abstract：:Colicins are unusual bacterial toxins because they are directed against close relatives of the producing strain. They kill their targets in one of three distinct ways; via a ribonuclease or deoxyribonuclease activity or by forming pores in the target cell's membrane. This review deals with the steps involved in pore-f...

journal_title：Toxicology

authors： Lakey JH,van der Goot FG,Pattus F

更新日期：1994-02-28 00:00:00