Abstract:
:Resistance to chemotherapy is a major obstacle for the effective treatment of cancers. The mechanism of chemo-resistance is still poorly understood, however, mounting evidence supports a role for microRNAs (miRNAs) in modulating key cellular pathways mediating response to chemotherapy. microRNA-21 (miR-21) has been implicated in many cancers and contributed to chemo-resistance, but its role in gastric cancer drug resistance still remains unexplored. The aim of this study was to investigate whether miR-21 mediated resistance of the gastric cancer cell line SGC7901 to the chemotherapeutic agent cisplatin (DDP). Our study found that the expression of miR-21 upregulated in the cisplatin resistant cell line SGC7901/DDP compared to its parental line SGC7901. Moreover, over-expression of miR-21 significantly decreased antiproliferative effects and apoptosis induced by cisplatin, while knockdown of miR-21 dramatically increased antiproliferative effects and apoptosis induction by cisplatin. In addition, miR-21 induced cell survival and cisplatin resistance through downregulating the expression of phosphatase and tension homolog deleted on chromosome 10 (PTEN) and activation of Akt pathway. Inhibition of Akt using PI3K inhibitor LY 294002 could abrogate miR-21 induced cell survival. These results suggest that miR-21 may provide a novel mechanism for understanding cisplatin resistance in gastric cancer by modulating PTEN/PI3K/Akt pathway.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Yang SM,Huang C,Li XF,Yu MZ,He Y,Li Jdoi
10.1016/j.tox.2013.02.014subject
Has Abstractpub_date
2013-04-05 00:00:00pages
162-8eissn
0300-483Xissn
1879-3185pii
S0300-483X(13)00060-7journal_volume
306pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::The present study was undertaken to examine the effects of iodoacetic acid, a non-phorbol tumor promoter, on metabolic cooperation between mutant human fibroblasts as measured by [14C]citrulline incorporation. Other thiol-reactive polyphenolic compounds such as hydroquinone and 2-hydroxyestrone were also examined. 12-...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90047-3
更新日期:1987-04-01 00:00:00
abstract::This study was designed to evaluate the cardioprotective potential of naringin on lipid peroxides, enzymatic and nonenzymatic antioxidants and histopathological findings in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Subcutaneous injection of ISO (85 mg/kg) to male Wistar rats showed a significant ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.09.005
更新日期:2006-12-07 00:00:00
abstract::Metallothionein, a low molecular weight cadmium-binding protein, has been determined for the first time in urine of "itai-itai" disease patients and other Japanese women environmentally exposed to cadmium. On a group basis, the urinary metallothionein levels of "itai-itai" disease patients and suspected patients were ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(81)90036-6
更新日期:1981-01-01 00:00:00
abstract::Some workers have suggested that 6 days xylitol administration to rats results in hepatic dysfunction. In our study xylitol was administered to rats by daily gastric intubation for a period of 14 days. Dose levels were 1.25, 2.5, 5 and 10 g/kg. During treatment (2, 5 and 14 days), animals were submitted to careful cli...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(77)90025-7
更新日期:1977-08-01 00:00:00
abstract::Valproic acid (VPA) and the unsaturated metabolites, 2-ene VPA and (E)-2,(Z)-3'-diene VPA, demonstrated dose-dependent cytotoxicity in primary cultures of rat hepatocytes, as evaluated by lactate dehydrogenase (LDH) leakage. Cellular glutathione (GSH) was depleted by adding buthionine sulfoximine (BSO) to the culture ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(96)03352-5
更新日期:1996-08-01 00:00:00
abstract::For half of the 30-odd years that diacetyl-exposed workers have developed disabling lung disease, obliterative bronchiolitis was unrecognized as an occupational risk. Delays in its recognition as an occupational lung disease are attributable to the absence of a work-related temporal pattern of symptoms; failure to rec...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2016.06.009
更新日期:2017-08-01 00:00:00
abstract::Both catecholamine (CA) released from adrenal chromaffin cells and hydrogen sulfide (H2S) have been shown to play critical roles in the regulation of hypoxic stress response. Our previous study has demonstrated that exogenous H2S directly induced quantal CA released from adult rat adrenal chromaffin cells (ARACCs) by ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2013.06.014
更新日期:2013-10-04 00:00:00
abstract:OBJECTIVE:Ozone has become a major air pollutant in recent years, which leading to a variety of lung diseases. This study aimed to explore the mechanisms of pyroptosis and related signaling pathways in ozone-induced lung injury. METHODS:We exposed 120 Wistar rats to ozone, 20 in each group (half male and half female)....
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152668
更新日期:2020-12-28 00:00:00
abstract::Inorganic arsenic (iAs) and its metabolites are transferred to the foetus through the placental barrier and this exposure can compromise the normal development of the unborn. For this reason, we assessed the toxicity of sodium arsenite (iAs(III)) and its metabolites dimethylarsinic acid (DMA(V)), monomethylarsonic aci...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2008.04.008
更新日期:2008-07-30 00:00:00
abstract::Although NO2-induced cytotoxic responses have been well characterized, the specific mechanisms responsible for initiating toxicity remain equivocal. The inhomogeneous distribution of epithelial injury suggests that differential interactions between NO2 and the lung surfaces may contribute to the extent of regional res...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(94)90099-x
更新日期:1994-05-20 00:00:00
abstract::Allergic reactions are among the common adverse effects in humans. However, it is widely assumed that there are practically no reliable animal models for preclinical tests of low-molecular weight drugs that are available to predict such reactions. This study was designed to compare the detecting ability of test method...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00118-2
更新日期:1997-11-21 00:00:00
abstract::CI-959 is an orally effective inhibitor of cellular activation in both in vitro and animal models. To assess the effects of CI-959 on immune function, male Fischer 344 rats were evaluated for splenic T- and B-lymphocyte populations, antibody-forming cell response to sheep red blood cells (sRBC), concanavalin A and pok...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)02985-4
更新日期:1995-04-12 00:00:00
abstract::Toluene is a widely abused inhaled solvent. This study was designed to determine whether toluene abuse affects the reproductive functions or general health of males. Seven-week-old male Sprague-Dawley rats were exposed to toluene vapor inhalation (0, 4000, or 6000 ppm; 2 h/day) daily for 5 weeks. Exposure-related supp...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(99)00120-1
更新日期:1999-12-06 00:00:00
abstract::The aim of this study was to compare the roles of dihydropyridine calcium antagonists nifedipine, nitrendipine, amlodipine on doxorubicin (DXR)-induced nephrotoxicity in rats using biochemical, histopathological and immunohistochemical approaches. Male Sprague-Dawley rats were randomly divided into five experimental g...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.11.067
更新日期:2007-02-28 00:00:00
abstract::It is well known that selenium is highly toxic to several species of mammals. Here we report the potential neurotoxicity of diselenides, as measured by the manifestation of seizures. The modulation of various neurotransmitter systems potentially involved in seizure episodes and death was also evaluated. The results of...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00423-7
更新日期:2003-02-01 00:00:00
abstract::The effect of tert-butyl hydroperoxide (tBH) on the nucleotide level in isolated cardiomyocytes from adult rats was examined. Incubation of myocytes with the hydroperoxide resulted in loss of both ATP and NAD from mitochondria and cytosol. In contrast, only the cytosolic level of NADP was increased. The effect on myoc...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(95)03158-c
更新日期:1996-01-08 00:00:00
abstract::Deltamethrin, an alpha-cyano type II synthetic pyrethroid insecticide is used to control a wide range of insects on a variety of crops. Deltamethrin is reported to cause many adverse effects on non-target species. Deltamethrin is reported to cause DNA damage and micronuclei induction in human lymphocytes. It is highly...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00416-9
更新日期:2001-05-28 00:00:00
abstract::Dietary exposure to vomitoxin (VT) results in hyperelevated serum IgA and IgA nephropathy in mice. To assess the possible role of cytokines in this IgA dysregulation, the effects of a single oral exposure in B6C3F1 male mice to 0, 5 or 25 mg/kg BW VT on production of IgA and cytokines in Peyer's patch (PP) and spleen ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00087-5
更新日期:1997-09-26 00:00:00
abstract::Myopathy is among the well documented and the most disturbing adverse effects of statins. The underlying mechanism is still unknown. Mitochondrial dysfunction related to coenzyme Q10 decline is one of the proposed theories. The present study aimed to investigate the mechanism of atorvastatin-induced myopathy in rats. ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2016.06.015
更新日期:2016-06-01 00:00:00
abstract::The toxicity of daily subcutaneously applied 500 mg/kg N-methylformamide (NMF) during a period of 8 days in female CD-mice was ameliorated when 100 mg/kg sodium ascorbate, 60 mg/kg menadione bisulfite or 80 mg/kg pyridoxal hydrochloride were applied simultaneously. The comparison of the daily s.c. application of 360 m...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90008-4
更新日期:1987-02-01 00:00:00
abstract::Maintenance of health is dependent on numerous regulatory interactions between organ systems. This review discusses interorgan communication between the nervous, endocrine, and immune systems and environmental and genetic influences on this neuroendocrine immune circuitry. Stresses of multiple types, including psychol...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(99)00144-4
更新日期:2000-01-17 00:00:00
abstract::Epithelial-to-mesenchymal transition (EMT) is a cellular process during which epithelial polarized cells become motile mesenchymal-appearing cells, which in turn promotes carcinoma invasion and metastasis. Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural polyphenolic compound found in grapes, red wine and se...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2012.09.017
更新日期:2013-01-07 00:00:00
abstract::A recent epidemiological study showed an increased risk for bone fractures after chronic low-level cadmium exposure. This finding agrees with those of cadmium accumulation in rat bones after chronic oral exposure which reduced the mechanical strength of the bones. There are indications that ossicular cadmium uptake ma...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00364-4
更新日期:2001-02-21 00:00:00
abstract::The use of accurate and sensitive methods for the measurement of cytokines in body fluids is an absolute prerequisite for the proper use of these mediators in clinical practice. Many factors contribute to the complexity of cytokines quantitation: these molecules circulate at very low levels (e.g. pg/ml) under various ...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(98)00063-8
更新日期:1998-08-07 00:00:00
abstract::Multidrug resistance type 1 P-glycoproteins (P-gp) and multidrug resistance associated proteins (MRP) were studied in differentiated primary human lung cells in culture, in comparison with permanent human lung cell lines and primary alveolar type II cells from rat lung. AII cells exhibited low basal levels of mdr1b mR...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(01)00458-9
更新日期:2001-10-05 00:00:00
abstract::Databases in science and technology dealing with toxicology subjects are of great and increasing interest to the scientific community. International hosts pay their tribute in creating toxicology clusters as a user-aid. Toxicology clusters of DataStar, DIALOG, DIMDI and STN are listed and compared. At the German Natio...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(95)03092-t
更新日期:1995-06-26 00:00:00
abstract::Food allergy is a significant health issue in the UK, affecting between 1 and 2% of adults and 5 and 8% of children. The UK Food Standards Agency seeks to ensure the safety of food allergic consumers by providing them with information and guidance on food choices. Since 1995, with the aim of addressing important polic...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2010.08.007
更新日期:2010-12-30 00:00:00
abstract::The toxicity to HeLa cells of 29 plasticizers was determined in the MIT-24 test system. The 7-day IC50 for HeLa cells varied from 260 to 1.5 g/l. Phthalates, adipates, sebacates, azelates and phosphates with long carbon chain alcohols were very non-toxic to the cells, probably due to insolubility in water of the compo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(82)90002-6
更新日期:1982-01-01 00:00:00
abstract::This paper presents an overview of issues related to surface water contamination arising from uranium mining activities in the Alligator Rivers Region (ARR) of northern Australia, and a program of research and monitoring that must assess the potential and actual effects on ecosystem and human health. The program of as...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(02)00470-5
更新日期:2002-12-27 00:00:00
abstract::Groups of 15 male and 15 female rats were give 0 (control), 50, 100, 200 or 800 ppm allyl alcohol in the drinking water for 15 weeks. There were no effects attributable to allyl alcohol in the results of the haematological examinations or analyses of serum. There was a dose-related reduction in the fluid intake at all...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(78)90029-x
更新日期:1978-02-01 00:00:00