Abstract：
:Metallothionein, a low molecular weight cadmium-binding protein, has been determined for the first time in urine of "itai-itai" disease patients and other Japanese women environmentally exposed to cadmium. On a group basis, the urinary metallothionein levels of "itai-itai" disease patients and suspected patients were significantly higher than that of women living in a cadmium-polluted area. Women living in a non-polluted area excreted significantly less metallothionein than women living in a cadmium-polluted area. A similar trend was observed for urinary beta 2-microglobulin, a nonspecific index of renal tubular dysfunction. However, mean levels of urinary cadmium in the "itai-itai" disease patients, suspected patients and women living in the cadmium-polluted area were similar. It is suggested that if, in addition to beta 2-microglobulin and cadmium, metallothionein is used as another index of cadmium exposure, monitoring of renal tubular dysfunction caused by cadmium may be more effectively carried out.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Tohyama C,Shaikh ZA,Nogawa K,Kobayashi E,Honda Rdoi
10.1016/0300-483x(81)90036-6subject
Has Abstractpub_date
1981-01-01 00:00:00pages
289-97issue
4eissn
0300-483Xissn
1879-3185pii
0300-483X(81)90036-6journal_volume
20pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Cyclosporine (CsA) is a universally used immunosuppressive drug which induces adverse side effects in several organs, but its impact on the heart is still controversial. Small heat shock proteins (sHSPs), such as HSP25 and alpha B-crystallin, are cytoprotective stress proteins exceptionally represented in the heart. T...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.06.007
更新日期：2009-08-21 00:00:00
abstract：:Nine structurally different polycyclic aromatic hydrocarbons (PAHs) were tested for their ability to either agonize or antagonize the human androgen receptor (hAR) in a sensitive reporter gene assay based on CHO cells transiently cotransfected with a hAR vector and an MMTV-LUC vector. Benz[a]anthracene (B[a]A), benzo[...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00143-8
更新日期：2000-04-14 00:00:00
abstract：:Utah Valley has provided an interesting and unique opportunity to evaluate the health effects of respirable particulate air pollution (PM10). Residents of this valley are predominantly nonsmoking members of the Church of Jesus Christ of Latter-day Saints (Mormons). The area has moderately high average PM10 levels with...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(96)03372-0
更新日期：1996-07-17 00:00:00
abstract：:Induction of lung aryl hydrocarbon hydroxylase (AHH) activity has been studied in rats following their exposure to different regimes of cigarette smoke produced from tobacco and the tobacco substitute NSM. The rate of induction of AHH was maximal during the first 3 days of exposure to tobacco smoke. The frequency of e...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(81)90135-9
更新日期：1981-01-01 00:00:00
abstract：:Treatment of rats with beta-alanine increases the urinary taurine levels and markedly reduces the concentration of taurine in the liver. Dosing with carbon tetrachloride (CCl4) during treatment with beta-alanine results in a marked decrease in urinary taurine concomitant with a decrease in food intake. Treatment of an...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90133-d
更新日期：1993-01-29 00:00:00
abstract：:Numerous dietary compounds, ubiquitous in fruits, vegetables and spices have been isolated and evaluated during recent years for their therapeutic potential. These compounds include flavonoid and non-flavonoid polyphenols, which describe beneficial effects against a variety of ailments. The notion that these plant pro...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2009.11.008
更新日期：2010-11-28 00:00:00
abstract：:To elucidate factors responsible for altered proliferation of preneoplastic hepatocytes in rat hepatocarcinogenesis in vivo, EGF-stimulated DNA synthesis of normal and nodular hepatocytes in primary culture was studied. In addition, the influence of 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated to clari...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00189-4
更新日期：2000-04-03 00:00:00
abstract：:The organophosphorus nerve agent soman is an irreversible cholinesterase (ChE) inhibitor that can produce long-lasting seizures and seizure-related brain damage (SRBD) in which acetylcholine and glutamate are involved. Since these neurotransmitters play a key-role in the auditory function, it was hypothesized that a h...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2010.08.014
更新日期：2010-11-09 00:00:00
abstract：:The effects of di-(2-ethylhexyl)adipate (DEHA) have been compared in female F344 rats and female B6C3F1 mice fed diets containing 0-4.0% DEHA and 0-2.5% DEHA, respectively, for periods of 1, 4 and 13 weeks. In both the rat and mouse treatment with DEHA at all time points produced a dose-dependent increase in relative ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(97)00125-x
更新日期：1997-12-05 00:00:00
abstract：:We compared the results of the multiple-dose guinea pig maximization test (GPMT) and the non-radioactive murine local lymph-node assay (LLNA) for various biocides. Thirteen out of 17 positive biocides in the GPMT gave positive results in the LLNA. In the GPMT, the minimum first induction doses ranged over four orders ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.02.014
更新日期：2005-07-01 00:00:00
abstract：:A mixture of 55% tallow alkyl ethoxylate sulfate (TAE3S) and 45% of linear alkylbenzene sulfonate (LAS) was fed to two generations of rats at dietary levels of 0.1, 0.5 or 1.0%. The rats were fed the surfactant mixture either continuously or during the organogenesis (days 6-15) period of six pregnancies. In addition,...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(75)90103-1
更新日期：1975-05-01 00:00:00
abstract：:To evaluate the developmental toxicity of uranium, 5 groups of 20 pregnant Swiss mice were given by gavage daily doses of 0, 5, 10, 25 and 50 mg/kg of uranyl acetate dihydrate on gestational days 6-15. Cesarean sections were performed on all females on gestation day 18. Fetuses were examined for external, visceral, an...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(89)90181-9
更新日期：1989-04-01 00:00:00
abstract：:Chronic treatment of BALB and GRS mice with BHT (2,6-di-tert-butyl-4-methylphenol) following a single urethane injection increases lung tumor multiplicity, but this does not occur in CXB4 mice. Previous data suggest that promotion requires the conversion of BHT to a tert-butyl-hydroxylated metabolite (BHTOH) in lung a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00449-2
更新日期：2001-03-07 00:00:00
abstract：:Mitochondria play a central role in the life and death of cells. These organelles serve as the major energy-producing power-house, whereby the generation of ATP is associated with the utilization of molecular oxygen. A significant fraction (2-3%) of molecular oxygen consumed by mitochondria may be reduced in a one-ele...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2004.11.027
更新日期：2005-03-15 00:00:00
abstract：:Databases in science and technology dealing with toxicology subjects are of great and increasing interest to the scientific community. International hosts pay their tribute in creating toxicology clusters as a user-aid. Toxicology clusters of DataStar, DIALOG, DIMDI and STN are listed and compared. At the German Natio...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(95)03092-t
更新日期：1995-06-26 00:00:00
abstract：:Lead is known to impede the male reproductive function, however, the mechanisms through which the adverse effects are mediated are not clearly elucidated. In order to get insight into those mechanisms, we have examined the effects of lead on the biosynthesis of steroid hormones by Leydig cells in the rat. To determine...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(95)03107-q
更新日期：1995-11-20 00:00:00
abstract：:The pharmacokinetics of selected aluminum-hydroxypyridinone (Al-HP complexes were determined in rats to better understand the relationship between their disposition and elimination parameters and the safety of HPs in the chelation therapy of Al intoxication. Five complexes were administered as i.v. bolus doses of Al-H...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90177-5
更新日期：1994-09-06 00:00:00
abstract：:Food allergy is a significant health issue in the UK, affecting between 1 and 2% of adults and 5 and 8% of children. The UK Food Standards Agency seeks to ensure the safety of food allergic consumers by providing them with information and guidance on food choices. Since 1995, with the aim of addressing important polic...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2010.08.007
更新日期：2010-12-30 00:00:00
abstract：:The ubiquitous presence of nanoparticles (NPs) together with increasing evidence linking them to negative health effects points towards the need to develop the understanding of mechanisms by which they exert toxic effects. This study was designed to investigate the role of surface area and oxidative stress in the cell...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.04.001
更新日期：2009-06-16 00:00:00
abstract：:We studied the effect of O,S,S-trimethyl phosphorodithioate (OSS-Me) on macrophage function and the immune responses of both T- and B-cells using an in vitro system. The involvement of glutathione (GSH) in the bioactivation of OSS-Me to suppress such responses was investigated after either direct culture with spleen o...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90155-1
更新日期：1986-04-01 00:00:00
abstract：:Cadmium being a potent immunotoxicant, affects both humoral and cell mediated immunity. However, its effect on spleen is not clearly understood. Hence, to delineate the action of Cd, mouse splenic lymphocytes were exposed to Cd (10, 25 and 50 microM) for 60 min, 1.5, 3, 6 and 18 h. At 6 h, apoptosis was reflected by D...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.11.027
更新日期：2006-03-01 00:00:00
abstract：:The neurotoxicity and developmental effects of a widely applied insecticide (methomyl) was investigated by a multi-level approach (behavior and biometry, biochemical alterations and neurodegeneration) in Caenorhabditis elegans upon a short-term exposure (1 h) and a post-exposure period (48 h). The 1-h exposure to sub-...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2021.152684
更新日期：2021-01-25 00:00:00
abstract：:The present study investigates the influence of different levels of Schistosoma mansoni infection (60, 120, 180, 300, 600 cercariae per mice) after 33 days on the activity of aryl hydrocarbon hydroxylase (AHH) and the formation of hepatic hydrogen peroxide (H(2)O(2)) during the metabolic activation of benzo(a)pyrene [...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00372-9
更新日期：2001-06-21 00:00:00
abstract：:The intragastric administration to male Wistar rats of T-2 toxin at 1-1.3 mg/kg body weight for 7 days caused a sharp decrease in the liver activity of lysosomal enzymes: beta-galactosidase, beta-N-acetylglucosaminidase, alpha-mannosidase, cathepsins A, B, C and D and in the activity of enzymes of the 1st phase of met...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90094-6
更新日期：1986-12-01 00:00:00
abstract：:BHK21 fibroblastic cells were exposed in vitro to lead microparticles produced by pyrolysis of the organic lead used as an antiknock agent in gasoline. Although non-cytolethal, 10 micrograms of lead/10(6) cells rapidly inhibited cell growth kinetics as well as [3H]thymidine and L-[3H]leucine incorporation by the BHK21...
journal_title：Toxicology
pub_type： 杂志文章
doi：
更新日期：1979-08-01 00:00:00
abstract：:Previous studies have shown that magnesium, unlike calcium, prevents cadmium carcinogenesis at the subcutaneous injection site, and that neither magnesium nor calcium has any significant influence on the production of testicular tumors by cadmium in rats. The present investigation attempts to disclose the nature of th...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(85)90173-8
更新日期：1985-03-15 00:00:00
abstract：:Ursodeoxycholic acid (UDCA) has been widely used for treating cholestatic liver diseases. However, in a recent review of clinical trial articles, its therapeutic benefits were not proven. Therefore, we investigated whether UDCA prevents or potentiates glycochenodeoxycholic acid (GCDCA)-induced apoptosis in isolated ra...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.05.025
更新日期：2005-10-15 00:00:00
abstract：:The possibility that nitrofurantoin is a complete carcinogen or is an initiator or promoter of urinary bladder carcinogenesis was evaluated in male weanling F344 rats. No increase in tumor incidence was observed in rats fed nitrofurantoin at a level of 0.187% of the diet for 2 years compared to a control group. Also, ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90056-m
更新日期：1990-06-01 00:00:00
abstract：:The majority of insecticides currently in use throughout the world belong to the class of the organophosphorus insecticides. Many of these compounds, such as the phosphorothioate insecticides, exert their mammalian toxicity only after undergoing metabolic activation by a variety of cytochrome P450 isoforms to produce ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(98)00125-5
更新日期：1998-11-16 00:00:00
abstract：:Gordonia axillaris (Roxb.) Dietrich (Theaceae) is a native to Taiwan and the leaves have been used as an astringent folk medicine. Camelliin B (CB), a macrocyclic hydrolyzable tannin, was isolated from G. axillaris and showed cytotoxic effects in human carcinoma cells. Among the target cells (SKHep-1, Ha-22T, DU-145, ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00452-8
更新日期：2001-11-30 00:00:00
